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FARMAKOLOGI PADA KEDARURATAN KLINIS

FARMAKOLOGI kedaruratan medik

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FARMAKOLOGIPADA KEDARURATAN

KLINIS

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MANIFESTASI KEDARURATANKLINIS

1. Kehilangan kesadaran (k !a"#. S$ k

%. Peningka&an &ekanan darah'. Sesak na as $ang )era&*. Rasa saki& $ang he)a&

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PRINSIP PENGGUNAAN O+ATPADA KEDARURATAN KLINIS

1. M,la ker-a $ang e/a& (Ra/id nse& a &i n"

#. Re0ersi)ili&as $ang e/a&%. E ek sa!/ing !ini!al'. Tidak )ersi a& an&igenik

*. T ksisi&as $ang rendah

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O+AT O+AT 2ANG LA3IMDIGUNAKAN

1. O)a& ,n&,k !enga&asi k ndisi hilangn$akesadaran ses,ai dengan /en$e)a)n$a

#. Analgesik / &en

%. 4as k ns&rik& r'. 4as dila& r*. S&i!,lan -an&,ng5. Di,re&ik,!6. An&i in7a!asi / &en8. +r nk dila& r (!,la ker-a e/a&"9. An&id &,! s/esi:k (/ada kera ,nan"

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O)a& ,n&,k !enga&asihilangn$a kesadaran(k !a"ses,ai dengan /en$e)a)n$a

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KOMA ;IPERGLIKEMIKUM

INSULINReg,lar ins,lin <

Sh r& a &ing s l,)le ins,lin da/a&di)erikan se ara i.0 a&a, denganin ,si n /,!/Sh r& a &ing s l,&i n r$s&aline =inins,lin di)erikan se ara s. > e ek&erliha& dala! 1* !eni& dan )erakhirse&elah * 6 -a!

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KOMA ;IPERGLIKEMIKUM

INSULIN;,!an ins,lin

Sa!a e ek&i n$a dengan ins,lin darihe?an @ si a& an&igenikn$a ins,lindari he?an

Ins,lin sh r& a &ing> in&er!edia&ea &ing> l ng a &ing

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K !/likasiBe ek sa!/ing/e!)erian ins,lin

• ;i/ glike!i• Alergi•

Resis&en &erhada/ ins,lin• A&r : -aringan le!ak s,) k,&an

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KOMA ;IPOGLIKEMIKUM

GLUCAGONMeningka&kan G /r &ein linked /adaak&i0i&as aden$l$l $ lase @ /r d,ksi

AMP !e! asili&asi ka&a) lis!eglik gen @ gl,k ne genesis danke& genesis kadar g,la darahA/likasi klinis<

k !a hi/ glike!ik,! Kera ,nan )a& /engha!)a& rese/& r

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ANALGESIK POTEN

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Analgesik / &en (analgesiknark &ik"

MORP;INEMe!/,n$ai ke!a!/,an ,n&,k!eng,)ah /erse/si dan reaksi rasasaki&Meningka&kan kadar a!)ang&erhada/ rasa saki&

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A/likasi klinis ! r/hine /adakedar,ra&an !edis

• Menga&asi rasa saki& $ang he)a& $ang &idakda/a& dia&asi leh analgesik n n nark &ik

n$eri /ada in ark !i ard

Okl,si /e!),l,h darah $ang ak,& n$eri /ada l,ka )akar> rak&,r> dll• E ek sa!/ing ! r/hine < & leransi

ke&ergan&,ngan /e &ek in&ra kranial De/resi /erna/asan> dll

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4ASOKONSTRIKTOR

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4as k ns&rik& r/ada kedar,ra&an !edis

D /a!in dan Adrenalin4as k ns&rik& r $ang / &en dans&i!,lan -an&,ng +eker-a !elal,i /erangsanganadren rese/& r > 1 > #

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A/likasi klinis adrenalin/ada kedar,ra&an !edis

1. Cardia & arres&#. Menga&asi s$ k ana:laksis

Merangsang ker-a -an&,ng4as k ns&riksi /e!).darah /eri er+r nk dila&asi (!e!,dahkan

a!)ilan ksigen"

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A/likasi klinis D /a!in/ada kedar,ra&an !edis

1. S$ k kardi genik#. S$ k se/&ik

%. Gagal -an&,ng

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4ASODILATOR

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4as dila& r/ada kedar,ra&an !edis

NITROGL2CERINDi)erikan se ara s,)ling,alMeningka&kan aliran darah k r nerMens&i!,lasi en=i! g,an$l $ lase /ada&r !) si& sehingga agregasi &r !) si&M,la ker-a e/a&

Di)erikan )ila &ekanan darah sis& lik 1!!;gA/likasi klinis < In ark !i ard dan angina

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4as dila& r/ada kedar,ra&an !edis

NITROPRUSSID4as dila& r $ang / &enMens&i!,lasi en=i! g,an$l$l $ lase shg

GMP !en$e)a)kan relaksasi & & / l s/e!).darahMen$e)a)kan 0as dila&asi ar&eri dan 0enaM,la ker-a e/a&> la!a ker-a singka&Di)erikan dengan in ,s /,!/ dandi/erl,kan ! ni& ringA/likasi klinis < ;i/er&ensi krisis

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STIMULAN HANTUNG

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S&i!,lan -an&,ng/ada kedar,ra&an !edis

1. Adrenaline#. Is /renalineBIs /r &eren l

%. D ),&a!ine A/likasi Klinis< Gagal -an&,ng danin ark !i kard

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DIURETIKUM

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Di,re&ik,!/ada kedar,ra&an !edis

FUROSEMIDEL / di,re&i $ang sanga& / &en

M,la ker-a e/a& A/likasi klinis< Gagal -an&,ng

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ANTI INFLAMASI POTEN

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An&i in7a!asi/ada kedar,ra&an !edis

KORTIKOSTEROIDMenginhi)isi &er)en&,kn$a asa!arakhid na& (/rek,rs r !edia& rin7a!asi"A/likasi klinis< As!a ak,& $ang)era&> s$ k ana:laksis

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+RONKODILATOR

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+r nk dila& r/ada kedar,ra&an !edis

S;ORT ACTING # AGONIS(SAL+UTAMOL"M,la ker-a e/a&Sinergis!e / &ensiasi denganinhalasi r&i s&er id (ICS"

Di)erikan !elal,i ne),lisasiA/likasi klinis< As!a ak,& $ang )era&

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