presentasi obat JIWA

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    LABORATORIUM ILMU KESEHATAN JIWA

    FAKULTAS KEDOKTERAN UNIVERSITAS MULAWARMAN

    RSJD. ATMA HUSADA MAHAKAM SAMARINDA

    2015

    ARIPIPRAZOLE & DIPHENDYRAMINE

    PRESENTASI

    Disusun Ol!"

    Putri Yekti Budiasih

    1#1002$001

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    Nama Generik :

    Aripipra!"eNama Merk :

    A#i"i$%ediaan :

    'a# (m) *+,+-./,012.,3s4'a# .,m) */5(-55,012.,3s4

    'a# .(m) *667-(,,012.,3s4

    irup .(,mL *(.+0+(,2#t"4

    In8 90(m)2.0/mL*+7+09,,2;ia"4

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    GOLONGAN OBA'

    antipsik!tik

    )enerasi kedua

    % 'R

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    FARMAKODINAMIK

    % &'(nis )&*si&l D2 + ,u'&

    -*u)&&n &'(nis )&*si&l

    *s)/(* 5HT1A &n

    s)*/i &n/i)si(/i l&in-nun,u&n )*(3il

    &n/&'(nis *s)/(* 5

    HT2A

    % A*i)i)*&4(l&n/&'(nis

    *s)/(* 5HT &n &'(nis

    )&*si&l *s)/(* 5HT26

    u&n7& n'&n &3ini/&s

    /in''i.

    % A*i)i)*&4(l --ilii

    &3ini/&s s&n' un/u

    !is/&-in &l3& &*n*'i

    &n *s)/(* D# &n ,u'&/*&ns)(*/* s*(/(nin

    n&-un /i& --ilii

    &3ini/&s 7&n' 8*!&*'&

    un/u *s)/(* -us&*ini

    (lin*'i

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    FARMAKOKINETIK

    % A*i)i)*&4(l -nu,u&n in/i lin&* &n >aktu paruh

    e"iminasi sekitar ( 8am. K(nsn/*&si )l&s-& s/&8il

    i9&)&i &l&- 1# !&*i. =!nsentrasi p"asma maksimum

    di?apai /1( 8am sete"ah d!sis !ra". Bi(&:&il&8ili/&s /&8l/(*&l si/&* $0; &n (8&/ ini -n'&l&-i meta#!"isme

    hepatik ekstensi$

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    INDI=AI

    % T*&)i &u/ si4(3*ni& )&&

    &s& + *-&,&

    % T*&)i /&-8&!&n un/u

    '&n''u&n )*si -&7(*

    % T*&)i *u-&/&n un/u

    '&n''u&n 8i)(l&* )&& &n&*-&,& + &s&

    [email protected]= AMPING

    % P&& &s& " Mu&l

    Mun/&! K(ns/i)&si S&i/)&l& Pusin' A&/isi&

    Ani/&s Ins(-ni& Clis&!

    % P&& &n&&n& " P*&s&&n

    -n'&n/u S&i/ )&l&Mun/&! F&/i' Pnin'&/&n

    n&3su -&&n Ins(-ni&

    Mu&l Hiun' /*su-8&/

    B*&/ 8&&n 8*/&-8&!Clis&! /*-(* &u (/(/

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    % M/&8(li/ &/i3 s&/us&/un7& 7&n' i/&!ui &&l&!

    !i*(&*i)i)*&4(l 7&n' 8i&s&n7& 8*&u-ul&si s&-)&i

    si/&* #0; (nsn/*&si &*i)i)*&4(l. O8&/ )&*n/*&ln7&

    is*si !&n7& s9&*& s&-&* &n -/&8(li/n7& 7&n'

    &/i3 -&u)un /i& diekskresi me"e>ati $ese dan urin.

    Bil& i8*i&n s/i&) !&*i (nsn/*&si &*i)i)*&4(l i (/&

    &&n -nin'&/ un/u )*i( 101# !&*i s8lu-

    -n9&)&i &&* s/&8il &n (ns/&n

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    PERHATIAN KHUSUS

    A*i)i)*&4(l tidak di)unakan)&& penderita

    psik!tik den)an demensia

    '&'&l ,&n/un' -&/i&n /i8&/i8& &/&u

    )nu-(ni&

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    % C&-8&* )*(uNama Generik :

    Diphenhidramineediaan :

    1 Ampu" . m" *., m)2m"4

    ia" .( m" *., m)2m"4

    %rup .+0( m)2( m"

    e"

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    GOLONGAN OBA'

    Di$enhidramin

    merupakan )enerasi

    pertama !#atantihistamin

    % 'R

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    FARMAKOKINETIK

    ABORBI

    % Di)!n!7*&-in

    -*u)&&n amines/&8il &n

    9)&/ is*&) )&&)-8*i&n s9&*& (*&l

    n'&n (nsn/*&si &*&!

    )un9& /*,&i )&& 2# ,&-.

    DI'RIB

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    CON'3

    % Di)!n!7*&-in --ilii&/u *,&u*&si sl&-&

    # ,&-.

    % --ilii &/u )&*u!

    li-in&si 2 ,&-&n [email protected] ,&- )&& )&sin

    '*i&/*i.

    % Bi(&:&il&8ili/&s )&&

    )-&&i&n (*&l -n9&)&i#0;

    ?0; &n si/&* ; /*i&/

    )&& )*(/in

    ME'ABOLIME

    % S8&'i&n 8s&* (8&/ inii-/&8(lis- &l&-

    !&/i &n -n'&l&-i first-

    pass efect n&-un 88*&)&

    i-/&8(lis- &l&- )&*u)&*u &n

    s7s/- 'in,&l

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    E==REI% is*si&n l&/ u*in

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    FARMAKODINAMIK

    % Di3n!i*&-in --8l(i*

    &si !is/&-in 7&i/u su&/u

    4&/ &l&- /u8u! 7&n'

    -n78&8&n ',&l& &l*'i

    % Di3n!i*&-in -n'!&-8&/

    )l)&s&n !is/&-in

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    % Di3n!i*&-in 8*,& s8&'&i &'n

    &n/i(lin*'i

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    INDI=AI

    % R&si &l*'i R!ini/is

    &l*'i& (n,un'/i:i/is&l*'i& -&8u )*,&l&n&n

    )&*ins(nis-

    [email protected]= AMPING

    % SSP " s&si -n'&n/u

    )usin' ins(-ni&

    % M&/& " )n'li!&/&n &8u*

    % Rs)i*&/(*i " s*/ 8*(ni

    -n'n/&l

    % K&*i(:&sul* " !i)(/nsi

    )&l)i/&si /&i&*i

    % CI " -u&l -un/&! i&*

    )nin'&/&n n&3su -&&n

    &n(*si&

    % CU " */nsi u*in

    s*in'sus&! BAK

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    PERHATIAN KHUSUS

    An&

    D&)&/ -ns/i-ul&si SSP )&*(si&l

    Bu-il

    K&/'(*i B

    /*u/&-& )&& /*i-s/* IBusui

    Mn'inusi s/i-ul&si SSP )&*&(si&l )&&

    8&7i &/&u ,&n' )&& 8&7i )*-&/u* +-n'!&-8&/ l&/&si

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    HATIHATI

    D&)&/ -n78&8&n s&si s&&/ -n'n&*&i

    &/&u -n,&l&n&n -sin

    Minu- ssu&i (sis

    Hin&*i )n''un&&n 8*s&-&&n '

    &n/i)*s&n &l(!(l &/&u )nn&n'

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    'ERIMA =AIH