presentasi obat JIWA

7/24/2019 presentasi obat JIWA

1/19

LABORATORIUM ILMU KESEHATAN JIWA

FAKULTAS KEDOKTERAN UNIVERSITAS MULAWARMAN

RSJD. ATMA HUSADA MAHAKAM SAMARINDA

2015

ARIPIPRAZOLE & DIPHENDYRAMINE

PRESENTASI

Disusun Ol!"

Putri Yekti Budiasih

1#1002$001


2/19

Nama Generik :

Aripipra!"eNama Merk :

A#i"i$%ediaan :

'a# (m) *+,+-./,012.,3s4'a# .,m) */5(-55,012.,3s4

'a# .(m) *667-(,,012.,3s4

irup .(,mL *(.+0+(,2#t"4

In8 90(m)2.0/mL*+7+09,,2;ia"4


3/19

GOLONGAN OBA'

antipsik!tik

)enerasi kedua

% 'R


4/19

FARMAKODINAMIK

% &'(nis )&*si&l D2 + ,u'&

-*u)&&n &'(nis )&*si&l

*s)/(* 5HT1A &n

s)*/i &n/i)si(/i l&in-nun,u&n )*(3il

&n/&'(nis *s)/(* 5

HT2A

% A*i)i)*&4(l&n/&'(nis

*s)/(* 5HT &n &'(nis

)&*si&l *s)/(* 5HT26

u&n7& n'&n &3ini/&s

/in''i.

% A*i)i)*&4(l --ilii

&3ini/&s s&n' un/u

!is/&-in &l3& &*n*'i

&n *s)/(* D# &n ,u'&/*&ns)(*/* s*(/(nin

n&-un /i& --ilii

&3ini/&s 7&n' 8*!&*'&

un/u *s)/(* -us&*ini

(lin*'i


5/19

FARMAKOKINETIK

% A*i)i)*&4(l -nu,u&n in/i lin&* &n >aktu paruh

e"iminasi sekitar ( 8am. K(nsn/*&si )l&s-& s/&8il

i9&)&i &l&- 1# !&*i. =!nsentrasi p"asma maksimum

di?apai /1( 8am sete"ah d!sis !ra". Bi(&:&il&8ili/&s /&8l/(*&l si/&* $0; &n (8&/ ini -n'&l&-i meta#!"isme

hepatik ekstensi$


6/19

INDI=AI

% T*&)i &u/ si4(3*ni& )&&

&s& + *-&,&

% T*&)i /&-8&!&n un/u

'&n''u&n )*si -&7(*

% T*&)i *u-&/&n un/u

'&n''u&n 8i)(l&* )&& &n&*-&,& + &s&

E@E= AMPING

% P&& &s& " Mu&l

Mun/&! K(ns/i)&si S&i/)&l& Pusin' A&/isi&

Ani/&s Ins(-ni& Clis&!

% P&& &n&&n& " P*&s&&n

-n'&n/u S&i/ )&l&Mun/&! F&/i' Pnin'&/&n

n&3su -&&n Ins(-ni&

Mu&l Hiun' /*su-8&/

B*&/ 8&&n 8*/&-8&!Clis&! /*-(* &u (/(/


7/19

% M/&8(li/ &/i3 s&/us&/un7& 7&n' i/&!ui &&l&!

!i*(&*i)i)*&4(l 7&n' 8i&s&n7& 8*&u-ul&si s&-)&i

si/&* #0; (nsn/*&si &*i)i)*&4(l. O8&/ )&*n/*&ln7&

is*si !&n7& s9&*& s&-&* &n -/&8(li/n7& 7&n'

&/i3 -&u)un /i& diekskresi me"e>ati $ese dan urin.

Bil& i8*i&n s/i&) !&*i (nsn/*&si &*i)i)*&4(l i (/&

&&n -nin'&/ un/u )*i( 101# !&*i s8lu-

-n9&)&i &&* s/&8il &n (ns/&n


8/19

PERHATIAN KHUSUS

A*i)i)*&4(l tidak di)unakan)&& penderita

psik!tik den)an demensia

'&'&l ,&n/un' -&/i&n /i8&/i8& &/&u

)nu-(ni&


9/19

% C&-8&* )*(uNama Generik :

Diphenhidramineediaan :

1 Ampu" . m" *., m)2m"4

ia" .( m" *., m)2m"4

%rup .+0( m)2( m"

e"


10/19

GOLONGAN OBA'

Di$enhidramin

merupakan )enerasi

pertama !#atantihistamin

% 'R


11/19

FARMAKOKINETIK

ABORBI

% Di)!n!7*&-in

-*u)&&n amines/&8il &n

9)&/ is*&) )&&)-8*i&n s9&*& (*&l

n'&n (nsn/*&si &*&!

)un9& /*,&i )&& 2# ,&-.

DI'RIB


12/19

CON'3

% Di)!n!7*&-in --ilii&/u *,&u*&si sl&-&

# ,&-.

% --ilii &/u )&*u!

li-in&si 2 ,&-&n 1@5 ,&- )&& )&sin

'*i&/*i.

% Bi(&:&il&8ili/&s )&&

)-&&i&n (*&l -n9&)&i#0;

?0; &n si/&* ; /*i&/

)&& )*(/in

ME'ABOLIME

% S8&'i&n 8s&* (8&/ inii-/&8(lis- &l&-

!&/i &n -n'&l&-i first-

pass efect n&-un 88*&)&

i-/&8(lis- &l&- )&*u)&*u &n

s7s/- 'in,&l


13/19

E==REI% is*si&n l&/ u*in


14/19

FARMAKODINAMIK

% Di3n!i*&-in --8l(i*

&si !is/&-in 7&i/u su&/u

4&/ &l&- /u8u! 7&n'

-n78&8&n ',&l& &l*'i

% Di3n!i*&-in -n'!&-8&/

)l)&s&n !is/&-in


15/19

% Di3n!i*&-in 8*,& s8&'&i &'n

&n/i(lin*'i


16/19

INDI=AI

% R&si &l*'i R!ini/is

&l*'i& (n,un'/i:i/is&l*'i& -&8u )*,&l&n&n

)&*ins(nis-

E@E= AMPING

% SSP " s&si -n'&n/u

)usin' ins(-ni&

% M&/& " )n'li!&/&n &8u*

% Rs)i*&/(*i " s*/ 8*(ni

-n'n/&l

% K&*i(:&sul* " !i)(/nsi

)&l)i/&si /&i&*i

% CI " -u&l -un/&! i&*

)nin'&/&n n&3su -&&n

&n(*si&

% CU " */nsi u*in

s*in'sus&! BAK


17/19

PERHATIAN KHUSUS

An&

D&)&/ -ns/i-ul&si SSP )&*(si&l

Bu-il

K&/'(*i B

/*u/&-& )&& /*i-s/* IBusui

Mn'inusi s/i-ul&si SSP )&*&(si&l )&&

8&7i &/&u ,&n' )&& 8&7i )*-&/u* +-n'!&-8&/ l&/&si


18/19

HATIHATI

D&)&/ -n78&8&n s&si s&&/ -n'n&*&i

&/&u -n,&l&n&n -sin

Minu- ssu&i (sis

Hin&*i )n''un&&n 8*s&-&&n '

&n/i)*s&n &l(!(l &/&u )nn&n'


19/19

'ERIMA =AIH

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presentasi obat JIWA