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GGGNNNIIIPPPSSSTTT BBBUUULLLLLLEEETTTIIINNN 222000111555 1st May, 2015 Volume No.: 44 Issue No.: 04

Vision

TO REACH THE PINNACLE OF GLORY AS A CENTRE OF EXCELLENCE IN THE FIELD OF PHARMACEUTICAL AND BIOLOGICAL SCIENCES BY KNOWLEDGE

BASED LEARNING AND PRACTICE

Contents • Message from PRINCIPAL• Editorial board• Historical article• News Update• Knowledge based Article• Disease Related Breaking

News• Upcoming Events• Drugs Update• Campus News• Student’s Section• Editor’s Note• Archive

GNIPST Photo Gallery For your comments/contribution OR For Back-Issues, mailto:gnipstbulletin@gmail.com

GURU NANAK INSTITUTE OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY

W e bs i t e : ht t p: / / gni ps t . a c. i n

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MESSAGE FROM PRINCIPAL

"It can happen. It does happen. But it can't happen if you quit." Lauren Dane.

‘We are what we repeatedly do. Excellence then is not an act, but a habit.’ Aristotle

It gives me immense pleasure to pen a few words for our e-bulletin. At the onset I would like to thank the last year’s editors and congratulate the newly selected editors for the current year.

Our first consideration is always in the best interest of the students. Our goal is to promote academic excellence and continuous improvement.

I believe that excellence in education is aided by creating a learning environment in which all learners are supported in maximizing their potential and talents. Education needs to focus on personalized learning and instruction, while promoting an education system that is impartial, universally accessible, and meeting the needs of all students.

It is of paramount importance that our learners have sufficient motivation and encouragement in order to achieve their aims. We are all very proud of you, our students, and your accomplishments and look forward to watching as you put your mark on the profession in the years ahead.

The call of the time is to progress, not merely to move ahead. Our progressive Management is looking forward and wants our Institute to flourish as a Post Graduate Institute of Excellence. Steps are taken in this direction and fruits of these efforts will be received by our students in the near future. Our Teachers are committed and dedicated for the development of the institution by imparting their knowledge and play the role of facilitator as well as role model to our students.

The Pharmacy profession is thriving with a multitude of possibilities, opportunities and positive challenges. At Guru Nanak Institute of Pharmaceutical Science and Technology, our focus is on holistic needs of our students.

I am confident that the students of GNIPST will recognize all the possibilities, take full advantage of the opportunities and meet the challenges with purpose and determination.

Excellence in Education is not a final destination, it is a continuous walk. I welcome you to join us on this path.

My best wishes to all.

Dr. A. Sengupta

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EDITORIAL BOARD

CHIEF EDITOR DR. ABHIJIT SENGUPTA EDITOR MS. JEENATARA BEGUM ASSOCIATE EDITOR MR. DIPANJAN MANDAL

HISTORICAL ARTICLE Stanislas Limousin – Pharmacal Inventor: One of those men singularly gifted in combining scientific knowledge with technical skill and with inventive genius was the french retail pharmacist, Stanislas Limousin (1831-1887). Among the many devices which he introduced to Pharmacy and Medicine were the medicine dropper; the system of coloring poisons (such as corrosive sublimate); and wafer cachets (which found favor prior to mass production of the gelatin capsule). His greatest contributions, however, were the development and perfection of apparatus for the inhalation and therapeutic administration of oxygen; and invention of glass ampoules that could be sealed and sterilized for preservation of solutions for hypodermic use. NEWS UPDATE

New potential melanoma drug target discovered: (01st May, 2015) A new treatment for melanoma could be on the horizon, thanks to a recent finding. In the study, authors report that they found high levels of an enzyme in melanoma samples that they believe is a potential drug target.

Practical gel simply 'clicks' for biomedical applications: (01st May, 2015) A novel, truly biocompatible alginate hydrogel has been developed that can be synthesized using 'click chemistry' towards better delivery of drugs, growth factors and living cells for biomedical

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applications. The gel is formed using chemical crosslinking strategies that allow engineers to entrap cells or molecules inside the gel without damaging them or rendering them inactive, scientists report.

Researchers create DNA repair map of the entire human genome: (01st May, 2015) When common chemotherapy drugs damage DNA in cancer cells, the cells can’t replicate. But the cells do have ways to repair the DNA and the cancer drugs aren’t effective to do so. Researchers have developed a way to find where this DNA repair happens. Their goal is to increase the potency of cancer drugs.

Genome library, blood test aim to minimize statin side effects, maximize benefits: (01st May, 2015) In the midst of the growing and often conflicting data around the benefits of statins, researchers are developing gene-based resources to help improve statin efficacy and cost-effectiveness and to reduce the incidence of adverse effects -- some of which can be fatal.

Link between inherited genetic variations, outcomes of non-small cell lung cancer patients discovered: (01st May, 2015) Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Patients diagnosed with NSCLC have a poor prognosis, with a 5-year survival rate of only 16 percent. Researchers hope to improve NSCLC patient survival with the results of a study that found that inherited genetic variations in interleukin genes are associated with improved patient survival and response to therapy.

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Lifetime intense physical activity may lower risk for non-Hodgkin lymphoma: (01st May, 2015) Performing vigorous physical activity over one's lifetime may lower risk for non-Hodgkin lymphoma. Because not much is known about what causes non-Hodgkin lymphoma, identifying risk factors is particularly important for the prevention and control of this cancer, the main researcher noted.

Many young ACL surgery patients need second surgery later on: (01st May, 2015) Orthopedic surgeons are seeing an epidemic of anterior cruciate ligament injuries among young athletes, and a large number of patients who have surgery to reconstruct a torn ACL undergo a second knee operation later on, according to a study.

Prolonged statin use may lower risk of lung cancer death : (01st May, 2015) Lung cancer patients who used statins in the year prior to a lung cancer diagnosis or after a lung cancer diagnosis had a reduction in the risk of death from the disease, researchers report at the conclusion of a recent study.

Frequent aspirin use reduces risk of cervical cancer by nearly half: (30th April, 2015) Long-term and frequent use of aspirin is associated with significantly decreased risk of cervical cancer, according to a study. According to the American Cancer Society, 12,900 new cases of cervical cancer will be diagnosed and 4,100 women will die from the disease in 2015.

For detail mail to editor

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KNOWLEDGE BASED ARTICLE Light -- not pain-killing drugs -- used to activate

brain's opioid receptors Despite the abuse potential of opioid drugs, they have long been the best option for patients suffering from severe pain. The drugs interact with receptors on brain cells to tamp down the body's pain response. But now, neuroscientists at Washington University School of Medicine in St. Louis have found a way to activate opioid receptors with light. In a test tube, the scientists melded the light-sensing protein rhodopsin to key parts of opioid receptors to activate receptor pathways using light. They also influenced the behavior of mice by injecting the receptors into the brain, using light instead of drugs to stimulate a reward response. Their findings are published online April 30 in the journal Neuron. The eventual hope is to develop ways to use light to relieve pain, a line of discovery that also could lead to better pain-killing drugs with fewer side effects. "It's conceivable that with much more research we could develop ways to use light to relieve pain without a patient needing to take a pain-killing drug with side effects," said first author Edward R. Siuda, a graduate student in the laboratory of Michael R. Bruchas, PhD, an assistant professor of anesthesiology and of neurobiology. But before that's possible, the researchers are attempting to learn the most effective ways to activate and deactivate the opioid receptor's pathways in brain cells. Bruchas, the study's principal investigator, explained that working with light rather than pain-killing drugs makes it much easier to understand how the receptors function within the complex array of cells and circuits in the brain and spinal cord. "It's been difficult to determine exactly how opioid receptors work because they have multiple functions in the body," Bruchas explained. "These receptors interact with pain-killing drugs called

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opiates, but they also are involved in breathing, are found in the gastrointestinal tract and play a role in the reward response." So the researchers sought a way to limit opioid receptors to performing a single task at a time, and it turned out to be almost as easy as flipping on a light switch, according to Bruchas, Siuda and their collaborators, including co-first author Bryan A. Copits, PhD, a postdoctoral research scholar in the laboratory of Robert W. Gereau, IV, PhD, the Dr. Seymour and Rose T. Brown Professor of Anesthesiology. By combining the rhodopsin protein, which senses light in the eye's retina, with a specific type of opioid receptor called a Mu opioid receptor, the researchers were able to build a receptor that responds to light in exactly the same way that standard opioid receptors respond to pain-killing drugs. When an opioid receptor is exposed to a pain-killing drug, it initiates activity in specific chemical pathways in the brain and spinal cord. And when the researchers shone light on the receptors that contained rhodopsin, the same cellular pathways were activated. In a test tube and in cells, Siuda exposed the receptors to light and then watched as they released the same chemicals that standard opioid receptors release. Then, in mice, the researchers implanted a light-emitting diode (LED) device the size of a human hair into a brain region linked to the reward response. They injected the light-sensing receptors they had genetically manufactured into the same brain region. Neurons in that part of the brain release chemicals such as dopamine that create feelings of euphoria. In decades of past opioid studies, researchers have observed mice and rats to press a lever to receive a dose of morphine, for example. The morphine would activate opioid receptors and the release of dopamine, and the animals would enjoy the response and press the lever again to continue feeling that reward sensation. This is one of the reasons opiates are so often abused in patients being treated for pain -- people like the way the drugs make them feel as much as

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the pain relief they provide -- and rates of abuse have skyrocketed over the past ten years. Working to deliver a similar reward sensation using light, the researchers put the mice into an enclosed chamber. In one part of the chamber, the lighted laser fiber-optic device stimulated the release of dopamine in the brain. When the animals left that part of the chamber, the light in the brain turned off. Soon after, the mice returned to the part of the chamber that activated the fiber-optic device so that the brain could receive more light stimulation. "By activating the receptors with light, we are presumably causing the brain to release more dopamine," Bruchas explained. "Rather than a drug such as morphine activating an opioid receptor, the light provides the reward." The researchers were able to vary the animals' response depending on the amount and type of light emitted by the LED. Different colors of light, longer and shorter exposure to light, and whether the light pulsed or was constant all produced slightly different effects. When a person takes an opioid drug such as Vicodin or OxyContin to relieve pain, such drugs interact with receptors in the brain to blunt pain sensations. But over time, patients develop tolerance and sometimes addiction. Opioids also can dramatically slow a person's breathing, too, and typically cause constipation. In theory, receptors tuned to light may not present the same danger. Siuda said it someday may be possible to activate, or deactivate, nerve cells without affecting any of the other receptors that pain-killing drugs trigger, although achieving that goal will be difficult. Bruchas' team is planning future studies that will use these receptors to test ways to control the brain cells that mediate pain and reward behavior with light rather than drugs. Jeenatara Begum Assistant Professor GNIPST

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DISEASE RELATED BREAKING NEWS Meningococcal disease - Niger: (29th April,

2015) Between 1 January and 25 April 2015, the Ministry of Public Health of Niger notified WHO of 1543 suspected cases of meningococcal disease, including 147 deaths. Suspected cases have been reported in seven of Niger’s eight regions. Meningococcal meningitis outbreaks have been confirmed in several areas of Dosso and Niamey regions. Read more

UPCOMING EVENTS 61st IPSF World Congress sponsored by Indian Pharmaceutical

Association (IPA) at Marriott Hotel, Hyderabad, India is going to on 30th July to 9th August, 2015.

DRUGS UPDATES FDA Approves Kybella (deoxycholic acid) to

Treat Submental Fullness, or 'Double Chin': (29th April, 2015) The U.S. Food and Drug Administration approved Kybella (deoxycholic acid), a treatment for adults with moderate-to-severe fat below the chin, known as submental fat. Using Kybella for the treatment of fat outside of the submental area is not approved and is not recommended. Read more

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CAMPUS NEWS

SPIRIT JIS 2015 On 03 to 05th April, 2015 JIS organised SPIRIT JIS 2015.

GPAT 2015 Result: The following B.Pharm. final year students have qualified, GPAT-2015. We congratulate them all. Diksha Kumari Rupanjay Bhattacharya Avik Paul

Xtasy 2015: GNIPST is going to organize the Tech Fest ‘Xtasy 2015’ from 30th March, 2015 to 1st April, 2015.

FINISHING SCHOOL TRAINING PROGRAMME: The FINISHING SCHOOL TRAINING PROGRAMME is going to organize by the Entrepreneurship Development Cell and Training & Placement Cell, GNIPST in collaboration with Indian Pharmacy Graduates’ Association (IPGA), Bengal Branch from 21st February to 11th April, 2015 at GNIPST Auditorium. On 21st February, 2015 the Finishing School Training Programme of GNIPST was inaugurated by Sri Soumen Mukhopadhyay, Deputy Director, Drug Control Office, Goutam Kr. Sen, President, IPGA, Mr. Subroto Saha, Asst. Directorate, Drug Control Office, Mr. Ranendra Chakraborty, Sales Manager and Associate Director Dr. Reddys Laboratory. On 28th February, 2015 Dr. D. Roy, Former Deputy Drug Controller, Mr. Sujoy Chakraborty, divisional Therapy Manager, Cipla and Mr. Vikranjit Biswas, Senior Manager, Learning & Development, Cipla delivered their valuable lectures in the 2nd day FINISHING SCHOOL TRAINING PROGRAMME of GNIPST.

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On 14th March, 2015 Mr. Milindra Bhattacharya, Senior Manager, QA & QC, Emami Ltd. and Mr. Joydev Bhoumik, Manager, Operation, Ranbaxy Laboratory Limited delivered their valuable lectures in the 3rd day FINISHING SCHOOL TRAINING PROGRAMME of GNIPST. On 21st March, 2015 Mr. Tridib Neogi, Associate Vice-President (Quality Assurance), Albert David Ltd. delivered his valuable lectures in the 4th FINISHING SCHOOL TRAINING PROGRAMME of GNIPST. On 28th March, 2015 Dr. Gautam Chaterjee, an Alumni of Jadavpur University and presently associated with NIPER delivered his valuable lectures in the 5th FINISHING SCHOOL TRAINING PROGRAMME of GNIPST. On 11th April, 2015 the closing ceremony of the FINISHING SCHOOL TRAINING PROGRAMME was held in GNIPST Auditorium.

JOBS: All the students of Final Year B. Pharm and M. Pharm are hereby informed that an interview will be conducted by GSK for sales and marketing job. Details given below:

Date : 27.03.2015 Time : 09:45 am Venue : GSK Consumer Healthcare Limited, Unit No. 208,

2nd Floor, Ecospace Campus B (3 B), New Town, Rajarhat, 24 Pgs (N). Kolkata-700156.

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THYROCARE provisionally selected 15 students from JIS Group. Amongst these, 3 students of B. Sc (H) Biotechnology and M. Sc Biotechnology have been selected.

Ipsita Mondal (M. Sc Biotechnology) Debriti Paul (M. Sc Biotechnology) Debopriya Chatterjee {B. Sc (H) Biotechnology}

The final year students of B.Pharm (31 students) and B.Sc (11 students) attended the pooled campus drive of Abbott India Ltd. on 10th March, 2015 at Jadavpur University. Among them 17 students have gone through to the final round of this pooled campus drive and short listed for final selection.

ACHIEVEMENT: Congratulations to Anurag Chanda, student of B.Pharm final year who have got the 1st prize in poster presentation event in Prakriti 2015 at Department of Agricultural and Food engineering, IIT, Kharagpur.

OTHERS:

On 24th and 25th February, 2015 Swamiji of Gourio Math was delivered some motivational lectuers in GNIPST.

The students of GNIPST participated in the 4th

Sardar Jodh Singh Trophy organised by NIT on 20th February, 2015.

On 8th February, 2015 Gnipst celebrated the Reunion programme “Reminiscence Reloaded 2015”.

The 2nd Annual Sports of GNIPST was held on 28th and 29th January,2015 in College campus ground.

Congratulations to all the winner of Annual Sports of GNIPST, 2015.

100 meter flat race (Girls):

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Priya Roy Nirmita Gupta Joyoti Ghosh 100 meter flat race (Boys): Arijit Mitra Thakur Deep Chakraborty Arindam Ganguly Three legged race (Girls):

Nayana Sinha Anjali Mondal Saheli Mukherjee Arjita Biswas Aindrila Bhowmick Archita Basu 200 meter flat race (Girls): Priya Roy Nirmita Gupta Anjali Mondal

Long Jump (Boys): Dipankar Kamila Arindam Ganguly Rohan Datta Skipping (Girls): Saheli Mukherjee Indira Saha Jayita Roy Shotput (Girls): Chandrika Saha Priya Roy Sneha Paul Shotput (Boys): Arijit Mitra Thakur Arindam Ganguly Rohan Datta Musical Chair (Staff): Mr. Abir Koley Ms. Priyanka Ray Mr. Debabrata Ghoshdastidar Discuss Throw(Girls): Priya Roy Arjita Biswas Varsha Shrivastava 50 meter female flat race (staff): Ms. Aparupa Bhattacharya Ms. Priyanka Ray Ms. Anuranjita Kundu

100 meter male flat race (staff): Mr. Debabrata Ghoshdastidar Mr. Mrinal Datta Mr. Ranjit Ghosh Walking race female (staff): Ms. Aparupa Bhattacharya Ms. Anuranjita Kundu Ms. Sumana Roy Balance race female (staff): Ms. Aparupa Bhattacharya Dr. Sriparna KunduSen Ms. Priyanka Ray

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Tug of war (Female staff): Ms. Priyanka Ray Ms. Aparupa Bhattacharya Ms. Prathama SenGupta Dr. Sriparna KunduSen Ms. Sumana Roy Tug of war (Male staff): Mr. Debabrata Ghoshdastidar Mr. Abir Koley Sk. Ziaur Rahman Mr. Ranjit Ghosh Mr. Koushik Dhar Balance race (Girls): Indira Saha Aindrila Bhowmick Pamolita Paul Long Jump (Girls): Aindrila Bhowmick Nirmita Gupta Krishnakali Basu 200 meter flat race (Boys): Dipankar Kamila Arijit Mitra Thakur Kaustav Sakar Sack race (Girls): Aindrila Bhowmick Nirmita Gupta Sayani Banerjee Sack race (Boys): Rohan Datta Souvik Debnath Sayantan Das Relay race (Boys): Dipankar Kamila

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Arijit Mitra Thakur Soumyajit Sinha Sneham Sen Relay race (Girls): Joyoti Ghosh Aindrila Bhowmick Anjali Mondal Poulami Sarkar Go for Goal (Boys): Abhijit Kumar Mondal Arkajyoti Hazra Abhinandan Mondal Tug of war (Boys): Dipu Roy Vishal Singh Sk Minhaz Uddin Ahmed Ritobroto Paul Rohan Dutta Tug of war (Girls): Krishnakali Basu Indira Saha Chandrika Saha Maitryee Banerjee Kajal Nagpal

The male faculties and staffs of GNIPST participated in the 4th

Sardar Jodh Singh Trophy organised by NIT on 15th January, 2015. An industrial tour and biodiversity tour was conducted in Sikkim

for B.Pharm, B.Sc. and M.Sc. students under the supervision of Mr. Dipanjan Mandal, Mr. Samrat Bose and Ms. Aparupa Bhattacharya from 5th January to 12th January, 2015.

GNIPST commemorated the Birth Anniversary of Swami Vivekananda on Monday, 12th January, 2015 & served Oldages and Orphanages.

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STUDENTS’ SECTION WHO CAN ANSWER FIRST????

Who is the author of The Seven Ages of man?

Answer of Previous Issue’s Questions:

A) Sukumar sen

Identify the person

Answer of Previous Issue’s Image:

R.k.Laxman

Send your thoughts/ Quiz/Puzzles/games/write-ups or any other contributions for Students’ Section& answers of this Section at gnipstbulletin@gmail.com

EDITOR’S NOTE

It is a great pleasure for me to publish the 4th issue of 44th Volume of GNIPST BULLETIN. All the followers of GNIPST BULLETIN are able to avail the bulletin through facebook account ‘GNIPST

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bulletin’ I am very much thankful to all the GNIPST members and readers who are giving their valuable comments, encouragements and supports. I am also thankful to Dr. Abhijit Sengupta, Director of GNIPST for his valuable advice and encouragement. Special thanks to Dr. Prerona Saha, Mr. Debabrata Ghosh Dastidar and Mr. Soumya Bhattacharya for their kind co-operation and technical supports. Thank you Mr. Soumya Bhattacharya for the questionnaires of the student section. An important part of the improvement of the bulletin is the contribution of the readers. You are invited to send in your write ups, notes, critiques or any kind of contribution for the forthcoming special and regular issue. ARCHIVE

AICTE has sanctioned a release of grant under Research Promotion Scheme (RPS) during the financial year 2012-13to GNIPST as per the details below: a. Beneficiary Institution: Guru Nanak Institution of Pharmaceutical Science & Technology. b. Principal Investigator: Dr. LopamudraDutta.

c. Grant-in-aid sanctioned:Rs. 16,25000/- only d. Approved duration: 3 years

e. Title of the project: Screening and identification of potential medicinal plant of Purulia & Bankura districts of West Bengal with respect to diseases such as diabetes, rheumatism, Jaundice, hypertension and developing biotechnological tools for enhancing bioactive molecules in these plants.

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Activity Clubs of GNIPST: Name of Club Member Faculty SPORTS Mr. Debabrata GhoshDastidar LITERARY AND PAINTING Ms. Jeenatara Begum SCIENCE AND INNOVATIVE MODELLING

Mr. Samrat Bose

ECO Ms. Sumana Roy SOCIAL SERVICES Dr. Asis Bala PHOTOGRAPHY Ms. Sanchari Bhattacharya CULTURAL Ms. Priyanka Ray DEBATE AND EXTEMPORE Mr. Soumya Bhattacharya

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