Gnipst Bulletin 28.4

7/29/2019 Gnipst Bulletin 28.4

1/12

1

1118-1177-4796-9849-7562-5062mail

GGGNNNIIIPPPSSSTTTBBBUUULLLLLLEEETTTIIINNN 222000111333

06th

September , 2013 Volume No.: 28 Issue No.

ContentsMessage from GNIPS

Letter to the EditorNews Update

Health awareness

Disease Outbreak Ne

Forth Coming Events

Drugs Update

Campus News

Students Section

Editors Note

Archive

Vision

TO GROW AS A CENTRE OF EXCELLENCE IN THE FIELD O

PHARMACEUTICAL AND BIOLOGICAL SCIENCE

EDITOR: Soumya BhattacharyaGURU NANAK INSTITUTE OF PHARMACEUTICAL SCIENCE AND

TECHNOLOGY

GNIPST Photo Gallery

For your comments/contributionORFor Back-Issues,

mailto:[email protected]
https://plus.google.com/u/0/photos/111714720327580099858/albums/5897323676427099873?sort=7mailto:[email protected]:[email protected]:[email protected]://plus.google.com/u/0/photos/111714720327580099858/albums/5897323676427099873?sort=7


2/12

06-09-2013

Click here to go at the top

MESSAGE FROM GNIPSTGNIPST BULLETIN is the official publication of Guru Nanak

Institute of Pharmaceutical Science & Technology. All the members

of GNIPST are proud to publish the 28th Volume of GNIPST

BULLETIN. Over the last two years this bulletin updating readers

with different scientific, cultural or sports activities of this prestigious

institute and promoting knowledge of recent development in

Pharmaceutical and Biological Sciences. Students section is

informing readers about some curious facts of drug discovery, science,

sports and other relevant fields. We look forward to seeing your

submission and welcome comments and ideas you may have.

LETTER TO THE EDITOR.

NEWS UPDATE

Detailed view of morphing parkinson's protein

revealed(6th

September, 2013)Researchers have taken detailed images and measurements of the

morphing structure of a brain protein thought to play a role in

Parkinson's disease, information that could aid the development of

medications to treat the condition. Researchers incubated the

protein in a laboratory and then used an electron microscope and a

technique called cryoelectron microscopy to snap thousands of

pictures over 24 hours, capturing its changing shape. The protein

was frozen at specific time intervals with liquid nitrogen. Read

more

1
http://www.sciencedaily.com/releases/2013/09/130906102532.htmhttp://www.sciencedaily.com/releases/2013/09/130906102532.htmhttp://www.sciencedaily.com/releases/2013/09/130906102532.htmhttp://www.sciencedaily.com/releases/2013/09/130906102532.htmhttp://www.sciencedaily.com/releases/2013/09/130906102532.htm


3/12

06-09-2013


Natural killer cell activity can be influenced by

phosphorylating a protein in NK cells(6th September,2013)

Scientists at the University of Veterinary Medicine, Vienna(Vetmeduni Vienna) provide evidence that NK cell activity can be

influenced by phosphorylating a protein (STAT1) in NK cells. The

results, which could be of immediate therapeutic relevance, are

published in the journal Cell Reports.Read more

Drug patch treatment sees new breakthrough(6thSeptember, 2013)An assistant professor with the Virginia Tech -- Wake ForestSchool of Biomedical Engineering has developed a flexible

microneedle patch that allows drugs to be delivered directly and

fully through the skin. The new patch can quicken drug delivery

time while cutting waste, and can likely minimize side-effects in

some cases, notable in vaccinations and cancer therapy Read

more

Novel therapeutic cancer vaccine goes to human

clinical trials(6th September, 2013)A cross-disciplinary team of scientists, engineers, and clinicians

announced today that they have begun a Phase I clinical trial of an

implantable vaccine to treat melanoma, the most lethal form of

skin cancer.Read more

Short-Term blood sugar control protects the

kidney but not the heart in patients with

diabetes (6th September,2013)

2
http://www.sciencedaily.com/releases/2013/09/130906101334.htmhttp://www.sciencedaily.com/releases/2013/09/130906101334.htmhttp://www.sciencedaily.com/releases/2013/09/130906101334.htmhttp://www.sciencedaily.com/releases/2013/09/130906214116.htmhttp://www.sciencedaily.com/releases/2013/09/130906214116.htmhttp://www.sciencedaily.com/releases/2013/09/130906214116.htmhttp://www.sciencedaily.com/releases/2013/09/130906141833.htmhttp://www.sciencedaily.com/releases/2013/09/130906141833.htmhttp://www.sciencedaily.com/releases/2013/09/130906141833.htmhttp://www.sciencedaily.com/releases/2013/09/130906141833.htmhttp://www.sciencedaily.com/releases/2013/09/130906214116.htmhttp://www.sciencedaily.com/releases/2013/09/130906214116.htmhttp://www.sciencedaily.com/releases/2013/09/130906101334.htm


4/12

06-09-2013


An international study has shown that short-term blood sugarcontrol in patients with diabetes has a limited effect on their risk

of cardiovascular problems, such as heart disease and stroke.Read

more

Cell death protein could offer new anti-

inflammatory drug target (5thSeptember, 2013)Scientists in Melbourne, Australia, have revealed the structure of aprotein that is essential for triggering a form of programmed celldeath called necroptosis, making possible the development of newdrugs to treat chronic inflammatory diseases such as Crohn's

disease and rheumatoid arthritis.Read more

HEALTH AWARENESS

Foodborne trematodiasesFoodborne trematodiases affect more than 56 million people

throughout the world.They are caused by trematode worms("flukes"), of which the most common species affecting humansare Clonorchis, Opisthorchis, Fasciola andParagonimus.

People become infected through the consumption of raw orpoorly cooked food: fish, crustaceans and vegetables that harbourthe minute larval stages of the parasites .Transmission

Foodborne trematodiases are zoonoses, i.e. they are naturally

transmissible from vertebrate animals to people and vice versa.Direct transmission is however not possible, as the relevantcausative parasites become infective only after having completedcomplex life-cycles that usually involve stages in intermediate,non-human hosts. The first intermediate host is in all cases afreshwater snail, while the second host differs: in clonorchiasis

3
http://www.sciencedaily.com/releases/2013/09/130906101340.htmhttp://www.sciencedaily.com/releases/2013/09/130906101340.htmhttp://www.sciencedaily.com/releases/2013/09/130906101340.htmhttp://www.sciencedaily.com/releases/2013/09/130906101340.htmhttp://www.sciencedaily.com/releases/2013/09/130905133922.htmhttp://www.sciencedaily.com/releases/2013/09/130905133922.htmhttp://www.sciencedaily.com/releases/2013/09/130905133922.htmhttp://www.sciencedaily.com/releases/2013/09/130905133922.htmhttp://www.sciencedaily.com/releases/2013/09/130906101340.htmhttp://www.sciencedaily.com/releases/2013/09/130906101340.htm


5/12

06-09-2013


and opisthorchiasis it is a freshwater fish, in paragonimiasis it is acrustacean, while fascioliasis does not require a secondintermediate host. The final host is always a mammal.

People become infected when they ingest the second

intermediate host that is infected with larval forms of the parasite.In the case of fascioliasis, people become infected when the larvaeare ingested together with the aquatic vegetables to which theyare attached .Epidemiology

In 2005, more than 56 million people worldwide wereinfected with foodborne trematodes and over 7000 people died.Cases of foodborne trematodiases have been reported from over 70

countries worldwide; however South-East Asia and SouthAmerica are the most affected areas. In these regions, infectionswith foodborne trematodes represent a significant public healthproblem.

Within countries, transmission is often restricted to limitedareas and reflects behavioural and ecological patterns, such aspeoples food habits, methods of food production and preparation,and the distribution of the intermediate hosts. Information on the

epidemiological status of foodborne trematode infections in Africais largely missing.The economic impact of foodborne trematodiases is

significant, and is mainly linked to losses in the expandingaquaculture industry due to restrictions on exports and reducedconsumer demand.Symptoms

The public health burden attributable to foodborne trematodiases

is predominantly due to morbidity rather than mortality.Early and light infections often pass unnoticed, as they areasymptomatic or only scarcely symptomatic. Conversely, if theworm load is high, general malaise is common and severe pain canoccur, especially in the abdominal region, and most frequently inthe case of fascioliasis.

4


6/12

06-09-2013


Chronic infections are invariably associated with severemorbidity. Symptoms are mainly organ-specific and reflect thefinal location of the adult worms in the body.

Inclonorchiasis and opisthorchiasis, the adult wormslodge in the smaller bile ducts of the liver, causing inflammationand fibrosis of the adjacent tissues and eventuallycholangiocarcinoma, a severe and fatal form of bile cancer. Both C.sinensis andO. viverrini, but not O. felineus, are classified ascarcinogenic agents.

Infascioliasis , the adult worms lodge in the larger bile ductsand the gall bladder, where they cause inflammation, fibrosis,blockage, colic pain and jaundice. Liver fibrosis and anaemia are

also frequent.Inparagonimiasis, the final location of the worms is the lung

tissue. They cause symptoms that can be confounded withtuberculosis: chronic cough with blood-stained sputum, chestpain, dyspnoea (shortness of breath) and fever. Migration of theworms is possible: cerebral locations are the most severe.Prevention and control

Control of foodborne trematodiases aims to reduce the risk of

infection and at controlling associated morbidity.Veterinary public health measures and food safety practices arerecommended to reduce the risk of infection, while, to controlmorbidity, WHO recommends improved access to treatment usingsafe and effective anthelminthic medicines (drugs that expel theworms).

Treatment can be offered through preventive chemotherapyor individual case-management. Preventive chemotherapy involvesa population-based approach whereby everyone in a given regionor area is given medicines, irrespective of their infection status; itis recommended in areas where large numbers of individuals areinfected. Individual case-management involves the treatment ofpeople with confirmed or suspected infection: this approach ismore appropriate where cases are less clustered and where healthfacilities are available.

5


7/12

06-09-2013


WHO response

WHOs work on foodborne trematodiases is part of an integrated

approach to the control of neglected tropical diseases, andincludes:

development of strategic directions and recommendations; support for mapping in endemic countries; support for pilot interventions and control programmes in

endemic countries; support for monitoring and evaluation of implemented activities;

and

documentation of the burden of foodborne trematodiases and theimpact of implemented interventions.WHO is working to include foodborne trematodiases in itsmainstream preventive chemotherapy strategy and ensure thattheir worst consequences (cancers of the bile duct and others) arefully prevented.WHO has also negotiated an agreement with Novartis Pharma AGwhereby this company will donate triclabendazole for thetreatment of human fascioliasis and paragonimiasis. The medicinesare shipped free of charge to ministries of health that apply forthem. WHO invites all endemic countries to take advantage of thisdonation programme.

DISEASE OUTBREAK NEWS

Middle East respiratory syndrome coronavirus

(MERS-CoV) (30th August,2013)WHO has been informed of an additional four laboratory-confirmed

cases of Middle East respiratory syndrome coronavirus (MERS-CoV)

infection in Saudi Arabia.Read more

6
http://www.who.int/csr/don/2013_08_30/en/index.htmlhttp://www.who.int/csr/don/2013_08_30/en/index.htmlhttp://www.who.int/csr/don/2013_08_30/en/index.htmlhttp://www.who.int/csr/don/2013_08_30/en/index.html


8/12

06-09-2013


FORTHCOMING EVENTS

The 2nd Pharm. Tech IAPST International Conference on "New insights into

diseases and recent therapeutic approaches" from 17th to 19th January 2014 in

Kolkata, India.Read more

DRUGS UPDATES

FDA approves Abraxane for late-stage

pancreatic cancer (6th

September, 2013)The U.S. Food and Drug Administration today expanded theapproved uses of Abraxane (paclitaxel protein-bound particles forinjectable suspension, albumin-bound) to treat patients with late-stage (metastatic) pancreatic cancer.Read more

CAMPUS NEWS

Teachers day was celebrated on 5th September, 2013 by

the students of GNIPST in GNIPST Auditorium.

Azalea (exotic flower ) , the fresher welcome programme fornewcomers of GNIPST in the session 2013-14 was held on 8th

August in GNIPST Auditorium.

One day seminar cum teachers development programme forschool teachers on the theme ofRecent Trends of Life Sciences

in Higher Education organized by GNIPST held on 29th June,

2013 at GNIPST auditorium. The programme was inaugurated by

Prof . Asit Guha, Director of JIS Group, Mr. U.S. Mukherjee, Dy

7
http://www.iapst.com/http://www.iapst.com/http://www.iapst.com/http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm367442.htmhttp://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm367442.htmhttp://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm367442.htmhttp://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm367442.htmhttp://www.iapst.com/


9/12

06-09-2013


Director of JIS Group and Dr. Abhijit Sengupta, Director cum

Principal of GNIPST with lamp lighting. The programme started

with an opening song performed by the B.Pharm students of this

institute. The seminar consists of a series of lectures, video

presentations and poster session. On the pre lunch session 4

lectures were given by Dr. Lopamudra Dutta, Mr. Debabrata

Ghosh Dastidar, Ms. Swati Nandy and Ms. Tamalika Chakraborty

respectively. On their presentation the speakers enlighten the

recent development of Pharmacy, Genetics and Microbiology and

their correlation with Life Sciences. On the post lunch session, Ms.

Saini Setua and Ms. Sanchari Bhattacharjee explained the recent

development and career opportunities in Biotechnology andHospital Management. The programme was concluded with

valedictory session and certificate distribution.

About 50 Higher secondary school teachers from different

schools of Kolkata and North& South 24 Parganas district of

West Bengal participated in this programme. A good interactive

session between participants and speakers was observed in the

seminar. The seminar was a great success with the effort offaculties, staffs and students of our Institute. It was a unique

discussion platform for school teachers and professional of the

emerging and newer branches of Life Science.

STUDENTS SECTION

WHO CAN ANSWER FIRST????

Which biotechnological technique was developedby Kary Mullis in 1983?

Isidor Rabi awarded Nobel Prize in 1944 inPhysics for which remarkable work?

8


10/12

06-09-2013


Answer of Previous Issues Questions:A) Dengue B)Dengue virus

Send your thoughts/ Quiz/Puzzles/games/write-ups or any other contributions for StudentsSection& answers of this Section [email protected]

EDITORS NOTE

I am proud to publish the 4th

issue of 28th

Volume of GNIPSTBULLETIN. GNIPST BULLETIN now connected globally through

facebook account GNIPST bulletin

I want to convey my thanks to all the GNIPST members and the

readers for their valuable comments, encouragement and supports.

I am thankful to Dr. Abhijit Sengupta, Director of GNIPST for his

valuable advice and encouragement. Special thanks to Dr. Prerona

Saha andMr. Debabrata Ghosh Dastidar for their kind co-operationand technical supports.

An important part of the improvement of the bulletin is the

contribution of the readers. You are invited to send in your write ups,

notes, critiques or any kind of contribution for the forthcoming special

and regular issue.

9


11/12

06-09-2013


ARCHIVE

The following B.Pharm. final year students have qualified,

GPAT-2013. We congratulate them all.

AAAmmmaaannnppprrreeeeeetttKKKaaauuurrr,,, MMMooohhhuuuaaa DDDaaasss,,,

SSSooouuurrraaavvvBBBaaagggccchhhiii,,, UUUddddddiiippptttaaa GGGhhhooossshhh DDDaaassstttiiidddaaarrr,,,

SSSiiiddddddaaarrrttthhh SSShhhaaahhh,,,PPPrrraaappptttiiiCCChhhaaakkkrrraaabbbooorrrtttyyy,,,

SSSuuubbbhhhrrraaadddiiipppRRRoooyyyccchhhooouuudddhhhuuurrryyy,,, SSSooouuummmyyyaaajjjiiittt DDDaaasss,,,

MMMooouuunnnooommmuuukkkhhhaaarrrBBBhhhaaattttttaaaccchhhaaarrrjjjeeeeee...

GGGNNNIIIPPPSSSTTT iiisss nnnooowww aaapppppprrrooovvveeedddbbbyyy AAAIIICCCTTTEEE aaannnddd aaaffffffiiillliiiaaattteeeddd tttooo

WWWBBBUUUTTT fffooorrr cccooonnnddduuuccctttiiinnnggg ttthhheee tttwwwoooyyyeeeaaarrrsss pppooosssttt gggrrraaaddduuuaaattteee cccooouuurrrssseee

(((MMM...PPPhhhaaarrrmmm))) iiinnn PPPHHHAAARRRMMMAAACCCEEEUUUTTTIIICCCSSS... TTThhheee aaapppppprrrooovvveeeddd nnnuuummmbbbeeerrr

ooofffssseeeaaatttiiisss 111888...

The general body meeting of APTI, Bengal Branch has been conducted

at GNIPST on 15th June, 2012. The program started with a nice

presentation by Dr. Pulok Kr. Mukherjee, School of Natural Products,

JU on the skill to write a good manuscript for publication in impact

journals. It was followed by nearly two hour long discussion among

more than thirty participants on different aspects of pharmacy

education. Five nonmember participants applied for membership on

that very day.

GNIPST is now approved by AICTE and affiliated to WBUT for

conducting the two years post graduate course (M.Pharm) in

P H A R M A C O L O G Y . The approved number of seat is 18.10


12/12

06-09-2013


The number of seats in B.Pharm. has been increased from 60 to 120.

AICTE has sanctioned a release of grant under Research Promotion

Scheme (RPS) during the financial year 2012-13to GNIPST as per the

details below:a. Beneficiary Institution: Guru Nanak Institution of Pharmaceutical

Science & Technology.

b.Principal Investigator: Dr. LopamudraDutta.

c. Grant-in-aid sanctioned:Rs. 16,25000/- only

d.Approved duration: 3 years

e. Title of the project: Screening and identification of potential

medicinal plant ofPurulia & Bankura districts of West Bengal withrespect to diseases such as diabetes, rheumatism, Jaundice,

hypertension and developing biotechnological tools for enhancing

bioactive molecules in these plants.

11

Documents

Gnipst Bulletin 28.4