Gnipst Bulletin 25.4

7/28/2019 Gnipst Bulletin 25.4

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MESSAGE FROM GNIPSTGNIPST BULLETIN is the official publication of Guru Nanak

Institute of Pharmaceutical Science & Technology. All the

members of GNIPST are proud to publish the 25thVolume of

GNIPST BULLETIN. Over the last two years this bulletin

updating readers with different scientific, cultural or sports

activities and promoting knowledge of recent development in

Pharmaceutical and Biological Sciences. Students section is

informing readers about some curious facts of drug discovery,

science, sports and other relevant fields. We look forward to seeing

your submission and welcome comments and ideas you may have.

LETTER TO THE EDITOR.

NEWS UPDATE

World Environment Day,2013:THINK.EAT.SAVE

World Environment day is celebrated every year on 5th June to

aware people about their role on saving environment. The World

Environment Day celebration began in 1972 and has grown to

become one of the main vehicles through which the United

Nations stimulates worldwide awareness of the environment and


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encourages political attention and action. The theme for this years

World Environment Day is based on anti-food waste and food loss

campaign Think.Eat.Save. According to the UN Food andAgriculture Organization (FAO), every year 1.3 billion tonnes of

food is wasted. This is equivalent to the same amount produced in

the whole of sub-Saharan Africa. At the same time, 1 in every 7

people in the world go to bed hungry and more than 20,000

children under the age of 5 die daily from hunger. This years

theme inform us about our small initiative can reduces theenvironmental impact of forced food production and population

outburst.Read more

Protein drugsfrom bacteria(5th June, 2013)

Using the bacterium E. coli, researchers from the University's

Faculty of Engineering showed it was possible to vastly increase

the efficiency of the cells producing specifically modified proteins,

as well as improve its performance and stability.Read more

Alzheimer's disease Drugs Linked to Reduced

Risk of Heart Attacks(5th June, 2013)

Clinical trial shows that cholinesterase inhibitors (ChEIs), such as

donepezil, rivastigmine and galantamine, which are used for

treating mild to moderate Alzheimer's disease are linked to a
http://www.unep.org/wed/about/http://www.unep.org/wed/about/http://www.sciencedaily.com/releases/2013/06/130605104428.htmhttp://www.sciencedaily.com/releases/2013/06/130605104428.htmhttp://www.sciencedaily.com/releases/2013/06/130605104428.htmhttp://www.unep.org/wed/about/


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reduced risk of heart attacks and death due to their beneficial

effect on the vagus nerve.Read more

PTSD patients also suffer from depression (4thJune, 2013)

About one of every two people diagnosed with posttraumatic

stress disorder (PTSD) also suffer symptoms of depression,

according to new research by Case Western Reserve University's

Department of Psychological Sciences.Read more

Genetic Editing Shows Promise in Duchenne

Muscular Dystrophy(4th June, 2013)

Using a novel genetic 'editing' technique, Duke University

biomedical engineers have been able to repair a defect responsible

for one of the most common inherited disorders, Duchenne

muscular dystrophy, in cell samples from Duchenne patients.

Read more

New treatment strategy for Neuroblastoma

(3rd

June, 2013)

A group of Swedish researcher have discovered asmall chemical

molecule that knock out MYCN protein are therefore a possible
http://www.sciencedaily.com/releases/2013/06/130605090257.htmhttp://www.sciencedaily.com/releases/2013/06/130605090257.htmhttp://www.sciencedaily.com/releases/2013/06/130604153515.htmhttp://www.sciencedaily.com/releases/2013/06/130604153515.htmhttp://www.sciencedaily.com/releases/2013/06/130604153946.htmhttp://www.sciencedaily.com/releases/2013/06/130604153946.htmhttp://www.sciencedaily.com/releases/2013/06/130604153946.htmhttp://www.sciencedaily.com/releases/2013/06/130604153515.htmhttp://www.sciencedaily.com/releases/2013/06/130605090257.htm


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therapy option for children with neuroblastoma as well as for

other MYC-driven tumours.Read more

Statinassociatedmusculoskeletal disorder

(3rdJune, 2013)

Clinical trial reveals that Cholesterol lowering statin users are

more prone to musculoskeletal disorders.Read more

Smartphone can disrupt sleep(3rdJune, 2013)

Smartphones and tablets can disrupt our sleep. The bright light-

emitting diodes that allow the use of mobile devices in dimly lit

rooms can interfere with melatonin, a hormone that helps control

the natural sleep-wake cycle. A Mayo Clinic study suggests

dimming the smartphone or tablet brightness settings and holding

the device at least 14 inches from your face while using it willreduce its potential to interfere with melatonin and impede sleep.

Read more

New kind of antibiotic may be more effective

against Tuberculosis, Anthrax and other

diseases (3rdJune, 2013)

46 previously untested compound has shown potential activity to

disrupt the trans-translation process of different bacteria like

E.coli, Shigella, Bacillus anthracis andM. tuberculosis.Read more
http://www.sciencedaily.com/releases/2013/06/130603163753.htmhttp://www.sciencedaily.com/releases/2013/06/130603163753.htmhttp://www.sciencedaily.com/releases/2013/06/130603164145.htmhttp://www.sciencedaily.com/releases/2013/06/130603163610.htmhttp://www.sciencedaily.com/releases/2013/06/130603163610.htmhttp://www.sciencedaily.com/releases/2013/06/130603163809.htmhttp://www.sciencedaily.com/releases/2013/06/130603163809.htmhttp://www.sciencedaily.com/releases/2013/06/130603163809.htmhttp://www.sciencedaily.com/releases/2013/06/130603163610.htmhttp://www.sciencedaily.com/releases/2013/06/130603164145.htmhttp://www.sciencedaily.com/releases/2013/06/130603163753.htm


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FDA recommends against prolonged use of

Magnesium Sulfate to stop pre-term labour dueto bone change in expossed baby Stem cell

injections improve(30thMay, 2013)

The U.S. Food and Drug Administration (FDA) is advising health

care professionals against using magnesium sulfate injection for

more than 5-7 days to stop pre-term labor in pregnant women.Administration of magnesium sulfate injection to pregnant women

longer than 5-7 days may lead to low calcium levels and bone

problems in the developing baby or fetus, including thin bones,

called osteopenia, and bone breaks.Read more

HEALTH AWARENESS

Climate Change and Human Health

Environment, human health and diseases form an essential triangle

for the survival of human race. Climate is an essential part of

environment and Changes in climate affect the average weather

conditions that we are accustomed to. The impacts of climate

change on health will depend on many factors. These factors

include age, sex, communities, geographical regions, length of

exposure to altered climate.
http://www.fda.gov/Drugs/DrugSafety/ucm353333.htm?source=govdeliveryhttp://www.fda.gov/Drugs/DrugSafety/ucm353333.htm?source=govdelivery


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Heat waves impact:

Heat waves can lead to heat stroke and dehydration, and arethe most common cause of weather-related deaths. It has been

observed that Young children, older adults, people with medicalconditions, and the poor are more vulnerable than others to heat-related illness. Climate change will likely lead to more frequent,more severe, and longer heat waves in the summer , as well as lesssevere cold spells in the winter. The impacts of future heat wavescould be especially severe in large metropolitan areas. Forexample, in Los Angeles, annual heat-related deaths are projectedto increase two- to seven-fold by the end of the 21st century,depending on the future growth of greenhouse gas emissions.Heat

waves are also often accompanied by periods of stagnant air,leading to increases in air pollution and the associated healtheffects

Extreme weather event impact:

Extreme weather like drought, storm, tsunami, rainfall can

directly or indirectly affect the human health. These conditions

may: Reduce the availability of fresh food and water.

Interrupt communication, utility, and health care services,

specially observed after tsunami in Indian Ocean region.

Contribute to carbon monoxide poisoning from portable

electric generators used during and after storms.

Increase stomach and intestinal illness.

Contribute to mental health impacts such as depression and

post-traumatic stress disorder.


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Reduced air quality impact:

The quality of air in urban region of developing countries is not in

desired standard. Even despite significant improvements in U.S.

air quality since the 1970s, as of 2008 more than 126 million

Americans lived in counties that did not meet national air quality

standards. This can lead to several deadly diseases.

Increasing ozone impact:

Ground-level ozone can damage lung tissue and can reduce lungfunction and inflame airways. This can increase respiratorysymptoms and aggravate asthma or other lung diseases. It isespecially harmful to children, older adults, outdoor workers,and those with asthma and other chronic lung diseases.

Ozone exposure also has been associated with increasedsusceptibility to respiratory infections, medication use, doctorvisits, and emergency department visits and hospitaladmissions for individuals with lung disease. Some studies

suggest that ozone may increase the risk of prematuremortality, and possibly even the development of asthma.

Ground-level ozone is formed when certain air pollutants, suchas carbon monoxide, oxides of nitrogen (also called NOX), andvolatile organic compounds, are exposed to each other insunlight. Ground-level ozone is one of the pollutants in smog.

Because warm, stagnant air tends to increase the formation of

ozone, climate change is likely to increase levels of ground-level

ozone in already-polluted areas of the United States and increase

the number of days with poor air quality. If emissions of air

pollutants remain fixed at today's levels until 2050, warming from

climate change alone could increase the number of Red Ozone


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Alert Days (when the air is unhealthy for everyone) by 68% in the

50 largest eastern U.S. cities.

Changes in suspended Particulate Matter:

Inhaling fine particles can lead to a broad range of adverse health

effects, including premature mortality, aggravation of

cardiovascular and respiratory disease, development of chronic

lung disease, exacerbation of asthma, and decreased lung function

growth in children. Sources of fine particle pollution include

power plants, gasoline and diesel engines, wood combustion, high-temperature industrial processes such as smelters and steel mills,

and forest fires. Due to the variety of sources and components of

fine particulate matter, scientists do not yet know whether

climate change will increase or decrease particulate matter

concentrations. However Climate change will also affect

particulates through changes in wildfires, which are expected to

become more frequent and intense in a warmer climate.

Changes in Allergens:Climate change may affect allergies and respiratory health. it is

mainly due to increased spring pollen season, increased carbon

dioxide and temperature.

Food-borne Diseases:Higher air temperatures can increase cases of salmonella and other

bacteria-related food poisoning because bacteria grow more

rapidly in warm environments. These diseases can cause

gastrointestinal distress and, in severe cases, death.


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Flooding and heavy rainfall can cause overflows from sewage

treatment plants into fresh water sources. Overflows could

contaminate certain food crops with pathogen-containing feces.

Vector borne diseases:

Malaria is a classic example of vector borne disease, the intensity

of which hugely altered with climate changes. The malaria

modelling shows that small temperature increases can greatly

affect transmission potential. Globally, temperature increases of 2-

3C would increase the number of people who, in climatic terms,

are at risk of malaria by around 3-5%, i.e. several hundred million.

Further, the seasonal duration of malaria would increase in manycurrently endemic areas.

For better quality of health it is essential to save environment for

further abrupt change in the climate.

DISEASE OUTBREAK NEWS

Poliovirus detected from environmental samples

in Israel(3rdJune, 2013)

Wild poliovirus type 1 (WPV1) was isolated from sewage samples

collected on 9 April 2013 in Rahat, southern Israel. The virus has

been detected in sewage only; no case of paralytic polio has been

reported.Read more
http://www.who.int/csr/don/2013_06_03/en/index.htmlhttp://www.who.int/csr/don/2013_06_03/en/index.htmlhttp://www.who.int/csr/don/2013_06_03/en/index.htmlhttp://www.who.int/csr/don/2013_06_03/en/index.html


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Middle East respiratory syndrome coronavirus

(MERS-CoV) (1st June, 2013)

The Ministry of Health in Italy, through the European Unions

Early Warning Response System, has notified WHO of a

laboratory-confirmed case with Middle East respiratory syndrome

coronavirus (MERS-CoV) in a resident in the country.Read more

FORTHCOMING EVENTS

Two short-term (2 weeks each) AICTE-sponsored refresher

courses on: Innovation and excellence in Pharmaceutical Sciences for

teaching staffs of the Indian Universities and colleges in QIP

Nodal Cell (Pharmacy), Department of Pharmaceutical

Technology, Jadavpur University, Kolkata-700 032 from 2ndJuly to

29th July,2013Read more

AICTE Sponsored Quality Improvement Program on Production

to Prescription - Opportunities for Innovation on MCOPS,

Manipal University from 1-13th July, 2013Read more

DRUGS UPDATES

FDA approves two drugs, companion diagnostic

test for advanced skin cancer(29 MAY 2013)
http://www.who.int/csr/don/2013_06_01_ncov/en/index.htmlhttp://www.who.int/csr/don/2013_06_01_ncov/en/index.htmlhttp://www.who.int/csr/don/2013_06_01_ncov/en/index.htmlhttp://www.jaduniv.edu.in/upload_files/asc_info/1368622884-1.pdfhttp://www.jaduniv.edu.in/upload_files/asc_info/1368622884-1.pdfhttp://www.manipal.edu/Institutions/Pharmacy/MCOPSManipal/Documents/events/QIP%20on%20Production%20to%20Prescription-%20Opportunities%20for%20Innovation.pdfhttp://www.manipal.edu/Institutions/Pharmacy/MCOPSManipal/Documents/events/QIP%20on%20Production%20to%20Prescription-%20Opportunities%20for%20Innovation.pdfhttp://www.manipal.edu/Institutions/Pharmacy/MCOPSManipal/Documents/events/QIP%20on%20Production%20to%20Prescription-%20Opportunities%20for%20Innovation.pdfhttp://www.manipal.edu/Institutions/Pharmacy/MCOPSManipal/Documents/events/QIP%20on%20Production%20to%20Prescription-%20Opportunities%20for%20Innovation.pdfhttp://www.jaduniv.edu.in/upload_files/asc_info/1368622884-1.pdfhttp://www.who.int/csr/don/2013_06_01_ncov/en/index.html


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The U.S. FDAapproved approved two new drugs, Tafinlar

(dabrafenib) and Mekinist (trametinib), for patients with

advanced (metastatic) or unresectable (cannot be removed by

surgery) melanoma, the most dangerous type of skin cancer.Readmore

FDA clears first blood tracking device that uses

Radio Frequency Identification technology(28 MAY

2013)iTrace for Blood Centers, (Version 1.0.924.0), the first applicationto use Radio Frequency Identification (RFID) technology in blood

establishments to assist in enhancing blood safety by preventing

the release of unsuitable blood components, was cleared today by

the U.S. Food and Drug Administration.Read more.

CAMPUS NEWS

The following B.Pharm. final year students have qualified, GPAT-

2013. We congratulate them all.

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STUDENTS SECTION

WHO CAN ANSWER FIRST???

Name of which medical device is derived from the name of dentist Charles Stent?

Which drug was first synthesized by AlbertHofmann in 1938?

Answer of Previous Issue Question:A) Petridish B)Micropipette

Send yourthoughts/ Quiz/Puzzles/games/write-ups or any other contributions for Students Section

& answers of this Section [email protected]
mailto:[email protected]:[email protected]:[email protected]


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EDITORS NOTE

I am honored to become the new editor of the official bulletin of our

prestigious institute and proud to publish the 4

th

issue of 25

th

VolumeofGNIPST BULLETIN. On behalf of the entire GNIPST members,

contributors and the valuable readers ofGNIPST BULLETIN I want

to thankMr. Debabrata Ghosh Dastidar who edited the bulletin last

one year with excellence.

GNIPST BULLETIN now connected globally through facebook

account GNIPST bulletin

I want to convey my thanks to all the GNIPST members and the

readers for their valuable comments, encouragement& supports.

I am thankful to Dr. Abhijit Sengupta, Director of GNIPST and

Prof. Dipankar Chakraborty, Registrar of GNIPST for their

valuable advice and encouragement. Special thanks toDr. Prerona

Saha and Mr. Debabrata Ghosh Dastidar for their kind co-

operation and technical supports.

An important part of the improvement of the bulletin is the

contribution of the readers. You are invited to send in your write ups,

notes, critiques or any kind of contribution for the forthcoming

special and regular issue


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ARCHIVE

The general body meeting of APTI, Bengal Branch has been

conducted at GNIPST on 15

th

June, 2012. The program startedwith a nice presentation by Dr. Pulok Kr. Mukherjee, School of

Natural Products, JU on the skill to write a good manuscript for

publication in impact journals. It was followed by nearly two hour

long discussion among more than thirty participants on different

aspects of pharmacy education. Five nonmember participants

applied for membership on that very day.

GNIPST is now approved by AICTE and affiliated to WBUT for

conducting the two years post graduate course (M.Pharm) in

PHARMACOLOGY. The approved number of seat is 18.

The number of seats in B.Pharm. has been increased from 60 to

120.

2nd World Congress on Ga-68 (Generators and Novel Radiopharmaceuticals),

Molecular Imaging (PET/CT), Targeted Radionuclide Therapy, and

Dosimetry (SWC-2013) : On the Way to Personalized Medicine

Dates 28 Feb 2013

02 Mar 2013Location: Chandigarh, India.Details.
http://www.2ndworldcongress-ga-68.de/http://www.2ndworldcongress-ga-68.de/http://www.2ndworldcongress-ga-68.de/http://www.2ndworldcongress-ga-68.de/


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AICTE has sanctioned a release of grant under Research

Promotion Scheme (RPS) during the financial year 2012-

13to GNIPST as per the details below:

a. Beneficiary Institution: Guru Nanak Institution of

Pharmaceutical Science & Technology.

b. Principal Investigator: Dr. Lopamudra Dutta.

c. Grant-in-aid sanctioned :Rs. 16,25000/- only

d.Approved duration: 3 years

e. Title of the project: Screening and identification ofpotential medicinal plant ofPurulia& Bankura districts of West

Bengal with respect to diseases such as diabetes, rheumatism,

Jaundice, hypertension and developing biotechnological tools for

enhancing bioactive molecules in these plants.