Chapter 44 (Sections 44.1-44.4) Internal Transport

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Chapter 44 (Sections 44.1-44.4) Internal Transport. Moving Materials. Cells require a continuous supply of nutrients and oxygen and removal of waste products - PowerPoint PPT Presentation

Text of Chapter 44 (Sections 44.1-44.4) Internal Transport

  • Moving Materials

    Cells require a continuous supply of nutrients and oxygen and removal of waste products

    In very small animals, materials are exchanged by diffusion, the net movement of particles from a region of higher concentration to a region of lower concentration

    Fluid between the cells (interstitial fluid) provides a medium for diffusion of oxygen, nutrients, and wastes

  • Circulatory Systems

    Evolution of specialized circulatory systems allowed animals to increase in size it transports oxygen, nutrients, hormones, and other materials to the interstitial fluid surrounding all the cells and removes metabolic wastes

    The human circulatory system (cardiovascular system) includes the heart, blood vessels, and blood

    Cardiovascular disease is the leading cause of death in the United States and throughout the world



    Compare and contrast internal transport in animals with no circulatory system, those with an open circulatory system, and those with a closed circulatory system

  • Animals With No Circulatory System

    No specialized circulatory structures are present in sponges, cnidarians (hydras, jellyfish), ctenophores (comb jellies), flatworms, or nematodes (roundworms)

    In cnidarians, the central gastrovascular cavity serves as a circulatory organ as well as a digestive organ

    The flattened body of the flatworm permits effective gas exchange by diffusion

    Fluid in the body cavity of nematodes circulates materials

  • Circulatory Systems

    Larger animals require a circulatory system to efficiently distribute materials

    A circulatory system typically consist of three parts:Blood, a connective tissue consisting of cells and cell fragments dispersed in fluid, usually called plasmaA pumping organ, generally a heartBlood vessels through which blood circulates

    Two main types of circulatory systems are open and closed systems

  • Open Circulatory Systems

    Arthropods and most mollusks have an open circulatory system, in which the heart pumps blood into vessels that have open ends

    Blood and interstitial fluid make up hemolymph, which fills large sinuses (the hemocoel or blood cavity)

    Hemolymph bathes the body cells, then re-enters the circulatory system through openings in the heart (arthropods) or through open-ended vessels that lead to gills (mollusks)

  • Open Circulatory Systems (cont.)

    Most mollusks have a heart with three chambers: two atria receive hemolymph from gills; a single ventricle pumps oxygen-rich hemolymph into blood vessels

    In arthropods, a tubular heart pumps hemolymph into arteries that deliver it to the sinuses of the hemocoel

    Some mollusks and arthropods have a copper-containing hemolymph pigment (hemocyanin) that transports oxygen

  • Invertebrates With Closed Circulatory Systems

    Annelids, cephalopod mollusks, and echinoderms have a closed circulatory system in which blood flows through a continuous circuit of blood vessels

    Gases, nutrients, and wastes diffuse between blood in the vessels and interstitial fluid that bathes the cells through the thin walls of capillaries

  • Invertebrates With Closed Circulatory Systems (cont.)

    Proboscis worms (phylum Nemertea) have a complete network of blood vessels but no heart

    Annelids (earthworms) have two main blood vessels, five pairs of contractile blood vessels that act as hearts, and a red pigment (hemoglobin) that transports oxygen

    Cephalopod mollusks (squids and octopods) have accessory hearts at the base of the gills, which speed passage of blood through the gills

  • The Vertebrate Circulatory System

    Vertebrates have a ventral, muscular heart that pumps blood into a closed system of blood vessels

    Capillaries, the smallest blood vessels, have very thin walls that permit exchange of materials between blood and interstitial fluid

    The vertebrate circulatory system consists of heart, blood vessels, blood, lymph, lymph vessels, and associated organs such as the thymus, spleen, and liver

  • Functions of the Vertebrate Circulatory System

    Transports nutrients from digestive system or storage to cellsTransports oxygen from respiratory structures to cellsTransports metabolic wastes from cells to excretory organsTransports hormones from endocrine glands to target tissuesHelps maintain fluid balanceHelps distribute metabolic heat and maintain body temperatureHelps maintain appropriate pHDefends the body against invading microorganisms


    Arthropods and most mollusks have an open circulatory system in which blood bathes the tissues directly

    Some invertebrates and all vertebrates have a closed circulatory system in which a heart pumps blood that flows through a continuous circuit of blood vessels



    Compare the structure and function of plasma, red blood cells, white blood cells, and platelets

    Summarize the sequence of events involved in blood clotting

  • Blood

    In vertebrates, blood consists of a fluid plasma in which red blood cells, white blood cells, and platelets are suspended

    In humans, blood volume is approximately 5 L (5.3 qt) in an adult female and about 5.5 L (5.8 qt) in an adult male

    About 55% of the blood volume is plasma and 45% is blood cells and platelets

  • Plasma

    Plasma consists of water (about 92%), proteins (about 7%), salts, and transported materials such as dissolved gases, nutrients, wastes, and hormones

    Plasma contains several kinds of plasma proteins:Fibrinogen is involved in clottingGlobulins: Alpha globulins (hormones and proteins that transport hormones); beta globulins (transport fats, cholesterol, vitamins and minerals); gamma globulin (contains many types of antibodies)Albumins help control bloods osmotic pressure

  • Red Blood Cells

    Erythrocytes or red blood cells (RBCs), are highly specialized for transporting oxygen

    In mammals, the RBC nucleus is ejected each RBC is a flexible, biconcave disc with an elastic internal framework

    Erythrocytes are produced in red bone marrow of vertebrae, ribs, breastbone, skull bones, and long bones

    As an RBC develops, it produces large quantities of the oxygen-transporting pigment hemoglobin

  • Red Blood Cells (cont.)

    A human RBC lives about 120 days; old RBCs are removed from circulation by phagocytic cells in the liver and spleen

    New RBCs are produced in bone marrow, regulated by a hormone released by the kidneys (erythropoietin)

    Anemia, a deficiency in hemoglobin, may be caused by: Loss of blood from hemorrhage or internal bleedingDecreased production of hemoglobin or red blood cells (iron-deficiency anemia or pernicious anemia)Increased rate of RBC destruction (hemolytic anemias)

  • White Blood Cells

    Leukocytes or white blood cells (WBCs) defend the body against harmful bacteria and other microorganisms

    Leukocytes are amoeba-like cells capable of independent movement some slip through the walls of blood vessels and enter the tissues

    Human blood contains three kinds of granular leukocytes and two types of agranular leukocytes all manufactured in the red bone marrow

  • Granular Leukocytes

    Granular leukocytes have large, lobed nuclei and distinctive granules in their cytoplasm

    Neutrophils are phagocytic cells that ingest bacteria and dead cells granules contain digestive enzymes

    Eosinophils contain lysosomes with enzymes that degrade cell membranes of parasitic worms and protozoa

    Basophils release histamine in injured tissues and in allergic responses; and heparin, an anticoagulant

  • Agranular Leukocytes

    Agranular leukocytes lack granules; their nuclei are rounded or kidney-shaped

    Lymphocytes fight infections; some produce antibodies, others directly attack invaders such as bacteria or viruses

    Monocytes are phagocytes that migrate from blood into tissues during an infection; they differentiate into:Macrophages that engulf bacteria, dead cells, and debrisDendritic cells, important in the immune system

  • Leukemia

    Leukemia is a form of cancer in which WBCs multiply rapidly within the bone marrow, crowding out developing RBCs and platelets, leading to anemia and impaired clotting

    Death is often caused by internal hemorrhaging, especially in the brain; or infection

    Leukemia is treated with chemotherapy, and sometimes with radiation therapy or bone marrow transplant

  • Platelets

    Most vertebrates other than mammals have small, oval, nucleated cells (thrombocytes) that function in blood clotting

    Mammals have platelets, tiny spherical or disc-shaped fragments of cytoplasm pinched off from large cells in the bone marrow (lacking nuclei)

    When a blood vessel is cut, platelets stick to the rough, cut edges and release substances that attract other platelets

  • Blood Clotting

    Platelets become sticky and adhere to collagen fibers in the blood vessel wall, forming a platelet plug or temporary clot

    Using clotting factors, calcium ions, and compounds released from platelets, prothrombin is converted to thrombin

    Thrombin catalyzes conversion of the soluble plasma protein fibrinogen to an insoluble protein, fibrin

    Fibrin polymerizes, producing long threads that form the webbing of the clot, trapping more blood cells and platelets


    Vertebrate blood consists of plasma, which transports nutrients, wastes, gases, and hormones; red blood cells, which are specialized to transport oxygen; white blood cells, which defen