PATOLOGI SISTEMIK II (PAP 442)PATOLOGI SISTEMIK II (PAP 442)PATOLOGI SISTEMIK II (PAP 442)PATOLOGI SISTEMIK II (PAP 442)
PATOLOGI ALAT REPRODUKSIPATOLOGI ALAT REPRODUKSIALAT KELAMIN JANTANALAT KELAMIN JANTANALAT KELAMIN JANTANALAT KELAMIN JANTAN
Dr. drh. Eva Harlina, MSi.Dr. drh. Eva Harlina, MSi.
Bagian Patologi Bagian Patologi Departemen Klinik, Reproduksi dan PatologiDepartemen Klinik, Reproduksi dan PatologiFakultas Kedokteran HewanFakultas Kedokteran Hewan IPBIPBFakultas Kedokteran HewanFakultas Kedokteran Hewan--IPBIPBJl. Agatis Kampus IPB Darmaga, Bogor Jl. Agatis Kampus IPB Darmaga, Bogor -- 1668016680
MALE REPRODUCTIVE SYSTEMMALE REPRODUCTIVE SYSTEMMALE REPRODUCTIVE SYSTEMMALE REPRODUCTIVE SYSTEM
•• TestisTestis
•• Excretory ductExcretory duct
•• Accessory glandsAccessory glands•• Accessory glandsAccessory glands
•• Penis and prepucePenis and prepucep pp p
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MALE REPRODUCTIVE SYSTEMMALE REPRODUCTIVE SYSTEM
•• TestisTestisSeminiferous tubules (contain germ cellsSeminiferous tubules (contain germ cellsSeminiferous tubules (contain germ cells Seminiferous tubules (contain germ cells in various stage of maturation), Sertoli in various stage of maturation), Sertoli cell Leydig cellscell Leydig cellscell, Leydig cellscell, Leydig cells
•• Excretory ductExcretory duct: epididymis, vas deferens: epididymis, vas deferens
•• Accessory glandsAccessory glands: seminal vesicles, : seminal vesicles, prostateprostate
•• Penis and prepucePenis and prepuce
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DISEASES OF THE MALE DISEASES OF THE MALE REPRODUCTIVE SYSTEMREPRODUCTIVE SYSTEM
Developmental disorders Developmental disorders
Diseases of the scrotum and contentsDiseases of the scrotum and contents
Diseases of the accessory glandsDiseases of the accessory glands Diseases of the accessory glandsDiseases of the accessory glands
Diseases of the penis and prepuceDiseases of the penis and prepuce
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DEVELOPMENTAL DISORDERSDEVELOPMENTAL DISORDERSDEVELOPMENTAL DISORDERSDEVELOPMENTAL DISORDERS
MAJOR ANOMALIESMAJOR ANOMALIESMAJOR ANOMALIESMAJOR ANOMALIES
Sexual dimorphism Sexual dimorphism pp
Segmental aplasia of epididymisSegmental aplasia of epididymis
CryptorchidismCryptorchidism
Testicular hypoplasiaTesticular hypoplasia Testicular hypoplasiaTesticular hypoplasia
Spermatic granuloma Spermatic granuloma
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SEXUAL DIMORPHISMSEXUAL DIMORPHISM
Errors of chromose, gonadal or phenotypic sexErrors of chromose, gonadal or phenotypic sex
1. Sex chromosomes (structure and number).1. Sex chromosomes (structure and number).
a. Abnormal structure of Y a. Abnormal structure of Y (isochromosome)(isochromosome)FFemale phenotype emale phenotype H l ti dH l ti dHypoplasctic gonadsHypoplasctic gonads
b.b. Duplication of one of the sex chromosomeDuplication of one of the sex chromosomeb.b. Duplication of one of the sex chromosome Duplication of one of the sex chromosome (XXY, XYY) (XXY, XYY) Testicular hypoplasia Testicular hypoplasia Kli f lt ’ d (t i l l t)Kli f lt ’ d (t i l l t)Klinefelter’s syndrome (tricolor male cat)Klinefelter’s syndrome (tricolor male cat)
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SEXUAL DIMORPHISM …SEXUAL DIMORPHISM …
2 Hermaprhodites2 Hermaprhodites2. Hermaprhodites2. Hermaprhodites
•• XY genotypeXY genotype
•• Androgen receptor disorderAndrogen receptor disorder
•• Abnormal gonads (have both Abnormal gonads (have both testicular and ovarium tissue)testicular and ovarium tissue)test cu a a d o a u t ssue)test cu a a d o a u t ssue)
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Male pseudo-Male pseudohermaphrodite: XY chromosome
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MINOR ANOMALIESMINOR ANOMALIES
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MINOR ANOMALIESMINOR ANOMALIESMINOR ANOMALIESMINOR ANOMALIES
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DISEASES OF THE SCROTUMDISEASES OF THE SCROTUMDISEASES OF THE SCROTUM DISEASES OF THE SCROTUM AND CONTENTSAND CONTENTS
The scrotumThe scrotum The scrotumThe scrotum
T i d E idid iT i d E idid i Testis and EpididymisTestis and Epididymis
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DISEASES OF THE SCROTUM DISEASES OF THE SCROTUM
Dermatitis Dermatitis TTTrauma Trauma Frosbite Frosbite E i t l i it tE i t l i it tEnvironmental irritants Environmental irritants Chorioptes bovisChorioptes bovis
Neoplasma Neoplasma ppMast cell tumor Mast cell tumor Melanoma Melanoma HemangiomaHemangioma
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DISEASES OF TESTIS AND DISEASES OF TESTIS AND EPIDIDYMISEPIDIDYMIS
Decreased sizeDecreased size
C t hidiC t hidi CryptorchidismCryptorchidism
HypoplasiaHypoplasiayp pyp p
Testicular degenerationTesticular degeneration
Segmental aplasiaSegmental aplasia
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Increased sizeIncreased size
Spermatic granuloma of epididymisSpermatic granuloma of epididymis
EpididymitisEpididymitis
OrchitisOrchitis
Testicular neoplasia: Testicular neoplasia: Seminoma Seminoma Sertoli cell tumor Sertoli cell tumor Interstitial cell tumorInterstitial cell tumor
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CRYPTORCHIDISMCRYPTORCHIDISMDecreased size …Decreased size …
Incomplete descent of testisIncomplete descent of testis
Oft il t lOft il t l Often unilateral Often unilateral
Hypoplasia or atrophyHypoplasia or atrophy Hypoplasia or atrophyHypoplasia or atrophy
Testis is small, fibrotic, hyaline thickening Testis is small, fibrotic, hyaline thickening of tubular basement membraneof tubular basement membraneof tubular basement membrane, of tubular basement membrane, degeneration of germinal epithelium, only a degeneration of germinal epithelium, only a few spermatogonia remain normal Sertolifew spermatogonia remain normal Sertolifew spermatogonia remain, normal Sertoli few spermatogonia remain, normal Sertoli cellscells
P t l i (S t li CT i )P t l i (S t li CT i ) Prone to neoplasia (Sertoli CT, seminoma)Prone to neoplasia (Sertoli CT, seminoma)Patologi Alat Kelamin Jantan 20Patologi Alat Kelamin Jantan 20
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HYPOPLASIAHYPOPLASIADecreased size …Decreased size …
Mild to severeMild to severe
Unilateral hypoplasiaUnilateral hypoplasia
Ab lit f ifi d iAb lit f ifi d i Abnormality of specific genes, endocrine, Abnormality of specific genes, endocrine, cytogeniccytogenic
Related to poor general nutrition, Zn deffRelated to poor general nutrition, Zn deff
HP: hypoplastic tubules, lined by sertoli HP: hypoplastic tubules, lined by sertoli cells, a few stem cells and spermatogoniacells, a few stem cells and spermatogonia
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TESTICULAR ATROPHYTESTICULAR ATROPHYDecreased size …Decreased size …
Reduce in size after pubertyReduce in size after puberty
Testicular degenerationTesticular degeneration Testicular degenerationTesticular degeneration
HP: deg. of the seminiferous tubulesHP: deg. of the seminiferous tubules
Causes by: inflammation, obstruction of Causes by: inflammation, obstruction of flow of spermatozoa (segmental flow of spermatozoa (segmental aplasia, injury of epididymis, torsion of aplasia, injury of epididymis, torsion of spermatic cord)spermatic cord)
Systemic injurious factor: Systemic injurious factor: hypovitaminosis A, Zn, antibiotic, hypovitaminosis A, Zn, antibiotic, toxins, estrogen produced by sertoli cell toxins, estrogen produced by sertoli cell tumortumor Patologi Alat Kelamin Jantan 25Patologi Alat Kelamin Jantan 25
Some Causes of Testicular Degeneration Some Causes of Testicular Degeneration Advancing ageAdvancing age EpididymitisEpididymitis ChemicalsChemicals HeatHeat HormonesHormones HormonesHormones Metal compound toxicosisMetal compound toxicosis NeoplasiaNeoplasia Nutritional disordersNutritional disorders Nutritional disordersNutritional disorders PlantsPlants RadiationRadiation StressStress TraumaTrauma UltrasoundUltrasound UltrasoundUltrasound Viral infectionViral infection
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EPIDIDYMITIS AND EPIDIDYMITIS AND SPERMATIC GRANULOMASPERMATIC GRANULOMA
Inflammation, testicular neoplasiaInflammation, testicular neoplasia
SPERMATIC GRANULOMASPERMATIC GRANULOMA
Inflammation, testicular neoplasiaInflammation, testicular neoplasia
Spermatic granuloma: congenital Spermatic granuloma: congenital obstruction inflammation as respon toobstruction inflammation as respon toobstruction, inflammation as respon to obstruction, inflammation as respon to spermiostatisspermiostatis
Epididymitis is almost accompanied by Epididymitis is almost accompanied by spermatic granuloma and periorchitisspermatic granuloma and periorchitis
Cause testicular degenerationCause testicular degeneration
B. abortus, E. coliB. abortus, E. coliPatologi Alat Kelamin Jantan 29Patologi Alat Kelamin Jantan 29
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Increased sizeIncreased sizec eased s ec eased s e
Spermatic granuloma of epididymisSpermatic granuloma of epididymis
EpididymitisEpididymitis
OrchitisOrchitis
PeriorchitisPeriorchitis PeriorchitisPeriorchitis
Testicular neoplasia Testicular neoplasia S iS iSeminoma Seminoma Teratoma Teratoma Sertoli cell tumorSertoli cell tumorSertoli cell tumor Sertoli cell tumor Interstitial cell tumorInterstitial cell tumor
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ORCHITISORCHITIS
Extension of epididymitisExtension of epididymitis
HematogenousHematogenous
B b t B iB b t B i B. abortus, B. suis, B. abortus, B. suis, C. pseudotuberculosisC. pseudotuberculosis
Intratubular orchitis, Intratubular orchitis, necrotizing orchitis, necrotizing orchitis,
l t hitil t hiti (M b i(M b igranulomatous orchitisgranulomatous orchitis (M. bovis, (M. bovis, mycotic orchitismycotic orchitis))
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TESTICULAR NEOPLASIATESTICULAR NEOPLASIA
Common in older dogCommon in older dog
TESTICULAR NEOPLASIATESTICULAR NEOPLASIA
gg
Arise from germ cellsArise from germ cells
Seminoma Seminoma
I t titi l ll tI t titi l ll t Interstitial cell tumorsInterstitial cell tumors
Sertoli cell tumors: feminizing effectSertoli cell tumors: feminizing effect Sertoli cell tumors: feminizing effect Sertoli cell tumors: feminizing effect ((GynecomasticaGynecomastica: enlargement of : enlargement of mammary gland)mammary gland)
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Veneric Sarcoma
Kulit hingga ke mukosa
Sel tumor menyebar seperti anggur
88
stroma
stromastroma
99
1010
Sertoli Cell Tumor
Stroma menebal
Tubuli seminiferi berisi sel Sertoli yangSertoli yang berproliferasi
1111
Ukuran tubuli seminiferi bervariasi: membesarmembesar, mengecill
Stroma menebal
1212
Sel Sertoli
1313
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