Tomorrow’s Science

Today

CEM Corporation – Who Are We?

• Founded in 1978

• Worldwide headquarters are in Matthews, NC

• First company to commercialize microwave

instrumentation for sample preparation

• Over 35,000 instruments in laboratories

• 5 CEM subsidiaries and over 50 distributors

throughout the world

CEM Corporation – North America Capabilities

• All R&D and manufacturing are done in Matthews, NC

• Our Personnel Include:

– In House Engineers – Design and Software

– Applications Specialists for Analytical Operations

– Sales Representatives with Science Degrees

– Field Service Engineers Located Across US and Canada for

Repairs IQ/OQ/PQ, etc.

CEM Corporation – North America Capabilities

Batch

vs

Sequential

The Best Batch Microwave Digestion

System in the World Just Got Better!!

Great News!

6th Generation of MARS

• Applied 30 years of lessons learned to this

system

– Easy to use • Touch Screen Interface

– Built In Intelligence • Sensors count vessels

• precise control of reaction conditions

• Virtually eliminates runaway rxns

– Highest power output – 1800W • Digests the most difficult matrices

Why Do Samples NOT Digest?

• Method – Acid mixture and acid volume is not correct for sample

type

– Digestion temperature is incorrect

– Ramp and hold times not appropriate for sample

• Operation

– Wrong type of vessel is selected

– Incorrect vessel assembly

– Not enough microwave power for the number of vessels

What went

wrong?

So what can CEM do to solve these problems

Build knowledge into the system!!

is…Touchscreen

• Icon driven touch

interface

• Select One Touch

method and start run

in one click

is…Software

• Applications information from CEM application notes is

included in One Touch Methods:

• A CEM Applications Chemist in a Box!!

is… Sensors

• Vessel Recognition

• Vessel Counting

is…Intuitive

Identifies

• Your vessel Type

• The number of vessels

being run

Determines

• The temperature needed

to achieve a complete

digest

• Optimum Power Output

• The correct ramp and hold

times

is…Your application support

is…Easy as

1. Load your samples

2. Choose your sample type

is…Easy as

3. Press “Start”

is…Easy as

And CEM puts a Chemist in every MARS 6 box

One Touch Technology

incorporates 30 years

of applications

expertise and

knowledge into

optimized methods

30 years

expertise

Your Chemists in the Box

CEM Analytical

Applications

Chemists

• Jason Keith

• Ivana Mrvalj

• Tina Restivo

• Daniel Iversen

• Elaine Hasty

• Latina Rivers

PowerMAXTM Technology

PowerMAX Technology

• Hardware and software work together

to optimize power output

• Better ability to control microwave

power to get a better digest

• Maximizes the “on time” for

microwave

• More overall power available for

system to completely digest samples

Traditional Microwave Heating

• 25 minute ramp to 200oC and 10 minute hold

• Magnetron was off for 8.75 of 35 minutes (25% of the time)

PowerMAX Technology

• 25 minute ramp to 200oC and 10 minute hold

• Magnetron was off for 1.90 of 35 minutes (5.5% of the

time)

PowerMAX Technology

• Increase in mag on time – 26.1%

OneTouch & PowerMAX Technology

• MARS 6 One Touch Technology Provides 30 years of CEM

Digestion Applications Knowledge At the Push of a

Button

• MARS 6 PowerMAX Technology Maximizes Microwave

Power On-Time, Resulting in Less Temperature Overshoot,

Better Reaction Control, and…

Better Digestion Quality!!

Safer Digestions!!

DuoTemp

All Vessel Temperature Control

DuoTemp All Vessel Control

• MARS 6 software displays

temperature of each vessel

graphically

• The control (most reactive, hottest)

vessel is shown in green

• As the control vessel changes during

the run, MARS 6 software monitors

and displays these changes

New MARS 6 Software

Methods

• One Touch – select and start a method with a single touch

• Classic – develop and run methods that are identical to

MARS 5

Complete monitoring w/optional on board printing

Complete Monitoring

New MARS 6 Software

Tools and Settings

• MARS 6 Tools and Settings screen are simple to navigate

• Provides an easy to trace audit trail

Easily Updatable Software

• As new One Touch methods are developed

software can be easily updated

– Downloaded from www.CEM.com

Advanced Connectivity

CONNECTIVITY

Avalable ports: 5 USB, 1 USB-B,

2 Ethernet, and 1 RS-232

MARS 6 Runs All Vessel Sets

Automated Sequential Microwave Digestion

• Fast – 10 minutes per

digestion

• Total Control of every sample

• Total Flexibility

– Mix Different Samples

– Mix Different Methods

• Real Sample Sizes

– 0.5g Organic

• Unattended Operation

– 6/Hr = 48 a day (or overnight!)

• Decks are 24/48, 36/72 and

48/96

SP–D with Explorer Options

SP–D with

Explorer

24 (35 mL vials) /

48 (10 mL vials)

SP–D with

Explorer 36/ 72

SP–D with

Explorer 48/96

The Discover Platform only Requires

• Single 120V Power

• Air Supply – Typically House Air

• Somewhere to vent exhaust – hood or trunk

line

• No need for special chillers, compressed

gases or multiple 208V lines

Temperature & Pressure Control

Infra-Red Temperature Control

• Provides Temperature Control of Every Sample

– Mix all types of organic and inorganic sample types

– Works with Pyrex & Quartz Vessels with or without

Teflon liners

ActiVent* Pressure Control

• Venting is active not passive as in batch systems

• Three preset venting options based on sample type

• Inorganic samples typically do not vent

ActiVent Technology

Advanced Pressure Management

The Effect of Simultaneous Cooling

• Cooling gas flow regulated

through system software

• Temperature feedback control

maximizes input microwave

power

• Typically allows a 5 fold

increase in microwave power

input speeding digestions and

lowering vapor pressure. The

cooling gas also rapidly cools

vessels at end of run

Cooling Gas

US Patent Nos. 6917023, 6744024

The Fastest Closed Vessel Preparation

Digestion Parameters

• A good starting point for digestions is a

4 minute ramp to 200oC with a 3 minute

hold

• Initial target temperature should be 200oC

for most organic samples

• Inorganic samples will usually require a

higher temperature

• The maximum temperature should not

exceed 240oC

Operating the System

CEM Synergy–D Computer Controlled Software

• Real time graphs

• Auto sampler control

• Sample queue

• Administrative

control

• Method development

• Built-in methods

• Sample reports

• Detailed operating

procedures for SOP

• Automatic Report

Generation

• GLP, ISO, CFR

Compliance

Sample Methodology

Plant Material

• 0.3g / 10mL conc. Nitric

• Ramp Time : 4 Minutes

• Target Temperature : 200oC

• Hold Time : 3 Minutes

• Total Time : 10 Minutes

0

500

1000

1500

2000

2500

3000

0 50 100 150 200 250 300 350 400 450

P/T

/W i

n 1

/10th

's

Seconds

200oC Plant Material (Max 1oC overshoot) 10 minutes total time with cool down

TargetT

Temp

Pressure

Power

When to Consider Automated Sequential Microwave Digestion

Workflow

• Many different sample types in your laboratory

• Work flow brings in a few samples at a time – several times

per day

• Rush samples are typical in daily routine

– Sample complete in ten minutes including cool down

• Work flow allows benefits from overnight sample prep

– Have up to 36 samples ready when arrive in morning

• Once you load auto sampler you are free to do other tasks

the rest of the day

When to Consider Automated Sequential Microwave Digestion

Best Applications

• Pharmaceutical – documentation of every sample, works

great with raw materials, intermediates, finished products

• Plant, Fish and Animal Tissues of all Types

• Food materials – can do all types with varied acids

necessary for complete digests

• Feeds and Grains

• Biological Materials

• Environmental samples

• Oils and Plastics (less than 240C)

• Inorganics (requiring little HF and less than 240C)

When to Consider Automated Sequential Microwave Digestion

Simplicity

• Smallest footprint of any microwave digestion system

• Only system that does not require a 208/230 volt outlet

• Easiest vessel assembly available (snap the cap)

• Documents run condition of every individual sample

• If you need the capabilities of microwave digestion but

only have a few samples per day or week

When to Consider Batch Microwave Digestion

Total Versatility

• Lots of a few type sample types where 40 sample throughput has an

advantage

– Typical of many commercial testing & Government labs that

support environmental, pharmaceutical or agricultural communities

(need highest throughput available)

• Organic samples that require greater than 0.5 grams or temps greater

than 240C

– Aromatics and brominated hydrocarbons for example need higher

temps to completely digest.

• Inorganic refractories requiring higher temps or generous amounts of

HF

• Labs requiring combination of high throughput and high temps.

Choose the System

That Best Meets

Your laboratory

Requirements