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SISTEM PENGHANTARAN OBAT
LIPOSOM
REDMI FERIS1301076S1-VI B
DOSEN PENGAJAR : DENI ANGGRAINI M.Farm ., A!
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LIPOSOM
L"#$#m a!a%&'('m)%*& ('ma+
aa(a $%a!% '$"+'(
)'ra"r /a*& "+'("("*&"#(' m'm)ra* (""(a"$ &a*a
%*"
(am'(ar a!a%m%(!"(am'(ar, a*!'r)'*!%+ $'ara$#*!a* +'!"+a
#$#(""2$%m)'r a(am$"*!'!"+4
""ra$" '*&a*$'5%m(a a"r.
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8/18/2019 ppt liposom
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OMPONENTAMALIPOSOM
#m#*'* %!ama L"#$#m aa(a
: F#$#("" a* #('$!'r#(.F#$#("" m'r%a+a* +#m#*'*$!r%+!%ra(
!'r)'$ar '*/%$%*m'm)ra* )"#(#&"$ $''r!"m'm)ra* $'(. F#$#(""
/a*&a("*& $'r"*& "&%*a+a* a(am'm)%a!a* ("#$#m
aa(a#$a!""(+#("*. F#$a!""(+#("*m'r%a+a*m#('+%( am8a!"+ /a*&
!'r"r"a!a$ :
9 a "r#"(" #(ar 'a &r#%,#$#+#("*9 a &(/'r#( )r"&'9 a
a"r # "r##)" a/("r#ar)#* a"*
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8/18/2019 ppt liposom
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S'ara %m%m #$#("" aa! "&am)ar+a* $')a&a")'r"+%! :
FOSFOLIPID
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8/18/2019 ppt liposom
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M#('+%( #$a!""(+#(#* !"a+ (ar%! a(am a"r. Da(am m'"a a"r
m#('+%(#$a!""(+#("* m'*a!a"r" a+a* $a("*& )'r'+a!a* %*!%+
m'm"*"ma("$"r "*!'ra+$" /a*& !"a+m'*&%*!%*&+a* a*!ara
a$' a"r '*&a* ra*!a" a*5a*& "r#+ar)#*('ma+ 2$'ara $#*!a*
&r% a$am ('ma+ a+a* $a("*& )'raaa* a*)a&"a* +'a(a
/a*& )'r$"a! #(ar a+a* )'raaa* '*&a* a$' a"r4.S'ara
$"*&+a! m#('+%( #$#("" a(am a"r aa! "&am)ar+a*
$')a&a")'r"+%! :
B')'raa #$#("" /a*&$'r"*& "a+a" a*!ara (a"*:
Na!%ra( #$#(""9 F#$a!""(+#("*9 F#$a!""('!a*#(am"*9
F#$a!""($'r"*
F#$#("" $"*!'!"+9 D"#('#"(#$a!""(+#("*9 D"$!'ar#"(#$a!""(+#("*9
D"#('#"(#$a!""('!a*#(am"*9
D"$!'ar#"(#$a!""('!a*#(am"*
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8/18/2019 ppt liposom
6/18
OLESTEROL
#('$!'r#( )'r%*&$" $')a&a" )%;'r
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8/18/2019 ppt liposom
7/18
Maam-maam L"#$#m
1. Sma(( *"(am'(ar V'$"(' 2SV, 1>-?>*m4
?. I*!'rm'"'!- $"@' *"(am'(ar V'$"('2IV, 100*m4
3. Lar&' *"(am'(ar V'$"(' 2L%, 1000*m4
. M%(!" Lam'(ar V'$"(' 2M(4
>. M%(!"'$"%(ar V'$"(' 2M4
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8/18/2019 ppt liposom
8/18
ara+!'r"$!"+MLV
L')" ar"$a!% (a/'r
E*+a$%(a$"#)a!
("#8("+%+%)'$ar
S!a)"(a(am
'*/"ma*
a* 5a*&+aa*5a*&
C'a!")'r$"+a*
#(' RES
M%a"$"a+a*
D")%a!'*&a*m'!#'!"* 8(m
/ra!"#*
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8/18/2019 ppt liposom
9/18
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8/18/2019 ppt liposom
10/18
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8/18/2019 ppt liposom
11/18
M'+a*"$m' "*!ra$'(%('r '*&a*!ara* #)a!("#$#m
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8/18/2019 ppt liposom
12/18
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8/18/2019 ppt liposom
13/18
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8/18/2019 ppt liposom
14/18
I*!'ra+$" ("#$#m '*&a* $'( aa! m'(a(%" m'+a*"$m'$')a&a"
)'r"+%!:
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8/18/2019 ppt liposom
15/18
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8/18/2019 ppt liposom
16/18
L"#$#m m'm"("+" +'!'r)a!a$a* $')a&a" 'm)a=a#)a! !'rma$%+
+%ra*& $!a)"( $'ara 8$"+a +"m"a,
r#)('m $!'r"("!a$, "*+#ma!")"("!a$ '*&a* #)a!,
''+"m%*#(#&" a* !#+$"+#(#&".P'*&&%*aa* ("#$#m
a(am)'*!%+ $%$'*$" )'ra"r m'*5a" !'r)a!a$ $'"*&&a#rm%(a$"
$')a"+*/a "$"ma* a(am )'*!%+ +'r"*&a* ""ra$" $')'(%m
"&%*a+a* %*!%+ m'*&a$"(+a*
$%$'*$" )'ra"r ("#$#m 2PROLIPOSOM4.
Pr#("#$#m m'r%a+a* &ra*%(ar /a*& r''
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ara+!'r"$a$" L"#$#m
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