Nobel Prize in Physiology or Medicine 2005 for their discovery of the bacterium Helicobacter pylori and its role in gastritis and peptic ulcer disease
Nobel Prize in Physiology or Medicine 2005for their discovery of the bacterium Helicobacter pylori and its role in gastritis andpeptic ulcer disease By Jeremy Moore
J. Robin WarrenBorn 1937 in North Adelaide, in South Australia
University of Adelaide, Australia
Barry J. MarshallBorn 1951Kalgoorlie, AustraliaH. pylori Research Laboratory, QUII Medical Center, and University of Western Australia
Before AwardMet in 1981and worked together for several years after
Work disagreed with early ideas that nothing could live in the stomach
Helicobacter pyloriGenerally contracted as a child from the mother
Can stay with person the rest of their life after infection
Is always associated with inflammation of the stomachs underlying gastric mucosa.
Known best for its cause of stomach ulcers
Helicobacter pyloriIdentified 1982
Harbored by about 50% of worlds population
Also found in other parts of the body like the eye
Believed that shape evolved to penetrate lining of stomach
Most infected people never experience many symptoms
Possible SymptomsLoss of appetite
Burning abdominal pain that is more intense when stomach is empty
Unintentional weight loss
What was learnedResearch of H. pylori led to the understanding of peptic ulcers. Once thought to be caused be stress and lifestyle choices alone, The peptic and gastric ulcers are cause by H. pylori 80-90% of the time.
With this we learned that in most cases on can simply take an antibiotic that deals with gram-negative bacteria, but because so prevalent adaptation is feared.
Possible Cancer AgentWith risk of ulcers and the infection of the corpus region of the stomach there is a chance of provoking stomach cancer is individuals.
MALT (mucosa associated lymphoid tissue) lymphoma was also found to be treatable by simply using antibiotic. This made the cancer regress.