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Next-gen GWAS.NOW.It’s a content revolution.
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Professor Tanke, why is curiosity
a building block of life?
Hans Tanke, a researcher and pioneer of digital fluorescence microscopy, is driven by
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Since 1848, AAAS has served as a prominent voice to advance science and as a valuable
resource for scientists, educators, and policy makers. For the past 100 years, part of
this mission has included publishing the journal Science, one of the world’s premier
peer-reviewed research journals. Working together to disseminate the most compelling
discoveries across all scientific disciplines, AAAS and Science continue to fulfill their
mission of advancing science for the benefit of all.
In addition to supporting Science, individual memberships are a driving force behind
critical AAAS programs and activities designed to strengthen the global scientific
enterprise. By becoming a AAAS member, you not only make a significant impact by
allowing AAAS to continue its mission of advancing science and serving society, but you
also gain powerful resources to develop your own career.
As a member, you’ll receive 51 issues of the journal Science delivered weekly as well
as online access to: groundbreaking research before it’s published; the Science online
archives dating back to 1880; and the current table of contents. In addition to all the
benefits provided by the journal Science, AAAS has partnered on behalf of its members
to provide substantial discounts with numerous organizations, including: Apple, VISA,
GEICO, Barnes & Noble, and more.
If you’re interested in becoming a AAASmember and changing the face of science, please
visit aaas.org. Join us. Together we can make a difference.
AAAS is here – bringing scientific expertise to policy making.
Good science policy is the result of politicians understanding science and scientists understanding policy. Toward this end,
AAAS manages the Science & Technology Policy Fellowships program, which embeds scientists and engineers in the federal
government for up to two years. From Congress to the State Department, each class of Fellows contributes to the policy-making
process while getting hands-on experience at the intersection of science and policy. As a AAASmember your dues support these
efforts. If you’re not yet a AAAS member, join us. Together we can make a difference.
To learn more, visit aaas.org/plusyou/fellows
AAAS is here – helping scientists achieve career success.
Every month, over 400,000 students and scientists visit ScienceCareers.org in search of the information, advice, and opportuni-
ties they need to take the next step in their careers.
A complete career resource, free to the public, Science Careers offers a suite of tools and services developed specifically for
scientists. With hundreds of career development articles, a grants and scholarships database, webinars and downloadable
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job listings in academia, government, and industry, Science Careers has helped countless individuals prepare themselves for
successful careers.
As a AAAS member, your dues help AAAS make this service freely available to the scientific community. If you’re not a member,
join us. Together we can make a difference.
To learn more, visit aaas.org/plusyou/sciencecareers
To learn more, visit aaas.org/plusyou/project2061
AAAS is here – promoting universal science literacy.
In 1985, AAAS founded Project 2061 with the goal of helping all Americans become literate in science, mathematics, and
technology. With its landmark publications Science for All Americans and Benchmarks for Science Literacy, Project 2061 set out
recommendations for what all students should know and be able to do in science, mathematics, and technology by the time they
graduate from high school. Today, many of the state standards in the United States have drawn their content from Project 2061.
Every day Project 2061 staff use their expertise as teachers, researchers, and scientists to evaluate textbooks and assessments,
create conceptual strand maps for educators, produce groundbreaking research and innovative books, CD-ROMs, and profes-
sional development workshops for educators, all in the service of achieving our goal of universal science literacy.
As a AAAS member, your dues help support Project 2061 as it works to improve science education. If you are not yet a AAAS
member, join us. Together we can make a difference.
AAAS is here – bringing educational infrastructure to the developing world.
AAAS is helping the Rwandan government rebuild its educational infrastructure as a way to help drive economic growth and
development. By providing materials such as the Project 2061 Atlas of Science Literacy, lesson plans from Science NetLinks,
and access to Science digital libraries, AAAS is helping the people of Rwanda work toward a future built around science and
technology. As a AAAS member your dues support these efforts. If you’re not yet a AAAS member, join us. Together we can make
a difference.
To learn more, visit aaas.org/plusyou/rwanda
AAAS is here – preparing minority students for careers in science.
Part of AAAS’s mission is to strengthen and diversify the scientific work force. To help achieve this goal AAAS partners with NSF
to present the Historically Black Colleges and Universities Undergraduate Program, a conference where students fromHBCUs get
experience presenting their research, networking with peers, meeting with representatives from graduate schools, and learning
about career opportunities. As a AAAS member your dues support these efforts. If you’re not yet a AAAS member, join us.
Together we can make a difference.
To learn more, visit aaas.org/plusyou/hbcuup
AAAS is here – connecting government to the scientific community.
As a part of its efforts to introduce fully open government, the White House is reaching out to the scientific community for a
conversation around America’s national scientific and technological priorities.
To enable the White House’s dialogue with scientists, AAAS launched Expert Labs, under the direction of blogger and tech guru
Anil Dash. Expert Labs is building online tools that allow government agencies to ask questions of the scientific community and
then sort and rank the answers they receive.
On April 12, 2010, AAAS asked scientists everywhere to submit their ideas to the Obama administration and at the same time
launched the first of Expert Labs tools, Think Tank, to help policy makers collect the subsequent responses. The result was
thousands of responses to the White House’s request, many of which are already under consideration by the Office of Science
and Technology Policy.
As a AAAS member, your dues support our efforts to help government base policy on direct feedback from the scientific
community. If you are not already a member, join us. Together we can make a difference.
To learn more, visit aaas.org/plusyou/expertlabs
Brought to you by theAAAS/Science Business Office
Webinar sponsored by Rocheand 454 Sequencing
DURING THIS WEBINAR, PANELISTS WILL:
• talk about best practices for setting up ampliconresequencing projects
• discuss the application of resequencing technologies to studyimmunologic and other forms of genetic diversity
• share their recent data and expert advice
• answer questions from the live, online audience in the field
August 31, 201012 noon ET, 9 am PT, 4 pm GMT
Characterizing the genetic diversity in a population comes withmany challenges, one of which is the shear number of samplesneeded for analysis in order to provide a clear reading of underlyinggenetic variation. An effective way to solve this problem is throughthe use of multiplex polymerase chain reaction (PCR) run withbarcoding, which offers the possibility of sequencing hundredsof unique samples per run using next generation sequencingtechnology. This process, known as amplicon resequencing, allowsfor each PCR amplicon to be sequenced individually, enabling boththe identification of rare variants and the assignment of haplotypes.
This webinar will provide an overview of amplicon resequencing–based approaches, from the point of view of investigating thecomplexity and diversity seen in immune system genes. Expertswill discuss topics such as site-specific recombination reactionsand cellular dysfunction, as well as how to utilize cutting-edgetechnology to discover pathways and specific patterns whichimpact such factors as the inability of the body to mount an im-mune response and somatic recombination in antibody production.
PARTICIPATING EXPERTS
Francois Vigneault, Ph.D.Harvard Medical SchoolBoston, MA
Henry A. Erlich, Ph.D.Children’s Hospital OaklandResearch InstituteOakland, CA
www.sciencemag.org/webinar
Sign Up At:
REGISTER NOW!
Michael W. Smith, Ph.D.SAIC-FrederickFrederick, MD
Mapping the Genetic Landscape Through
Next Generation Sequencing
www.keystonesymposia.org • 1.800.253.0685 • 1.970.262.1230
OCTOBER 2010Immunological Mechanisms of Vaccination (S1), Seattle,Washington, USA
JANUARY 2011TGF-b in Immune Responses: From Bench to Bedside (A2),Snowbird, Utah, USA
Functional Consequences of Structural Variation inthe Genome (A1), Steamboat Springs, Colorado, USA
Frontiers of NMR in Biology (A3), Big Sky, Montana, USA
NK and NKT Cell Biology: Specificity and Redundancy (A4),Breckenridge, Colorado, USA
Adult Neurogenesis (A5), Taos, New Mexico, USA
Histone Code: Fact or Fiction? (A6), Midway, Utah, USA
Type 2 Diabetes, Insulin Resistance and Metabolic Dysfunction (J1),joint with Obesity (J2), Keystone, Colorado, USA
Tuberculosis: Immunology, Cell Biology and Novel VaccinationStrategies (J3) joint with
Mycobacteria: Physiology, Metabolism and Pathogenesis –Back to the Basics (J4), Vancouver, British Columbia, Canada
Plant Abiotic Stress Tolerance Mechanisms, Water and GlobalAgriculture (A7), Keystone, Colorado, USA
Epithelial Plasticity and Epithelial to Mesenchymal Transition (A8),Vancouver, British Columbia, Canada
Transmembrane Signaling by GPCRs and Channels (B1), Taos,New Mexico, USA
Extracellular Matrix and Cardiovascular Remodeling (B2),Tahoe City, California, USA
The Evolution of Protein Phosphorylation (F1), Keystone, Colorado, USA
Stem Cells in Development, Tissue Homeostasis and Disease (B3),Santa Fe, New Mexico, USA
Genomic Instability and DNA Repair (B4), Keystone, Colorado, USA
FEBRUARY 2011Lung Development and Repair (B5), Santa Fe, New Mexico, USA
Immunologic Memory, Persisting Microbes and Chronic Disease(B6), Banff, Alberta, Canada
Antibodies as Drugs (B7), Keystone, Colorado, USA
MicroRNAs and Non-Coding RNAs and Cancer (J5) joint withMicroRNAs and Human Disease (J6), Banff, Alberta, Canada
Dendritic Cells and the Initiation of Adaptive Immunity (J7) joint withCancer Control by Tumor Suppressors and Immune Effectors (J8),Santa Fe, New Mexico, USA
Inositide Signaling in Pharmacology and Disease (X1) joint withPI 3-Kinase Signaling Pathways (X2), Keystone, Colorado, USA
Genetics, Immunology and Repair in Multiple Sclerosis (B8),Taos, New Mexico, USA
FEBRUARY 2011 (continued)Neurodegenerative Diseases: The Molecular and Cellular Basisfor Neurodegeneration (F2), Taos, New Mexico, USA
Mechanisms of Cardiac Growth, Death and Regeneration (X3)joint with Molecular Cardiology: Disease Mechanismsand Experimental Therapeutics (X4), Keystone, Colorado, USA
Mucosal Biology: A Fine Balance Between Tolerance andAutoimmunity (X5) joint with
Immunity in the Respiratory Tract: Challenges of the LungEnvironment (X6), Vancouver, British Columbia, Canada
Evolutionary Developmental Biology (C1), Tahoe City, California, USA
DNA Replication and Recombination (C2), Keystone, Colorado, USA
MARCH 2011Biofuels (C3), Singapore, Singapore
Stem Cells, Cancer and Metastasis (C4), Keystone, Colorado, USA
New Frontiers at the Interface of Immunity and Glycobiology (C5),Lake Louise, Alberta, Canada
AAA and Related ATP-Driven Protein Machines (C6), Tahoe City,California, USA
Mechanism and Biology of Silencing (C7), Monterey, California, USA
HIV Evolution, Genomics and Pathogenesis (X7) joint withProtection from HIV: Targeted Intervention Strategies (X8),Whistler, British Columbia, Canada
Microbial Communities as Drivers of Ecosystem Complexity (C8),Breckenridge, Colorado, USA
Autophagy (D1), Whistler, British Columbia, Canada
Hematopoiesis (D2), Big Sky, Montana, USA
Environmental Epigenomics and Disease Susceptibility (D3),Asheville, North Carolina, USA
APRIL 2011Metabolic Responses to Extreme Conditions (D4), Big Sky, Montana, USA
Immunoregulatory Networks (D5), Breckenridge, Colorado, USA
Drugs from Bugs: The Anti-Inflammatory Drugs of Tomorrow (Z1) jointwith Evolving Approaches to Early-Stage Drug Discovery (Z2),Snowbird, Utah, USA
B Cells: New Insights into Normal versus Dysregulated Function(D6), Whistler, British Columbia, Canada
MAY 2011Omics Meets Cell Biology (E1), Alpbach, Austria
Lipid Biology and Lipotoxicity (E2), Killarney, County Kerry, Ireland
Pathogenesis of Influenza: Virus-Host Interactions (E3), Hong Kong, China
JUNE 2011Changing Landscape of the Cancer Genome (F3), Boston,Massachusetts, USA
Abstract and scholarship deadlines precede meetings by four months. Please check www.keystonesymposia.org/2011meetings for details.Global Health Travel Award application deadlines for the six designated Global Health conferences precede meeting dates by five months.
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Big Gains for Journal of Physical Chemistry CThe Journal of Physical Chemistry C saw an impressive 140% increase in its
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Uri Banin
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862 13 AUGUST 2010 VOL 329 SCIENCE www.sciencemag.org/products
NEW PRODUCTS FOCUS: SEQUENCING TECHNOLOGIES
LIFE SCIENCE TECHNOLOGIES AAAS/Science Business Office
Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations
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DNA EXTRACTIONThe GET AGAROSE DNA kit supplies a method for fast and effi cient
isolation of DNA fragments from agarose gels. The kit is based on
G-Biosciences’ GET Spin Columns which have a high binding affi nity
for DNA. The isolation step involves the release of nucleic acid
fragments from gel pieces followed by the capture of the fragments
on GET Spin Columns. Washing and elution of the clean nucleic acid
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the kit include rapid isolation of DNA that is ready for downstream
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bp sized fragments and is compatible with TAE and TBE buffer gels.
GET AGAROSE DNA kits are supplied in 50 or 100 prep packages.
G-Biosciences/Genotech
For info: 800-628-7730 www.GBiosciences.com
BIOFILM DNA/RNA ISOLATION PowerBiofi lm DNA Isolation Kit and PowerBiofi lm RNA Isolation Kit
are designed to isolate high-quality DNA or RNA from virtually any
type of biofi lm sample, from dental plaque to microbial mats. Bio-
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to bioremediation. These are the fi rst commercial kits designed to
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DNA ISOLATION AND PURIFICATIONDNAdvance SP is an extraction kit for the isolation and purifi cation
of DNA from saliva samples collected with DNA Genotek’s
Oragene•DNA Self Collection Kits. The high throughput genomic
DNA isolation reagent system enables the purifi cation of high-
quality DNA from saliva samples, making it ideal for genotyping
applications (SNP, fragment analysis), sequencing, and quantitative
polymerase chain reaction. Oragene•DNA is an all-in-one system for
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DNA Genotek/Beckman Coulter Genomics
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AMPLICON TAGGING A new protocol for the Access Array System enables sequencing
of amplicon libraries using GS FLX Titanium Series reagents on
the 454 GS FLX sequencing system. The Access Array integrated
fl uidic circuit (IFC) automatically generates emulsion polymerase
chain reaction (emPCR)-ready libraries by simultaneously combining
48 samples and 48 primer sets to produce 48 uniquely barcoded
samples per chip. Fluidigm’s Access Array IFC, when used with a
454 Titanium sequencer, can capture up to 24 kb of sequence data
per sample, or 1.15 MB per IFC. The addition of the GS FLX Titanium
Series reagents with longer reads expands the amount of sequence
that can be captured using the Access Array System. By incorporat-
ing adaptor sequences into the primer design, the fi nal PCR product
is ready for emPCR as it already contains the necessary capture se-
quences. The 48.48 Access Array IFC is the fi rst chip that features
the ability to recover reaction products automatically.
Fluidigm
For info: 866-358-4354 www.fl uidigm.com
BENCHTOP DNA SEQUENCER
GS Junior Benchtop System provides an integrated sequencing and bioinformatics
solution, all in a size that is no bigger than a typical desktop laser printer. This
system sequences over 35 million bases of DNA in a single 10-hour instrument run,
with average read lengths in the range of 400 base pairs. With the ability to deep
sequence gene loci and the sensitivity to identify rare drug-resistant viral variants
down to one percent frequency, the technology offers signifi cant advantages over
current standards in many areas of medical research. A suite of high-performance
data analysis software is included with the system that provides tools for de novo
genome and transcriptome assembly and mapping, as well as amplicon variant
analysis for the identifi cation of rare variants in targeted sequencing studies.
454 Life Sciences/Roche
For info: 800-262-4911 www.gsjunior.com
Visualization in all its
forms has the power to
illuminate and educate. It
explains and makes clear
all aspects of the world
around us. It feeds insight
and provokes curiosity.
The National Science
Foundation (NSF) and the
journal Science, published by the
American Association for the
Advancement of Science, invite
you to participate in this year’s
Challenge. The competition
recognizes scientists, engineers,
visualization specialists, and
artists who produce innovative
work in visual communication.
Winning entries will be
published in Science and Science
Online, and will be displayed on
the NSF website.
Award Categories
• Photography
• I l lustrat ions
• Informational Posters
and Graphics
• Interac tive Games
• Non- Interac tive Media
I N T E R N A T I O N A L S C I E N C E & E N G I N E E R I N G
V I S U A L I Z A T I O N C H A L L E N G E
COMPETITION DEADLINE
APPROACHING
’
ENTRY DEADLINE: SEPTEMBER 15, 2010
C E I:
..//
Optimized for TaqMan®
Array Micro Fluidic Cardsand reagents.
FOR RESEARCH, FORENSIC OR PATERNITY USE ONLY. NOT INTENDED FOR ANY ANIMAL OR HUMAN THERAPEUTIC OR DIAGNOSTIC USE. The trademarks mentioned herein are the property of Life Technologies Corporation or their respective owners.
TaqMan is a registered trademark of Roche Molecular Systems, Inc. © 2010 Life Technologies Corporation.
ThenewViiA™ 7Real-TimePCRSystemputs high-productivity qPCRat yourfingertips.
With a streamlined workflow, one-button protocol feature, and intuitive software, the new ViiA™ 7
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The biggest advance in qPCR since the q.
