Date of Document June 27, 2015

CURRICULUM VITAE

David P. Bick MD

OFFICE ADDRESS:HudsonAlpha Institute for Biotechnology601 Genome Way Huntsville, AL 35806

EDUCATION: 8/1973 - 5/1977 AB, Cornell University, Ithaca, NY8/1977 - 5/1981 MD, George Washington University School of Medicine, Washington, DC

POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: 7/1981 - 7/1982 Intern in Pediatrics, Yale New Haven Hospital, New Haven, CT7/1982 - 7/1983 Resident in Pediatrics, Yale New Haven Hospital, New Haven, CT7/1984 - 7/1986 Fellow, Department of Human Genetics, Human Genetics and Pediatrics, Yale School of

Medicine, New Haven, CT7/1986 - 7/1987 Postdoctoral Research Fellow, Department of Human Genetics, Yale University School of

Medicine, New Haven, CT

FACULTY APPOINTMENTS: 7/1987 - 7/1989 Assistant Professor, Pediatrics, and Cellular and Structural Biology, University of Texas

Health Science Center, San Antonio, TX9/1989 - 12/2001 Clinical Geneticist, Genetics and IVF Institute, Fairfax, VA7/1991 - 12/2001 Affiliate Assistant Professor, Department of Human Genetics, School of Medicine,

Medical College of Virginia, Richmond, VA7/1996 - 12/2001 Clinical Assistant Professor, School of Medicine, University of Virginia Health Sciences

Center , Charlottesville, VA1/2002 - 7/2008 Associate Professor, Department of Pediatrics, Division of Medical Genetics, Medical

College of Wisconsin, Milwaukee, WI10/2004 - 7/2008 Associate Professor, Department of Obstetrics & Gynecology, Medical College of

Wisconsin, Milwaukee, WI7/2008 – 7/2015 Professor, Departments of Pediatrics and Obstetrics & Gynecology, Medical College of

Wisconsin, Milwaukee, WI9/2015 – present Faculty Investigator, HudsonAlpha Institute for Biotechnology, Huntsville, AL

ADMINISTRATIVE APPOINTMENTS: 5/1999 - 12/2001 President & CEO, Genetics & IVF Institute, Fairfax, VA4/2008 - 1/2011 Interim Chief of Division of Genetics, Department of Pediatrics, Medical College of

Wisconsin, Milwaukee, WI1/2011 – 7/2015 Section Chief, Department of Pediatrics, Division of Genetics, Medical College of

Wisconsin, Milwaukee, WI9/2015 – present Medical Director, HudsonAlpha Medical Genomics Program, HudsonAlpha Institute for

Biotechnology, Huntsville, AL

HOSPITAL AND CLINICAL ADMINISTRATIVE APPOINTMENTS: 5/2009 – 7/2015 Director, Advanced Genomics Laboratory, Department of Pediatrics, Medical College of

Wisconsin, Milwaukee, WI2/20/2012 – 7/2015 Medical Director, Genetics Clinic, Children's Hospital of Wisconsin, Milwaukee, WI

HOSPITAL STAFF PRIVILEGES: 1/2002 - Present Froedtert Memorial Lutheran Hospital, 9200 W. Wisconsin Ave, Milwaukee, WI 532261/2002 - Present Children’s Hospital of Wisconsin, 9000 W. Wisconsin Ave., Milwaukee, WI 532261/2007 - Present Children’s Hospital of Wisconsin, Fox Valley, 130 2nd St., Neenah, WI 54956

SPECIALTY BOARDS AND CERTIFICATION: Board Certified

Issue Date

Expiration

National Board of Medical Examiners

7/1/1982

None

American Board of Pediatrics

3/23/1986

None

American Board of Medical Genetics, Clinical Genetics

9/15/1987

None

American Board of Medical Genetics, Clinical Molecular Genetics

9/24/1993

12/31/2019

Licensure

Number

Issue Date

Expiration

Wisconsin License

43761-020

10/31/2013

10/31/2015

AWARDS AND HONORS:

5/1981 Alpha Omega Alpha Medical Honor Society6/2006 Clinical Scholarship Award, Medical College of Wisconsin, Department of Pediatrics Clinical

Physician 8/2009 Outstanding Faculty Service Award, Medical College of Wisconsin2009 Best Doctors in America2009 - 2010 Outstanding Medical Student Teachers for 2009-2010, Medical College of Wisconsin2010 Best Doctors in America2011 Faculty Service Award 2011, Medical College of Wisconsin2011 Best Doctors in America2012 Best Doctors in America2013 Best Doctors in America2014 Best Doctors in America

MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: American College of Medical Genetics (Founding Fellow) American Society of Human Genetics (Member) American Academy of Pediatrics (Fellow)

EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: Journal Review

American Journal of Human Genetics Pediatric Dermatology Journal Journal of Assisted Reproduction and Genetics

LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: 3/1/2006 - Present Member, Advisory Committee, Wisconsin Genetics System

NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: 7/2010 - Present Member, Organizing Committee, Next Generation Sequencing – Standardization of

Clinical Testing (NEx-StoCT) Conferences12/2013 - Present Member, Scientific Advisory Comittee, Genomics England, United Kingdom2013 - Present Member, ACMG Interpretation of Sequence Variants Workgroup, American College of

Medical Genetics and Genomics and ACMG Foundation for Genetic and Genomic Medicine

INVITED LECTURES/WORKSHOPS/PRESENTATIONS: Local1. Preimplantation Genetic Diagnosis, Perinatal Assessment Center, Memorial Hospital of Burlington,

Burlington, WI, 4/15/20022. The Science and Ethics of Pre-implantation Genetic Diagnosis, Milwaukee Biotechnology Interest

Group, Alumni Center, Medical College of Wisconsin, Milwaukee, WI, 4/29/20023. Genes and Neurodevelopment Disorders, Pediatric Grand Rounds, St. Luke’s Hospital, Racine, WI,

12/10/20024. Options for Patients with a Family History of a Genetic Disease, Resident Lecture, St. Michael

Hospital, Family Care Center, Milwaukee, WI, 1/7/20035. Preimplantation Genetic Diagnosis, Perinatal Case Review Conference, Waukesha Memorial

Hospital, Waukesha, WI, 1/23/20036. Genetics in 2003, St. Mary’s Hospital, Resident Lecture, Milwaukee, WI, 2/5/20037. Molecular Genetic Approach to Neurodevelopmental Disabilities, Wisconsin Genetics Exchange,

Children’s Hospital of Wisconsin, Milwaukee, WI, 2/28/20038. Preimplantation Genetic Testing, Children’s Hospital of Wisconsin-Kenosha, Kenosha, WI, 5/7/20039. Recent Advances in the Genetics of Neurodevelopmental Disabilities, Grand Rounds, Children’s

Hospital of Wisconsin Fox Valley, 5/14/200310. Preimplantation Genetic Testing, Children’s Hospital of Wisconsin, Pediatric Surgeon Fellowship

Rounds, Milwaukee, WI, 8/1/200311. Preimplantation Genetic Diagnosis, Aurora Healthcare, Women’s Pavilion Presentation,

Milwaukee, WI, 9/2/200312. Molecular Genetic Approach to Neurodevelopmental Disabilities, Medical College of Wisconsin,

Department of Neurology/Neuropsychiatry Noon Conference, Milwaukee, WI, 9/16/200313. Prenatal and Preconception Options for Couples with a History of Genetic Disorder, Pediatric Noon

Conference, Medical College of Wisconsin, Department of Pediatrics, Milwaukee, WI, 10/10/2003

14. F. Jackson Stoddard Memorial Lecture: A Practical Approach to Genetic Screening, Milwaukee Gynecological Society, Milwaukee, WI, 2/3/2004

15. Personalized Medicine, St. Mary’s Hospital, Grand Rounds, Milwaukee, WI, 2/4/200416. Genetics for the Obstetrician and Gynecologist, St. Mary’s Hospital, Resident Lecture, Milwaukee,

WI, 4/7/200417. Updates in Prenatal Genetics, Kenosha Hospital Medical Center, Kenosha, WI, 5/5/200418. Preimplantation Genetics: Diagnoses and Treatment, American College of Obstetricians &

Gynecologists and Wisconsin Society of Obstetrics & Gynecology 2004 Annual Meeting, Wisconsin Dells, WI, 7/24/2004

19. Reproductive Options for Patients with Fragile X Syndrome, Medical Ethics Committee, Aurora Sheboygan Memorial Hospital, 11/17/2004

20. Updates in Prenatal Genetics, Continuing Medical Education Program, Waukesha Memorial Hospital, Waukesha, WI, 1/4/2005

21. Personalized Medicine, Waukesha Memorial Hospital, 8/2/200522. Infertility and Genetics: What the Healthcare Provider Should Know, Reproductive Medicine

Symposium: Building Families Through Teamwork and Technology, Waukesha, WI, 9/23/2005

23. Preimplantation Genetic Diagnosis in 2005, Wisconsin Genetics Exchange, Children’s Hospital of Wisconsin, Milwaukee, WI, 10/14/2005

24. Infertility and Genetics: What the Healthcare Provider Should Know, Midwest Infertility Nurse’s Council, Sheboygan, WI, 2/2/2006

25. Genetic Testing: Overview of Your Options, Froedtert Hospital Community Education Class, Milwaukee, WI, 5/22/2006

26. When should you offer preimplantation genetic diagnosis to your patients?, Second Annual Reproductive Medicine Symposium: Building Families Through Teamwork and Technology, Waukesha, WI, 9/29/2006

27. Genetics in clinical investigation: Bedside to Bench and back!, Genetics Seminar Series, General Clinical Research Center, Medical College of Wisconsin, Milwaukee, WI, 10/17/2006

28. Use of multiplex amplifiable probe hybridization to detect the etiology of mental retardation, Human Molecular Genetics Center Seminar, Medical College of Wisconsin, Milwaukee, WI, 10/19/2006

29. Indications for preimplantation genetic diagnosis, 31st Annual Perinatal Day, Fox Valley Perinatal Association, Appleton, WI, 11/1/2006

30. Genetics in 2007: What practitioners need to know about cystic fibrosis and other genetic disorders, Waukesha Memorial Hospital, Grand Rounds, Waukesha, WI, 3/13/2007

31. Genetic Disorders with Orthopedic manifestations, Orthopedic Residents, Children’s Hospital of Wisconsin, Milwaukee, WI, 4/11/2007

32. Preimplantation Genetic Diagnosis (PGD), Blood Center of Wisconsin, Milwaukee, WI, 5/29/200733. Personalized Medicine, Columbia St. Mary's Hospital, Milwaukee, WI, 6/5/200734. Genetic Screening in 2007: What Should I Offer to My Patients?, Lake Forest Outpatient and Acute

Care Center, Grand Rounds, Grayslake, IL, 8/10/200735. Personalized Medicine in Pediatrics, Young Presidents Organization, Children’s Hospital of

Wisconsin, Milwaukee, WI, 10/2/200736. Personalized Medicine, Primary Care Conference, St. Mary's Hospital, Madison, WI, 10/3/200737. Etiology of Proteus Syndrome, CRI Noon Academic Conference, Children’s Hospital of Wisconsin,

Milwaukee, WI, 10/5/200738. Etiology of Proteus Syndrome, Human Molecular Genetics Center Seminar Series, Medical College

of Wisconsin, Milwaukee, WI, 1/17/200839. Personalized Medicine and Pharmacogenetics, Cardiac Research Focus Group Meeting, Children’s

Hospital of Wisconsin, Milwaukee, WI, 2/12/200840. Genetic Screening in 2008: What Should I Offer to My Patients?, Practices in Pediatrics

Conference, Wisconsin Dells, WI, 3/7/200841. Personalized Medicine, Medical-Surgical Conference, Beloit Memorial Hospital, Beloit, WI,

4/16/200842. Pre-Implantation Genetic Diagnosis (PGD) 2008: What’s New, Children’s Hospital of Wisconsin

Pediatrics Grand Rounds, Milwaukee, WI, 8/22/200843. Genetic Screening in 2008: What Should I Offer to My Patients?, Children’s Hospital of Wisconsin

Fox Valley, Grand Rounds, 9/10/200844. Personalized Medicine, Case Management Society of America 8th Annual CMSA Conference,

Waukesha, WI, 9/24/2008

45. Testing for Copy Number Changes Using the Affymetrix 6.0 Array in Patients with Neurodevelopmental Disabilities and Dysmorphology, Medical College of Wisconsin, Human Molecular Genetics Center, Milwaukee, WI, 12/18/2008

46. Genetic Disorders with Orthopaedic Manifestations, MCW Basic Science Lecture Series, Children’s Hospital of Wisconsin, Milwaukee, WI, 3/18/2009

47. Genetic Screening in 2009: What Should I Offer to My Patients?, Waukesha Memorial Hospital All-Staff Conference, Waukesha, WI, 8/4/2009

48. Use of Affymetrix DNA Microarray in the Genetic Clinic, Wisconsin Genetics Exchange, Children’s Hospital of Wisconsin, Milwaukee, WI, 10/9/2009

49. Use of Affymetrix Genome-Wide Human SNP Array 6.0 in the clinic, Human and Molecular Genetics Center Lecture, Medical College of Wisconsin, Milwaukee, WI, 11/19/2009

50. Use of Affymetrix Genome-Wide Human SNP Array 6.0 in the clinic, NICU CME Conference, Children’s Hospital of Wisconsin, Milwaukee, WI, 1/5/2010

51. Preimplantation Genetic Diagnosis, MCW Technology Innovation Council, Medical College of Wisconsin, Milwaukee, WI, 1/19/2010

52. Use of Affymetrix Genome-Wide Human SNP Array 6.0 in the Clinic, Pediatrics Academic Noon Conference, Children’s Hospital of Wisconsin, Milwaukee, WI, 3/19/2010

53. Genetic Screening 2010: What should I offer to my patients?, Resident Noon Conference, Children’s Hospital of Wisconsin, Milwaukee, WI, 4/20/2010

54. Use of Affymetric Genome-Wide Human SNP Array 6.0 in clinical neurological care, Neurology Conference, Children’s Hospital of Wisconsin, Milwaukee, WI, 5/21/2010

55. Genetic Screening: What Should I Offer to My Patients?, Annual Ethics Week Lecture Series, United Healthcare System, Kenosha Medical Center, Kenosha, WI, 10/27/2010

56. Practical Pediatrics Webcast: Genetic Screening: What Should I Offer to My Patients?, Children’s Hospital of Wisconsin Internet, Milwaukee, WI, 4/18/2011

57. Whole Genome Sequencing: Helping Children Today, Annual Spring Estate Planning Seminar IX for Professionals, Children’s Hospital of Wisconsin, Milwaukee, WI, 5/17/2011

58. Whole Genome Sequencing: Helping Children Today, Annual Joint CHHSF Planned Giving Council, Milwaukee, WI, 6/21/2011

59. Whole Genome Sequencing: Helping Children Today, Annual Women's Seminar, Wisconsin Club, Milwaukee, WI, 10/18/2011

60. Whole Genome Sequencing: Helping Children Today, Children's Hospital and Health System Foundation, Bluemound Country Club, Wauwatosa, WI, 10/19/2011

61. Whole Genome Sequencing: Moving a research technique into the clinic, Children’s Research Institute Research Conference, Milwaukee, WI, 10/20/2011

62. Whole Genome Sequencing: Helping Children Today, Annual Women's Seminar, Westmoor Country Club, Brookfield, WI, 10/25/2011

63. Clinical Use of Whole Genome and Whole Exome Sequencing , Physician Scientist Pathway Course, Medical College of Wisconsin, Milwaukee, WI, 11/17/2011

64. Genetic Screening : What Should I Offer to My Patients?, CHW Resident Noon Conference, Milwaukee, WI, 1/4/2012

65. Whole Genome Sequencing: Moving a research technique into the clinic, MCW Medical Scientist Training Program, Milwaukee, WI, 2/9/2012

66. Whole Genome Sequencing: Helping Children Today, Children's Hospital and Health System Foundation, St. John’s on the Lake, Milwaukee, WI, 4/20/2012

67. Whole Genome Sequencing: Helping Children Today, Greater Milwaukee Foundation Donor Breakfast, Milwaukee, WI, 7/20/2012

68. Online Resources for Genetics, MCW and China Medical Association Intensive Developmental and Behavioral pediatrics Training for Chinese Pediatricians, Medical College of Wisconsin, Milwaukee, WI, 9/10/2012

69. Genome Sequencing in Clinical Practice, Children's Research Institute Noon Conference, Medical College of Wisconsin, Milwaukee, WI, 1/11/2013

70. Genetic Testing in 2013, MCW Billing & Collections Team Meeting American Academy of Professional Coders (AAPC) CEU Lecture, Milwaukee, WI, 2/13/2013

71. Kabuki Syndrome and Histone deacetylase inhibitors, Kabuki Karnival - Kabuki Parent Support Group Mtg, Mukwonago, WI, 7/13/2013

72. MCW/CHW clinical and laboratory genomic medicine program – a progress report, Human and Molecular Genetics Center Lectures Series, Medical College of Wisconsin, Milwaukee, WI, 7/18/2013

73. Infantile Myofribromatosis, Tumor Board, Medical College of Wisconsin, Milwaukee, WI, 10/17/2013

74. Genomic Sequencing in Clinical Practice, Department of Ophthalmology Grand Rounds, Medical College of Wisconsin, Milwaukee, WI, 4/2/2014

75. Genetics 101: Fundamental Principles and Prenatal Genetics for the Pediatrician, Noon Conference for Hospitalist Program, Medical College of Wisconsin, Milwaukee, WI, 5/20/2014

76. Using Genomic Sequencing in Clinical Practice Today, Laboratory Lecture, Children's Hospital of Wisconsin, Milwaukee, WI, 6/12/2014

77. Genetic Testing in the Era of Next Generation Sequencing, Children's Community Health Plan, West Allis, WI, 2/27/2015

Regional1. Genes and Neurodevelopment Disorders, Saint Therese Medical Center, Waukegan, IL, 3/14/20032. Updates in Prenatal Genetics, 2004 Pediatric Grand Rounds, St. Therese Medical Center, Waukegan,

IL, 8/13/20043. MCW/CHW Whole Genome Sequencing Program, Genomic Medicine Institute's Colloquium:C

linical Implementation of Genomic Discoveries, Chicago, IL, 6/29/20114. Whole Genome Sequencing, BIOMG 2810 Genetics and Genomics, Ithaca, NY, 7/29/20115. Whole Genome Sequencing in Clinical Practice, Emory University School of Medicine Grand

Rounds, Atlanta, GA, 11/12/20126. Current State of Practice: Whole Genome Sequencing in Clinical Use Today, Clinical &

Translational Science Institute Conference: Genomic & Personalized Medicine: Analysis and Clinical Implementation, Marquette University Alumni Memorial Union, Milwaukee, WI, 12/17/2012

7. Genetic Testing 2013 and Beyond, Best Practices in Pediatrics, Winter 2013 CME Conference, Wisconsin Dells, WI, 3/9/2013

8. Developing a clinical and laboratory genomic medicine program, Invited Lecturer, Cincinnati Children's Medical Center, Cincinnati, OH, 4/9/2013

9. Whole Genome Sequencing, BIOMG 2810 Genetics and Genomics, Cornell University, Ithaca, NY, 7/25/2013

10. Using Genomic Sequencing in Clinical Practice Today, Prevention Genetics Seminar Series, Marshfield, WI, 11/14/2013

11. Whole Genome Sequencing, BIOMG 2810 Genetics and Genomics, Cornell University, Ithaca, New York, 7/25/2014

12. Developing a Clinical and Laboratory Genomic Medicine Program, Nationwide Children's Hospital, Columbus, OH, 10/31/2014

13. Developing a Clinical and Laboratory Genomic Medicine Program, University of Alabama, School of Medicine, Birmingham, AL, 4/20/2015

National1. Whole Genome Sequencing in the Diagnosis of Mendelian Genetic Disorders, CAP-Illumina

Meeting, Boston, MA, 10/19/20102. Clinical Use of Whole Genome and Whole Exome Sequencing Today, College of American

Pathologists Personalized Health Care, Webinar Series, 12/14/20113. Impact of NGS on Clinical Genetics, ACMG CME Short Course: Next generation sequencing:

Clinical utility, laboratory implementation and bioinformatics analysis, American College of Medical Genetics and Genomics 2012 Annual Clinical Genetics Meeting, Charlotte, NC, 3/27/2012

4. Effective communication of whole genome sequencing results, ACMG CME Short Course: Next generation sequencing: Clinical utility, laboratory implementation and bioinformatics analysis, American College of Medical Genetics and Genomics 2012 Annual Clinical Genetics Meeting, Charlotte, NC, 3/27/2012

5. Whole Genome Sequencing in Clinical Practice Today, Genomic and Personalized Medicine Forum, Duke Institute for Genome Sciences & Policy,Duke University Health Systems, Durham, NC, 5/17/2012

6. Whole Genome Sequencing, BIOMG 2810 Genetics and Genomics, Ithaca, NY, 7/27/20127. Informatics in Next - Generation Sequencing: NGS Will Change the Practice of Medicine, Centers

for Disease Control and Prevention Conference, Nex-StoCT II, Atlanta, GA, 10/11/20128. Whole Genome and Whole Exome Sequencing in the Clinic, Association for Molecular Pathology

Annual Meeting, Genomic Medicine 2012, Long Beach, CA, 10/26/20129. Whole Genome Sequencing in Children: Ready for Prime Time?, American Academy of Pediatrics

2013, Meet-the-Expert Discussion, Orlando, FL, 10/26/2013

10. Whole Genome Sequencing in Children: Ready for Prime Time?, American Academy of Pediatrics 2013, Meet-the-Expert Discussion, Orlando, FL, 10/27/2013

11. How should physicians integrate the new variant classification guidelines into clinica care?, American College of Medical Genetics Annual Meeting, Nashville, TN, 3/25/2014 - 3/29/2014

12. When to Order an Exome (Versus Other Genetic Tests) and Variant Interpretation in the Context of WES vs. Single Genes and Panels, American College of Medical Genetics Annual Meeting, Short Course, Salt Lake City, UT, 3/24/2015

13. Overview of NGS: A Comparison of WGS/WES Versus Microarray Testing in the Evaluation of Intellectual Disability, Autism and/or Multiple Congenital Anomalies, American College of Medical Genetics Annual Meeting. Satellite Symposium, Salt Lake City, UT, 3/25/2015

International1. Genetic Screening and Testing, Editor’s Choice Conference, Rzeszow, Poland, 6/13/20082. Ambiguous Genitalia (Disorders of Sex Development), Editor’s Choice Conference, Rzeszow,

Poland, 6/14/20083. Using Whole Genome Sequencing in Clinical Practice, Inivted Lecture, Wellcome Trust Center for

Human Genetics, Oxford University, Oxford, United Kingdom, 10/10/20114. Using Genomic Sequencing in Clinical Practice Today, University of Oxford, Oxford Biomedical

Research Centre, Oxford, UK, 6/26/2014

PEER REVIEWED WORKSHOPS/PRESENTATIONS: Local1. Preimplantation Genetic Diagnosis, Pediatric Grand Rounds, Children’s Hospital of Wisconsin,

Milwaukee, WI, 3/1/20022. Preimplantation Genetic Diagnosis, Grand Rounds, Department of Obstetrics and Gynecology,

Medical College of Wisconsin, Milwaukee, WI, 5/8/20023. Genes and Neurodevelopmental Disabilities, Pediatric Grand Rounds, Children’s Hospital of

Wisconsin, Milwaukee, WI, 6/6/20034. Personalized Medicine, Pediatric Grand Rounds, Children’s Hospital of Wisconsin, Milwaukee, WI,

7/30/20045. Updates in Prenatal Genetics, Resident Noon Conference, Children’s Hospital of Wisconsin,

Milwaukee, WI, 2/18/20056. Skeletal Dysplasia, Orthopedic Resident Noon Conference, Children’s Hospital of Wisconsin,

Milwaukee, WI, 3/16/20057. Indications for Preimplantation Genetic Diagnosis (PGD), Grand Rounds, Department of Obstetrics

and Gynecology, Medical College of Wisconsin, Milwaukee, WI, 3/30/20058. Preimplantation Genetic Diagnosis in 2006, Pediatric Grand Rounds, Children’s Hospital of

Wisconsin, Milwaukee, WI, 1/20/20069. Cardiology and Genetics, Cardiology Fellow Grand Rounds, Froedtert Memorial Lutheran Hospital,

Milwaukee, WI, 4/13/200610. Prenatal Genetics for the Pediatrician, Noon Conferences for Pediatric Residents, Children’s

Hospital of Wisconsin, Milwaukee, WI, 4/13/200611. Clinical use of DNA Microarray to Diagnose Patients with Birth Defects and Neurodevelopmental

Disorders, Grand Rounds, Children’s Hospital of Wisconsin, Milwaukee, WI, 1/29/201012. Whole Genome Sequencing: Moving a Research Technique to the Clinic, CRI Research

Conference, Children's Hospital of Wisconsin, Milwaukee, WI, 10/20/2011

National1. Whole Genome and Whole Exome Sequencing in the Clinic, Association for Molecular Pathology,

Plenary Session, Long Beach, CA, 10/25/2012 - 10/27/20122. Challenges and Accomplishments of Exome and Genome Sequencing, American College of Medical

Genetics 2013 Annual Meeting, Phoenix, AZ, 3/23/20133. Medical College of Wisconsin Experience: Reimbursement Successes and Failures in "In House"

WES/WGS, American College of Medical Genetics 2013 Annual Meeting, Phoenix, AZ, 3/23/2013

COMMITTEE SERVICE: Medical College

7/2002 - 12/2006 Member, General Clinical Research Center Committee, Medical College of Wisconsin

5/2006 - 9/2006 Member, Curriculum and Evaluation Committee, Genetics Education Subcommittee, Medical College of Wisconsin

12/2006 - Present Project Leader, Joint Effort of Children’s Hospital of Wisconsin, Pharmacogenetics and Genomic Medicine Initiative, Department of Pediatrics and the Children’s Research Center, Medical College of Wisconsin

7/2008 - 6/2011 Member, Library Committee, Medical College of Wisconsin

MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: Medical Students

Brook Daniels, Medical College of Wisconsin, 2007 - 2008 Medical Student AdvisorAyuko Iverson, Medical College of Wisconsin, 2011 - Present Advisor

Graduate StudentsPhD Committees

Kelly Duffy, Medical College of Wisconsin, 2006 - 2007 PhD Thesis CommitteeMS Committees

Elad Amir , Medical College of Wisconsin, 2007 - 2008 Masters Thesis CommitteeNavin Kumar, Medical College of Wisconsin, 2009 - 2011 Scholarship Oversight CommitteeDaniel Helbling, Medical College of Wisconsin, 2010 - 2013 Masters Thesis Committee

PROGRAMMATIC DEVELOPMENTS:

Clinical Programs2002 - Present Chorionic Villus Sampling Program2002 - 2012 Preimplantation Genetic Diagnosis Program2002 - Present Molecular Genetics Laboratory

GRANTS: 7/1978 - Present National Foundation March of Dimes Summer Science Research Grant Program for

Medical Students9/1988 - 8/1989 University of Texas Health Science Center at San Antonio Institutional Research Grant:

“Physical mapping of the X-linked Kallmann syndrome locus.” 7/1993 - 7/1994 Institute of Research and Education INOVA Health System: “Molecular Analysis of

Colorectal Cancer Susceptibility Gene in Patients with Colorectal Polyps and Cancer.” $9,500

BIBLIOGRAPHY

Refereed Journal Publications/Original Papers1. Mahoney, M.J. and BICK, D.P. Recent advances in the inherited methylmalonic acidemias. Acta Paediatr Scand 76:689-696, 1987.

2. BICK, D.P., Balkite, E.A., Baumgarten, A., Hobbins, J.C., Mahoney, M.J.: The association of congenital skin disorders with acetylcholinesterase in amniotic fluid. Prenat Diagn 7:543-549, 1987.

3. BICK, D.P., Markowitz, R., Horwich, A. Trisomy 18 associated with ectopia cordis and occipital meningocele. Am J Med Genet 30:805-810, 1988.

4. BICK, D.P., Curry, C.J.R., McGill, J., Schorderet, D.F., Bux, R.C., Moore, C.M. A male infant with ichthyosis, Kallmann syndrome, chondrodysplasia punctata and an Xp chromosome deletion. Am J Med Genet 33:100-107, 1989.

5. Schwanzel-Fukuda, M., BICK, D.P., Pfaff, D.W. Luteinizing hormone-releasing hormone (LHRH)-expressing cells do not migrate normally in an inherited hypogonadal (Kallmann) syndrome. Mol Brain Research 6:311-326, 1989.

6. Ballabio, A., Bardoni, B., Carrozzo, R., Andria, G., BICK, D.P., Campbell, L., Hamel, B., Ferguson-Smith, M.A., Gimelli, G., Fraccaro, M., Maraschio, P., Zuffardi, O., Guioli, S., Camerino, G. Contiguous gene syndromes due to deletions in the distal short arm of the human X chromosome. Proc Natl Acad Sci 86:10001-10005, 1989.

7. Swaroop, A., Agarwal, N., Gruen, J.R., BICK, D., Weissman, S.M. Differential Expression of Novel Gsα Signal Transduction Protein cDNA Species. Nucleic Acids Res 19:4725-4729, 1991.

8. BICK, D.P., Schorderet al, D.F., Price, P.A., Campbell, L., Huff, R.W., Shapiro, L.J., Moore, C.M. Prenatal diagnosis and investigation of a fetus with chondrodysplasia punctata, ichthyosis, and Kallmann syndrome due to an Xp deletion. Prenat Diagn 12:19-29, 1992.

9. BICK, D.P., Franco, B., Sherins, R.J., Heye, B., Pike, L., Crawford J., Maddalena, A., Incerti, B., Pragliola, A., Mettinger, T., Ballabio, A. Brief Report: Intragenic deletion of the KALIG-1 gene in Kallmann's syndrome. N Eng J Med 326:1752-1755, 1992.

10. Maddalena, A., BICK, D.P., Schulman, J.D. Molecular Diagnosis of Genetic Disease. J Reprod Med 37:437-444, 1992.

11. Schnur, R.E., Wick, P.A., Sosnoski, D.N., Ballabio, A., BICK, D.P., Nussbaum, R.L. Deletion mapping and a highly reduced radiation hybrid in the Xp22.2-p22.3 region. Genomics 15:500-506, 1993.

12. Buehler, B.A., BICK, D.P., Delimont, D. Letter to the Editor: Prenatal prediction of risk of the fetal hydantoin syndrome. N Eng J Med 322:1660-1661, 1993.

13. Heuertz, S., Nelen, M., Wilkie, A.O.M., Le Merrer, M., Del Rieu, O., Larget-Piet, L., Tranebjaerg, L., BICK, D.P., Hamel, B., van Oost, B.A., Maroteaux, P. and Hors-Cayla, M.C. The gene for spondyloepiphyseal dysplasia (SEDL) maps to Xp22 between DXS16 and DXS92. Genomics 18:100-104, 1993.

14. BICK, D.P., Ballabio, A. Commentary: Bringing Kallmann Syndrome into focus. Am J of Neurorad 14:852-854, 1993.

15. Black, S.H., BICK, D.P., Maddalena, A., Schulman, J.D., Jones, S. Letter to the Editor: Pregnancy screening for cystic fibrosis. Lancet 30:342, 1993.

16. Levinson, G., Maddalena, A., Palmer, F.T., Harton, G.L., BICK, D.P., Howard-Peebles, P.N., Black, S.H., Schulman, J.D. Improved sizing of fragile X CGG repeats by nested PCR. Am J Med Genet 51:527-534, 1994.

17. Spence, W.C., Maddalena, A., Demers, D.B., BICK, D.P. Molecular analysis of the Rh locus in an individual with the DU phenotype. Transfusion 34:741-742, 1994.

18. Spence, W.C., Maddalena, A., Demers, D.B., BICK, D.P. Molecular analysis of the RhD genotype in fetuses at risk for RhD hemolytic disease. Obstet Gynecol 296-298, 1995.

19. Levinson, G., Keyvanfar, K., Wu, J.C., Fugger, E.F., Fields, R.A., Harton, G.L., Palmer, F.T., Sisson, M.E., Starr, K.M., Dennison-Lagos, L., Calvo, L., Sherins, R.J., BICK, D.P., Schulman, J.D., Black, S.H. DNA-based X-enriched sperm separation as an adjunct to preimplantation genetic testing for the prevention of X-linked disease. Human Mol Reprod 1:979-982, 1995.

20. Spence, W.C., Potter, P., Maddalena, A., Demers, D.B. BICK, D.P. DNA-based prenatal determination of the RhE genotype. Obstet Gynecol 21:670-672, 1995.

21. Howard-Peebles, P.N., Maddalena, A., Black, S.H., Levinson, G., BICK, D.P.. Schulman, J.D. Fragile X screening in pediatric & obstetrical patients. Dev Brain Dysfunct 8:408-410, 1995.

22. BICK, D.P. Genetic disease diagnosis: Challenges and opportunities. IEEE Engineering in Medicine and Biology Magazine 14(2):226-228 March-April, 1995.

23. Spence, W.C., Black, S.H., Fallon, L., Maddalena, A., Cummings, E., Menapace-Drew, G., BICK, D.P., Levinson, G., Schulman, J.D., Howard-Peebles, P.N. Molecular fragile X screening in normal populations. Am J Med Genet 64:181-183, 1996.

24. Spence, W.C., Maddalena, A., Demers, D.B., BICK, D.P. Prenatal determination of genotypes Kell and Cellano in at-risk pregnancies. J Reprod Med 42:353-357, 1997.

25. Layman, L.C., Cohen, D.P., Jin, M., Xie, J., Li, Z., Reindollar, R.H., Bolbolan, S., BICK, D.P., Sherins, R.J., Duck, L.W., Musgrove, L.C., Sellers, J.C., Neill, J.D. Mutations in gonadotropin-releasing hormone receptor gene cause hypogonadotropic hypogonadism. Nat Genet 18:14-15, 1998.

26. BICK, D.P., Fugger, E.F., Pool, S., Hazelrigg, W.B., Yadvish, K.N., Spence, W.C., Maddalena, A., Howard-Peebles, P.N., Schulman, J.D. Semen donor screening for hereditary diseases: The Fairfax Cryobank Experience. J Reprod Med 43:423-428, 1998.

27. Stavropoulos, D.J., BICK, D.P., Kalousek, D.K. Molecular cytogenetic detection of confined gonadal mosaicism in a conceptus with trisomy 16 placental mosaicism. Am J Hum Genet 63:1912-1914, 1998.

28. BICK, D.B., McCorkle, D., Stanley, W.S., Stern, H.J., Staszak, P., Berkovitz, G.D., Meyers, C.M., Kelley, R.I. Short Communication: Prenatal diagnosis of Smith-Lemli-Opitz syndrome in a pregnancy with low maternal serum oestriol and a sex-reversed fetus. Prenat Diagn 19:68-71, 1999.

29. Fallon, L., Harton, G.L., Sisson, M.E., Rodriguez, E., Field, L.K., Fugger, E.F., Geltinger, M., Sun, Y., Dorfmann, A., Schoener, C., BICK, D., Schulman, J., Levinson, G., Black, S.H. Preimplantation genetic diagnosis for spinal muscular atrophy type I. Neurology 53:1087-1090, 1999.

30. Taylor, H.S., Block, K., BICK, D.P., Sherins, R.J., Layman, L.C. Mutation analysis of the EMX2 gene in Kallmann's syndrome. Fertil Steril 72:910-914, 1999.

31. Achermann, J.C., Gu, W-X., Kotlar, T.J., Meeks, J.J., Sabacan, L.P., Seminara, S.B., Habiby, R.L., Hindmarsh, P.C., BICK, D.P., Sherins, R.J., Crowley Jr., W.F., Layman, L.C., Jameson, J.L. Mutational analysis of DAX1 in patients with hypogonadotropic hypogonadism or pubertal delay. J Clin Endocrinol Metab 84:4497-4500, 1999.

32. Park J.K., Ozata M., Chorich L.P., Cheng L., BICK, D.P., Sherins R.J., Ozdemir I.C., Cogan J, Phillips J.A. III, Layman L.C. Analysis of the PROP1 gene in a large sample of patients with idiopathic hypogonadotropic hypogonadism. Clin Endocrinol (Oxf) 60(1):147-149, 2004.

33. Klein, O.D., Cotter, P.D., Schmidt, A.M., BICK,D.P., Tidyma, W.I., Albertson, D.G., Pinkel, D., Rauen, K.A. Interstitial deletion of chromosome 12q: Genotype-Phenotype correlation of two patients utilizing array comparative genomic hybridization. .Am J Med Genet 138(4):349-54, 2005.

34. Bhagavath, B., Ozata, M., Ozdemir, I.C., Bolu, E., BICK, D.P., Sherins, R.J., Layman, L.C. The prevalence of gonadotropin-releasing hormone receptor mutations in a large cohort of patients with hypogonadotropic hypogonadism. Fertil Steril 84(4):951-7, 2005.

35. BICK, D.P., Lau, E.C. Preimplantation Genetic Diagnosis. Pediatr Clin North Am 53(4):559-577, 2006.

36. Bhagavath, B., Podolsky, R.H., Ozata, M., Bolu, E., BICK, D.P., Kulharya, A., Sherins, R.J., Layman, L.C. Clinical and molecular characterization of a large sample of patients with hypogonadotrophic hypogonadism. Fertil Steril 85(3):706-13, 2006.

37. Johnston, J.J., Walker, R.L., Davis, S., Facio, F., Turner, J.T., BICK, D.P., Daentl, D.L., Ellison, J.W., Meltzer, P.S., Biesecker, L.G. Zoom-in CGH arrays for the characterization of variable breakpoint contiguous gene syndromes. J Med Genet 44(1): e59, 2007.

38. Bhagavath, B., Xu, N., Ozata, M., Rosenfield, R.L., BICK, D.P., Sherins, R.J., Layman, L.C. KAL1 mutations are not a common cause of idiopathic hypogonadotrophic hypogonadism in humans. Mol Hum Reprod 13(3):165-70, 2007.

39. Swanson, A., Strawn, E., Lau, E., BICK, D. Preimplantation Genetic Diagnosis: Technology and Clinical Applications. Wis Med J 106(3):145-151, 2007.

40. Pedersen-White, J.R., Chorich, L.P., BICK, D.P., Sherins, R.J., Layman, L.C. The prevalence of intragenic deletions in patients with idiopathic hypogonadotropic hypogonadism and Kallmann Syndrome. Mol Hum Reprod. 14(6):367-370, 2008.

41. Bick, S.L., BICK, D.P., Wells, B.E., Roesler M.R., Strawn, E.Y. Lau, E.C. Preimplantation HLA haplotyping using tri-, tetra-, and pentanucleotide short tandem repeats for HLA matching. J Assist Reprod Genet, 25(7):323-31, 2008.

42. Margaret M. Samyn, DAVID P. BICK, John A. Humphrey and Kimberly L. Gandy. Successful congenital heart surgery for a toddler with idiopathic infantile arterial calcification. Pediatr Cardiol, 31:1096-1099, 2010.

43. Kim, H.G., Kurth, I., Lan, F., Meliciani, I., Wenzel, W., Eom, S.H., Kang, G.B., Rosenberger, G., Tekin, M., Metin, O., BICK, D.P., Sherins, R., Walker, S., Shi, Y., Gusella, J., Layman, L.C. Mutations in CHD7, encoding a chromatin remodeling protein, cause idiopathic hpogonadotropic hypogonadism and Kallman syndrome. Am J of Hum Genet, 83(4):511-9, 2008.

44. Strawn, E.Y. Jr, BICK, D., Swanson, A. Is it the patient or the IVF? Beckwith-Wiedemann syndrome in both spontaneous and assisted reproductive conceptions. Fertil Steril, 94(2):754.e1-2, 2010. Epub 2010 Mar 24.

45. Lau, E.C., Janson, M.M., Roesler, M.R., Avner, E. D., Strawn, E.Y., BICK, D.P. Birth of a healthy infant following preimplantation PKHD1 halotyping for autosomal recessive polycystic kidney disease using multiple displacement amplification. J Ass Repro Gen, 27:397-407, 2010.

46. Kim, H.G., Ahn, J.W., Kurth, I., Ullmann, R., Kim, H.T., Kulharya, A., Ha, K.S., Itokawa, Y., Meliciani, I., Wenzel, W., Lee, D., Rosenberger, G., Ozata, M., BICK, D.P., Sherins, R.J., Nagase, T., Tekin, M., Kim, S.H., Kim, C.H., Ropers, H.H., Gusella, J.F., Kalscheuer, V., Choi, C.Y., Layman, L.C. WDR11, a WD protein that interacts with transcription factor EMX1, is mutated in idiopathic hypogonadotropic hypogonadism and Kallmann syndrome. Am J Hum Genet, 87(4):465-79, Oct. 8, 2010.

47. Xu, N., Kim, H., Bhagavath, B., Cho, S., Lee, J. H., Ha, K., Meliciani, I., Wenzel, W., Podolsky, R.S., Chorich, L.P., Stackhouse, K.A., Grove, A.M.H., Odom, L.N., Ozata, M., BICK, D. P., Sherins, R.J., Kim, S., Cameron, R.S., Layman, L.C. Nasal Embryonic LHRH Factor (NELF) Mutations in Patients with Normosmic Hypogonadotropic Hypogonadism and Kallmann Syndrome. Fertil Steril, 95(5):1613-20, Apr 2011.

48. Lindhurst, M.J., Sapp, J.C., Teer, J.K., Johnston, J.J., Finn, E.M., Peters, K., Turner, J., Cannons, J.L., BICK, D., Blakemore, L., Blumhorst, C., Brockmann, K., Calder, P., Cherman, N., Deardorff, M.A., Everman, D.B., Golas, G., Greenstein, R.M., Kato, B.M., Keppler-Noreuil, K.M., Kuznetsov, S.A., Miyamoto, R.T., Newman, K., Ng, D., O'Brien, K., Rothenberg, S., Schwartzentruber, D.J., Singhal, V., Tirabosco, R., Upton, J., Wientroub, S., Zackai, E.H., Hoag, K., Whitewood-Neal, T., Robey, P.G., Schwartzberg, P.L., Darling, T.N., Tosi, L.L., Mullikin, J.C., Biesecker, L.G. A mosaic activating mutation in AKT1 associated with the Proteus syndrome. N Engl J Med, 365(7):611-619, Aug 2011.

49. Mayer, A.N., Dimmock, D.P., Arca, M.J., BICK, D.P., Verbsky, J.W., Worthey, E.A., Jacob, H.J., Margolis, D.A. A timely arrival for genomic medicine. Gen Med, 13:195-196, Dec 2011.

50. Worthey, E.A., Mayer, A.N., Syverson, G.D., Helbling, D., Bonacci, B.B., Decker, B., Serpe, J.M., Dasu, T., Tschannen, M.R., Veith, R.L., Basehore, M.J., Broeckel, U., Tomita-Mitchell, A., Arca, M.J., Casper, J.T., Margolis, D.A., BICK, D.P., Hessner, M.J., Routes, J.M., Verbsky, J.W., Jacob, H.J., Dimmock, D.P. Making a definitive diagnosis: Successful clinical application of whole genome sequencing in a child with intractable inflammatory bowel disease. Gen Med, 13:255-262, Dec 2011.

51. BICK, D., Dimmock, D. Whole exome and whole genome sequencing. Curr Opin Pediatr, 23(6):594-600, Dec 2011.

52. Quaynor, S.D., Kim, H.G., Cappello, E.M., Williams, T., Chorich, L.P., BICK, D.P., Sherins, R.J., Layman, L.C. The prevalence of digenic mutations in patients with normosmic hypogonadotropic hypogonadism and Kallmann syndrome. Fertil Steril, 96(6):1424-1430, Dec 2011.

53. Kumar, N., Leverence, J., BICK, D., Sampath, V. Ontogeny of growth-regulating genes in the placenta. Placenta, 33(2):94-99, Feb 2012.

54. Tomita-Mitchell A, Mahnke DK, Struble CA, Tuffnell ME, Stamm KD, Hidestrand M, Harris SE, Goetsch MA, Simpson PM, BICK DP, Broeckel U, Pelech AN, Tweddell JS, Mitchell ME. Human gene copy number spectra analysis in congenital heart malformations. Physiol Genomics 44(9):518-41, May 2012.

55. Lemke, A., BICK, D.P., Simpson, P., Veith, R. Perspectives of clinical genetics professionals toward genome sequencing and incidental findings: A survey study. Clin Genet, Nov 20, 2012 [Epub ahead of print]

56. Manolio, T.A., Chisholm, R.L., Ozenberger, B., Roden, D.M., Marc S. Williams, M.S., Wilson, R., BICK, D., et al. Implementing genomic medicine in the clinic: the future is here. Genet Med, 2013, Apr;15(4):258-267. Advance online publication 10 January 2013. doi:10.1038/gim.2012.157.

57. Schiller, J.J., Hopp, K.A., Peitz, B.C., BICK, D.P., Lau, E.C., Ellis, T.M. A simplified method for screening siblings for HLA identity using short tandem repeat (STR) polymorphims. Human Immun, 74:5, 562-566, May 20, 2013.

58. Jacob, H.J., Abrams, K., BICK D.P., Brodie, K., Dimmock, D.P., Farrell, M., Geurts, J., Harris, J., Helbling, D., Joers, B.J., Kliegman, R., Kowalski, G., Lazar, J., Margolis, D.A., North, P., Northup, J., Roquemore-Goins, A., Scharer, G., Shimoyama, M., Strong, K., Taylor, B., Tsaih, S.W., Tschannen, M.R., Veith, R.L., Wendt-Andrae, J., Wilk, B., Worthey, E.A. Genomics in clinical practice: lessons from the front lines. Sci Transl Med 2013 Jul 17;5(194):194cm5 PMID 23863829.

59. Lindhurst, M.J., Wang, J., Bloomhardt, H., Wikowski, A.M. Singh, L.N., BICK, D.P., Gambello, M.J., Powerll, C.M. Chia, C., Lee, R., Darling, T.N. Biesecker, L.G. AKT1 gene mutation levels are correlated with the type of dermatologic lesions in patients with Proteus syndrome. J Invest Dermatol 2013 Jul 24.

60. Weh, E., Reis, L.M., Tyler, R.C., BICK, D.P., Rhead, W.J., Wallace, S., McGregor, T.L., Dills, S.K., Chao, M.C., Murray, J.C., Semina, E.V. Novel B3GALTL mutations in classic Peters Plus syndrome and lack of mutations in a large cohort of patients with similar phenotypes. Clin Genet. 2013 Jul 24. doi: 10.1111/cge.12241. [Epub ahead of print]

61. Strong, K.A., Derse, A.R., Dimmock, D.P., Zusevics, K.L., Jeruzal, J., Worthey, E., BICK, D., Scharer, G., La Pean Kirschner, A., Spellecy, R., Farrell, M.H., Geurts, J., Veith, R., May, T. In the absence of evidentiary harm, existing societal norms regarding parental authority should prevail. Am J Bioeth 2014 Mar;14(3):24-6.

62. Deml, B., Reis, L., Maheshwarti, M., Griffis, C., BICK, D., Semina, E. Whole exome analysis identifies dominant COL4A1 mutations in patients with complex ocular phenotypes involving microphthalmia. Mar 2014, Clin Genet, doi: 10.111/cge12379[Epub ahead of print].

63. Strong, K.A., Zusevics1,K.L., BICK,D., Veith, R. Views of Non-Medical, Health System Professionals Regarding the Return of Whole Genome Sequencing Incidental Findings. Clin Genet, Mar 27, 2014, PMID: 24673592.

64. Yuen, M., Sandaradura, S.A., Dowling, J.J., Kostyukova, A.S., Moroz, N., Quinlan, K.G., Lehtokari, V.L., Ravenscroft, G., Todd, E.J., Ceyhan-Birsoy, O., Gokhin, D.S., Maluenda, J., Lek, M., Nolent, F., Pappas, C.T., Novak, S.M., D'Amico, A., Malfatti, E., Thomas, B.P., Gabriel, S.B., Gupta, N., Daly, M.J., Ilkovski, B., Houweling, P.J., Davidson, A.E., Swanson, L.C., Brownstein, C.A., Gupta, V.A., Medne, L., Shannon, P., Martin, N., BICK, D.P., Flisberg, A., Holmberg, E., Van den Bergh, P., Lapunzina, P., Waddell, L.B., Sloboda, D.D., Bertini, E., Chitayat, D., Telfer, W.R., Laquerrière, A., Gregorio, C.C., Ottenheijm, C.A., Bönnemann, C.G., Pelin, K., Beggs, A.H., Hayashi, Y.K., Romero, N.B., Laing, N.G., Nishino, I., Wallgren-Pettersson, C., Melki, J., Fowler, V.M., MacArthur, D.G., North, K.N., Clarke, N.F. Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy. J Clin Invest. 2014 Sep 24. pii: 75199. doi: 10.1172/JCI75199. [Epub ahead of print] PMID: 25250574

65. Dimmock, D.P., BICK, D.P. Ehtical issues in DNA sequencing in the neonate. Clin Perinatol, Dec;41(4):993-1000, 2014.

66. Strong, A., Zusevics. L., BICK, D.P., Veith, R. Views of nonmedical, health system professionals regarding the return of whole genome sequencing incidental findings. Oct;113(5):179-84, WMJ 2014.

Books, Chapters, and Reviews1. Lau, E.C., Janson, M.M., Ball, C.B., Roesler M.R., VanTuinen, P., BICK, D.P., Strawn, E.Y. In Vitro Fertilization: Innovative Clinical and Laboratory Aspects, Chapter 8: Preimplantation Genetic Testing: Current Status and Future Prospects. ISBN: 978-953-51-0503-9. 2012

2. Duffy, K.J., Kelly, M.E., BICK, D. Sander & North's Vascular Tumors and Developmental Malformations: Pathogenic Mechanisms and Molecular Diagnosis. Chapter 3: Vascular Groth, in press.

Editorials, Letters to Editor, Other1. Gargis, A.S., Kalman, L., Berry, M.W., BICK, D.P., Dimmock, D.P., Hambuch, T., Lu, F., Lyon, E., Voelkerding, K.V., Zehnbauer, B.A., Agarwala, R., Bennett, S.F., Chen, B., Chin, E.L., Compton, J.G., Das, S., Farkas, D.H., Ferber, M.J., Funke, B.H., Furtado, M.R., Ganova-Raeva, L.M., Geigenmüller, U., Gunselman, S.J., Hegde, M.R., Johnson, P.L., Kasarskis, A., Kulkarni, S., Lenk, T., Liu, C.S., Manion, M., Manolio, T.A.,

Mardis, E.R., Merker, J.D., Rajeevan, M.S., Reese, M.G., Rehm, H.L., Simen, B.B., Yeakley, J.M., Zook, J.M., Lubin, I.M. Assuring the quality of next-generation sequencing in clinical laboratory practice. Nat Biotechnol 2012 Nov 30(11):1033-6.

2. Jacob, H.J., Abrams, K., BICK, D.P, Brodie, K., Dimmock, D.P., Farrell, M., Geurts, J., Harris, J., Helbling, D., Joers, B.J., Kliegman, R., Kowalski, G., Lazar, J., Margolis, D.A., North, P., Northup, J., Roquemore-Goins, A., Scharer, G., Shimoyama, M., Strong, K., Taylor, B., Tsaih, S.W., Tschannen, M.R., Veith, R.L., Wendt-Andrae, J., Wilk, B., Worthey, E.A. Genomics in clinical practice: lessons from the front lines. Sci Transl Med 2013 Jul 17;5(194):194cm5

3. BICK, D.P., Ballabio, A. Letter to the Editor: Chromosome abnormalities in and pathogenesis of Kallmann Syndrome. Am J Med Genet 37:298, 1990.

4. BICK, D.P., Maddalena, A., Black, S.H., Headrick, E.G., Cummings, E., Jones, S.L., Costakos, D., Becker, R., Schulman, J.D. Letter to the Editor: Prenatal screening for the delta-F508 cystic fibrosis mutation in a population not selected for cystic fibrosis. Lancet 336:1324, 1990.

5. Schulman, J.D., Maddalena, A., Black, S.H., BICK, D.P. Letter to the Editor: Screening for Cystic Fibrosis Carriers. Am J Hum Genet 47:740, 1990.

Abstracts1. BICK, D.P., Balkite, E., Baumgarten, A., Hobbins, J.C., Maloney, M.J. Occurrence of amniotic fluid acetylcholinesterase in association with congenital skin disorders. Am J Hum Genet, 37:A213, 1985.

2. BICK, D.P., Fenton, W.A., Kalousek, F., Kraus, J.P., and Rosenberg, L.E. Molecular cloning of a human methylmalonyl CoA mutase cDNA. Clinical Research, 1987.

3. BICK, D.P., Schorderet, D.F., McGill, J.R., Bux, R.C., Moore, C.M. Ichthyosis, Kallmann syndrome and chondrodysplasia punctata in a male infant and an Xp chromosome deletion: relationship to warfarin embryopathy. Am J Hum Genet, 43:A39 (Supplement), September 1988.

4. Jorgenson, R.J. and BICK, D.P. A new syndrome of dwarfism, trichodysplasia, cleft palate and unusual facies. March of Dimes Clinical Genetics Conference. Baltimore, Maryland. 1988.

5. BICK, D.P., Snead, M., Yen, P.H., McGill, J., Schorderet, D., Hejtmancik, J.F., Ballabio, A., Campbell, L., L., Moore, C., Curry, C.J., Lau, E.C., Shapiro, L. Mapping chondrodysplasia punctata, ichthyosis, Kallmann Syndrome and DNA markers in male patients with Xp chromosome deletions. Human Gene Mapping 10. Cytogenet Cell Genet 51:962, 1989.

6. Ballabio, A., Carrozzo, R., BICK, D.P., Andria, G., Fraccaro, M. Deletion map of the Xp22.3-pter region obtained by the study of patients with contiguous gene syndromes. Human Gene Mapping 10. Cytogenet Cell Genet 51:957, 1989.

7. Schwanzel-Fukuda, M., BICK, D.P., Pfaff, D.W. Luteinizing hormone-releasing hormone (LHRH) cells do not migrate normally in Kallmann's syndrome (hypogonadotropic hypogonadism with anosmia). Soc for Neurosci, 1989.

8. BICK, D.P., Schwanzel-Fukuda, M., Pfaff, D.W., Schorderet, D.F., Price, P.A., Campbell, L., Huff, R.W., Moore, C.M. Prenatal diagnosis and investigation of a fetus with chondrodysplasia punctata, ichthyosis and Kallmann syndrome due to an Xp deletion: Evidence for a neuronal migration defect in Kallmann syndrome. Am J Hum Genet 45:A252, 1989.

9. Ryan, S.G., BICK, D.P., Mackley, R.W., Naylor, S.L. Hereditary startle disease: clinical features and response to clonazepam in a large pedigree amenable to linkage analysis. Am J Hum Genet 45:A61, 1989.

10. Cheah, M.S.C., McDonald, S., BICK, D.P. Regulation of the human fgr proto-oncogene expression during fetal liver development. The American Pediatric Society/The Society for Pediatric Research, 1990.

11. BICK, D.P., Maddalena, A., Black, S.H., Costakos, D., Cummings, E., Jones, S.L., Headrick, E.G. Pilot study of prenatal screening for the delta-F508 cystic fibrosis (CF) mutation in an unselected population. Am J Hum Genet 47:A209, 1990.

12. Maddalena, A., BICK, D.P., Fugger, E., Jones, S., Schulman, J.D. Screening of sperm bank donors for the delta-F508 cystic fibrosis mutation. Am J Hum Genet 47:A290, 1990.

13. Park, C.Y., BICK, D.P., Bustamante, S.A. Disaccharidase activity in the human fetal intestine: focus on early ontogeny. Southern Society for Pediatric Research, 1991.

14. Black, S.H., Maddalena, A., BICK, D.P., Levinson, G., Howard-Peebles, P.N., Schulman, J.D. Molecular fragile X screening in a pregnant population with family histories of mental retardation (MR) or learning disabilities (LD). Am J Hum Genet 51:A20, 1992.

15. Schulman, J.D., Maddalena, A., Black, S.H., BICK, D.P., Howard-Peebles, P.N. Carrier testing of persons with suggestive family histories confirms a high frequency of fragile X. eds. R. J. Hagerman, P. McKenzie. Third International Fragile X Conference. June, 1992.

16. Levinson, G., Maddalena, A., Palmer, F.T., Harton, G.L., BICK, D.P., Howard-Peebles, P.N., Black, S.H., Schulman, J.D. Sizing fragile X premutations and normal alleles with nested PCR. eds. R. J. Hagerman, and P. McKenzie. Third International Fragile X Conference, 1992.

17. Black, S.H., BICK, D.P., Schulman, J.D. Selected aspects of risks of chorionic villus sampling (CVS) in a large series. Gametes to Embryo. VI International Conference on Early Prenatal Diagnosis of Genetic Disease, 1992.

18. Maddalena, A., Black, S.H., BICK, D.P., Schulman, J.D., Howard-Peebles, P.N. Fragile X screening in an obstetrical population selected for suggestive family histories. 24th Annual March of Dimes-Clinical Genetics Conference, Stanford, CA. July 12-15, 1992.

19. Levinson, G., Maddalena, A., Palmer, F.T., Harton, G.L., BICK, D.P., Howard-Peebles, P.N., Black, S.H., Schulman, J.D. Improved sizing of fragile X repeats by nested PCR. Sixth International Workshop on Fragile X and X-Linked Mental Retardation, Queensland, Australia. August 3-6, 1993.

20. BICK, D.P. The X-linked Kallmann gene: homology to neural cell adhesions molecules. Presented to the Endocrine Society Meeting. Las Vegas, Nevada, June 9-12, 1993.

21. Stetka, D.G., BICK, D.P., Meck, J.M., Baty, E.B., Schulman, J.D. Two cases of mosaic variegated aneuploidy with microcephaly: a mutation that results in mitotic non-disjunction? Amer J Hum Genet 53:604, 1993.

22. Howard-Peebles, P.N., Fallon, L., Black, S.H., Maddalena, A., BICK, D.P., Levinson, G., Schulman, J.D. Fragile X carrier screening in an obstetric population. Fourth International Fragile X Conference, Albuquerque, NM. August 8-12, 1994.

23. Spence, W.C., Maddalena, A., Demers, D.B., BICK, D.P. Prenatal determination of the genotype in fetuses at risk for RhD and RhE hemolytic disease of the newborn. Am J Hum Genet 55:A9, 1994.

24. Black, S.H., Fallon, L., Cummings, E., Menapace-Drew, G., Maddalena, A., Spence, W.C., Bick, D.P., Levinson, G., Howard-Peebles, P.N. Molecular fragile X screening in pregnancy and egg donor populations. Am J Hum Genet 55:A10, 1994.

25. Meck, J.M., Kozina, C., Stratakis, C., Garnica, A., BICK, D.P., Motz, M.K., Qin, N., Rennert, O. Mosaic variegated aneuploidy with microcephaly: A rare cytogenetic syndrome. Am J Hum Genet 55:A111, 1994.

26. Layman, L.C., Peak, D.B., BICK, D.P., Sherins, R.J., Gray, M.R., Reindollar, R.H. Exon four gonadotropin releasing hormone (GnRH) gene mutation in a sample of 117 patients with idiopathic hypogonadotropic hypogonadism. American Society for Reproductive Medicine. Seattle, WA. Oct. 7-12, 1995.

27. Black, S.H., Fallon, L., Maddalena, A., Cummings, E., Menapace-Drew, G., Spence, W.C., BICK, D.P., Levinson, G., Schulman, J.D., Howard-Peebles, P.N. Molecular Fragile X screening in normal populations. Seventh International Workshop on the Fragile X and X-linked Mental Retardation. Tromso, Norway. August 2-5, 1995.

28. Maddalena, A., Spence, W.C., Demers, D.B., BICK, D.P. Prenatal detection of RhD, Rhc, RhE, and Kell genotypes for management of pregnancies at risk for hemolytic disease of the newborn. Am J Hum Genet 57:A50, 1995.

29. Spence, W.C., Maddalena, A., Howard-Peebles, P.N., BICK, D.P. Contribution of the molecular genetics laboratory to the evaluation of the persistently hypotonic infant. Am Ped Society and Society Pediatr Research 39(4) pt. 2:148A, 1996.

30. BICK, D.P., Stanley, W.S., Stern, H.J., Berkovitz, G.D., Meyers, C.M., Kelley, R.I. Prenatal diagnosis of Smith-Lemli-Opitz syndrome (SLO) in a sex-reversed fetus. Am J Hum Genet 61:4(A838), 1997.

31. Stavropoulos, D.J., Barrett, I.J., Lomax, B.L., BICK, D.P., Bernasconi, F., Robinson, W.P., Kalousek, D.K. Association of prenatally diagnosed confined placental mosaicism (CPM) and fetal gonadal mosaicism. Am J Hum Genet 61:4(A934), 1997.

32. Layman, L.C., Kalimullah, E., Boachie-Ansah, G., Xie, J., Jin, M., Amde, S., Shah, S. Kawada, P., Pampoonsup, W., Sherins, R.J., BICK, D.P. The low frequency of Kallmann syndrome (KAL) gene mutations in humans with hypogonadotropic hypogonadism suggests non-X linked modes of inheritance. Society of Gynecologic Investigation, 1997.

33. Lavenstein, B., BICK, D.P., Rinaldo, P. Ethylmalonic aciduria in short-chain acyl CoA dehydrogenase deficiency: Recognition of the phenotype, genetic polymorphism and clinical implications. Ann of Neuro 42:P118, 1997.

34. Joseph, N., BICK, D.P., Howard-Peebles, P.N., Overhauser, J., Marinescu, R. C., Li, M.M. Molecular characterization of a patient with oculo-auriculo-vertebral spectrum. Am J Hum Genet 63:4(A784), 1998.

35. Bhagavath, B., Ozata, M., Golu, E., Ozdemir, I.C., BICK, D.P., Sherins, R, Layman, LC. Prevalence of gonadotropin-releasing hormone receptor mutations in humans with idiopathic hypogonadotropic hypogonadism. Endocrine Society Meeting, 85th Annual Meeting, June, 2003.

36. Klein, O.D, Cotter, P.D., Weiss, A., BICK, D.P., Albertson, D.G., Pinkel, D., Rauen, K.A. Interstitial deletion of chromosome 12q: Genotype-phenotype correlation of 2 patients utilizing array comparative genomic hybridization. ACMG, 10th Annual Meeting, Kissimmee, FL, March, 2004.

37. Duffy, K., BICK, D.P., vanTuinen, P., Dugan, S., Olivier, M. Somatic partial chromosome 11 duplication in a patient with Proteus Syndrome. ACMG 13th Annual Meeting, Nashville, TN, March, 2007.

38. Schneider, R.J., Lau, E., Schur, B., Wong, S., BICK, D.P. Development of a rapid protocol for molecular diagnosis of spinal muscular atrophy in preimplantation genetic diagnosis by whole genome amplification and pyrosequencing. Clin Chem, 53(6):A152-A153 C-158 Supp. S. June, 2007.

39. Duffy, K., BICK, D.P., vanTuinen, P., Dugan, S., Yilmaz, A., Schwartz, C., Foulkes, W., Olivier, M. Somatic partial chromosome 11 duplication in patients with Proteus Syndrome. ASHG Annual Meeting, San Diego, CA, October, 2007.

40. Trapane, P., Jarzembowski, J., BICK, D.P., Rhead, W., Wargowski, D., Aradhya, S., Mitchell, A., Veith, R. Microdeletion at 9q33.3q34.11 encompassing the LMX1B and ENG genes: A case report. American Society of Human Genetics Annual Meeting, Philadelphia, PA, November 11-16, 2008.

41. Veith, R., Swanson, A., Denny, A., Leuthner, S., Mitchell, A., BICK, D. P. 18q12.1 Interstitial microduplication in mother and child: A case report. American Society of Human Genetics Annual Meeting, Philadelphia, PA, November 11-16, 2008.

42. Mirza, S.P., Duffy, K., Chesnik, M.A., Cole, R., BICK, D.P., Olivier, M. Revealing the mystery behind 'The Elephant Man': Proteomic characterization of Proteus Syndrome. 57th ASMS Conference on Mass Spectrometry, Philadelphia, PA, May 31, 2009.

43. Rhead, W.R., Wells, C., Bick, D.P., Margolis, D., Kishnani, P., Bali, D., Young, S., White, A. Immune Modulation Therapy in a CRIM Negative Pompe Disease Patient Blocks Antibody Formation Towards Myozyme, Reverses Cardiomyopathy, and Prolongs Survival. International Congress of Inborn Errors of Metabolism, San Diego, CA, August 29-September 2, 2009.

44. Dimmock, D., Worthy, E., Mayer, A., Verbsky, J., BICK, D.P., Routes, J., Schannen, M., Helbling, D., Schauer, D., Veith, R., Jacob, H.. Clinical Utility of Whole Exome Sequencing in the Diagnosis of a Child. American College of Medical Genetics Annual Meeting, Albuquerque, NM, March, 2010.

45. Sekhri, N., VanTuinen,P., Broeckel, U., BICK, D.P. 11p15.4p15.5 Duplication Associated with Russell-Silver Syndrome. American College of Medical Genetics Annual Meeting, Albuquerque, NM, March 24, 2010.

46. Lau, E., Janson, M., Ball, C., Roesler, M., Strawn, E., BICK, D.P. Advances in PGD. BIT Life Sciences 2nd World DNA and Genome Day-2011 Congress. Dalian, China, April 25, 2011.

47. Veith, R., Dimmock, D., BICK, D.,White, A., Dugan, S. Clinical Whole Genome Sequencing: Genetic Counseling and Informed Consent for Anticipated Incidental Findings Collection. American College of Medical Genetics Annual Meeting, Vancouver, Canada, March, 2011.

48. Dimmock, D., Willoughby Jr., R., Leuthner, S., Veith, R., Gutzeit, M., May, T., Hambuch, T., Worthey, E., Jacob, H., Tschannen, M., North, P., BICK, D. Clinical Whole Genome Sequencing: One Center's Experience. American College of Medical Genetics Annual Meeting, Vancouver, Canada, March, 2011.

49. Taylor, B., Jacob, H., Schauer, D., North, P., Sander, T., McQuestion, G., BICK, D., Dimmock, D. Experience with the analysis and management of data from whole genome sequencing in clinical practice. American College of Medical Genetics, Vancouver, Canada, March, 2011.

50. Gargis, A.S., Kalman, L.V., Berry, M., BICK, D.P., Dimmock, D.P., Hambauch, T.M., Lu, F., Lyon, E., Voelkerding, K.V., Zehnbauer, B.A., Lubin, L.M., and Working Group. Next Generation Sequencing-Standardization of clinical testing (NEX-StoCT): Approaches to quality assurance and complying with regulatory and professional standards. Association for Molecular Pathology's 2011 Annual Meeting, Grapevine, TX, November 17-19, 2011.

51. Lemke, A.A., BICK, D., Dimmock, D., Veith, R. Perspectives of Genetic Professionals toward Clinical Genome Sequencing and Incidental Findings. American Society of Bioethics and Humanities. Annual Education Conference, Raleigh, NC. 2012, Submitted.

52. Schiller, J.J., Hopp, K.A., Pietz, B.C., BICK, D.P., Lau, E.C., Ellis, T.M. A Simplified Method for Screening Siblings for HLA Identity Using Short Tandem Repeat (STR) Polymorphisms. Hum Immunol 2013 Jan 3.

53. Lindhurst, M.J., Wang, J., Bloomhardt, H., Wikowski, A.M., Singh, L.N., BICK, D.P., Gambello, M.J., Powell, C.M., Darling, T.N., Lee, C. R., Biesecker, L.G. AKT1 gene mutation levels are correlated with the type of dermatologic lesions in patients with Proteus syndrome. American Society of Human Genetics Annual Meeting, Boston, MA, Oct 22, 2013.

54. Kreissl, M., Sandaraduar, S.A., Dowling, J.J., Kostyukova, A.S., Moroz, N., Quilan, K.G., Vilma-Lotta, L., Ravenscroft, G., TAodd, E.J., Ceyhan-Dirsoy, O., Gokhin D.S>, Maluenda, J., Lek, M., Nolent, F., Pappas, C.T., Novak, S.M., D'Amico, A., Malfatti, E., Thomas, B.P., Gabriel, S.B., Gupta, N., Daly, MJ., Ilkovski, B., Houweling, P.J., Swanson, L.C., Brownstein, C.A., Gupta, V.A., Medne, Shannon, P., Martin, N., BICK, D.P., Flisberg, A., et. al. Mutations in LMOD3 cause severe nemalin myopathy by disrupting thin filament organisation in skeletal muscle. Submitted to World Muscle Society, 10-7-14 and New Directions in Biology and Disease of Skeletal Muscle Conference, 06-29-14.

55. Intragenic SCN1A microdeletion in a patient with infantile-onset epilepsy highlights the range and limitations of microarrays and DNA sequencing. ACMG Annual Meeting, Salt Lake City, UT, March 2015.