Front Matter

Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 75, No. 3 (Mar., 1978), pp. v-xiiPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/67930 .

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MARCH 1978

VOLUME 75

NUMBER 3

fA .~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~N

(: THE UNITED STATES O)F AMEERICA



THE PROCEEDINGS OF THE

National Academy of Sclences OF THE UNITED STATES OF AMERICA

Officers PHILIP HANDLER President of the SAUNDERS MAC LANE Vice President Academy DAVID R. GODDARD Home Secretary

GEORGE S. HAMMOND Foreign Secretary E. R. PIORE Treasurer

Editorial Board ROBERT L. SINSHEIMER Chairman of the ROBERT M. SOLOW Vice Chairman Proceedings HARRISON SHULL Vice Chairman

DAVID R. GODDARD Home Secretary GEORGE S. HAMMOND Foreign Secretary E. R. PIORE Treasurer

K. FRANK AUSTEN ALEXANDER G. BEARN P. D. BOYER JULIUS H. COMROE, JR. JOHN E. DOWLING HARRY EAGLE RICHARD M. HELD

HENRY S. KAPLAN

S. M. LIPSET EUGENE P. ODUM ALEXANDER RICH E. R. STADTMAN ELIAS M. STEIN HOWARD M. TEMIN JAMES TOBIN

Managing Editor: BERNARD K. FORSCHER Associate Editor: GARY T. COCKS Associate Editor: MURRIE W. BURGAN Associate Editor: SHEILA L. RoSENTHAIL

Editorial correspondence: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, Washington, DC 20418.

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA is published monthly by THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, Washington, DC 20418 ? 1978 by THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.



AUTHOR INDEX, MARCH 1978

Abdel-Meguid, S. 1056 Achtman, M. 1237 Albuquerque, E. X. 1596 Allende, C. C. 1242 Allende, J. E. 1242 Allfrey, V. G. 1116 Aragoncillo, C. 1446 Arias, I. M. 1213 Arscott, P. G. 1250 Axel, R. 1299 Bada, J. L. 1204 Baldessarini, R. J. 1605 Ball, L. A. 1167 Bank, A. 1222 Barbanti-Brodano, G.

1126 Barrell, B. G. 1081 Barrio, J. R. 1199 Basu, S. 1289 Battenberg, E. 1591 Beck, B. D. 1250 Beglau, J. M. 1096 Behrman, H. R. 1344 Berger, T. W. 1572 Berk, A. J. 1274 Bernard, 0. 1485 Bessman, S. P. 1562 Bhattacharya, P. 1289 Birnstiel, M. L. 1176 Blaser, K. 1495 Bloom, A. 1222 Bloom, B. R. 1554 Bloom, F. 1591 Bloom, F. E. 1608 Blout, E. R. 1199 Boon, T. 1519 Borrero, L. M. 1329 Bradbury, E. M. 1116 Brauman, J. I. 1052 Bravo, R. 1242 Brown, A. 1451 Brown, K. T. 1587 Brugge, J. S. 1567 Butler, J. D. 1361 Cable, M. B. 1227 Cammer, W. 1554 Carbonero, P. 1446 Cardinale, G. J. 1379 Carroll, R. J. 1260 Caughey, W. S. 1076 Cedar, H. 1299 Chance, G. W. 1542 Chan-Palay, V. 1582 Chen-Kiang, S. 1379 Chock, P. B. 1255 Chou, J. Y. 1409 Christian, C. 1314 Clarkson, S. G. 1176 Cohen, S. N. 1265 Collett, M. S. 1284 Collman, J. P. 1052 Copeland, T. D. 1404 Cotzias, G. C. 1546 Croce, C. M. 1510 Croissant, 0. 1537 Cuatrecasas, P. 1608 Curtis, P. J. 1309 Dahlberg, J. E. 1071 Datta, A. 1148 David, D. N. 1294 Davidson, R. L. 1470 Day, V. W. 1056 De Brabander, M. 1339 de Haro, C. 1148 Deisseroth, A. 1456 Delmotte, F. 1324

DeMartino, G. N. 1369 De Mey, J. 1339 de Neve, R. 1136 Dockter, M. E. 1319 Dorflinger, L. J. 1344 Downie, J. A. 1437 Dreyfuss, G. 1199 Dubnau, D. 1428 Duguid, J. R. 1260 Duvall, E. J. 1423 Edelman, G. M. 1304 Ehrlich, S. D. 1433 Eisen, H. N. 1495 Emanuilov, I. 1389 Eng, M. 1559 Englert, A. 1050 Enright, T. J. 1063 Er, S. S. 1542 Erikson, E. 1567 Erikson, R. L. 1567 Esko, J. D. 1190 Essex, M. 1505 Evans, G. A. 1294 Evans, W. J. 1056 Faras, A. J. 1284 Farber, R. A. 1470 Favre, M. 1537 Fenoglio, C. 1524 Fenoglio, C. 1529 Fernandes, G. 1500 Fey, G. 1279 Fiddes, J. C. 1081 Finch, C. 1559 Flaming, D. G. 1587 Foriers, A. 1136 Freienstein, C. 1389 Friend, P. 1500 Friesen, J. D. 1091 Furuichi, Y. 1086 Gage, P. W. 1596 Garcia-Olmedo, F. 1446 Gatmaitan, Z. 1213 Geiser, M. 1140 Gerhard, W. 1510 Gershman, H. 1418 Gershon, N. D. 1357 Geuens, G. 1339 Ghiron, C. A. 1172 Giaever, I. 1366 Gilbert, W. 1485 Gilden, R. V. 1404 Giles, R. 1456 Godson, G. N. 1081 Goldberg, A. L. 1369 Gonzalez-Serratos, H.

1329 Good, R. A. 1500 Gordon, J. 1140 Gordon, S. 1554 Graessmann, A. 1279 Gross, J. 1232 Gryczan, T. J. - 1428 Guillemin, R. 1591 Guillemin, R. 1608 Gyles, C. L. 1384 Hackenberg, R. 1418 Hardy, S. J. S. 1209 Hastie, N. D. 1217 Hauser, H. 1577 Hayaishi, 0. 1111 Hegsted, D. M. 1600 Heinrikson, R. L. 1260 Held, W. A. 1217 Helene, C. 1324 Helms, C. 1437 Helmuth, R. 1237

Henderson, L. E. 1404 Henry, N. 1515 Hicks, B. 1172 Hill, T. L. 1101 Hishinuma, F. 1270 Hodgson, H. J. F. 1549 Holladay, C. R. 1414 Honig, G. R. 1475 Houtchens, R. 1076 Hsia, J. C. 1542 Hsu, I.-C. 1451 Hu, R. 1524 Huebers, H. 1559 Hurwitz, D. R. 1480 Ihle, J. N. 1404 Isselbacher, K. J. 1549 Jablonska, S. 1537 Jacobson, A. 1250 Jacobus, J. 1227 Jameson, J. L. 1608 Jarzabek-Chorzelska, M.

1537 Johnson, E. M. 1116 Joniau, M. 1339 Jonsson, G. 1582 Josefsson, L.-G. 1209 Kakunaga, T. 1334 Kanarek, L. 1136 Kaplan, N. 0. 1096 Kapmeyer, W. 1096 Katz, M. J. 1349 Keggins, K. M. 1423 Keim, P. S. 1260 Keydar, I. 1524 Keydar, I. 1529 Kikuchi, Y. 1270 Kintner, C. 1071 Kirner, J. F. 1056 Koch, R. 1562 Konotey-Ahulu, F. 1222 Koprowski, H. 1510 Kressmann, A. 1176 Krieger, D. T. 1577 Krzyzek, R. A. 1284 Kuntz, R. R. 1172 Kwan, N. H. 1542 Labrecque, A. D. 1260 Lai, T. L. 1068 Lake, J. A. 1389 Lalley, P. 1361 Lappi, D. A. 1096 Lasek, R. J. 1349 Lau, A. F. 1284 Lawrence, J. 1456 Leclerc, M. 1050 Leder, P. 1309 Lehmann, J. 1181 Leibowitz, D. 1222 Leis, J. P. 1284 Leloir, L. F. 1162 Leonard, N. J. 1199 Levin, D. 1121 Lin, H. C. 1045 Ling, N. 1591 Ling, N. 1608 Lippard, S. J. 1181 Listowsky, I. 1213 Liu, F.-T. 1199 London, I. M. 1121 Long, C. W. 1404 Lopes, D. 1510 Lovett, P. S. 1423 Lucchesi, J. C. 1480 Lund, E. 1071 Maas, W. K. 1384 McClellan, G. 1329

v



AUTHOR INDEX, MARCH 1978

McConnell, H. M. 1515 MacDonald, E. 1608 McGee, R. 1314 MacHattie, L. A. 1490 Magnuson, J. A. 1319 Maness, P. F. 1304 Marme, D. 1232 Marsaglia, G. 1559 Martin, M. A. 1131 Mason, R. G. 1475 Masters, P. M. 1204 Mata, M. 1314 Matthews, H. R. 1116 Maxam, A. M. 1485 Mears, J. G. 1222 Meneguzzi, G. 1126 Mesa-Tejada, R. 1524 Mesa-Tejada, R. 1529 Milanesi, G. 1126 Miller, C. A. 1265 Miller, M. J. 1399 Miller, R. E. 1418 Minick, S. 1608 Moens, W. 1339 Monsigny, M. 1324 Morgan, J. L. 1414 Moxon, E. R. 1534 Muetterties, E. L. 1056 Mukherjee, A. B. 1361 Murphy, P. A. 1534 Nagel, A. 1060 Nakamura, F. 1222 Narang, S. C. 1045 Neel, J. V. 1442 Nelson, P. 1314 Neuhard, J. 1194 Nienhuis, A. 1456 Nirenberg, M. 1314 Noon, J. P. 1605 Norton, W. T. 1554 Novogrodsky, A. 1157 Ochoa, S. 1148 Ohno, T. 1524 Ohno, T. 1529 Okayama, H. 1111 Olah, G. A. 1045 Olah, J. A. 1045 Orloff, S. 1361 Oroszlan, S. 1404 Orth, G. 1537 Otero, C. 1242 Palay, S. L. 1582 Parce, J. W. 1515 Parker, J. 1091 Patzelt, C. 1260 Perdue, M. L. 1284 Pereira-Smith, 0. M.

1353 Pero, J. 1185 Perutz, M. F. 1076 Phillips, S. E. V. 1076 Pignatti, P. F. 1126

Pirrotta, V. 1176 Pollard, J. W. 1091 Powell, G. L. 1227 Price, A. R. 1194 Purchio, A. F. 1567 Quittner, S. 1157 Raetz, C. R. H. 1190 Ramanarayanan, M.

1524 Ramanarayanan, M.

1529 Ramirez, F. 1222 Randall, L. L. 1209 Rapaport, E. 1145 Rhee, S. G. 1255 Rice, P. J. 1605 Robbins, H. 1068 Rodman, J. S. 1399 Rodriguez-Loperena, M.

A. 1446 Rose, E. 1052 Rosenfeld, M. G. 1294 Rossier, J. 1591 Rossier, J. 1608 Rubin, A. L. 1157 Ruddle, F. H. 1456 Rzesa, G. 1537 Sabatini, D. D. 1389 Sachs, L. 1374 Sakaguchi, K. 1270 Salcedo, G. 1446 Samonds, K. W. 1600 Sandoval, I. V. 1608 Schack, L. 1194 Schlesinger, P. H. 1399 Schneider, E. L. 1353 Schulman, J. D. 1361 Schwartz, K. 1199 Seeman, P. 1153 Sen, A. 1505 Shamsuddin, M. 1475 Shapiro, J. A. 1490 Sharp, P. A. 1274 Sherman, F. 1437 Sherr, C. J. 1505 Shuman, H. 1329 Silva, M. L. M. 1384 Simmons, D. T. 1131 Simpson, P. 1314 Sinclair, D. 1153 Sinensky, M. 1247 Skarberg, K. 1559 Sliski, A. 1505 Smith, J. R. 1353 Somlyo, A. P. 1329 Somlyo, A. V. 1329 Spiegelman, S. 1524 Spiegelman, S. 1529 Spooner, B. S. 1414 Springer, W. D. 1461 Spruill, W. A. 1480 Srb, A. M. 1461

Stahl, P. D. 1399 Stanbridge, E. J. 1466 Staneloni, R. J. 1162 Stanners, C. P. 1091 Stein, E. M. 1060 Steiner, A. L. 1480 Steiner, D. F. 1260 Stenzel, K. H. 1157 Stephenson, J. R. 1404 Stewart, J. W. 1437 Strosberg, A. D. 1136 Strothkamp, K. G. 1181 Suslick, K. S. 1052 Sweet, R. 1299 Talkington, C. 1185 Tang, L. C. 1546 Tavanaiepour, I. 1056 Tennant, R. W. 1451 Thomas, J.-P. 1344 Thomassen, E. 1194 Thompson, E. A. 1442 Thompson, R. F. 1572 Tiemeier, D. C. 1309 Tilghman, S. M. 1309 Titeler, M. 1153 Tizard, R. 1485 Tjian, R. 1279 Todaro, G. J. 1505 Tonegawa, S. 1485 Triche, T. 1361 Trumble, W. R. 1319 Tucker, P. W. 1076 Turner, P. 1456 Udenfriend, S. 1379 Ueda, K. 1111 Vandekerckhove, J. 1106 Van Pel, A. 1519 Vargo, T. M. 1608 Vida, L. N. 1475 Villafranca, J. J. 1255 Volkert, W. A. 1172 Wainger, S. 1060 Walker, P. R. 1394 Wands, J. R. 1549 Ward, E. 1366 Watson, P. L. 1056 Weber, K. 1106 Weinreich, P. 1153 Weinstock, R. 1299 Weiss, B. 1374 Weiss, M. 1299 Weissmann, C. 1309 White, C. N. 1167 White, M. 1172 Whitfield, J. F. 1394 Wilkinson, J. 1466 Williamson, M. L. 1562 Wood, D. J. 1542 Yang, W. K. 1451 Yunis, E. J. 1500 Zachariasen, W. H. 1066 Zamecnik, P. C. 1145 Zigler, J. S., Jr. 1204

vi



Contents (Continued from page ix)

PHYSIOLOGICAL SCIENCES

1600-1604 Kenneth W. Samonds and D. M. Hegsted Protein deficiency and energy restriction in young cebus monkeys (protein-calorie malnutrition/albumin/anemia/protein

requirements)

1605-1607 James P. Noon, Peter J. Rice, and Ross J. Baldessarini Calcium leakage as a cause of the high resting tension in vascular smooth muscle from the spontaneously hypertensive rat

(cardiovascular physiologyla-adrenergic receptor/membrane permeability/norepinephrine)

Corrections

BIOCHEMISTRY

1608 Ignacio V. Sandoval, Eve MacDonald, James L. Jameson, and Pedro Cautrecasas Role of nucleotides in tubulin polymerization: Effect of guanylyl 5'-methylenediphosphonate (microtubules/guanosine

nucleotides/high molecular weight basic proteins/calcium/electron microscopy)

NEUROBIOLOGY

1608 J. Rossier, T. M. Vargo, S. Minick, N. Ling, F. E. Bloom, and R. Guillemin Regional dissociation of fl-endorphin and enkephalin contents in rat brain and pituitary (opiates/radioimmunoassay/

neurotransmitter/adrenalectomny and hypophysectomy/myelin basic protein)

viii



Contents (Continued from page x)

1515-1518 J. Wallace Parce, Nicole Henry, and Harden M. McConnell Specific antibody-dependent binding of complement component Clq to hapten-sensitized lipid vesicles (solid and fluid lipid

membranes/spin labels/C1 activation)

1519-1523 Thierry Boon and Aline Van Pel Teratocarcinoma cell variants rejected by syngeneic mice: Protection of mice immunized with these variants against other variants

and against the original malignant cell line (tumor immunology)

MEDICAL SCIENCES

1524-1528 I. Keydar, R. Mesa-Tejada, M. Ramanarayanan, T. Ohno, C. Fenoglio, R. Hu, and S. Spiegelman Detection of viral proteins in mouse mammary tumors by immunoperoxidase staining of paraffin sections (immunohistochemistry/

tumor antigen/glycoproteins)

1529-1533 R. Mesa-Tejada, I. Keydar, M. Ramanarayanan, T. Ohno, C. Fenoglio, and S. Spiegelman Detection in human breast carcinomas of an antigen immunologically related to a group-specific antigen of mouse mammary tumor

virus (immunoperoxidase staining/paraffin sections/cancer antigen)

1534-1536 E. Richard Moxon and Patrick A. Murphy Haemophilus influenzae bacteremia and meningitis resulting from survival of a single organism (streptomycin/central nervous

system/nasopharyngeal colonization/pathogenesis of central nervous system infections/encapsulated bacteria)

1537-1541 Gerard Orth, Stefania Jablonska, Michel Favre, Odile Croissant, Maria Jarzabek-Chorzelska, and Genowefa Rzesa Characterization of two types of human papillomaviruses in lesions of epidermodysplasia verruciformis (malignant

transformation/molecular hybridization/antigenic properties/skin/wart viruses)

1542-1545 J. C. Hsia, N. H. Kwan, S. S. Er, D. J. Wood, and G. W. Chance Development of a spin assay for reserve bilirubin loading capacity of human serum (electron spin resonance/spin-label/neonate/

reserve bilirubin binding capacity/hyperbilirubinemia/jaundice)

1546-1548 Lily C. Tang and George C. Cotzias Morphine sulfate stimulates the adenylate cyclase in mouse caudate nuclei (opiates/dopaminergic neuron/pain)

1549-1553 Humphrey J. F. Hodgson, Jack R. Wands, and Kurt J. Isselbacher Alteration in suppressor cell activity in chronic active hepatitis (concanavalin A/lymphocytes/prednisone/cell culture)

1554-1558 Wendy Cammer, Barry R. Bloom, William T. Norton, and Siamon Gordon Degradation of basic protein in myelin by neutral proteases secreted by stimulated macrophages: A possible mechanism of

inflammatory demyelination (plasminogen activator/plasmin/cell-mediated immunity/urokinase/protease inhibitors)

1559-1561 Karl Skarberg, Mary Eng, Helmut Huebers, George Marsaglia, and Clement Finch Plasma radioiron kinetics in man: Explanation for the effect of plasma iron concentration (transferrin/erythrocytes)

1562-1566 Samuel P. Bessman, Malcolm L. Williamson, and Richard Koch Diet, genetics, and mental retardation interaction between phenylketonuric heterozygous mother and fetus to produce nonspecific

diminution of IQ: Evidence in support of the justification hypothesis (genetics and malnutrition/fetal malnutrition/ nonessential amino acid deficiency/maternal malnutrition)

MICROBIOLOGY

1567-1571 A. F. Purchio, Eleanor Erikson, Joan S. Brugge, and R. L. Erikson Identification of a polypeptide encoded by the avian sarcoma virus src gene (cell-free protein synthesis/translation of viral RNA/

immunoprecipitation/peptide fingerprints)

NEUROBIOLOGY

1572-1576 Theodore W. Berger and Richard F. Thompson Identification of pyramidal cells as the critical elements in hippocampal neuronal plasticity during learning

1577-1581 Dorothy T. Krieger and Herbert Hauser Comparison of synchronization of circadian corticosteroid rhythms by photoperiod and food (temperature/phase shift)

1582-1586 Victoria Chan-Palay, G6sta Jonsson, and Sanford L. Palay Serotonin and substance P coexist in neurons of the rat's central nervous system (autoradiography/fluorescence histochemistry/

microspectrofluorimetry/immunofluorescence/unlabeled antibody-peroxidase antiperoxidase)

1587-1590 Kenneth T. Brown and Dale G. Flaming Opposing effects of calcium and barium in vertebrate rod photoreceptors (visual transduction/ionic control of vertebrate rods/

adaptation in vertebrate rods)

1591-1595 F. Bloom, E. Battenberg, J. Rossier, N. Ling, and R. Guillemin Neurons containing f3-endorphin in rat brain exist separately from those containing enkephalin: Immunocytochemical studies

( peptid es/hypothalamus/thalamus/pituitary )

1596-1599 E. X. Albuquerque and P. W. Gage Differential effects of perhydrohistrionicotoxin on neurally and iontophoretically evoked endplate currents (synaptic noise/

acetylcholine receptors/ionic channel/denervated muscles/rat extensor and soleus muscles)

1608 J. Rossier, T. M. Vargo, S. Minick, N. Ling, F. E. Bloom, and R. Guillemin Regional dissociation of d3-endorphin and enkephalin contents in rat brain and pituitary (Correction) (opiates/radioimmunoassay/

neurotransmitter/adrenalectomy and hypophysectomy/myelin basic protein)

ix ~~~~~~~~~~~~~~~~(Continued on page viii)



Contents (Continued from page xi)

1414-1417 Janet L. Morgan, Carter R. Holladay, and Brian S. Spooner Species-dependent immunological differences between vertebrate brain tubulins (radjoimmunoassay/iodination/coprecipitation)

1418-1422 Richard E. Miller, Richard Hackenberg, and Howard Gershman Regulation of glutamine synthetase in cultured 3T3-L1 cells by insulin, hydrocortisone, and dibutyryl cyclic AMP (3T3-Ll

adipocytes/hexokinase/glucose-6-P dehydrogenase)

GENETICS

1423-1427 Kathleen M. Keggins, Paul S. Lovett, and Elizabeth J. Duvall Molecular cloning of genetically active fragments of Bacillus DNA in Bacillus subtilis and properties of the vector plasmid

pUB110 (genetic complementation/tryptophan/EcoR1 endonuclease)

1428-1432 Thomas J..Gryczan and David Dubnau Construction and properties of chimeric plasmids in Bacillus subtilis (molecular cloning/endonuclease Xba I/antibiotic

resistance)

1433-1436 Stanislav D. Ehrlich DNA cloning in Bacillus subtilis (plasmids/recombinant molecules/heterospecific gene expression)

1437-1441 Fred Sherman, John W. Stewart, Cynthia Helms, and J. Allan Downie Chromosome mapping of the CYC7 gene determining yeast iso-2-cytochrome c: Structural and regulatory regions (regulatory

mutation/amino acid sequence/Saccharomyces cerevisiae)

1442-1445 E. A. Thompson and J. V. Neel Probability of founder effect in a tribal population (Amerindian/genetic variant/branching processes/private variants!

demographic history)

1446-1450 C. Aragoncillo, M. A. Rodriguez-Loperena, G. Salcedo, P. Carbonero, and F. Garca-Olmedo Influence of homoeologous chromosomes on gene-dosage effects in allohexaploid wheat (Triticum aestivum L.) (polyploid

evolution/gene expression/endosperm proteins/electrofocusing-electrophoresis)

1451-1455 Ih-Chang Hsu, Wen K. Yang, Raymond W. Tennant, and Arthur Brown Transfection of Fv-1 permissive and restrictive mouse cells with integrated DNA of murine leukemia viruses (host range

restriction/Fv-1 gene/DNA transfection)

1456-1460 Albert Deisseroth, Arthur Nienhuis, Jeanne Lawrence, Richard Giles, Patricia Turner, and Frank H. Ruddle Chromosomal localization of human ,B globin gene on human chromosome 11 in somatic cell hybrids (gene mapping/cloning!

- cDNA/fibroblasts/molecular hybridization)

1461-1465 Warren D. Springer and Adrian M. Srb Molecular alteration in a Neurospora crassa morphological mutant and its phenocopy (glycan/cell wall/sorbose)

1466-1469 Eric J. Stanbridge and Joyce Wilkinson Analysis of malignancy in human cells: Malignant and transformed phenotypes are under separate genetic control (human cell

hybrids/fibroblasts/HeLa cells/tumorigenicity/neoplastic progression)

1470-1474 Rosann A. Farber and Richard L. Davidson Altered pattern of replication of human chromosomes in a human fibroblast-mouse cell hybrid (autoradiography/quinacrine

banding)

1475-1479 George R. Honig, Mir Shamsuddin, R. George Mason, and Loyda N. Vida Hemoglobin Lincoln Park: A /B( fusion (anti-Lepore) variant with an amino acid deletion in the a chain-derived segment (gene

hybrid/amino acid sequence)

1480-1484 W. Austin Spruill, David R. Hurwitz, John C. Lucchesi, and Alton L. Steiner Association of cyclic GMP with gene expression of polytene chromosomes of Drosophila melanogaster (immunofluorescence/cyclic

AMP/subchromosomal distribution/heat-shock/transcription)

1485-1489 Susumu Tonegawa, Allan M. Maxam, Richard Tizard, Ora Bernard, and Walter Gilbert Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain (X light chain/hypervariable region!

DNA sequencing/interspersed noncoding sequences)

1490-1494 L. A. MacHattie and J. A. Shapiro Chromosomal integration of phage X by means of a DNA insertion element (ISI insertion sequence/chloramphenicol resistance

transposon Tn9/integrative recombination)

IMMUNOLOGY

1495-1499 Kurt Blaser and Herman N. Eisen X2 light chains in normal mouse immunoglobulins (synthetic peptides/peptide maps/inbred mice/myeloma proteins)

1500-1504 G. Fernandes, P. Friend, E. J. Yunis, and R. A. Good Influence of dietary restriction on immunologic functions and renal disease in (NZB X NZW)F1 mice (calories/autoimmunity/

longevity/immunity/hi stopat hology )

1505-1509 Charles J. She rr, Arup Sen, George J. Todaro, Ann Slishi, and Max Essex Pseudotypes of feline sarcoma virus contain an 85,000-dalton protein with feline oncornavirus-associated cell membrane antigen

(FOCMA) activity (viral transformation/viral-coded antigens/tumor immunity)

1510-1514 W. Gerhard, C. M. Croce, D.* Lopes, and H. Koprowski Repertoire of antiviral antibodies expressed by somatic cell hybrids (mouse hybridomas/influenza/parainfluenza)

(Continued on page tX) X.



Contents (Continued from page xii)

1608 Ignacio V. Sandoval, Eve MacDonald, James L. Jameson, and Pedro Cuatrecasas Role of nucleotides in tubulin polymerization: Effect of guanylyl 5'-methylenediphosphonate (Correction) (microtubulesl

guanosine nucleotides/high molecular weight basic proteins/calcium/electron microscopy)

BIOPHYSICS

1319-1323 Michael E. Dockter, William R. Trumble, and James A. Magnuson Membrane lateral phase separations and chlortetracycline transport by Bacillus megaterium (fluorescence/spin label

partitioning/N-phenyl-l-naphthylamine/2,2-dimethyl-4-butyl-4-pentyl-N-oxyloxazolidine)

1324-1328 Michel Monsigny, Francis Delmotte, and Claude Helene Ligands containing heavy atoms: Perturbation of phosphorescence of a tryptophan residue in the binding site of wheat germ

agglutinin (heavy atom effect/lectin/protein-sugar interaction)

1329-1333 Hugo Gonzalez-Serratos, Avril V. Somlyo, George McClellan, Henry Shuman, Luis M. Borrero, and Andrew P. Somlyo Composition of vacuoles and sarcoplasmic reticulum in fatigued muscle: Electron probe analysis (fatigue/cryo-ultramicrotomy/

mitochondrial calcium/striated muscle/muscle calcium)

CELL BIOLOGY

1334-1338 Takeo Kakunaga Neoplastic transformation of human diploid fibroblast cells by chemical carcinogens (morphological alteration/growth in soft

agar/transplantability in nude mice/4-nitroquinoline 1-oxide)

1339-1343 J. De Mey, M. Joniau, M. De Brabander, W. Moens, and G. Geuens Evidence for unaltered structure and in vivo assembly of microtubules in transformed cells (antibodies to tubulin/

immunocytochemistry/cytoplasmic microtubule complex/cell morphology/surface modulating assembly)

1344-1348 Jean-Pierre Thomas, Laneta J. Dorflinger, and Harold R. Behrman Mechanism of the rapid antigonadotropic action of prostaglandins in cultured luteal cells (prostaglandin F2,/luteolysis/

gonadotropin receptor/adenylate cyclase)

1349-1352 Michael J. Katz and Raymond J. Lasek Evolution of the nervous system: Role of ontogenetic mechanisms in the evolution of matching populations (cell death/evolution

experiments/excess cells/matching populations/neural ontogeny)

1353-1356 James R. Smith, Olivia M. Pereira-Smith, and Edward L. Schneider Colony size distributions as a measure of in vivo and in vitro aging (human diploid cells/cloning/in vitro life-span)

1357-1360 N. D. Gershon Model for capping of membrane receptors based on boundary surface effects (cap formation/cell surface/cell membrane proteins)

1361-1365 Anil B. Mukherjee, Sheldon Orloff, Jean DeB. Butler, Timothy Triche, Peter Lalley, and Joseph D. Schulman Entrapment of metaphase chromosomes into phospholipid vesicles (lipochromosomes): Carrier potential in gene transfer (gene

mapping/somatic cell genetics/liposomes/encapsulation)

1366-1368 Ivar Giaever and Elsie Ward Cell adhesion to substrates containing adsorbed or attached IgG (protein adsorption/cell interactions/immunology)

1369-1373 George N. DeMartino and Alfred L. Goldberg Thyroid hormones control lysosomal enzyme activities in liver and skeletal muscle (intracellular proteases/protein turnover/

thyroxine/triiodothyronine/lyperthyroidism and hypothyroidism)

1374-1378 Benny Weiss and Leo Sachs Indirect induction of differentiation in myeloid leukemic cells by lipid A (lipopolysaccharide/genetic susceptibility/macrophages/

MG1 protein)

1379-1383 Selina Chen-Kiang, George J. Cardinale, and Sidney Udenfriend Expression of collagen biosynthetic activities in lymphocytic cells (prolyl hydroxylase/mitogens/derepression/MCP-11 cells)

1384-1388 M. L. M. Silva, W. K. Maas, and C. L. Gyles Isolation and characterization of enterotoxin-deficient mutants of Escherichia coli (plasmid genetics/mutant enrichment/

drug-resistant pathogens/altered mutant molecules/toxin immunology)

1389-1393 Ivan Emanuilov, David D. Sabatini, James A. Lake, and Christoph Freienstein Localization of eukaryotic initiation factor 3 on native small ribosomal subunits (protein synthesis/electron microscopy/

ribosomes)

1394-1398 P. Roy Walker and James F. Whitfield Inhibition by colchicine of changes in amino acid transport and initiation of DNA synthesis in regenerating rat liver (microtubules/

intracellular translocation/proliferative activation/a-aminoisobutyric acid)

1399-1403 Philip D. Stahl, Jane Somsel Rodman, M. Jill Miller, and Paul H. Schlesinger Evidence for receptor-mediated binding of glycoproteins, glycoconjugates, and lysosomal glycosidases by alveolar macrophages

(mannosyl-glucosyl receptor/mammalian lectin/pinocytosis)

1404-1408 Stephen Oroszlan, Louis E. Henderson, John R. Stephenson, Terry D. Copeland, Cedric W. Long, James N. Ihle, and Raymond V. Gilden

Amino- and carboxyl-terminal amino acid sequences of proteins coded by gag gene of murine leukemia virus (Rauscher leukemia virus/AKR leukemia virus/type C virus/structural proteins)

1409-1413 Janice Y. Chou Human placental cells transformed by tsA mutants of simian virus 40: A model system for the study of placental functions (human

chorionic gonadotropin/placental alkaline phosphatase/thymidine kinase) (Continued on page x)

X1



Contents (Continued from inside back cover)

1217-1221 Nicholas D. Hastie and William A. Held Analysis of mRNA populations by cDNA-mRNA hybrid-mediated inhibition of cell-free protein synthesis (globin mRNA/

hybridization/translation/abundant liver mRNAs)

1222-1226 J. Gregory Mears, Francesco Ramirez, David Leibowitz, Frank Nakamura, Arthur Bloom, Felix Konotey-Ahulu, and Arthur Bank

Changes in restricted human cellular DNA fragments containing globin gene sequences in thalassemias and related disorders (3 thalassemia/restriction enzyme digestion/"blot" hybridization/cellular DNA)

1227-1231 Michael B. Cable, John Jacobus, and Gary L. Powell Cardiolipin: A stereospecifically spin-labeled analogue and its specific enzymic hydrolysis (diphosphatidylglycerol/phospholipid/

phospholipase/electron spin resonance/biological membranes)

1232-1236 Joachim Gross and Dieter Marme ATP-dependent Ca2+ uptake into plant membrane vesicles (nucleotide specificity/ionophores/oxalate/Mg2+-ATPase/adenylate

kinase)

1237-1241 Reiner Helmuth and Mark Achtman Cell-cell interactions in conjugating Escherichia coli: Purification of F pili with biological activity (F pilus overproducer/surface

receptor/male-specific bacteriophage)

1242-1246 Rodrigo Bravo, Carlos Otero, Catherine C. Allende, and Jorge E. Allende Amphibian oocyte maturation and protein synthesis: Related inhibition by cyclic AMP, theophylline, and papaverine (hormone

induction/progesterone/cyclic AMP phosphodiesterase/meiosis/translational regulation)

1247-1249 Michael Sinensky Defective regulation of cholesterol biosynthesis and plasma membrane fluidity in a Chinese hamster ovary cell mutant (electron

spin resonance/25-hydroxycholesterol)

1250-1254 Barbara D. Beck, Patricia G. Arscott, and Allan Jacobson Novel properties of bacterial elongation factor Tu (polymerization complex/elongation factor Ts/filaments/DNase I binding)

1255-1259 J. J. Villafranca, S. G. Rhee, and P. 13. Chock Topographical analysis of regulatory and metal ion binding sites on glutamine synthetase from Escherichia coli: 13C and 31p

nuclear magnetic resonance and fluorescence energy transfer study (covalent modification/distance determination/ f-ATP/[13C]ATP/adenylylation)

1260-1264 Christoph Patzelt, Allen D. Labrecque, John R. Duguid, Raymond J. Carroll, Pamela S. Keim, Robert L. Heinrikson, and Donald F. Steiner

Detection and kinetic behavior of preproinsulin in pancreatic islets (secretory prepeptides/precursor cleavage/proinsulin/ insulinoma/polyacrylamide gel electrophoresis-fluorography)

1265-1269 Christine A. Miller and Stanley N. Cohen Phenotypically cryptic EcoRJ endonuclease activity specified by the ColEl plasmid (restriction/modification/DNA/

recombination)

1270-1273 Yo Kukuchi, Fumio Hishinuma, and Kenji Sakaguchi Addition of mononucleotides to oligoribonucleotide acceptors with T4 RNA ligase (oligonucleotide synthesis/minimal substrate/

5'-adenylylated pCp)

1274-1278 Arnold J. Berk and Phillip A. Sharp Spliced early mRNAs of simian virus 40 (S, endonuclease/exonuclease VII/transcription mapping/viable deletion mutants)

1279-1283 R. Tjian, G. Fey, and A. Graessmann Biological activity of purified simian virus 40 T antigen proteins (adenovirus-simian virus 40 hybrids/microinjection/DNA

replication/helper function)

1284-1288 R. A. Krzyzek, M. S. Collett, A. F. Lau, M. L. Perdue, J. P. Leis, and A. J. Faras Evidence for splicing of avian sarcoma virus 5'-terminal genomic sequences onto viral-specific RNA in infected cells (gene splicing/

retrovirus RNA/hybridization/RNase H hydrolysis)

1289-1293 Prabir Bhattacharya and Subhash Basu DNA polymerase activities in differentiating mouse neuroblastoma N-18 cells (5-bromodeoxyuridine/control of DNA replication!

DNA nucleotidyltransferase/Escherichia coli RNA nucleotidyltransferase)

1294-1298 Glen A. Evans, Denise N. David, and Michael G. Rosenfeld Regulation of prolactin and somatotropin mRNAs by thyroliberin (thyrotropin-releasing hormone/growth hormone/cDNA/

RNA-DNA hybridization/pituitary tumor cells)

1299-1303 Ruth Weinstock, Raymond Sweet, Michael Weiss, Howard Cedar, and Richard Axel Intragenic DNA spacers interrupt the ovalbumin gene (restriction endonuclease mapping/intragenic spacers/gene organization)

1304-1308 Patricia F. Maness and Gerald M. Edelman Inactivation and chemical alteration of mating factor a by cells and spheroplasts of yeast (a factor/yeast mating types/

pheromones/Saccharomyces cerevisiae)

1309-1313 Shirley M. Tilghman, Peter J. Curt-is, David C. Tiemeier, Philip Leder, and Charles Weissman The intervening sequence of a mouse d3-globin gene is transcribed within the i5S /3-globin mRNA precursor (cloned DNA /R-loop

mapping)

1314-1318 Richard McGee, Paul Simpson, Clifford Christian, Marina Mata, Phillip Nelson, and Marshall Nirenberg Regulation of acetylcholine release from neuroblastoma X glioma hybrid cells (synapse formation/dibutyryl cyclic AMP/neuron

development)

(Continued on page xi)

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