Merck Index Front Matter

  • Published on
    29-Nov-2015

  • View
    124

  • Download
    4

Embed Size (px)

Transcript

  • 40270 -- Merck BATCH RIGHT

    top of RHbase of RHtop of textbase of text

    shortstandard

    T H E MERCK I ND EXFOURTEENTH EDITION

    1st Edition18892nd Edition18963rd Edition19074th Edition19305th Edition19406th Edition19527th Edition19608th Edition19689th Edition197610th Edition198311th Edition198912th Edition199613th Edition200114th Edition2006

  • 40270 -- Merck BATCH LEFT

    top of RHbase of RHtop of textbase of text

    shortstandard

    top of RFbase of RF

    OTHER MERCK HANDBOOKS

    THE MERCK MANUAL OF DIAGNOSIS AND THERAPYFirst Edition, 1899

    THE MERCK VETERINARY MANUALFirst Edition, 1955

    THE MERCK MANUAL OF GERIATRICSFirst Edition, 1990

    THE MERCK MANUAL OF MEDICAL INFORMATIONHOME EDITIONFirst Edition, 1997

    THE MERCK MANUAL OF HEALTH & AGINGFirst Edition, 2004

    The Merck Handbooks are published as a not-for-prot serviceto the scientic community and the public.

  • 40270 -- Merck BATCH RIGHT

    top of RHbase of RHtop of textbase of text

    shortstandard

    THEMERCK INDEX

    AN ENCYCLOPEDIA OFCHEMICALS, DRUGS, AND BIOLOGICALS

    FOURTEENTH EDITION

    Maryadele J. ONeil, EditorPatricia E. Heckelman, Senior Associate Editor

    Cherie B. Koch, Associate EditorKristin J. Roman, Assistant Editor

    Catherine M. Kenny, Editorial AssistantMaryann R. DArecca, Administrative Associate

    Published byMerck Research Laboratories

    Division ofMERCK & CO., INC.

    Whitehouse Station, NJ, USA

    2006

  • 40270 -- Merck BATCH LEFT

    top of RHbase of RHtop of textbase of text

    shortstandard

    top of RFbase of RF

    Library of Congress Catalog Card Number 89-60001ISBN Number 0-911910-00-X

    ISBN Number 978-0-911910-00-1

    Copyright 2006 by MERCK & CO., INC., Whitehouse Station, NJ, USA

    All rights reserved. No part of this book or electronic product may be reproduced or used in any form or by any means,electronic or mechanical, including photocopying, or by any information storage and retrieval system, without permissionin writing from the Publisher. Inquiries should be addressed to The Merck Index Editorial Ofces, P.O. Box 2000, Merck& Co., Inc., Rahway, NJ 07065.

    Printed in the USA

  • 40270 -- Merck BATCH RIGHT

    top of RHbase of RHtop of textbase of text

    shortstandard

    v

    FOREWORD

    For more than a century, The Merck Index, Chemistrys Constant Com-panion, has provided quick and reliable answers to questions arising in thecourse of the scientists work. The Fourteenth Edition continues this traditionto publish an authoritative, multidisciplinary reference handbook committed toscientic excellence.

    Each edition is reective of key scientic discoveries of its time period. Onceagain, signicant new compounds have been carefully selected from biomedi-cine, agriculture, and various disciplines of chemistry. With the particular needsof the research scientist in mind, every effort has been made to include addi-tional physical property information in the monographs. Coverage of importantnew tools for pharmacological research and organic synthesis has been ex-panded and includes more than 140 monographs on Name Reagents. The Or-ganic Name Reactions have again been updated and now include 450 entries.

    The Supplemental Tables have been extensively revised. More than 70 pagesof hard-to-nd information complement the material presented in the othersections. New for this edition is a table describing vaccine preparations for usein the prevention of infectious disease, an area of research never before coveredin this reference work. Another new table provides the expanded meanings foracronyms encountered in biomedical and pharmaceutical research.

    An important new feature introduced for this edition is the companion CDthat accompanies the printed volume. This new multimedia reference set allowsthe scientist to use whichever format is most usefulhardcopy at the lab benchand CD in the laptop. The text searchable CD uses CambridgeSofts Chem-Finder software to enable quick retrieval of data and provides access to nearly1000 monographs retired from the 12th and 13th editions that are no longeravailable in print.

    Merck & Co., Inc. is one of the worlds largest pharmaceutical companies.Merck is committed to providing trusted medical and scientic information andcontinues to publish The Merck Index and all of the Merck Handbooks as anot-for-prot service to the scientic community and the public. We hope thatthis edition of The Merck Index will be an indispensable resource to all whouse it.

  • vi

    40270 -- Merck BATCH LEFT

    top of RHbase of RHtop of textbase of text

    shortstandard

    top of RFbase of RF

    ACKNOWLEDGMENTS

    The successful publication of the Fourteenth Edition of The Merck Indexwould not have been possible without the close collaboration of many dedicatedpeople who have generously contributed their expertise and special talents.

    The Merck Index Staff wishes to acknowledge our coworkers whose contri-butions have been particularly signicant: Beverly Grodzinski for system sup-port and for organizing and tracking the production process; John Ho and BobDougherty for computer expertise, custom programming and technical guid-ance; Sharon OBrien for designing the CD artwork; Debra Shelinsky Greeneand Hilary Wandall for advice and counsel on intellectual property and con-tractual issues; Pamela Barnes-Paul for coordinating the advertising and mar-keting effort;Margaret Hill, Ann Smith, and the entire staff of the MRL Libraryfor their ongoing assistance.

    We are especially indebted to the many readers who took the time to contactus with comments, additions and corrections and to the generations of Merckscientists who have contributed to this and previous editions of The MerckIndex.

    Finally, special thanks are due to Dr. John D. Irvin of Merck Research Lab-oratories for his personal interest, encouragement and support; and to GaryZelko, our publisher, for his collaboration and expertise in producing thisedition.

  • 40270 -- Merck BATCH RIGHT

    top of RHbase of RHtop of textbase of text

    shortstandard

    vii

    TABLE OF CONTENTS

    Periodic chart . . . . . . . . . . . . . . . . . . . . . inside front coverForeword . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vAcknowledgments. . . . . . . . . . . . . . . . . . . . . . . . . . viExplanatory notes . . . . . . . . . . . . . . . . . . . . . . . . . . viiiTable of Abbreviations . . . . . . . . . . . . . . . . . . . . . . . . xiiiMONOGRAPHS . . . . . . . . . . . . . . . . . . . . . . . . 11756SUPPLEMENTAL TABLES . . . . . . . . . . . . . TABLE-1TABLE-70Alphabetical List of Tables . . . . . . . . . . . . . . . . . . TABLE-1Glossary. . . . . . . . . . . . . . . . . . . . . . . . . . TABLE-2Acronyms . . . . . . . . . . . . . . . . . . . . . . . . . TABLE-7Vaccines . . . . . . . . . . . . . . . . . . . . . . . . . TABLE-13International Patent Country Codes . . . . . . . . . . . . . . . TABLE-18Company Register. . . . . . . . . . . . . . . . . . . . . . TABLE-19Code Letters Used by Companies for Experimental Substances . . . . TABLE-29Terms for Radicals and Groups Used for Nonproprietary Names. . . . TABLE-32Radioactive Isotopes Used in Medical Diagnosis and Therapy . . . . TABLE-34Amino Acids Found in Proteins . . . . . . . . . . . . . . . . TABLE-40Chemical Terms Translator . . . . . . . . . . . . . . . . . . TABLE-42Selected Hexoses and Pentoses . . . . . . . . . . . . . . . . TABLE-44International System of Units (SI) . . . . . . . . . . . . . . . TABLE-46Numerical Prexes Commonly Used in Forming Chemical Names . . . TABLE-47Alchemical Symbols Used in Biology and Botany . . . . . . . . . TABLE-47Prescription Notation . . . . . . . . . . . . . . . . . . . . TABLE-47Latin Terms . . . . . . . . . . . . . . . . . . . . . . . . TABLE-48Greek Alphabet . . . . . . . . . . . . . . . . . . . . . . . TABLE-50Russian Alphabet . . . . . . . . . . . . . . . . . . . . . . TABLE-50Roman Numerals . . . . . . . . . . . . . . . . . . . . . . TABLE-50Common Heterocyclic Ring Systems . . . . . . . . . . . . . . TABLE-51Fundamental Physical and Mathematical Constants . . . . . . . . TABLE-52Thermometric Equivalents . . . . . . . . . . . . . . . . . . TABLE-52Universal Conversion Factors . . . . . . . . . . . . . . . . . TABLE-53Table of Minerals . . . . . . . . . . . . . . . . . . . . . . TABLE-63

    ORGANIC NAME REACTIONS . . . . . . . . . . . . . ONR-1ONR-111CAS REGISTRY NUMBER INDEX . . . . . . . . . . . . REG-1REG-73THERAPEUTIC CATEGORY AND BIOLOGICAL

    ACTIVITY INDEX . . . . . . . . . . . . . . . . THER-1THER-31FORMULA INDEX . . . . . . . . . . . . . . . . . . . . . . FI-1FI-80NAME INDEX . . . . . . . . . . . . . . . . . . . . . . . NI-1NI-363Atomic weights . . . . . . . . . . . . . . . . . . . . . inside back cover

  • viii

    40270 -- Merck BATCH LEFT

    top of RHbase of RHtop of textbase of text

    shortstandard

    top of RFbase of RF

    EXPLANATORY NOTES

    The Fourteenth edition of The Merck Index contains 10,200 monographsdescribing signicant chemicals, drugs, and biological substances. The entriescover a wide range of compounds which have been selected on the basis ofpresent or historic importance and interest. Since the publication of the Thir-teenth Edition in 2001, over 5,000 monographs have been signicantly revisedand updated. More than ve hundred monographs have either been combinedor deleted from the manuscript to make room for hundreds of new entries.Nearly 450 of these monographs, as well as 540 monographs archived from theTwelfth Edition, are presented in their original form on the companion CDwhich accompanies this volume.Entries are generally limited to single substances and related compounds such

    as isomers or salts.