etiologi sirosis

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Text of etiologi sirosis

  • ETIOLOGI SIROSIS HATIILHAM SURYO W.1061050190

  • SIROSIS HATI

    NEKROSIS HEPATOSIT KONTINYU

    REGENERASI

    FIBROSIS*

    *peran sel stellata - kolagen

  • TYPE OF CHIRROSIS1. ALCOHOLIC CHIRROSIS

    2. POST HEPATIC & CRYPTOGENIC CHIRROSIS

    3. BILIARY CHIRROSIS

    4. CARDIAC CHIRROSIS

  • A) ALCOHOLIC CHIRROSIS

  • = SIROSIS LAENNECAlkohol Metabolisme di hepar

    asetatasetaldehida

    as. Ko Atoksik

    as. Lemak

    Fatty liversteatosis hepatitis sirosis!

  • B) POST HEPATIC & CRYPTOGENIC CIRRHOSIS

    Post hepatic = Post necrotic :Hepatitis B & C--kronisHBV : sex

    HCV : transfusi darah

  • B) TOXIC AND DRUG INDUCEDTOXIC-EX: sp. Amanita dan GalerinaJamur hepatotoksik , dosis letal : 10 mg-nekrosis masifDRUG-EX: TetracyclineDosis IV : > 1.5 mg / hari deposit lemak pada hepar

  • >> obatwater insolubleHepar water soluble-eksresi di ginjal / bilier

    Fase 1 : oksidasi yg dimediasi Sitokrom P450 --- metabolit --- toksikdiikutiFase 2 : glukoronidasi / inaktivasi oleh glutathione

  • CRYPYOGENIC

    = IDIOPATHIC

    -AUTO IMUN

    -autoantibodi / antibodi terhadap antigen tubuh sendiri

  • BILIARY CHIRROSIS

  • BILIARY CHIRROSISPRIMER DAN SEKUNDERPRIMER - ??SEKUNDER:Stasis EmpeduPeriportal necrosissteril/infectedkolangitis

    fibrosisakumulasi PMN

  • CARDIAC CHIRROSIS

  • CARDIAC CHIRROSISRHFperfusi

    Kongestifhepariskemia

    nekrosis sentrolobular

    fibrosis