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Prevalence and risk factors for
gastroesophageal reflux in pregnancy.
Ramu B, Mohan P, Rajasekaran MS, Jayanthi V.
Department of Gastroenterology, Stanley Medical College, Old
Jail Road, Royapuram, Chennai,
600 001, India.
Abstract
BACKGROUND AND AIM: Prevalence of gastroesophageal reflux (GER)
increases during
pregnancy, due to several factors like decreased lower
esophageal sphincter pressure, increasedintra-abdominal pressure
secondary to the enlarged gravid uterus and alteration in
gastrointestinal transit. The present study aimed to determine
the prevalence of GER in
pregnancy in a southern State of the Indian subcontinent and
determine the risk factorsassociated with it.
METHODS: Consecutive pregnant females (n=400) at various stages
of pregnancy attendingthe antenatal clinic or admitted in the
antenatal wards were enrolled. Patients with heartburn or
regurgitation or both (n=182) for at least a week were defined
as cases, and controls werethose without these symptoms (n=218).
Data on demographic variables and symptoms were
analyzed using Pearson chi-square, Yates corrected chi-square
and Fischer exact test and studentindependent t-test as
appropriate; p
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Departemen Gastroenterologi, Stanley Medical College, Jalan
Penjara Lama, Royapuram, Chennai, 600
001, India.
Abstrak
LATAR BELAKANG DAN AIM: Prevalensi gastroesophageal reflux (GER)
meningkat selama kehamilan,
karena beberapa faktor seperti penurunan tekanan yang lebih
rendah esophageal sphincter,
meningkatkan tekanan intra-abdomen sekunder pada uterus yang
matang membesar dan perubahan
dalam transit gastrointestinal. Studi ini bertujuan untuk
menentukan prevalensi APK pada kehamilan di
Negara selatan anak benua India dan menentukan faktor risiko
yang terkait dengan itu.
METODE: betina hamil Consecutive (n = 400) pada berbagai tahap
kehamilan mengunjungi klinik
antenatal atau dirawat di bangsal antenatal yang terdaftar.
Pasien dengan mulas atau regurgitasi atau
keduanya (n = 182) selama minimal seminggu didefinisikan sebagai
kasus, dan kontrol mereka yang tidak
memiliki gejala-gejala ini (n = 218). Data tentang
variabel-variabel demografis dan gejala dianalisis
dengan Pearson chi-square, Andrea dikoreksi exact test
chi-square dan Fischer dan siswa uji t-
independen yang sesuai; p
