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p non en search Gol clinical nd stage h ld standar f rd high s EBM function specificity early d ebm PICO high sen detection renge select nsitivity EBM diagnos dip tion bayas stic va % pstick s spec alue cific

ebm ÌáÓå 3 - med-esf92.zohosites.commed-esf92.zohosites.com/files/ebm جلسه 3.pdf · EBM early detection ebm PICO high sensitivity renge selection bayas EBM diagnostic dipstick

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Page 1: ebm ÌáÓå 3 - med-esf92.zohosites.commed-esf92.zohosites.com/files/ebm جلسه 3.pdf · EBM early detection ebm PICO high sensitivity renge selection bayas EBM diagnostic dipstick

p p

non

end stage

search

Gold standard

clinical

end stage

search

Gold standard

function

Gold standard

high specificity

EBM

function

high specificity

early detection

ebm

PICO

high sensitivity

early detection

renge

selection bayas

high sensitivity

EBM

diagnostic

dipstick

selection bayas

diagnostic

value%

dipstick

selection bayas

specific

value

specific

Page 2: ebm ÌáÓå 3 - med-esf92.zohosites.commed-esf92.zohosites.com/files/ebm جلسه 3.pdf · EBM early detection ebm PICO high sensitivity renge selection bayas EBM diagnostic dipstick

Gold standardGold standard

MsMRI

blind

MSMRI

blind p valueGold standard

Gold standard

negativepositive

designpositivenegative

resulttrue positivefalse positive

True positive

False positive

True negative

False negative

true Gold standard

result

Page 3: ebm ÌáÓå 3 - med-esf92.zohosites.commed-esf92.zohosites.com/files/ebm جلسه 3.pdf · EBM early detection ebm PICO high sensitivity renge selection bayas EBM diagnostic dipstick

Reference Standard Disease Positive

Reference Standard Disease Negative

Study Test Positive

True Positive

False Positive

Study Test Negative

False negative

True Negative

Gold standardendex test

PICO

PproblemIindex testcGold standard

Oout come mortalitysensitivityspecificityp value

PICO

Gold standard

index test

False negative

False positive

Page 4: ebm ÌáÓå 3 - med-esf92.zohosites.commed-esf92.zohosites.com/files/ebm جلسه 3.pdf · EBM early detection ebm PICO high sensitivity renge selection bayas EBM diagnostic dipstick

Dyspepsia

Stool Pylori

PICO

P: Dyspepsia

I (Index):

C (Comparison Gold Standard):

O (Out come):sensitivity; specificity

PICO

SLE

Test Sensitivity% Specificity%

ANA 99 80

Page 5: ebm ÌáÓå 3 - med-esf92.zohosites.commed-esf92.zohosites.com/files/ebm جلسه 3.pdf · EBM early detection ebm PICO high sensitivity renge selection bayas EBM diagnostic dipstick

dsDNA 70 95

ssDNA 80 50

Histone 30-80 50

Nucleoprotein 58 50

Sm 25 99

RNP 50 87-94

PCNA 5 95

SpecificitySensitivity

BMI

SpecificitySensitivityverticalSensitivity

Specificity

SensitivityIndex text

Specificity

SpecificitySensitivityMissHigh Sensitivity

SensitivityHigh SensitivitySpecificity

HIV

Page 6: ebm ÌáÓå 3 - med-esf92.zohosites.commed-esf92.zohosites.com/files/ebm جلسه 3.pdf · EBM early detection ebm PICO high sensitivity renge selection bayas EBM diagnostic dipstick

PPV:

NPV:

NPV = D / (C+D)

PPV = A / (A+B)

PPV:

NPV:

Sensitivity

NPV = D / (C+D)

PPV = A / (A+B)

NPV

Sensitivity

NPV = D / (C+D)

PPV = A / (A+B)

NPV

NPV

NPV

SpecificitySensitivity

NPV = D / (C+D)

PPV = A / (A +B )

PPV

Specificity

PPV

PPV

PPV

PPV

High level

Sensitivity

Sensitivity

Horizontal

High level

SpecificitySensitivity

Sensitivity

NPVHorizontal

Specificity

SpecificitySensitivity

PPVNPV

Specificity

PPV

Page 7: ebm ÌáÓå 3 - med-esf92.zohosites.commed-esf92.zohosites.com/files/ebm جلسه 3.pdf · EBM early detection ebm PICO high sensitivity renge selection bayas EBM diagnostic dipstick

pre test

PPV

pre test

PPV

Page 8: ebm ÌáÓå 3 - med-esf92.zohosites.commed-esf92.zohosites.com/files/ebm جلسه 3.pdf · EBM early detection ebm PICO high sensitivity renge selection bayas EBM diagnostic dipstick

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