CURRICULUM VITAE

PERSONAL : DR. MANIKA PAL BHADRA. FNASc DESIGNATION: Wellcome Trust Fellow (International) 2005 Program Coordinator

Department of Chemical Biology Indian institute of Chemical Technology Uppal Road , Hyderabad-500007, India

Tel : 91-40-27193236 Fax : 91-40-27193030 e-mail : manika@iict.res.in manikapb@gmail.com

EDUCATION:

Qualifications Name of the University Subject Grade / Percentage

Ph.D Calcutta University, India Adv. Cytology and Mol, Genetics

Awarded

M.Sc Calcutta University, India Genetics and Molecular Biology

Ist Division

B.Sc Calcutta University, India Specialization in Cytogenetics

Ist Division

RESEARCH EXPERIENCE:

Junior Research Fellowship award, 1989-1991, Sponsored by TIFR, India

Senior Research Fellowship award, 1991-1993, Sponsored by CSIR, Indi

Post doctoral Research Associate, 1995- 1998, University of Missouri, Columbia

Senior Research investigator, 1998-2000, University of Missouri

Research Assistant Professor, 2002 - 2003, University Of Missouri

Visiting Scientist, CCMB, Hyderabad, India 2003-2004

Senior Scientist, IICT- 2004 to 2008

Principal Scientist, IICT- 2008 to 2012

Head of Department for Chemical Biology Division, IICT- 2012 onwards

Industrial/ Commercial

Program Co-ordinator, 2001 –2001 Exelixis Incorporation, Palo Alta, San Francisco, USA

Group Leader, 2001-2002 Functional Genomics and clinical Diagonostics,

Shantha Biotechniques Pvt. Ltd.

Scientific Advisor – Bioserve Biotechnologies Ltd 2003-2005

Scientific Board Member – M/s Vimta Labs 2008 – continuing.

Chief Scientific Consultant – M/s Bioplus Pvt Ltd 2008 – till date

Scientific Consultant, Saarum Sciences Pvt. Ltd.-2012 - continuing

ACADEMIC AWARDS:

NASI Reliance award for the year 2011 – 2012

IICT Best women scientist award for the year 2011 - 2012

Wellcome Trust Senior Research International Fellowship 2005

IICT Roll Of Honour Award 2006 - 2007

IICT Best Woman Scientist Award 2006 – 2007

IICT Award Of Excellence For Best Publication 2005 -2006

National Young Scientist Award in India 1991.

Prof. Adhiresh Dey Memorial Outstanding Student Award 1985.

Prof. Shyamal Chakraborty Memorial Outstanding Student Award 1985

National Scholar in India 1985

Career Merit Award in Undergraduate and Graduate levels.

SUPERVISION OF THE PROJECTS.

IN UNIV. OF MISSOURI

Cosuppression of Adh-w transgenes in Drosophila.

Cosuppression in Drosophila: Gene silencing of engrailed-white transgenes

Dosage compensation in Drosophia: Role of MSL complex on X-linked gene regulation.

IN IICT (INDIA)

Role of RNAi in Hetero-Chromatin Remodelling

Computational prediction of micro RNA encoding region in human viral genome

Genome wide screening of evolutionary conserved domain required for threshold

dependent post transcription gene silencing

Development and biological evaluation orally deliverable nanovehicles for drug

delivery

In vitro and In vivo screening of natural and chemical compounds for developing

novel drugs for cancer

PhD Students Guided/ Guiding:

Anita Krishnan: “Role of RNAi in Heterochromatin Formation and Chromatin

Remodeling Awarded 2010”

Arpita Sarkar: “Chromatin architecture and its remodelling factors in Drosophila”

Laxminarayan Reddy. T: “Development, characterisation and delivery of new

biological entities in live tissues.”

G. Koteswara Rao, “Identification and characterisation of modulator of RNAi

in Drosophila”

Indira Bag, “Lip: A Central Link of RNAi factor & heterochromatin formation”.

Bhanu Ramya, “Dosage Compensation and sex determination in Drosophila”.

Debasmita Mukhopadhyay, “Small modifiers of microRNA and RNA

interference in search of new therapeutics for cancer”.

Chatla Srinivas: “Understanding the biology and identification of novel potent

small molecules for treatment of retinoblastoma eye tumor”.

Pranjal Sarma: “Epigenetic modification in cell proliferation”.

Dhananjaya Pal: “Identification and characterization of modulator of miRNA

involved in cardiomyopathy”.

AVS Lavanya: “Identification and characterization of novel tumor suppressor

microRNAs”.

Swathi: “Design, synthesis and biological evaluation of hybrid molecules

derived from Resveratrol and SAHA analogues”.

Tanmoy Mondal: “RNAi associated protein complex and its functional role".

Debabrata Chowdhury: "Understanding the Complex Biology of

Cardiomyopathy by Proteomics Approach".

M.Sc DISSERTATION SUPERVISED:

Mohammad Mohsen Honarpisheh: “Cloning of 3’ UTR of RPS6KB1 gene

and functional studies for identification of potential micro-RNA”.

Elham Poorrajabiabarchouei: “ Prediction and functional ssays for the

regulation of PTEN gene by miR-21 in breast cancer cells”.

Monideepa Shah: “ Identification and Cloning of 3’ UTR of Cyclin D1 as the

target for miR15 and miR16”.

Rupa Bhowmick: “Cloning of microRNA 17 and 20 that targets cyclin D1

Gene in human breast cancer”.

M Manoj Kumar: “Efficient Delivery of Bcl2 targeted siRNA via “Biodegradable

Nanoparticles Synthesized from Organic Acids”.

Maheswari.R: “Molecular Cloning of ddsA Gene from Gluconobacter

suboxydans”.

Ms Prashanthi.: Biological Evolution of BIS Indole Pyrrolebenzodiazepine

(PBD) As cytotixic and cell cycle regulators in MCF-7 (Breast cancer cells)”.

Manorama Kumari: “ Proteomic approach for identification of key proteins

involved in sibling effect and recognition in cereal crop oryza sativa.

Shine Thomas: “Screening o f Synthetic analogs of natural products as

Nuclear Factor KappaB inhibitors using various invitro tests”.

Prakash Saudagar: “Cloning of Drosophila melanogaster hsp70 gene”.

Devika Sadhukhan: “Cloning and Expression study of Drosophila

Heterochromatin Protein 1 Gene”.

R. Rohit: “Design and cloning o fP-Element construct for transgenesis in

Drosophila Melanogaster & Cloning of Lamin dmo Gene”

Vinay Gopal: “Cloning and expression studies of Lamin Dm0 gene from

Drosop9hikla menalogaster”.

Surojit Bera: “Biological Evaluation of CA-BT Derivatives laws Potential

Anticancer Agent”.

Vishala Rao:” Cloning and Expression studies of Drosophila P53”.

Dinesh Kumar: “Design and cloning of P element construct for trangenesis in

Drosophila melanogaster.

B Divya: “Biological Evaluation of Brnzopthiazole analogues as MAP Kinase

pathway Inhibitors for anticancer activity using in vitro assays”.

Matoori Priyanka: “ Screening of Spirolactam Compouns for Cytotoxic and

Cytostatic Nature: Potential to use as Anti-Cancer Agents”

Tanya Tejeswita: “Biological Evaluation of Novel Benzathizole Analogues

towards anticancer activity”.

R. Maheshwari: “ Molecular Cloning of ddsA gene from Gluconobacter

suboxydans”.

Ms Amala: “ Biological Evolution of Bis Indole Pyrrolebenzodiazepine (PBD)

as Cytotoxic and Cell Cycle Regulators in (Colo-205, Colon Cancer Cells)”

K. Anjali : “Molecular Cloning of full length Lamin DMO gene”.

D. Sreenivasulu: Proteomic analysis of heart disease: a special emphasis on

cardiomyopathy.

Rajeswari Basu: “ Cloning and Expression of DMP53

Dhanalakshmi Bandaru : Identification and Screening of Drosophila Lamin

Dm0 Gene”

Poulami Chaudhuri: “Subcloning and expression of cDNA of a Mammalian

gene”

K. Prathyusha: “ Cloning of Drosophila melanogaster hsp70 gene.

P. Paul Varghese: “Genome wide screening of evolutionarily conserved

domain required for threshold dependent post transcriptional gene silencing”

Misbhauddin Ahmad: Computational prediction of microRNA Endoding

regions of human viral genomes.

Srilaxsmi Mutyala: “Prediction of miRNA target regions on candidate genes

involved in type 2 Diabetes mellitus using a computational approach”

Srilakshmi Dingari: “Prediction of miRNA target regions on candidate genes

involved in heart failure using a computational approach”

Sheheray Bano, Neeraja & Panchakshari: “ Cellular uptake of nanotubes in

Human cell lines.

INDUSTRIAL OR COMMERCIAL

M/s.Shantha Biotechniques

Identifying new drug candidates for Malaria, oral Cancer

Chip based new diagnostic kits for early detection and sub-classification of

Cancer.

Therapeutics antiviral drug development using RNA interference and Microarray

based technology.

M/s. Bioserve Biotechnologies Ltd:

Development of PCR based and microarray based diagnostic kits

M/s. Bioplus Ltd. Cloning and development of therapeutic proteins

Development of novel biodegradable drug delivery vehicle for siRNA delivery

M/s. Sarum Sciences:

Scientific advisor

CURRENT PROJECTS:

Role Of RNAi on heterochromatin silencing and its assembly in Drosophila

Screening and development of novel drug targets that act as histone

deacetylases inhibitors

Development and biological evaluation of nanoparticles for targeted delivery of

siRNA to cells.

Screening of biological evaluation of small molecule for potent HDAC and NF-

KappaB inhibitors.

SCIENTIFIC REVIEWS:

Wellcome Trust Review Committee For Grants 2005 onwards

Current Science 2006

Genetics Journal (USA) 1999-2001

Molecular and general genetics (Germany) 1999

INVITED REVIEW ARTICLES:

Nature Genetics (1999)

Current Opinion of Genes and Development (2000)

Developmental Biology (2001)

Genetica (Russia) 2002.

FEEBS Letter. 2008

FUNDINGS:

Wellcome Trust Organisation UK; 2006-2011; Rs. 7.8 crores

Identification of characterization of modulators of RNAi in Drosphila; DBT

2012 – 2015 – 1.0 crore

Screening of small molecules in lead explorations (SMiLE) – CSIR –2012 to 2017 - 22.6

crores

Nanomaterials for small regulatory RNA Delivery – DBT, 2008-2011; Rs. 90 lakhs

Department of Science and Technology India; 2007-2012; Rs. 24.9 crores

(For National Facility for biological evaluation of Combinatorial Natural Products)

Council Of Scientific and Industrial Research India; 2008-2012; Rs. 26.7 crores

(For developing the Facility for Chemical Biology).

Consultancy Project, M/s Bioplus Pvt Ltd, Bangalore: 2008-2013 Rs.20.0lakhs

List of Publication:-

Sl. No

Name of all the authors as they

Title of the paper Name of Journal

Year of

Volume

Page No

appear in each paper Publication

1. Kamal A, Viswanath A, Ramaiah MJ, Murty JN, Sultana F, Bharathi EV, Ramakrishna G, Sarma P, Lavanya A, Pushpavalli SN, Bhadra MP.

Synthesis and Biological Evaluation of Diaryl Ether Linked DC-81 Conjugates as Potential Antitumor Agents.

Anticancer Agents Med Chem. 2013 Feb 7. [Epub ahead of print]

PMID:23438825

2 Pushpavalli SN, Sarkar A, Ramaiah MJ, Chowdhury DR, Bhadra U, Pal-Bhadra M.

Drosophila MOF controls Checkpoint protein2 and regulates genomic stability during early embryogenesis.

BMC Mol Biol

2013

24 14:1

3 Kamal A, Mallareddy A, Janaki Ramaiah M, Pushpavalli SN, Suresh P, Kishor C, Murty JN, Rao NS, Ghosh S, Addlagatta A, Pal-Bhadra M.

Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents.

Eur J Med Chem.

2012 56 166-78

4 Pushpavalli SN, Ramaiah MJ, Lavanya A, Ganesh AR, Kumbhare RM, Bhadra K, Bhadra U, Pal-Bhadra M.

Imidazo-benzothiazoles a potent microRNA modulator involved in cell proliferation.

Bioorg Med Chem Lett.;

2012 22(20) 6418-24.

5 Kumbhare RM, Kosurkar UB, Janaki Ramaiah M, Dadmal TL, Pushpavalli SN, Pal-Bhadra M

Synthesis and biological evaluation of novel triazoles and isoxazoles linked 2-phenyl benzothiazole as potential anticancer agents.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5424-7.

2012 22(17) 5424-7

6 Sudip Mukherjee, V Sushma, Sujata Patra, Ayan Kumar Barui, Manika Pal Bhadra,

Green chemistry approach for the synthesis and stabilization of

Nanotechnology

2012 23 45 doi:10.1088/095

Bojja Sreedhar and Chitta Ranjan Patra

biocompatible gold nanoparticles and their potential applications in cancer therapy

7-4484/23/45/455103

7 Kamal A, Tamboli JR, Ramaiah MJ, Adil SF, Koteswara Rao G, Viswanath A, Mallareddy A, Pushpavalli SN, Pal-Bhadra M.

Anthranilamide-pyrazolo[1,5-a]pyrimidine conjugates as p53 activators in cervical cancer cells.

ChemMedChem. 2012

2012 7(8) 1453-64

8 Pal-Bhadra M, Ramaiah MJ, Reddy TL, Krishnan A, Pushpavalli SN, Babu KS, Tiwari AK, Rao JM, Yadav JS, Bhadra U.

Plant HDAC inhibitor chrysin arrest cell growth and induce p21WAF1 by altering chromatin of STAT response element in A375 cells.

BMC Cancer.

2012 12 180

9 Kamal A, Suresh P, Ramaiah MJ, Mallareddy A, Imthiajali S, Pushpavalli SN, Lavanya A, Pal-Bhadra M.

Synthesis and biological evaluation of 4β-sulphonamido and 4β-[(4'-sulphonamido)benzamide]podophyllotoxins as DNA topoisomerase-IIα and apoptosis inducing agents.

Bioorg Med Chem.

2012 20(6) 2054

10 Kamal A, Sultana F, Ramaiah MJ, Srikanth YV, Viswanath A, Kishor C, Sharma P, Pushpavalli SN, Addlagatta A, Pal-Bhadra M.

3-substituted 2-phenylimidazo[2,1-b]benzothiazoles: synthesis, anticancer activity, and inhibition of tubulin polymerization.

ChemMedChem.

2012 7(2) 292-300

11 Ahmed Kamal, A. Viswanath, M. Janaki

Synthesis of tetrazole–

Med. Chem.

2012 3 1386

Ramaiah, J. N. S. R. C. Murty, Farheen Sultana,G. Ramakrishna, Jaki R. Tamboli, S. N. C. V. L. Pushpavalli, Dhananjaya pal, Chandan Kishor,Anthony Addlagatta and Manika pal Bhadra

isoxazoline hybrids as a new class of tubulin polymerization inhibitors

Commun., 2012, 3, 1386 ( Cover page aticle )

12 Ahmed Kamal, Farheen Sultana, M. Janaki Ramaiah, Y. V. V. Srikanth, A. Viswanath, E. Vijaya Bharathi, Ranjita Nayak, S. N. C. V. L. Pushpavalli, Chatla Srinivas and Manika Pal-Bhadra

3-Diarylethyne quinazolinones: a new class of senescence inducers 1 Ahmed Kamal, Farheen Sultana, M. Janaki Ramaiah, Y. V. V. Srikanth, A. Viswanath, E. Vijaya Bharathi, Ranjita Nayak, S. N. C. V. L. Pushpavalli, Chatla Srinivas and Manika Pal-Bhadra

Med. Chem. Commun.,

2013 1-8 1

13 Ahmed Kamal, G. Ramakrishna, M. Janaki Ramaiah, A. Viswanath, A. V. Subba Rao, Chandrakant Bagul, Debasmitha Mukhopadyay, S. N. C. V. L. Pushpavalli and Manika Pal-Bhadra

Design, synthesis and biological evaluation of imidazo [1,5-a]pyridine–PBD conjugates as potential DNA-directed alkylating agents 1

Med. Chem. Commun., 2012, xx, 1–8 | 1

2012 1-8 1

14 Kamal A, Srikanth YV, Ramaiah MJ, Khan MN, Kashi Reddy M, Ashraf M, Lavanya A, Pushpavalli SN, Pal-Bhadra M.

Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-

Bioorg Med Chem Lett.

2012 22(1) 571-8

c][1,4]benzodiazepine conjugates.

15 S.N.C.V.L Pushpa Valli, Arpita Sarkar, Indira Bag, M.Janaki Ramaiah. Utpal bhadra and Manika Pal Bhadra.

Role of Drosophila RNAi silencing protein Ago-1 in cell proliferation.

BMC

biology

2011

16 Ahmed kamal, Dastagiri, M.Janaki Ramaiah, Laxminarayan Reddy, Anjana Devi, SNCVL Pushpavalli, Surendranath Reddy, Manika Pal Bhadra.

Synthesis and apoptosis inducing ability of new anilino substituted pyrimidine sulfonamides as potential anticancer agents.

Eur J Med Chem.

2011 46 (12) 5817-24

17 Ahmed Kamal, M. Kashi Reddy, M. Janaki Ramaiah, Rajender, J. Surendranadha Reddy, Y.V.V. Srikanth, D. Dastagiri, E. Vijaya Bharathi, S.N.C.V.L. Pushpavalli,Pranjal Sarma, Manika Pal-Bhadra

Synthesis and biological evaluation of estradiol linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates as potential anticancer agents.

Bioorg Med Chem.

2011 19 (8) 2565-81

18 Ravindra M. Kumbhare*, K. Vijay Kumar, M. Janaki Ramaiah, Tulshiram , Dadmal, S.N.C.V.L. Pushpa valli, debasmita Mukhopadyay, Umesh kosurkar and Manika Pal Bhadra*

Synthesis and biological evaluation of novel Mannich bases of 2-arylimidazo[2,1-b]benzothiazoles as potential anti-cancer agents.

Eur J Med Chem.

2011 46(9) 258-66

19 Kamal A, Prabhakar S, Janaki Ramaiah M, Venkat Reddy P, Ratna Reddy Ch, Mallareddy A, Shankaraiah N, Lakshmi Narayan Reddy T, Pushpavalli SN, Pal-Bhadra M.

Synthesis and anticancer activity of chalcone-pyrrolobenzodiazepine conjugates linked via 1,2,3-triazole ring side-armed with alkane spacers.

Eur J Med Chem..

2011 46(9) 820-31

20 Kamal A, Suresh P, Janaki Ramaiah M, Mallareddy A, Kumar BA, Raju P, Vinay Gopal J, Pushpavalli SN, Lavanya A, Sarma P, Pal-Bhadra M.

Synthesis and biological evaluation of 4β-acrylamidopodophyllotoxin congeners as DNA damaging agents.

Bioorg Med Chem.

2011 19(5) 4589-600

21 Kamal A, Reddy MK, Ramaiah MJ, Srikanth YV, Rajender, Reddy VS, Kumar GB, Pushpavalli SN, Bag I, Juvekar A, Sen S, Zingde SM, Pal-Bhadra M.

Synthesis of aryl-substituted naphthalene-linked pyrrolobenzodiazepine conjugates as potential anticancer agents with apoptosis-inducing ability.

Chem

Med

Comm

2011 6(9) 1665-79

22 Pushpavalli S, Ramaiah MJ, Srinivas Ch, Mukhopadhya D, Aditya J, Kumbhare RM, Bhadra U, Bhadra MP.

Effect of Benzothiazole based conjugates in causing apoptosis by Regulating p53, PTEN and MAP Kinase proteins affecting miR-195a and miR-101-1.

Cancer Cell Int.

2011 11 36

23. Bhadra MP, Horikoshi N, Pushpavallipvalli SN, Sarkar A, Bag I, Krishnan A, Lucchesi JC, Kumar R, Yang Q, Pandita RK, Singh M, Bhadra U, Eissenberg JC, Pandita TK.

The role of MOF in the ionizing radiation response is conserved in Drosophila melanogaster.

Chromosoma. [Epub ahead of print]

2011

24. Yadav JS, Das PP, Reddy TL, Bag I, Lavanya PM, Jagannadh B, Mohapatra DK, Bhadra MP, Bhadra U

Sub-cellular internalization and organ specific oral delivery of PABA nanoparticles by side chain variation

J. Nanobiotec-hnology.

2011 28(9) 10

25. M.Janaki Ramaiah, Pranjal shrama, Rama

Apoptotic inducing ability of chalcone

Cancer cell 2011 11 11

Krishna, SNCVL pushpavalli, Ahmedkamal, Utpal bhadra and Manika pal bhadra.

sulphanamides by affecting telomeres (TRF2).

Internation

al

26. Kamal, A., Rajesh, V.C.R.N.C. Shetti., M.Janaki Ramaiah.,P.Swapna., K.Srinivasa Reddy., A.MallaReddy., P. Narasimha Rao., Mukesh Chourasia., G.Narahari sastry., Aarti Juvekar., Suresh Zingde., Pranjal Sharma., S.N.C.V.L. Pushpavalli and Manika Pal Bhadra.

Carbazole-pyrrolo[2,1-c][1,4]benzodiazepine conjugates: Design, synthesis, cytotoxicity and effect on cellular targets. Med Chem Comm (Submitted).

Med chem. commun

2011 2 780-788

27. Jörn Boeke., Indira Bag., M. Janaki Ramaiah., Irene Vetter., ElisabethKremmer., Manika Pal-Bhadra., Utpal Bhadra., and Axel Imhof.

The DEAD/Box helicase dRM62 cooperates with dSu(var)3-9 to re-silence active transcription in Drosophila melanogaster\

PLoS One 2011 6(6) E207

28. Ramaiah MJ, Pushpavalli S, Krishna GR, Sarma P, Mukhopadhyay D, Kamal A, Bhadra U, Bhadra MP

Chalcone-imidazolone conjugates induce apoptosis through DNA damage pathway by affecting telomeres.

Cancer Cell Int

2011 v.11; 2011

29. Ahmed kamal, E.Vijayabharati, M.Janaki Ramaiah, SNCVL pushpavalli and Manika Pal- Bhadra

Quinazolinone linked pyrrolo(2,1-C) benzodiazepine (PBD) conjugates: Design, synthesis and Biological evaluation as potential anti-cancer agents.

Bioorg. Med. Chem

2010 18(2) 526–542

30. Ahmed Kamal, Kokkonda Sreekanth,P.,Praveen kumar,Nagula sankaraiah, Balakishan, M.Janaki Ramaiah, SNCVL Pushpavalli and Manika Pal-Bhadra.

Synthesis and potential cytotoxic activity of Phenanthrylphenol-pyrrolo benzodiazepine conjugates that act through cyclin D1 /cdk4 path way.

European Journalof Medicinal Chemistry

2010 45(6) 2173–2181

31. Ahmed kamal,E.Vijaya bharati,M.Janaki Ramaiah, SNCVL pushpavalli and Manika Pal-Bhadra

Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates.

Bioorg Med Chem Lett.

2010 20(11) 3310-13.

32. Kamal A, Surendranadha Reddy J, Janaki Ramaiah M, Dastagiri D, Vijaya Bharathi E, Ameruddin Azhar M, Sultana F, Pushpavalli SN, Pal-Bhadra M, Juvekar A, Sen S, Zingde S.

Design, synthesis as potential anticancer agents.

Eur J Med Chem.

2010 45(9) 3924-37

33. Ahmed Kamal , K. Srinivasa Reddy , M. Naseer A. Khan , Rajesh V. C. R. N. C. Shetti ,M. Janaki Ramaiah , S. N. C. V. L. Pushpavalli , Chatla Srinivas, Manika Pal-Bhadra , Mukesh Chourasia ,G. Narahari Sastry , Aarti Juvekar , Surekha Zingde , Madan Barkume

Synthesis, DNA-binding ability and anticancer activity of benzothiazole/benzoxazole–pyrrolo[2,1-c][1,4]benzodiazepine conjugates

Bioorg. Med. Chem.

2010 May

34. Ahmed Kamal, J. Surendranadha Reddy, M. Janaki Ramaiah, E. Vijaya Bharathi,

Synthesis and biological evaluation of anilino substituted

Bioorg Med Chem Lett.

2010 20(17) 5232-5236

Dastagiri, M. Kashi Reddy, S. N. C. V. L . Pushpavalli, and Manika Pal-Bhadra

pyrimidine linked pyrrolobenzodiazepines as potential anticancer agent

35. Ahmed Kamal, G. Ramakrishna, P. Raju, A. Viswanath, M.Janaki Ramaiah, , G. Balakishan Manika Pal-Bhadra.

Synthesis and anticancer activity of chalcone linked imidazolones

Bioorg.Med Chem Lett.

2010 20(16) 4865-4869

36. Ahmed Kamal,D. Dastagiri, M. Janaki Ramaiah, E. Vijaya Bharathi, J. Surendranadha Reddy, G. Balakishan, Pranjal Sarma, S. N. C. V. L. Pushpavalli, Manika Pal-Bhadra, Aarti Juvekar, Subrata Sen, Surekha Zingde

Synthesis, anticancer activity and mitochondrial mediated apoptosis inducing ability of 2,5-diaryloxadiazole-pyrrolobenzodiazepine conjugates

Bioorg. Med. Chem

2010 18(18) 6666-6667

37. Ahmed Kamal, D. Dastagiri, M. Janaki Ramaiah, J. Surendranadha Reddy,E. Vijaya Bharathi, Srinivas Chatla, S. N. C. V. L. Pushpavalli, Dhananjaya Pal, Manika Pal-Bhadra

Synthesis of Imidazothiazole-Chalcone Derivatives as Anticancer and apoptosis Inducing Agents. Accepted

Chem-med- chem.

2010 Sep10

38. Kamal, A., E. Vijaya Bharathi., J. Surendranadha Reddy., M. Janaki Ramaiah., D. Dastagiri., A. Haribabu., A.Viswanath., T. Lakshminarayan Reddy., T. Basha Shaik., S. N. C. V. L. Pushpavalli Manika Pal Bhadra.

Synthesis and Biological Evaluation of 3,5-Diaryl isoxazoline/isoxazole Linked 2,3-Dihydroquinazolinone Hybrids as Anticancer agents

European Journal of Medicinal chemistry (Submitted).

2010

39 Kamal, A., Rajesh, V.C.R.N.C. Shetti., M.Janaki Ramaiah., P.Swapna., K.Srinivasa Reddy., A.MallaReddy., P. Narasimha Rao., Mukesh Chourasia., G.Narahari sastry., Aarti Juvekar., Suresh Zingde., Pranjal Sharma., S.N.C.V.L. Pushpavalli and Manika Pal Bhadra.

Carbazole-pyrrolo[2,1-c][1,4]benzodiazepine conjugates: Design, synthesis, cytotoxicity and effect on cellular targets. Med Chem Comm (Submitted).

2010

40. Santosh P S, Arora N, Sarma P, Pal-Bhadra M, Bhadra U.

Interaction map and selection of microRNA targets in Parkinson's disease-related genes.

J Biomed Biotechnol.

2009 36 31-45.

41. Chandrasekhar S, Rao CL, Seenaiah M, Naresh P, Jagadeesh B, Manjeera D, Sarkar A, Bhadra MP

Total synthesis of azumamide E and sugar amino acid-containing analogue.

J Org Chem.

2009 74(1)

401-4.

42. Utpal Bhadra, Sunit Kumar Singh, Praveensingh B Hajeri and Manika Pal-Bhadra

microRNA Tales in Fly Development: In Book” “Regulation of Gene Expression by Small RNA

Eds J.J. Rossi and R.K. Gaur. CRC Press, California, USA,

2009 123-148

43. Ahmed Kamal, Vankatesh Tekumalla, Anita Krishnan, Manika Pal-Bhadra and Utpal Bhadra

Development of Novel Pyrrolo[2,1-c][1,4]Benzodiazepi

ne -Galactoside Prodrugs for Selective Therapy of Cancer by ADEPT and PMT.

Chem Med Chem

2008 2008

3 275

794-802. 4929-4444

44. Sunit K. Singh, Manika Pal Bhadra, Hermann J Girschick and Utpal Bhadra

MicroRNAs – micro in size but macro in function..

FEBS J.

45 Manika Pal-Bhadra, Linga Mamatha, Pil-Hoon Park, Shivendra D. Shukla and Utpal Bhadra.

Histone H3 methylation is an epigenetic imprint for alcohol induced liver injury

Life Sciences

2007 81 979-987

46. J. S. Yadav, Manoj Kumar Gupta, I. Prathap, Manika Pal Bhadra, Parsi K. Mohan and Bulusu Jagannadh

Synthesis and cellular uptake of cell delivering 2,6-pyridinediylbisalkanamide submicron-sized sheets in HeLa cells.

Chem. Commun.

2007 3832-3834.

47. Manika Pal-Bhadra, Utpal Bhadra and J.A. Birchler

Misregulation of Sex-lethal and disruption of MSL complex localization in Drosophila species hybrids

Genetics 2006 174 927-935

48. Charlotte Grimaud, Frédéric Bantignies, Manika Pal-Bhadra, Pallavi Ghana, Utpal Bhadra, and Giacomo Cavalli.

RNAi components are required for nuclear clustering of Polycomb group response elements

Cell 2006 124 957-971

49. Bhadra, U., Pal-Bhadra, M., J. Kundu, and Birchler J.A. (First two authors contributed equally).

MSL complex insulates the response of Histone modifiers to x linked genes in males.

Genetics

2005

169

2061-2074

50. Pal-Bhadra M., U. Bhadra and J.A. Birchler ()2004;

Interrelationship between transcriptional and post transcriptional silencing.

In Book Cold Spring Harbor Symposium

2004 69 433-8.

51. Pal- Bhadra, M., Leibovitch B. A. Gandhi,

Heterochromatin Silencing and HP1

Science 2004 303 669-672.

S, G, Rao, M., Bhadra U., Birchler J.A.and Elgin S.C.R.

localization in Drosophila are dependent on the RNAi machinery.

52. Birchler, J. A., Bhadra U. and Pal–Bhadra, M.

Transgene cosuppression in Drosophila. In Book ‘RNAi:a guide to Gene Silencing

Eds. Gregory Hannon, Cold Spring Harbor Laboratory Press, Cold Spring Harbor,NewYork

2004 pp23-43

53. Birchler, J. A., Bhadra, U. and Pal-Bhadra M.

Role of trans-acting dosage modifiers in X chromosomal dosage compensation (review)

Genetica 2003 117 179-190.

54. Bhadra, U and Pal-Bhadra M.

Transgene insertion, genomic stress and Cell surveillance: a lesson from Drosophila. In Book ‘Bioresources and Environmental Stresses’ Eds by Prof. Hideaki Matsumoto, University of Okayama press, Okayama , Japan

2003 9-14.

56. Pal-Bhadra, M., Bhadra, U. and Birchler, J. A. (First two authors contributed equally).

RNAi related mechanisms affect both transcriptional and post-transcriptional transgene silencing in Drosophila

Molecular Cell

2002 9 315-323

57. Birchler J. A., Bhadra Dosage dependent Developm 2001 234 275-

U., Pal -Bhadra M. and Auger D.L. .

gene regulation in multicellular eukaryotes: dosage compensation, aneuploid syndromes and polygenic quantitative traits

ental Biology

288

58. Birchler J. A., Pal Bhadra M. and Bhadra ,U

Making noise about silence : Repression of Repeated genes in animals..

Curr. Opin. of Genes and Development

2000

10

211-216

59. U. Bhadra, Pal-Bhadra M. and Birchler J. A.

Histone acetylation and gene expression of Sex-lethal mutants in Drosophila.

Genetics 2000 155 753-763.

60. Pal-Bhadra M., Bhadra U. and Birchler J. A. (First two authors contributed equally).

Cosuppression in nonhomologous transgenes involves mutually related endogenous sequences

Cell 1999 99 35-46

61. Birchler J. A., Pal Bhadra M. and Bhadra U.

Less from More: cosuppression of transposable elements

Nature Genetics

1999 21 148-151.

62. Bhadra U., Pal Bhadra M. and Birchler J. A.

Role of male specific lethal genes in modifying the effects of sex chromosomal dosage in Drosophila.

Genetics 1999 152

249-168

63. Bhadra. U., Pal-Bhadra M. and Birchler J. A.

Interaction among dosage dependent trans-acting modifiers of gene expression and position effect

Genetics 1998 150 251-263

variegation in Drosophil.

64. Pal-Bhadra M., Bhadra. U. and Birchler J. A.

Role of multiple trans-acting regulators in modifying the effect of the retrotransposon, copia, on host gene expression in Drosophila.

Mol. Gen. Genet.

1998 259 198-206.

65. Pal Bhadra M., Bhadra U. and Birchler J. A. (First two authors contributed equally).

Cosuppression in Drosophila: gene silencing of Alcohol dehydrogenase gene by white-Adh transgenes is Polycomb dependent.

Cell 1997 90 (3) 479-490.

66. Bhadra U., Pal-Bhadra M. and Birchler, J. A.

A sex-influenced modifier in Drosophila that affects a broad spectrum of target loci including the histone repeats.

Genetics 1997a 146 903-917

67. Bhadra U., Pal-Bhadra, M. and Birchler, J. A.(Berl.)

A trans-acting modifier causing extensive overexpression of genes in Drosophila melanogaster

Mol. Gen. Genet

1997b 254 621-634.

68. Pal-Bhadra M., Bhadra U. and Chatterjee R.N.

In situ transcription analysis of chromatin template activity of 3L trisomies of inter specific hybrids of Drosophila melanogaster and Drosophila simulans

Cell and Chromosome Research

1993 16(1) 16-22

69. Bhadra U., Pal-Bhadra, M. and Chatterjee R.N.

Effect of gene dosage on autosomal gene transcription in D. melanogaster

Prospective of Cytology and Genetics

1991 7 959-967.

70. Chatterjee R.N., Bhadra U., Mukherjee, J. and Pal, M.

Regulation of X chromosomal organization for dosage compensation in Drosophila

Advances in Molecular Biology

1990 1 298-307.

Book chapters published:-

1. Utpal Bhadra, Sunit Kumar Singh, Praveensingh B Hajeri and Manika Pal-

Bhadra (2009) microRNA Tales in Fly Development: In Book “Regulation of

Gene Expression by Small RNAs” Eds J.J. Rossi and R.K. Gaur. CRC

Press, California, USA, pp123-148.

2. Pal-Bhadra M., U. Bhadra and J.A. Birchler (2005) Interrelationship between

transcriptional and post transcriptional silencing. In Book Cold Spring

Harbor Symposium 2004;69:433-8.

3. Birchler, J. A., Bhadra U. and Pal–Bhadra, M. (2004) Transgene

cosuppression in Drosophila. In Book ‘RNAi:a guide to Gene Silencing’ Eds.

Gregory Hannon, Cold Spring Harbor Laboratory Press, Cold Spring

Harbor, New York pp23-43

4. Bhadra, U and Pal-Bhadra M. (2003) Transgene insertion, genomic stress

and Cell surveillance: a lesson from Drosophila. In Book ‘Bioresources and

Environmental Stresses’ Eds by Prof. Hideaki Matsumoto, University of

Okayama press, Okayama , Japan pp 9-14.

Reports Bhadra U. and Chatterjee R. N. (1986) A method of polytene chromosome preparation of salivary gland of Drosophila for in situ transcription and in situ hybridization technique. Drosophila Information Service 63: 140-141. Bhadra U., Pal-Bhadra. M. and Chatterjee R. N. (1991) The larval denticle

distribution pattern in the strains of autosomal trisomies in Drosophila melanogaster Drosophila Information Service 71 : 243-44. Pal-Bhadra M., Bhadra U. and Chatterjee R.N. (1991) MgCl2 induced 93D and other puffs in Drosophila melanogaster. Drosophila Information Service 71 : 242-43.

INTERNATIONAL PATENTS:

1. Development of effective gene knock out system using gene silencing, University of Missouri, Columbia, USA

2. PABA nanotubes for oral delivery in Drosophila

3. PARA Amino Benzoic Acids based Nanotubes. Yadav Jhillu Singh, Lavanya

Madugula, Das Pragna P, Krishnan Anita, Jagannad Bulusu, Pal Bhadra

Manika, Bhadra Utpal, Indian Patent Application No:1584/CHE/2009, filling date

3/7/2009

INVITED TALKS:

Michigan State University, Ann Arbor, Michigan (December, 1999) Dosage compensation and transacting regulators in Drosophila.

University of Toledo, Ohio, USA (October 2000) Cosuppression in Drosophila: its

impact on reverse genetics

Institut Jacques Monod, CNRS, Universites Paris Paris Cedex 05, France (November 2000) Noise about Silence: Transcriptional and post-transcriptional gene silencing in Drosophila.

Institut de genetique humaine, CNRS, Montpellier-Cedex 5, France (November,

2000) Gene silencing in Drosophila: where more is always less.

University of Missouri, Missouri, USA (June, 2001) Functional genomics using Post- transcriptional gene silencing is a useful tool for other insects.

Shantha Biotechniques Pvt. Ltd (October 2001) Most comprehensive pathways

for drug development using microarray and RNA interference.

Shantha Biotechniques Pvt. Ltd (March 2001) A new approach for molecular diagonostics for early detection and subclassification of Cancer.

1st Asia-Pacific Affymetrix user meeting, Ring rose Hotel, Singapore November 2-5, 2004.

HUGO Conference September 27-30 (2008) – Identification and molecular

characterization of novel protein partners of piwi in Droaophila melanogaster.

Wellcome Trust (Oct 5th -7th’ 2008) UK; PIWI associated heterochromatin complex in Drosophila

University of Minnesota ( 2009) - Role of Drosophila Ago-1 in cell cycle

progression. Indo US Conference, Hyderabad (2009)- Synthesis and biological evaluation of

orally deliverable nanotubes for small RNA delivery.

ORGANIZING EXPERIENCE

1) 10th ADNAT Convention on “RNAi and microRNA in Development and Health”

in February 23-25, 2006

2) Hands on Training Course on RNAi in Gene Knockdown and Viral Resistance

February 26- march 10, 2006

3) First Indo French Conference December 12-14 (2007) “RNAi in Genome Control”

4) Head of the Genomic Division - Santha Biotechnology 2001-2002

5) Setting up“ Department of Chemical Biology” in Indian institute of Chemical

Technology 2005-2008.

6) Setting up “Pre-Biotech Incubation Centre” in Indian Institute of Chemical

Technology.

7) First Indo US workshop December 16-18 (2009) “Epigenetic Regulation and

Genome Control.”