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CURRICULUM VITAE (March, 2008)
Personal Data
Name: Anthony R. Caggiula
Address: 100 Denniston St. #20
Home: Pittsburgh, PA. 15206
Professional: Department of Psychology, 3131 Sennott Square
University of Pittsburgh, Pittsburgh, PA 15260
History: Born on March 3, 1941, in Philadelphia, PA.
Education
1958-62 B.S. in Psychology, St. Joseph's College
1962-64 M.S. in Psychology, University of Delaware
1964-66 M.A. and Ph.D. in Psychology, Princeton University
1966-68 Postdoctoral Fellow, Brain Research Laboratory, University of Michigan
Professional History
1962-64 Research Fellow, Center for Research on Social Behavior,
University of Delaware
1963-64 Research Assistant, Small Crew Effectiveness Division,
Behavioral Sciences Department, Naval Medical Research
Institute, Bethesda, Maryland
1964-65 Research Assistant in Physiological Psychology, Department of
Psychology, Princeton University
1965-66 N.I.H. Predoctoral Fellow, Department of Psychology, Princeton
University
1966-68 N.I.H. Postdoctoral Fellow, Brain Research Laboratory,
Department of Psychology, University of Michigan
1967-68 Lecturer, Department of Psychology, University of Michigan
2
1968- Assistant - Full Professor of Psychology, University of Pittsburgh
1968-73 Assistant Professor (Secondary) of Pharmacology, University of
Pittsburgh School of Medicine
1986-89 Associate Professor (Secondary) of Behavioral Neuroscience,
University of Pittsburgh
1990-96 Chair, Biopsychology Graduate Training Program, Department of
Psychology, University of Pittsburgh
1996-97 Acting Chair, Health Psychology Graduate Training Program, Department
of Psychology, University of Pittsburgh
1991- Member, University of Pittsburgh Cancer Institute
1994- Associate - Full Professor (Secondary) of Psychiatry, University of
Pittsburgh School of Medicine
1997 Acting Chair, Department of Psychology, University of Pittsburgh
1998 Chair, Department of Psychology, University of Pittsburgh
Professional Organizations
American Association for the Advancement of Science
American Psychological Society
International Society for Psychoneuroendocrinology
International Society for Neuroimmunomodulation
New York Academy of Sciences
Society for Behavioral Medicine
Society for Neuroscience
Society for Research on Nicotine and Tobacco
College on Problems of Drug Addiction
Awards
Ph.D. Dissertation: honorable mention in Creative Talents Awards Program 1967,
American Institutes for Research
External Grant Support
3
A. Prior Support
1969 Peripheral determinants of sexual- NIMH
aggressive behavior (P.I.)
1972-1973 Sexual behavior and brain biogenic amines NIMH
(P.I.)
1969-1981 Neurophysiological correlates of sexual NIMH
behavior (P.I.)
1986-1988 The effects of housing (number of mice/ ONR
cage) on immunologic competence
(Co-Investigator)
1987-1990 CHD risk, behavioral stress, and NHLBI
reproductive hormones (Co-P.I.)
1989-1992 Environmental control over chronic toler- NSF
ance to nicotine (P.I.)
1990-1992 Stress-induced time dependent sensitization NIAAA
and ethanol consumption (Co-P.I.)
1991-1993 Ovarian hormones, stress and immunologic NIMH
responsiveness (P.I.)
1991-1994 Long-term sensitization after acute NIMH
stressors (Co-P.I.)
1994-1996 Ovarian hormones, stress and immunologic NIMH
responsiveness (P.I.)
1992-1996 Conditioned tolerance to nicotine (P.I.) NIDA
1994-1997 On-off effects of cocaine on dopamine efflux NIDA
(Co-P.I.)
1994-1997 The Immunologic Effects of Nicotine (Co-P.I.) NIDA
1997-2000 Conditioned tolerance to nicotine (P.I.) NIDA
TDC(IndC): $351,778(155,137)
4
1997-2000 Effects of self-administered vs noncontingent NIDA
nicotine (P.I.)
TDC(IndC): $351,430(155,907)
1997-2002 Smoking, stress and immune function (P.I - 1997 NIDA
to 2000; Co-P.I. - 2000 to 2002)
TDC(IndC): $862,713(411,506)
2000-2004 Effects of self-administered vs noncontingent NIDA
nicotine (P.I.)
TDC(IndC):$600,000 ($277,565).
2000-2004 (Co-P.I.) Sex differences in nicotine reinforcement: NIDA
Human/Animal (Ken Perkins .P.I.)
TDC (IndC): $900,000 ($421,575)
B. Current Support
2004-2008 (P.I.) Effects of self-administered vs noncontingent NIDA
nicotine
TDC (IndC):$800,000 ($$378,300).
2004-2007 (Co-I.) Extinction in smokers: Renewal and spontaneous NIDA
Recovery (Cynthia Conklin P.I.)
TDC (IndC) $450,000 ($218,250)
2005-2010 (Co- I.) Pharmacology of cue-induced nicotine relapse NIDA
(Xiu Liu P.I.)
TDC (IndC) $$900,000 ($436,500)
Administrative Experience: Departmental
Departmental Executive Committee
Student-Faculty Liason Committee (Ch.)
Colloquium Committee (Ch.)
Animal Care Committee (Ch.)
Chair, Psychobiology Program
Psychobiology Training Grant Executive Committee
Director, Psychobiology Graduate Student Teacher-Training Program
Long Range Planning Committee
Graduate Education Council
Chair, Biopsychology Program
Search Committee for Departmental Chair
Acting Chair, Health Psychology Program
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Acting Chair, Department of Psychology
Chair, Department of Psychology
Administrative Experience: University
Faculty of Arts and Sciences Representative to University Animal
Resources Committee
College of Arts and Sciences Curriculum Reform Committee
College of Arts and Sciences Curriculum Review Committee
Faculty of Arts and Sciences Graduate Council
Clinical Research Center for Affective Disorders Seed Money
Review Committee
Advisory Board on Science Education for the Non-Specialist
Natural Sciences Council
Chair, Natural Sciences Council (1999-2000)
Planning Committee, New Department Chairs Orientation Meeting
Numerous ad hoc committees
Additional Professional Functions
1) Reviewer for Physiology and Behavior; Science;
Psychopharmacology; Brain Research Bulletin;
Behavioral Biology; Pharmacology, Biochemistry & Behavior;
Hormones & Behavior; Physiological Psychology; Behavioral and Brain
Sciences; Journal of Applied Biobehavioral Research,
Neuropsychopharmacology,
International Journal of Psychopharmacology, Drug and Alcohol Dependence
2) Member of NSF Grant Review Panel (Integrative and Motor Processes). 1983-
1986
3) Book reviewer for Prentice Hall, William C. Brown Co.,
Allyn & Bacon Inc.
4) Study section member, NIAAA review of RFA on nicotine and alcohol; ad hoc
member of several NIH study sections
5) Member, Technical Advisory Committee, Tobacco and Health Research Institute;
1998-2002
6) Consultant, Minneapolis Medical Research Foundation, Hennepin County
Medical Center and University of Minnesota, Minneapolis, MN. 2000-2003
6
Teaching
Introduction to Psychology (Undergrad.)
Introduction to Psychology as a Natural Science (Undergrad.)
Introduction to Biopsychology (Undergrad.)
Biopsychology of Health (Undergrad. honors)
Behavioral Endocrinology (Undergrad. and Graduate)
Psychoneuroimmunology (Undergrad. and Graduate)
Seminar in Behavioral Pharmacology (Graduate)
Seminar in Behavioral Medicine: Stress and Drugs (Graduate)
Seminar on Sexual Differentiation (Graduate)
Research Methods in Biopsychology (Graduate)
Biological Basis of Psychopathology (Graduate)
Ph.D. Dissertations Directed
Szechtman, H. Systematic, surgical isolation of the preoptic area with a microknife: A
neuroanatomical and behavioral analysis of the disruption of sexual behavior in male rats 1975
Booth, Jr., A.M. Nervous control of penile erection and copulatory behavior in the rat 1976
Clark, T.K. The region of the ascending dorsal noradrenergic bundle of the locus coeruleus in
relation to male copulatory behavior 1979
Bradshaw, W.G. The effects of testosterone and 5alpha-reduced androgens on male copulatory
behavior in the rat. 1980
Chiodo, L.A. Studies on the regulation of the responsiveness of substantia nigra dopamine
neurons to sensory stimuli 1981
Ostrowski, N.L. Morphine-dopamine interactions: behavioral and electrophysiological studies
1984
Donny, E.C. Nicotine self-administration in male and female rats: sex differences and estrous
cycle effects. 1999
McCallum, S.E. The effects of injection regimen and competitive or non-competitive blockade
on tolerance and nicotine-induced receptor upregulation in rats. 1999
Chaudhri, N. Complex interactions between nicotine and nonpharmacological stimuli reveal a
novel role for nicotine in reinforcement 2005
Publications: Refereed Articles
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1. Wheeler, L. and Caggiula, A.R. The contagion of aggression. Journal of Experimental
Social Psychology, 1966, 2, 1-10.
2. Caggiula, A.R. and Hoebel, B.G. Copulation-reward site in the posterior hypothalamus.
Science, 1966, 153, 1284-1285.
3. Caggiula, A.R. and Eibergen, R. Copulation of virgin male rats evoked by painful
peripheral stimulation. Journal of Comparative and Physiological Psychology, 1969, 69,
414-419.
4. Caggiula, A.R. Analysis of the copulation-reward properties of posterior hypothalamic
stimulation in male rats. Journal of Comparative and Physiological Psychology, 1970,
70, 399-412.
5. Caggiula, A.R. and Szechtman, H. Hypothalamic stimulation: A biphasic influence on
copulation of the male rat. Behavioral Biology, 1972, 7, 591-598.
6. Caggiula, A.R. Shock-elicited copulation and aggression. Journal of Comparative and
Physiological Psychology, 1972, 80, 393-397.
7. Caggiula, A.R., Antelman, S., & Zigmond, M.J. Disruption of copulation in male rats
after hypothalamic lesions: A behavioral, anatomical and neurochemical analysis. Brain
Research, 1973, 59, 273-287.
8. Eibergen, R.D. and Caggiula, A.R. Ventral midbrain involvement in copulatory behavior
of the male rat. Physiology and Behavior, 1973, 10, 435-441.
9. Caggiula, A.R., Antelman, S., & Zigmond, M.J. Ineffectiveness of sexually arousing
stimulation after hypothalamic lesions in the male rat. Physiology and Behavior, 1974,
12, 313-316.
10. Caggiula, A.R. and Vlahoulis, M. Modifications in the copulatory performance of male
rats by repeated peripheral shock. Behavioral Biology, 1974, 11, 269-274.
11. Szechtman, H., Lambrou, P.J., Caggiula, A.R., & Redgate, E.S. Plasma corticosterone
levels during sexual behavior in male rats. Hormones & Behavior, 1974, 5, 191-200.
12. Caggiula, A.R., Gay, V., Antelman, S.M., & Leggens, J. Disruption of copulatory
behavior in male rats after hypothalamic lesions: A neuroendocrine analysis.
Neuroendocrinology, 1975, 17, 193-202.
13. Eibergen, R. and Caggiula, A.R. Acceleration and pacing of copulatory performance of
male rats by repeated, aversive brain stimulation. Physiology and Behavior, 1975, 15,
253-258.
14. Clark, T.K., Caggiula, A.R., McConnell, R.A., & Antelman, S.M. Sexual inhibition is
reduced by rostral midbrain lesions in the male rat. Science, 1975, 190, 169-171.
15. Antelman, S.M., Herndon, J.G., Jr., Caggiula, A.R., & Shaw, D.H. Dopamine-receptor
blockade: Prevention of shock-activated sexual behavior in naive rats.
Psychopharmacological Bulletin, 1975, 11, 45-46.
16. Caggiula, A.R., Shaw, D.H., Antelman, S.M. & Edwards, D.J. Interactive effects of brain
catecholamines and variations in sexual and non-sexual arousal on copulatory behavior of
male rats. Brain Research, 1976, 111, 321-336.
17. Antelman, S.M. and Caggiula, A.R. Norepinephrine-dopamine interactions and behavior.
Science, 1977, 195, 646-653.
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18. Herndon, J.G., Jr., Caggiula, A.R., Sharp, D., Ellis, D., & Redgate, E.S. Selective
enhancement of the lordotic component of female sexual behavior in rats following
destruction of central catecholamine-containing systems. Brain Research, 1978, 141,
137-151.
19. Szechtman, H., Caggiula, A.R.. & Wulkan, D. Preoptic knife cuts and sexual behavior in
male rats. Brain Research, 1978, 150, 569-591.
20. Antelman, S.M., Caggiula, A.R., Black, C., & Edwards, D.J. Stress reverses the anorexia
induced by amphetamine and methylphenidate, but not fenfluramine. Brain Research,
1978, 143, 580-585.
21. Caggiula, A.R., Herndon, J.G., Jr., Scanlon, R., Greenstone, D., Bradshaw, W., & Sharp,
D. Dissociation of active from immobility components of sexual behavior in female rats
by central 6-hydroxydopamine: Implications for CA involvement in sexual behavior and
sensorimotor responsiveness. Brain Research, 1979, 172, 505-520.
22. Pang, S.F., Caggiula, A.R., Gay, V.L., Goodman, R.L., & Pang, C.S.F. Serum
concentrations of testosterone, oestrogens, luteinizing hormone and follicle-stimulating
hormone in male and female rats during the critical period of neuronal sexual
differentiation. J. Endocr., 1979, 80, 103-110.
23. Chiodo, L.A., Caggiula, A.R., & Saller, C.F. Estrogen increases both spirperone-induced
catalepsy and brain levels of 3H-spirperone in the rat. Brain Research, 1979, 172, 360-
366.
24. Chiodo, L.A., Caggiula, A.R., Antelman, S.M., & Lineberry, C.G. Reciprocal influences
of activating and immobilizing stimuli on the activity of nigrostriatal dopamine neurons.
Brain Research, 1979, 176, 385-390.
25. Chiodo, L.A., Antelman, S.M., Caggiula, A.R., & Lineberry, C.G. Sensory stimuli alter
the discharge rate of dopamine (DA) neurons: Evidence for two functional types of DA
cells in the substantia nigra. Brain Research, 1980, 189, 544-549.
26. Chiodo, L.A. & Caggiula, A.R. Alterations in basal firing rate and autoreceptor
sensitivity of dopamine neurons in the substantia nigra following acute and extended
exposure to estrogen. European Journal of Pharmacology, 1980, 67, 165-166.
27. Chiodo, L.A., Caggiula, A.R., & Saller, C.F. Estrogen potentiates the stereotypy
produced by dopamine agonists in the rat. Life Sciences, 1981, 28, 827-835.
28. Ostrowski, N.L., Hatfield, C.B., & Caggiula, A.R. The effects of low doses of morphine
on the activity of dopamine-containing cells and on behavior. Life Sciences, 1982, 31,
2347-2350.
29. Chiodo, L.A. & Caggiula, A.R. Substantia nigra dopamine neurons: Alterations in basal
discharge rates and autoreceptor sensitivity induced by estrogen. J. of
Neuropharmacology, 1983, 22, 593-599.
30. Rabin, B.S., Lyte, M., Epstein, L.H., & Caggiula, A.R. Alteration of immune
competency by number of mice housed per cage. Ann. N.Y. Academy of Science, 1987,
496, 492-500.
31. Lysle, D.T., Cunnick, J.E., Wu, R., Caggiula, A.R., Wood, P.G. & Rabin, B.S. 2-deoxy-
D-glucose modulation of T-lymphocyte reactivity: differential effects on lymphoid
compartments. Brain, Behavior and Immunity, 1988, 2: 212-221
9
32. Epstein, L.H., Caggiula, A.R. & Stiller, R.L. Environment - specific tolerance to nicotine
Psychopharmacology, 1989, 97: 235-237
33. Caggiula, A.R., Antelman, S.M. Aul, E., Knopf, S. & Edwards, D.J. Prior stress
attenuates the analgesic response but sensitizes the corticosterone and cortical dopamine
response to stress 10 days later Psychopharmacology, 1989, 99: 233-237
34. Caggiula, A.R., Epstein, L.H. and Stiller, R.L. Changing environmental cues reduces
tolerance to nicotine-induced anorexia Psychopharmacology, 1989, 99: 389-392
35. Stoney, C.M., Owens, J., Matthews, K.A., Davis, M.C. and Caggiula, A. Influence of the
normal menstrual cycle on physiologic functioning during behavioral stress
Psychophysiology 1990, 27(2): 125-135
36. Caggiula, A.R., Stoney, K., Owens, J., Matthews, K.A. and Rabin, B. T-lymphocyte
reactivity during the menstrual cycle in women Clin Immunology and Immunopath 1990,
56(1): 130-134
37. Antelman, S.M., Cunnick, J.E., Lysle, D.T., Caggiula, A.R., Knopf, S., Kocan, D.J.,
Rabin, B.S., and Edwards, D.J. Immobilization 12 days (but not one hour) earlier
enhanced 2-deoxy-d-glucose-induced immunosuppression: evidence for stressor-induced
time-dependent sensitization of the immune system Progress in Neuro-
psychopharmacology and Biological Psychiatry 1990, 14: 579-590
38. Matthews, K.A., Davis, M.C., Stoney, C.M., Owens, J.F. and Caggiula, A.R. Does the
gender relevance of the stressor influence sex differences in psychophysiological
responses? Health Psychology 1991 10(2):112-120
39. Ostrowski, N.L. and Caggiula, A.R. Correlation between locomotor stimulation and the
electrophysiological effects of low doses of morphine on substantia nigra dopamine
neurons: I. Acute drug administration. J Pharmacol Exp Ther 1991 257(1):72-81
40. Epstein, L.H., Caggiula, A.R., Perkins, K.A., Bennett, S.M. & Smith, J. Context-
dependent tolerance to the heart rate effects of smoking Pharmacol Biochem Behav 1991
39:15-19
41. Caggiula, A.R., Epstein, L.H., Antelman, S.M., Saylor, S.S., Perkins, K.A., Knopf, S. and
Stiller, R. Conditioned tolerance to the anorectic and corticosterone-elevating effects of
nicotine Pharmacol Biochem Behav 1991 40:53-59
42. Antelman, S.M., Caggiula, A.R., Kocan, D., Knopf, S., Meyer, D., Edwards, D. and
Barry III, H. One Experience with "lower" or "higher" intensity stressors, respectively
enhances or diminishes responsiveness to haloperidol weeks later: Implications for
understanding drug variability Brain Research 1991 566:276-283
43. Epstein, L.H., Bulik, C.M., Perkins, K.A., Caggiula, A.R. and Rodefer, J. Behavioral
economic analysis of smoking: Money and food as alternatives 1991 Pharmacol Biochem
Behav 38: 715-721
44. Antelman, S.M., Caggiula, A.R., Knopf, S., Kocan, D. J. and Edwards, D.J.
Amphetamine or haloperidol two weeks earlier antagonized the plasma corticosterone
response to amphetamine; evidence for the stressful/foreign nature of drugs
Psychopharmacology 1992 107(2-3): 331-336
45. Antelman, S.M., Kocan D., Knopf, S., Edwards, D.J. and Caggiula, A.R. One brief
exposure to a psychological stressor induces long-lasting, time-dependent sensitization of
both the cataleptic and neurochemical response to haloperidol Life Sci 1992 51:261-266
10
46. Perkins, K.A., Grobe, J.E., Epstein, L.H., Caggiula, A.R. and Stiller, R.L. Subjective
effects of nicotine may be dependent on baseline subjective state J Substance Abuse 1992
4:131-141
47. Caggiula, A.R., McAllister, C.M., Epstein, L.H., Antelman, S.M., Knopf, S., Saylor, S
and Perkins, K.A.. Nicotine suppresses the proliferative response of peripheral blood
lymphocytes in rats Drug Development Research 1992 26(4): 473-479
48. Epstein, L.H., Caggiula, A.R., Perkins, K.A., Mitchell, S. and Roedefer, J. Abstenence
from smoking decreases habituation to food cues Physiol Behav 1992 52:641-646
49. Epstein, L.H., Rodefer, J.S., Wisniewski, L. and Caggiula, A.R. Habituation and
dishabituation of the human salivary response Pharmacol Biochem Behav 1992 51(5):
945-950
50. Wisniewski, L., Epstein, L.H. and Caggiula, A.R. The effects of food change on
consumption hedonics and salivation in non-deprived subjects Physiol Behav 1992
Physiol Behav 1992 52:21-26
51. Epstein, L.H., Mitchell, S.L. and Caggiula, A.R. The effect of subjective and
physiological arousal on dishabituation of salivation Physiol Behav 1993 53:593-597
52. Perkins, K.A., Grobe, J.E., Epstein, L.H., Caggiula, A.R., Stiller, R.L. and Jacobs, R.G.
Chronic and acute tolerance to subjective effects of nicotine Pharmacol Biochem Behav
1993 45:375-381
53. Epstein, L.H., Caggiula, A.R., Rodefer, J.S., Wisniewski, L., and Mitchell, S.L. The
effects of calories and taste on habituation of the human salivary response. Addictive
Behav 1993 18: 179-185
54. Caggiula, A.R., Epstein, L.H., Antelman, S.M., Saylor, S., Knopf, S., Perkins, K.A. and
Stiller, R.L. Acute stress or corticosterone administration reduces responsiveness to
nicotine: Implications for a mechanism of conditioned tolerance Psychopharmacology
1993 111: 499-507
55. McAllister, C.G., Caggiula, A.R., Knopf, S., Epstein, L.H., Miller, A.L., Antelman, S.M.
and Perkins, K.A. Immunological effects of acute and chronic nicotine administration in
rats. J Neuroimmunology 1994 50: 43-49
56. Perkins, K.A., Grobe, J.E., Stiller, R.L., Scierka, A., Fonte, C., Goettler, J., Reynolds,
W.A., Caggiula, A.R. and Jacobs, R.G. Chronic and acute tolerance to the subjective,
cardiovascular and behavioral effects of nicotine in humans J Pharmacol Exp Ther 1994
270:628-638
57. Antelman, S.M., Caggiula, A.R., Kiss, S., Edwards, D.J., Kocan, D. and Stiller, R.
Neurochemical and physiological effects of cocaine oscillate with sequential drug
treatment: possibly a major factor in drug variability Neuropsychopharmacology 1995
12: 297-306
58. Caggiula, A.R., McAllister, C.G., Matthews, K.A., Berga, S.L., Owens, J.F. and Miller,
A.L. Psychological stress and immunological responsiveness in normally cycling,
follicular-stage women J Neuroimmunology 1995 59: 103-111
59. Matthews, K.A., Caggiula, A.R., McAllister, C.G., Berga, S.L., Owens, J.F., Flory, J.D.
and Miller, A.L. Sympathetic reactivity to acute stress and immune response in women
Psychosomatic Med. 1995 57: 564-571
11
60. Caggiula, A.R., Epstein, L.H., Perkins, K.A. and Saylor, S. Different methods of
assessing nicotine-induced antinociception may engage somewhat different neural
mechanisms Psychopharmacology 1995 122: 301-306
61. Donny, E., Caggiula, A.R., Knopf, S. and Brown, C. Nicotine self-administration in rats
Psychopharmacology 1995 122: 390-394.
62. Perkins, K.A., Grobe, J.E., Mitchell, S.L., Goettler, J., Caggiula, A.R., Stiller, R.L. and
Scierka, A. Acute tolerance to nicotine in smokers: lack of dissipation within 2 hours.
Psychopharmacology 1995 118: 164-170
63. Antelman, S.M. and Caggiula, A.R. Oscillation follows drug sensitization: Implications.
Crit. Reviews in Neurobiology 1996, 10(1): 101-117
64. Caggiula, A.R., Antelman, S.M., Palmer, A., Kiss, S., Edwards, D.J., and Kocan, D. The
effects of ethanol on striatal dopamine and frontal cortical D-[3H]aspartate efflux
oscillate with repeated ethanol treatment: Relevance to individual differences in drug
variability Neuropsychopharmacology 1996 15(2): 125-132
65. Perkins, K.A., Grobe, J.E., Weiss, D, Fonte, C and Caggiula, A.R. Nicotine preference in
smokers as a function of smoking abstinence Pharmacol. Biochem. Behav. 1996 55(2)
257-263
66. Perkins, K.A., Grobe, J.E. and Caggiula, A.R. Acute reinforcing effects of low-dose
nicotine nasal spray in humans. Pharmacol. Biochem. Behav. 1997 56(2): 235-241
67. Robinson-Vanderwerf, T.M., DiPirro, J.M., Caggiula, A.R. and Kristal, M.B. The
analgesia-enhancing property of ingested amniotic fluid does not affect nicotine-induced
antinociception in naltrexone-treated rats. Pharmacol. Biochem. Behav. 1997 58(1) 147-
151.
68. Donny, E.C., Caggiula, A.R., Mielke, M.M., Jacobs, K.S., Rose, C.A. and Sved, A.F.
Acquisition of nicotine self-administration in rats: The effects of dose, feeding schedule
and drug contingency Psychopharmacol 1998 136(1): 83-90
69. Caggiula, A.R., Antelman, S.M., Kucinski, B., Fowler, H., Edwards, D.J., Austin, M.C.,
Samuel Gershon and Stiller, R. Oscillatory-sensitization model of repeated drug
exposure: Cocaine's effects on shock-induced hypoalgesia Prog. in Neuro-
Psychopharmacol. & Biol. Psychiat. 1998 22: 511-521
70. Antelman, S.M., Caggiula, A.R., Kucinski, B.J., Fowler, H., Gershon, S., Edwards, D.J.,
Austin, M.C., Stiller, R., Kiss, S., and Kocan, D. The effects of lithium on a potential
cycling model of bipolar disorder Prog. in Neuro-Psychopharmacol. & Biol. Psychiat.
1998 22: 495-519
71. Kucinski, B.J., Antelman, S.M., Caggiula, A.R., Fowler, H., Gershon, S, Edwards, D.J.
and Austin, M.C. The oscillatory effects of repeated morphine on shock-induced
hypoalgesia and β-endorphin Synapse 1998 30: 30-37
72. McCallum, S.E., Caggiula, A.R., Epstein, L.H., Saylor, S., Ploskina, T., and Sved, A.F.
Mecamylamine blocks the development of tolerance to nicotine in rats: implications for
the mechanisms of tolerance Psychopharmacol 1999 141(3): 332-338.
73. Kucinski, B.J., Antelman, S.M., Caggiula, A.R., Fowler, H., Gershon, S, Edwards, D.J.
Cocaine-induced oscillation is conditionable Pharmacol. Biochem. Behav. 1999 63(3):
449-455
12
74. Donny, E.C., Caggiula, A.R., Mielke, M.M., Booth, S., Gharib, M.A., Hoffman, A.,
Maldovan, V., Shupenko, C. and McCallum, S. Nicotine self-administration in rats on a
progressive ratio schedule of reinforcement Psychopharmacol1999 147: 135-142
75. Antelman, S.M., Caggiula, A.R., Edwards, D.J., Gershon, S., Kucinski, B., Kiss, S. and
Kocan, D. Long-term oscillation of corticosterone following intermittent cocaine. J.
Neural Transmission 2000 107(3): 369-375
76. McCallum, S.E., Caggiula, A.R., Booth, S., Breese, C., Lee, M.J., Donny, E.C., Leonard,
S. and Sved, A.F. Mecamylamine prevents tolerance but enhances whole brain
[3H]epibatidine binding in response to repeated nicotine administration in rats
Psychopharmacol 2000 150:1-8
77. Donny, E.C., Caggiula, A.R., Rowell, P, Maldovan, V., Booth, S., Gharib, M.A., Mielke,
M.M., Hoffman, A. and McCallum, S. Nicotine self-administration: Estrous cycle effects,
sex differences and nicotinic receptor binding Psychopharmacol 2000 151:392-405
78. Donny, E.C., Caggiula, A.R., Rose, C.A., Jacobs, K.S., Mielke, M.M. and Sved, S.F.
Differential hormonal effects of response contingent and response independent nicotine
in rats European J Phamacol 2000 402: 231-240
79. Caggiula, A.R., Donny, E.C., White, A.R., Chaudhri, N., Booth, S., Gharib, M.A.,
Hoffman, A., Perkins, K.A. and Sved, A.F. Cue-dependency of nicotine self-
administration and smoking Pharmacol Biochem Behav (Special issue on nicotine) 2001
70: 515-530
80. Caggiula, A.R., Donny, E.C., White, A.R., Chaudhri, N., , Booth, S., Gharib, M.A., ,
Hoffman, A., Perkins, K.A., & Sved, A.F. Environmental stimuli promote the acquisition
of nicotine self-administration in rats Psychopharmacol. 2002 163: 230-237
81. Flory, J.D., Matthews, K.A., Sistilli, C.G., Caggiula, A.R., Berga, S.L. and Owens, J.F.
Short-term suppression of ovarian hormones and immune function in women.
Psychoneuroendocrinology 2002 27(6): 749-768
82. Perkins, K.A., Jacobs, L., Pelayo, E., Sanders, M. & Caggiula, A.R. Sex differences in
the subjective and reinforcing effects of cigarette nicotine dose. Psychopharmacology
2002 163: 194-201
83. Caggiula, A.R.; Donny, E.C.; Chaudhri, N.; Booth, S.; Gharib, M.; Hoffman, A.;
Clemens, L.; Perkins, K.A.; Evans-Martin, F.F. and Sved, A.F. Importance of non-
pharmacological factors in nicotine self-administration Physiol. Behav. 2002 77: 683-687
84. Donny, E.C., Chaudhri, N., Caggiula, A.R., Booth, S., Gharib, M.A., Evans-Martin, F.F.,
Clements, L.A. and Sved, A.F. Operant responding for a visual reinforcer in rats is
enhanced by non-contingent nicotine: Implications for nicotine self-administration and
reinforcement Psychopharmacology (2003) 169(1): 68-76
85. Perkins, K.A., Ciccocioppo, M., Jacobs, L., Doyle, T., Caggiula, A. (2003) The
subjective and reinforcing effects of visual and olfactory stimuli in alcohol drinking. Exp.
Clin Psychopharmacology 11(4) 269-275
86. Donny, E.C., Lanza, S.T., Balster, R.L., Collins, L.M., Caggiula, A.R. and Rowell, P.
(2004) Using growth models to relate acquisition of nicotine self-administration to break
point and nicotine receptor binding. Drug and Alcohol Dependence 75(1), 23-35
13
87. Perkins, K.A., Jacobs, L., Ciccocioppo, M., Conklin, C., Sayette, M., Caggiula, A. (2004)
The influence of instructions and nicotine dose on the subjective and reinforcing effects
of smoking. Exp. Clin Psychopharmacology 12(2) 91-101
88. Chaudhri, N., Caggiula, A.R., Donny, E.C., Booth, S., Gharib, M.A., Craven, L.A.,
Allen, S.S., Sved, A.F., Perkins, K.A. (2005) Sex Differences in the contribution of
nicotine and nonpharmacological stimuli to nicotine self-administration in rats.
Psychopharmacology 180(2) 258-266.
89. Liu X, Caggiula AR, Yee SK, Nobuta H, Poland RE, Pechnick RN. (2006) Reinstatement
of nicotine-seeking behavior by drug-associated stimuli after extinction in rats
Psychopharmacology 184 (3-4), 417-425.
90. Perkins KA, Doyle T, Ciccocioppo M, Conklin C, Sayette M, Caggiula A. (2006) Sex
differences in the influence of nicotine dose instructions on the reinforcing and self-
reported rewarding effects of smoking Psychopharmacology 184 (3-4), 600-607
91. Palmatier M , Evans-Martin FF, Hoffman A, Caggiula AR, Chaudhri N, Donny EC, Liu
X, Booth S, Gharib M, Craven L, Sved, A. (2006) Dissociating the primary reinforcing
and reinforcement enhancing effects of nicotine using a rat self-administration paradigm
with concurrently available drug and environmental reinforcers Psychopharmacology
184(3-4), 391-400
92. Chaudhri N, Caggiula AR, Donny EC, Booth S, Gharib MA, Craven LA, Sved AF.(2006) Operant responding for conditioned and unconditioned reinforcers in rats is differentially
enhanced by the primary reinforcing and reinforcement-enhancing effects of nicotine
Psychopharmacology (189(1) 27-36
93. Chaudhri N, Caggiula AR, Donny EC, Palmatier MI, Booth S, Gharib MA, Craven LA,
Sved AF. (2007) Self-administered and noncontingent nicotine enhance operant
responding for a visual stimulus in rats: the impact of dose and reinforcement-schedule
Psychopharmacology 190(3) 353-362
94. Liu X, Caggiula AR, Yee SK, Nobuta H, Sved AF, Pechnick RN, Poland RE (2007)
Mecamylamine attenuates cue-induced reinstatement of nicotine-seeking behavior in rats.
Neuropsychopharmacology Mar;32(3):710-8.
95. Palmitier MI, Liu X, Caggiula AR, Donny EC, Booth S, Gahrib M, Craven L, Sved AF
(2007) The role of nicotinic acetylcholine receptors in the primary reinforcing and
reinforcement enhancing effects of nicotine Neuropsychopharmacology 32: 1098-1108
96. Palmatier MI, Matteson GL, Black JJ, Liu X, Caggiula AR, Sved AF (2007). The
reinforcement enhancing effects of nicotine depend on the incentive value of non-drug
reinforcers and increase with repeated drug injections. Drug and Alcohol Dependence.
Jun 15;89(1):52-9.
97. Liu X, Caggiula AR, Palmitier, MI, Donny EC, Booth S, Gahrib M, Craven L (2007)
Reinforcement enhancing effects of nicotine and its attenuation by nicotinic antagonists
in rats Psychopharmacology Nov;194(4):463-73.
98. Palmatier MI, Liu X, Matteson G, Caggiula AR, Donny EC, Sved AF (2007)
Conditioned reinforcement established with self-administered nicotine and enhanced by
non-contingent nicotine. Psychopharmacology 195 (2): 235-243
14
99. Liu X, Caggiula A, Palmatier M, Donny E, Sved A. (2007) Cue-induced reinstatement of
nicotine-seeking behavior in rats: effect of bupropion, persistence over repeated tests and
its dependence on training dose Psychopharmacology Oct 12; [Epub ahead of print]
100. Palmatier MI, Liu X, Donny EC, Caggiula AR, Sved AF Metabotropic glutamate 5
receptor (mGluR5) antagonists decrease nicotine seeking, but do not affect the
reinforcement enhancing effects of nicotine Neurosychopharmacology (in Press)
Publications: Invited Articles, Reviews, Book Chapters and Books
1. Caggiula, A.R. Stability of behavior produced by electrical stimulation of the rat
hypothalamus. Brain, Behavior and Evolution, 1969, 2, 343-358.
2. Antelman, S.M. & Caggiula, A.R. Tails of stress-related behavior: A
neuropharmacological model. In I. Hanin & E. Usdin (Eds.): Animal Models in
Psychiatry & Neurology, 1977, Pergamon Press, N.Y., 227-245.
3. Caggiula, A.R., Antelman, S.M., Chiodo, L.A., & Lineberry,C.G. Brain dopamine &
sexual behavior: Psychopharmacological and electrophysiological evidence for a
dissociation between active and passive components. In E. Usdin, I.J. Kopin & J.
Barchas (Eds.): Catecholamines: Basic and Clinical Frontiers 1979 Pergamon Press.
1765-1767
4. Antelman, S.M., Caggiula, A.R., Eichler, A.J., & Lucik, R.R. The importance of stress in
assessing the effects of anorectic drugs. Current Medical Research & Opinion, 1979, b
Suppl. 73-82.
5. Antelman, S.M. & Caggiula, A.R. Stress-induced behavior: Chemotherapy without
drugs. In J.M. Davidson and R.J. Davidson (Eds.): The Psychobiology of Consciousness
1980, Plenum Press.
6. Ostrowski, N.L., Chiodo, L.A., Keller, R., and Caggiula, A.R. Morphine produces
different effects on subtypes of mesencephalic dopamine systems. In: H. Takagi & E.J.
Simon (Eds.): Advances in Endogenous and Exogenous Opioids 1982, Elsevier,
Amsterdam.
7. Antelman, S.M., Knopf, S., Caggiula, A.R., Kocan, D., Lysle, D.T. & Edwards, D.J.
Stress and enhanced dopamine utilization in the frontal cortex: The myth and the reality.
In P.W. Kalivas and C.B. Nemeroff (Eds.) The Mesocortical Dopamine System Ann.
N.Y. Academy of Sciences 1988, 537:262-272
8. Caggiula, A.R. & Frieze, I. Sex differences. In H. Tierney (Ed.) The Women's Studies
Encyclopedia, Vol.I: Views from the Sciences 1989, Greenwood Press.
9. Antelman, S.M. and Caggiula, A.R. Mechanisms of stimulant and stress sensitization:
Where to look. Clin. Neuropharm. 1990, 13(Suppl 2), 585-586
10. Antelman, S.M. and Caggiula, A.R. The effects of acute stressors and drugs grow with
the passage of time. In A. Oliviero and S. Puglisi-Allegra (Eds.) Psychobiology of Stress,
1990, Kluwer:Dordrecht, 161-170.
11. Antelman, S.M. and Caggiula, A.R. Norepinephrine-dopamine interactions; one step
beyond. In M. Briley and M. Marien (Eds.) Noradrenergic Mechanisms in Parkinson's
Disease 1994, CRC Press, pp.127-138
15
12. Caggiula, A.R., Epstein, L.H, Antelman, S.M., Knopf, S., Perkins, K.A., Saylor, S.,
Donny, E. and Stiller, R. Conditioned tolerance to nicotine in rats. In P.B.S. Clarke, M.
Quik, F. Adlkofer and K. Thurau (Eds.) The Effects of Nicotine on Biological Systems II
1995, Birkhäuser Verlag (Basel-Boston-Berlin), 101-107
13. Antelman, S.M., Caggiula, A.R., Gershon, S., Edwards, D.J., Austin, M.C., Kiss, S. and
Kocan, D. Stressor-induced oscillation: A possible model of the bidirectional symptoms
of PTSD Ann. NY Acad. Sci. 1997.
14. Caggiula, A.R., Donny, E.C., Epstein, L.H., Sved, A.F., Knopf, S., Rose, C.A.,
McAllister, C.G., Antelman, S.M. and Perkins, K.A. The role of corticosteroids in
nicotine’s physiological and behavioral effects Psychoneuroendocrinol. 1998 23(2): 143-
159
15. McAllister-Sistilli, C.G., Caggiula, A.R., Knopf, S., Rose, C.A., Miller, A.L. and Donny,
E.C. The effects of nicotine on the immune system Psychoneuroendocrinol. 1998 23(2):
175-187
16. Perkins, K.A., Donny, E. and Caggiula, A.R. Sex differences in nicotine effects and self-
administration: human and animal evidence Nicotine and Tobacco Research 1999 1: 301-
315.
17. Antelman, S.M., Levine, J., Gershon, S. Caggiula, A.R. and Edwards, D.J. Cyclic and
oscillatory behaviors in biological systems: A relevant model for bipolar disorders? In
J.C. Soares and S. Gershon (Eds.) Bipolar Disorders: Basic Mechanisms and Therapuetic
Implications 2000 Marcel Dekker, Inc. NY 49-58
18. Perkins, K., Sayette, M., Conklin, C. and Caggiula, A. Placebo effects of tobacco
smoking and other nicotine intake. Nicotine and Tobacco Research 2003 5(5): 695-709
19. Donny, E.C., Chaudhri, N., Caggiula, A.R., Sved, A.F. (2003) Multiple effects of
nicotine on behavior: A reply to Frenk and Dar Psychopharmacology 171(4) 474-476
20. Chaudhri, N., Caggiula, A.R., Donny, E.C., Palmatier, M.I., Lui, X., and Sved, A.F.
(2006) Complex interactions between nicotine and nonpharmacological stimuli reveal
multiple roles for nicotine in reinforcement Psychopharmacology 184 (3-4), 353-366
(Invited theoretical paper)
21. Matta, S.G., Balfour, D.J., Benowitz, N.L., Boyd, R.T., Buccafusco, J.J., Caggiula, A.R.,
Craig,C.R., Collins, A.C., Corrigall, W.A., Damaj, M.I., Donny, E.C., Gardiner, P.S.,
Grady, S.R., Heberlein, U., Leonard, S.S., Levin, E.D., Lukas, R.J., Markou, A, Marks,
M.J., McCallum, S.E., Parameswaran, N., Perkins, K.A., Picciotto, M.R., Quik, M, Rose,
J.E., Rothenfluh, A, Schafer, W.R., Stolerman, I.P., Tyndale, R.F., Wehner, J.M., Zirger,
J.M. (2007) Guidelines for nicotine dose selection for in vivo research: theoretical
underpinnings Psychopharmacology 190(3) 269-319 (Invited theoretical paper)
22. Caggiula A.R., Donny E.C., Palmatier, M.I., Liu, X., Chaudhri, N and Sved, A.F. The
role of nicotine in smoking: A dual reinforcement model. In Bivins, R.A. and Caggiula,
A.R. (Eds) The 55th
Nebraska Symposium on Motivation: The Motivational Impact of
Nicotine and It’s Role in Tobacco Use (Springer, in press)
23. Bivins, R.A. and Caggiula, A.R. (Eds) The 55th
Nebraska Symposium on Motivation:
The Motivational Impact of Nicotine and It’s Role in Tobacco Use (Springer, in press)
16
Presentations
Caggiula, A.R. Copulation-reward site in the posterior hypothalamus. Eastern Psychological
Assn, New York, 1966.
Caggiula, A.R. Specificity of copulation-reward systems in the posterior hypothalamus.
American Psychologycal Assn, Washington, D.C., 1967.
Caggiula, A.R. Stability of copulation-reward effects from posterior hypothalamic electrodes. In
symposium: Motivation, emotion and behavior elicited by activation of central nervous system
sites. Americal Psychological Assn, 1969, Washington, D.C.
Caggiula, A.R. Copulation of virgin male rats evoked by painful peripheral stimulation. Eastern
Psychological Assn, 1969, Philadelphia, Pennsylvania.
Caggiula, A.R. Stability of behavior from electrical stimulation of the rat hypothalamus. In
workshop held at the Third Annual Winter Conference on Brain Research, 1970, Snowmass-at-
Aspen, Colorado.
Caggiula, A.R. The effects on copulation of stimulating either end of a male rat. Given at the
1970 Eastern Regional Conference on Reproductive Behavior, 1970, Boca Raton, Florida.
Caggiula, A.R. Shock-elicited copulation and aggression. Eastern Psychological Association,
1971, New York.
Caggiula, A.R., Antelman, S.M., & Zigmond, M.J. Disruption of copulatory behavior in the
male rat by posterior hypothalamic lesions. The Society of Neurosciences First Annual Meeting,
Washington, D.C., 1971.
Caggiula, A.R. Discussant, Workshop on Neural Mechanisms of Motivation. Winter conference
on Brain Research, Vail, Colorado, 1972.
Caggiula, A.R. & Eibergen, R. Ventral midbrain involvement in the control of copulatory
behavior of the male rat. Eastern Psychological Association, Boston, Massachusetts, 1972.
Caggiula, A.R. The effects of hypothalamic and brain stem lesions on the copulatory behavior of
male rats. Eastern Regional Conference on Reproductive Behavior, New Orleans, Louisiana,
1972.
Caggiula, A.R., Antelman, S.M., & Zigmond, M.J. Ineffectiveness of sexually arousing
stimulation after hypothalamic lesions in male rats. A.P.A., 1974, Philadelphia, Pennsylvania.
Caggiula, A.R. Discussant, in Workshop on Research Methods in Sex Research. Eastern
Regional Conference on Reproductive Behavior, 1974, Atlanta, Georgia.
17
Caggiula, A.R. Neural control of sexual behavior in male rats. Talk given to Department of
Psychology, Purdue University, 1974.
Caggiula, A.R. & Antelman, S.M. Organizers and discussants of workshop on
Neuropharmacology of Mating Behavior. Eastern Regional Conference on Reproductive
Behavior, Nags Head, North Carolina,1975.
Caggiula, A.R. The medial preoptic-medial forebrain bundle "continuum" and sexual behavior in
male rats: An anatomical, neurochemical, and behavior dissection approach. Invited workshop
on Brain Control of Sociosexual Behavior. Winter Conference on Brain Research, Steamboat
Springs, Colorado, 1975.
Caggiula, A.R., Herndon, J.G., Jr., Antelman, S.M., Sharp, D., Scanlon, R., Greenstone, D. &
Bradshaw, W. Brain catecholamines and copulatory behavior of male and female rats. Paper
presented at Eastern Conference on Reproductive Behavior, Storrs, Connecticut, June, 1977.
Caggiula, A.R. Invited speaker in round table discussion "The relevance of animal studies to
problems of human reproductive behavior" organized by L. Aronson & M. Cooper at Eastern
Conference on Reproductive Behavior. Storrs, Connecticut, June, 1977.
Caggiula, A.R., Herndon, J.G., Jr., Scanlon, R., Greenstone, D., Bradshaw, W. & Sharp, D.
Dissociation of active from passive components of sexual behavior in female rats by destruction
of brain catecholamine-containing pathways. Society for Neuroscience, 1977, Anaheim,
California.
Caggiula, A.R. Invited colloquium presentation at the University of Buffalo, Department of
Psychology, February, 1977
Caggiula, A.R. Invited colloquium presentation at the University of Pennsylvania, Department of
Biology, December, 1977.
Caggiula, A.R. & Antelman, S.M. Brain catecholamines and sexual behavior. Winter
Conference on Brain Research, January, 1978.
Caggiula, A.R. Brain catecholamines and sexually dimorphic patterns of copulatory behavior:
A new perspective. Fourth International Catecholamine Symposium. Asilomar, California,
September, 1978.
Caggiula, A.R., Chiodo, L.A., Antelman, S.M. & Lineberry, C.G. Tail pinch-stress activates
nigrostriatal DA neurons and behavior: The reversal of both effects by cervical probing. Society
for Neuroscience, 1978. Abstract #44.21.
Caggiula, A.R. Invited colloquium presentation at the Mental Health Research Institute,
University of Michigan, February, 1979.
18
Caggiula, A.R. & Chiodo, L.A. Brain dopamine and sexual behavior: Paper presented at
Eastern Conference on Reproductive Behavior, New Orleans, 1979.
Caggiula, A.R. & Chiodo, L.A. An immobilizing stimulus significantly attenuates both
amphetamine and apomorphine-induced stereotypies. Society for Neuroscience, Atlanta, 1979.
Caggiula, A.R. Invited to participate in roundtable discussion on "Nonsteroidal factors in
reproductive behavior." Eastern Conference on Reproductive Behavior, New York, New York,
June, 1980.
Caggiula, A.R. Invited colloquium presentation at Neurotoxicology Section, NINCDS-NIH,
Bethesda, Maryland, August, 1980.
Caggiula, A.R. Invited colloquium presentation at Department of Psychology, Skidmore College,
Saratoga Springs, New York, December, 1980.
Caggiula, A.R. Invited colloquium presentation at Department of Behavioral Sciences,
University of Chicago, Illinois, February, 1981.
Caggiula, A.R. & Chiodo, L.A. Estrogen's influence on brain DA containing systems:
Electrophysiological and behavioral evidence. European Winter Conference on Brain Research,
Vars, France, March, 1981.
Caggiula, A.R. Invited colloquium presentation at Department of Psychology, University of
Buffalo, May, 1981.
Caggiula, A.R. Organizer of a Roundtable entitled: Hormonal modulation of neurotransmitter
function: Neurophysiological, behavioral and clinical effects. Winter Conference on Brain
Research, Steamboat Springs, Colorado, January, 1982.
Caggiula, A.R. & Chiodo, L.A. Estrogen-induced alterations in brain dopamine function:
Behavioral and electrophysiological evidence. Winter Conference on Brain Research, Steamboat
Springs, Colorado, January, 1982.
Caggiula, A.R. Invited colloquium presentation of Department of Anatomy, University of
Rochester, School of Medicine, June, 1984.
Caggiula, A.R., Antelman, S.M. Aul, E., Knopf, S. & Edwards, D.J. Prior stress attenuates the
analgesic response but sensitizes the corticosterone and cortical dopamine response to stress 10
days later Soc. for Neuroscience, Toronto, Canada, 1988
Caggiula, A.R. Both immediate and historical environmental factors modulate reactivity to drugs
and stress. Invited colloquium, Department of Psychology, University of Buffalo. April, 1989
19
Caggiula, A.R. Both immediate and historical environmental factors modulate reactivity to drugs
and stress. Invited colloquium, Department of Psychology, Allegheny College, May, 1989
Caggiula, A.R., Epstein, L.H., Antelman, S.M., Saylor, S. and Perkins, K.A. Changing
environmental cues uniquely associated with drug delivery reduces tolerance to nicotine-induced
anorexia and corticosterone release. Soc. for Neuroscience, St. Louis, MO, 1990
Caggiula, A.R. Drugs and Stress: The role of environmental context in modifications of
reactivity. Fourth Annual I. Ralph Hyatt Leadership Lecture. St. Joseph's University March,
1990
Caggiula, A.R., Epstein, L.H., Antelman, S.M., Knopf, S., Saylor, S., and Perkins, K.A.
Corticosterone accelerates the development of tolerance to nicotine-induced analgesia in rats
Soc. for Neuroscience, New Orleans, LA, 1991
Caggiula, A.R. Invited Colloquium, Department of Psychology, Allegheny College, 1991
Caggiula, A.R. (organizer and presenter) Symposium: The role of conditioning in chronic drug
effects: Implications for theories of drug abuse and therepeutic drug efficacy. Society for
Behavioral Medicine, New York, March, 1992
Antelman, S.M., Caggiula, A.R. (Speaker), Edwards, D.J., Kiss, S., Kocan D. and Barry III, H.
Acute stress or ethanol (ETOH) can have a very long lasting influence on in vitro dopamine
(DA) release from striatal slices. Soc. for Neuroscience Anaheim, CA, Nov., 1992.
Caggiula, A.R., McAllister, C.G., Matthews, K.A., Berga, S.A., and Owens J.F. Stress, ovarian
hormones and immunologic responsiveness in normally cycling women Society for Behavioral
Medicine, San Francisco, CA, March, 1993.
Caggiula, A.R. Invited colloquium, Department of Psychology, Princeton University. October,
1993
Caggiula, A.R., Epstein, L.H., Antelman, S.M., Knopf, S., Perkins, K.A., Saylor, S., Donny, E.,
and Stiller, R. Conditioned tolerance to nicotine in rats. Invited talk at International Symposium
on Nicotine, Montreal, Canada, July, 1994
Caggiula, A.R., Epstein, L.H., Perkins, K.A., and Saylor, S. Different methods of assessing
nicotine-induced antinociception may engage somewhat different neural mechanisms. Poster at
International Symposium on Nicotine, Montreal, Canada, July, 1994
S. Knopf, A. R. Caggiula, C. G. McAllister, L. H. Epstein, S. M. Antelman, K. A. Perkins, S.
Saylor, and R. Stiller. The effects of cholinergic and ß-adrenergic antagonists on nicotine-
induced suppression of blood and spleen leukocytes in rats. Poster at International Symposium
on Nicotine, Montreal, Canada, July, 1994
20
Caggiula, A.R., Antelman, S.M., Edwards, D.J., Kiss, S., Kocan D., and Stiller, R.
Oscillatory effects of cocaine on dopamine efflux in rat Soc. for Neuroscience Miami, Fla.,
November, 1994
Donny, E, Caggiula, A.R. and Knopf, S. Nicotine self-administration in rats. Poster presented at
Society for Research on Nicotine and Tobacco, San Diego, CA March 24-25, 1995
Donny, E.C., Caggiula, A.R. and Knopf, S. Nicotine self-administration in rats. Soc for
Neuroscience (1995) San Diego, CA Nov 11-16, 1995
Knopf, S., Caggiula, A.R., Sved, A.F., Schreihofer, A.M., & McAllister, C.G. Selective central
or peripheral nicotinic antagonism by chlorisondamine. Soc for Neuroscience San Diego, CA
Nov 11-16, 1995
Knopf, S., Sved, A.F., McAllister, C.G. and Caggiula, A.R. Selective central or peripheral
nicotine antagonism by chlorisondamine blocks nicotine's immunological effects. Soc. for
Research on Nicotine and Tobacco Washington, DC March 15-17, 1996
Donny, E.C., Caggiula, A.R., Knopf, S., Rose, C., McAllister, C.G., Sved, A and Perkins, K.A.
Does self-administered nicotine produce the same effects as experimenter-administered nicotine?
Soc. for Research on Nicotine and Tobacco Washington, DC March 15-17, 1996
Donny, E.C., Caggiula, A.R., Jacobs, K.S., Shaida, P. and Mielke, M.M. The role of dose and
feeding schedule in the acquisition of IV nicotine self-administration. Soc. for Research on
Nicotine and Tobacco Washington, DC March 15-17, 1996
Caggiula, A.R. The role of corticosterone in nicotine’s behavioral and physiological effects.
Invited presentation at the Nicotine Roundtable of the American Society of Addiction Medicine
Meetings, Washington, DC November 14, 1996.
S.E. Strong, S.E., Caggiula, A.R., Saylor, S. and Ploskina, T.M. Time course of the selective
peripheral antagonism of nicotine by chlorisondamine Society for Neuroscience, New Orleans,
La. Oct. 25-30, 1997
Caggiula, A.R., Antelman, S.M., Kucinski, B.J., Fowler, H., Gershon, S., Edwards, D.J., Austin,
M.C., Stiller, R., Kiss, S. and Kocan, D. Oscillatory-sensitization model of repeated drug
exposure: induction by cocaine and blockade by lithium Society for Neuroscience, New Orleans,
La. Oct. 25-30, 1997
Kucinski, B.J., Antelman, S.M., Caggiula, A.R., Fowler, H., Gershon, S., Edwards, D.J., Austin,
M.C., Kiss, S. and Kocan, D. Oscillatory-sensitization effects are produced by repeated
morphine pre-exposures and are blocked by chronic lithium treatments Society for Neuroscience,
New Orleans, La.Oct. 25-30, 1997
21
Donny, E.C., Caggiula, A.R., Mielke, M.M., Strong, S.E., Rose, C., Ploskina, T.M., Jacobs, K.S.
and Shupanko, C.D. Use of progressive ratio schedules in nicotine self-administration. Society
for Neuroscience, New Orleans, La.Oct. 25-30, 1997
Donny, E.C., Caggiula, A.R., Rose, C., Jacobs, K.S., Mielke, M.M. and Strong, S. Nicotine self-
administration using a progressive ratio schedule of reinforcement. Society for Research on
Nicotine and Tobacco Nashville, TN June 13-14, 1997
McCallum, S.E., Caggiula, A.R., Epstein, L.H., Saylor, S., Ploskina, T. and Sved, A.F.
Mecamylamine blocks tolerance to nicotine in rats: Implications for the mechanisms of
tolerance. College on Problems of Drug Dependence Scottsdale, AZ June 13-18, 1998
Donny, E.D., Caggiula, A.R., Shupenko, C.D., Mielke, M.M., Booth, S., Hoffmna, A.S., Imerito,
C.A., Rose, C., McCallum, S.E. and Perkins, K. Effect of dose, extinction, and drug-paired cues
on nicotine self-administration under a progressive ratio. College on Problems of Drug
Dependence Scottsdale, AZ June 13-18, 1998
Donny, E.C., Caggiula, A.R.,Shupanko, C.D., Mielke, M.M., Booth, S., Hoffman, A.S., Imerito,
C.A., Rose, McCallum, S.E. Nicotine self-administration in male and female rats on fixed and
progressive ratio schedules of reinforcement. Society for Neuroscience, Los Angeles, CA
November 7-12, 1998
Kucinski, B.J., Antelman, S.M., Caggiula, A.R., Fowler, H., Gershon, S, Edwards, D.J.
Cocaine-induced oscillation is conditionable Society for Neuroscience Los Angeles, CA
November 7-12, 1998
Antelman, S.M., Edwards, D.J., Caggiula, A.R., Gershon, S., Kocan, D. and Kiss, S. Inositol
prevents cycling in a possible animal model of bipolar disorder: A challenge to the inositol-
depletion hypothesis of lithium action. American College of Neuropsychopharmacology San
Juan, PR. December, 1998
Caggiula, A.R. The psychology of nicotine pharmacology. Invited colloquium, University of
Kentucky, May, 1999
Caggiula, A.R. Pharmacological and non-pharmacological factors in nicotine reinforcement.
Invited Colloquium, University of Minnesota, April 7, 2000
Caggiula, A.R., Donny, E.C., White, A.R., Sved, A., Gharib, M, Maldovan, V., Booth, S and
Chaudhri, N. The role of environmental cues in the acquisition, extinction and reinstatement of
nicotine self-administration in rats. Society for Neuroscience New Orleans, LA 2000
Donny, E.C., Caggiula, A.R., Rowell, P.P., Gharib, M.A., Maldovan, V., Booth, S, Hoffman,
A., Mielke, M.M., McCallum, S. Nicotinic receptor binding and plasma and brain nicotine levels
22
following nicotine self-administration in male and female rats. Society for Neuroscience New
Orleans, LA 2000
Caggiula, A.R., Donny, E.C., White, A.R., Sved, A.F., Gharib, M., Booth, S., Chaudhri, N. The
role of environmental cues in the acquisition, extinction and reinstatement of nicotine self-
administration. Society for Research on Nicotine and Tobacco, Seattle, WA 2001
White, R., Chaudhri, N., Caggiula, A.R., Donny, E.C., Gharib, M, Booth, S., Sved, A.F.
Contingently-presented environmental stimuli enhance nicotine self-administration in rats
Society for Neuroscience Meetings, San Diego, 2001
Caggiula, A.R., Donny, E.C., White, R., Chaudhri, N., Gharib, M., Booth, S., Sved, A.F. Non-
contingent nicotine enhances responding maintained by behaviorally contingent environmental
cues. Society for Neuroscience Meetings, San Diego, 2001
Donny, E.C. and Caggiula, A.R. Sex differences in the behavioral and reinforcing effects of
nicotine in rats. Invited presentation, Symposium on “The effects of hormones on nicotine
dependence” Society for Research on Nicotine and Tobacco Meetings, March., 2001. (Eric
Donny gave the presentation in my stead).
Donny, E.C. and Caggiula, A.R. The role of environmental stimuli and response-contingency in
the acquisition of nicotine self-administration in rats. Invited presentation at the ISGIDAR
Meetings in Scotsdale, AZ, June, 2001 (Eric Donny gave the presentation because I had a
scheduling conflict).
Caggiula, A.R. Cue dependence of nicotine self-administration and smoking. Invited
presentation at the Treatment Research Center, Department of Psychiatry, University of
Pennsylvania. September 17, 2001
Caggiula, A.R. The role of environmental stimuli in the acquisition, maintenance and
reinstatement of nicotine self-administration. Invited presentation at the Society for Research on
Nicotine and Tobacco, Savannah, GA February, 23, 2002
Caggiula, A.R. Gender differences in nicotine reinforcement using an animal self-administration
model. Invited presentation at the Winter Conference on Neurochemistry, Solden, Austria, April
5, 2003
Chaudhri, N., Caggiula, A.R. Donny, E.C., Perkins, K.A. & Sved, A.F. Sex differences and
nicotine reinforcement in humans and animals. Invitation to A.R. Caggiula to provide a female
post-doc or graduate student to present our research in a symposium sponsored by American
Society of Pharmacology and Experimental Therapeutics at the Experimental Biology Meetings,
April 14, 2003, San Diego, CA
Caggiula, A.R. “From sex to drugs to ....” Invited presentation in the Department of Psychology,
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Princeton University, November, 2003
Perkins, K.A., Jacobs, L., Conklin, C., Sayette, M., Caggiula, A.R. The influence of instructions
and nicotine dose on the subjective and reinforcing effects of smoking. Poster at Society for
Research on Nicotine and Tobacco New Orleans, LA February, 2003
Chaudhri, N., Caggiula, A.R., Donny, E.C., Gharib, M.A., Booth, S., Clements, L.A., Perkins, K.A.
Sved, A.F. Dissociating the primary reinforcing and reward-enhancing effects of nicotine: analysis
of sex, dose and drug contingency on operant responding in rats. Poster at College on Problems of
Drug Dependence, Miami Beach, FL June, 2003
Chaudhri, N., Caggiula, A.R., Donny, E.C., Gharib, M.A., Booth, S., Clements, L.A., Perkins, K.A.
Sved, A.F. Enhancement of reinforced operant responding by nicotine and cocaine in rats: analysis
of dose and drug-contingency. Poster at Society for Neuroscience meeting, New Orleans, LA Nov,
2003
Chaudhri, N, Evans-Martin, F., Caggiula, A.R., Donny, E.C., Sved, A.F., Booth, S., Gharib, M.A.,
Craven, L.A. Evidence for dual actions of nicotine on reinforced behavior. Paper given at the
Society for Research on Nicotine and Tobacco Scottsdale, AZ February 19, 2004
Caggiula, A.R., Chaudhri, N., Donny, E.C. and Sved, A.F. Dual reinforcement model of nicotine.
Poster at Society for Neurochemistry meeting in Solden, Austria. April, 2004
Palmatier M, Evans-Martin FF, Hoffman A, Caggiula AR, Chaudhri N, Sved AF. Self-
administration of nicotine and environmental cues under concurrent schedules of reinforcement.
Paper given at the Winter Conference on Animal Learning and Behavior Winter Park, Colorado
February 7 - 11, 2004
Caggiula, AR Dual Reinforcement model of nicotine self-administration and smoking. Research
Institute on Addictions, Buffalo, NY November, 2004
Caggiula, AR Dual Reinforcement model of nicotine self-administration and smoking. Duke
Conference on Nicotine and Smoking. Durham, NC October, 2004
Chaudhri N, Caggiula AR, Donny EC, Sved AF. A Dual Role for Nicotine in Reinforcement: The
interaction between nicotine and non-drug cues. Invited presentation at NIDA Frontiers of
Addiction Symposium. San Diego, CA October, 2004 (given by N Chaudhri in my absence)
Perkins KA, Jacobs L, Conklin C, Sayette M, Caggiula AR The influence of instructions and
nicotine dose on the subjective and reinforcing effects of smoking. International Study Group
Investigating Drugs as Reinforcers Orlando, FL June, 2005
Palmitier M, Evans-Martin FF, Hoffman A, Caggiula AR, Chaudhri N, Sved AF. Nicotine
enhances responding for a visual reinforcer in a novel self-administration paradigm. Paper given at
24
the Society for Research on Nicotine and Tobacco Prague, CZ March, 2005
Caggiula AR, Chaudhri N, Donny EC, Palmatier MI, Liu X, Sved AF (2005). Nicotine enhances
responding for nonpharmacological stimuli: impact of dose and reinforcement schedule. 35th
Annual Meeting of Society for Neuroscience.
Chaudhri N, Caggiula AR, Donny EC, Palmatier MI, Liu X, Sved AF (2005). Dissociable
behavioral actions of nicotine in reinforcement. 35th Annual Meeting of Society for Neuroscience.
Liu X, Caggiula AR, Palmatier MI, Booth S, Gharib M, Craven L, Donny EC, Sved AF (2006).
Reinforcement enhancing effect of nicotine and its attenuation by nicotinic and dopaminergic
antagonists. 12th Annual Meeting of the Society for Research on Nicotine and Tobacco.
Liu X, Caggiula AR, Palmatier MI, Donny EC, Chaudhri N, Sved AF (2005). Reinforcement
enhancing effect of nicotine depends on the reinforcement valence of non-drug stimulus. 35th
Annual Meeting of Society for Neuroscience.
Palmatier MI, Liu X, Caggiula AR, Donny EC, and Sved AF (2006). A pharmacological
dissociation of the primary reinforcing and reinforcment enhancing effects of nicotine. 12th Annual
Meeting of the Society for Research on Nicotine and Tobacco.
Palmatier MI, Evans-Martin FF, Hoffman A, Caggiula AR, Chaudhri N, Donny EC, Liu X, and
Sved AF (2005). Self-administered nicotine enhances responding for a concurrently available visual
reinforcer. 35th Annual Meeting of Society for Neuroscience.
Palmatier MI, Evans-Martin FF, Hoffman A, Caggiula AR, Chaudhri N, and Sved AF (2005).
Nicotine enhances responding for a visual reinforcer in a novel self-administration paradigm. 11th
Annual Meeting of the Society for Research on Nicotine and Tobacco.
Matteson GL, Palmatier MI, Liu X, Chaudhri N, Caggiula AR, Donny EC, Sved AF (2006). The
reinforcement enhancing effect of nicotine depends on the incentive value of a nonpharmacological
reinforcer. 12th Annual Meeting of the Society for Research on Nicotine and Tobacco.
Thiels E, Palmatier MI, Shiflett MW, Caggiula AR, Sved AF (2005). ERK activation during drug-
primed reinstatement of nicotine self-administration. 35th Annual Meeting of Society for
Neuroscience
Caggiula AR. (2006) Human and animal approaches to discover the bases of nicotine
reinforcement: Associative and non-associative mechanisms" Invited presentation at the Presidential
Symposium, Eastern Psychological Association, Baltimore, MD
Caggiula AR (2005) Dual reinforcement model of nicotine reinforcement in rats. Invited
symposium presentation. Society for Research on Nicotine and Tobacco, Prague, CZ
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Caggiula AR (2005) (discussant) Novartis Foundation Symposium: Understanding nicotine and
tobacco addiction, London UK
Caggiula AR (2005) Human and animal approaches to discover the bases of nicotine reinforcement.
Novartis Foundation Symposium: Understanding nicotine and tobacco addiction. Invited
presentation at the Open Meeting. London, UK
Caggiula AR (2005) A dual reinforcement model of nicotine. Invited symposium presentation.
European Behavioral Pharmacology Society, Barcelona, Spain,
Caggiula AR (2005) A dual reinforcement model of nicotine self-administration and smoking.
Invited presentation at the Center for the Neural Basis of Cognition Retreat, Hidden Valley, PA
Caggiula AR (2006) A dual reinforcement model of nicotine self-administration and smoking.
Invited presentation at the National Institute on Drug Abuse Intramural Program, Baltimore, MD
Matteson G, Palmatier MI, Liu X, Caggiula AR, Black JJ, Gaily L, Donny EC, Sved AF (2006) The
reinforcement enhancing effects of nicotine depend on the incentive value of non-drug reinforcers
and the acute action of nicotine. 36th Annual Meeting of the Society for Neuroscience, Atlanta, GA
M.I. Palmatier MI, Liu X, Caggiula AR, Donny EC, Sved AF. (2006) Nicotine self-administration
in rats: Response-rates match outcome-value when nicotine infusions and a visual reinforcer are
contingent upon separate operants. 36th Annual Meeting of the Society for Neuroscience, Atlanta,
GA
Liu X, Palmatier MI, A.R. Caggiula AR, E.C. Donny EC, A.F. Sved
AF. (2006) Cue-induced reinstatement of nicotine-seeking behavior
in rats: effects of training dose and delay of extinction. 36th
Annual Meeting of the Society for Neuroscience, Atlanta, GA
Caggiula AR (2006) Human and animal approaches to discover the bases of nicotine reinforcement:
Associative and non-associative mechanisms Invited presentation at the Presidential Symposium, Eastern
Psychological Association, Baltimore, MD
Caggiula AR, Palmatier MI, Liu X, Donny EC, Sved AF. (2006)
Pharmacological properties of the primary reinforcing and
reinforcement enhancing effects of nicotine. Annual meeting of the College on
Problems of Drug Dependence, Scottsdale, AZ
Caggiula AR (2006) Nonpharmacological stimuli in nicotine reinforcement. Invited presentation at the
European Society for Research on Nicotine and Tobacco, Kusadasi, Turkey
Caggiula AR (2006) Multiple roles for nicotine in self-administration and smoking. Invited presentation
at the European Society for Research on Nicotine and Tobacco, Kusadasi, Turkey
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Caggiula AR (2006) What is the role of nicotine in smoking: a perspective from animal research? Invited
presentation at the Department of Psychiatry, University of Pennsylvania School of Medicine
Philadelphia, PA
Caggiula AR (2007) What is the role of nicotine in smoking: a perspective from animal research? Invited
Plenary Pre-Clinical Theme Lecture, Annual Meeting of the Society for Research on Nicotine and
Tobacco, Austin Texas
Caggiula AR (2007) What is the role of nicotine in smoking? A perspective from animal research.
Invited presentation, Nebraska Symposium on Motivation, University of Nebraska, Lincoln NE
Palmatier MI, Donny EC, Liu X, Matteson GL, Caggiula AR, Sved AF (2007) Conditioned
reinforcement established with self-administered nicotine: Motivational effects of stimuli associated with
different unit nicotine doses. Society for Neuroscience. Society for Neuroscience, San Diego.
Kara L. Mays, Melissa E. Levin, Kasia M. Bak, Matthew I. Palmatier, Xiu Liu, Anthony R. Caggiula,
Eric C. Donny, Alan F. Sved (2007) Nicotine and bupropion have similar effects on responding for
reinforcing non-drug stimuli. 13th Annual Meeting of the Society for Research on Nicotine and Tobacco,
Austin, TX.
Palmatier MI, Matteson GL, Liu X, Caggiula AR, Donny EC, Sved AF (2007) Conditioned
reinforcement is established with self-administered nicotine. 13th Annual Meeting of the Society for
Research on Nicotine and Tobacco, Austin, TX.