Differences in preoperative CEA serum levels and relationship with metastasis between Colon Cancer and Rectal Cancer in Dr

Kariadi Hospital Semarang in the period January 2010 - December 2012

Luqman Alwi*, Parish Budiono**

*) General Surgery Resident Diponegoro University / RSUP Dr.Kariadi, Semarang**) Staff on Digestive Department Diponegoro University / RSUP Dr.Kariadi, Semarang

Abstract

IntroductionColorectal cancer and CEA levels are two things that are related to the diagnosis, treatment planning, and prognosis. There are differences in the anatomical location of the tumor to the peritoneal reflection especially on the overlying stroma. This study aimed to compare differences in preoperative CEA serum levels and relationship with metastasis in patients with colon cancer and rectal cancer at initial diagnosis is made.

MethodThis retrospective study included 75 patients with colorectal cancer were retrieved from medical records from January 2010 to December 2012, consisted of 36 women and 39 men, the location of the tumor in the colon or rectum, preoperative serum levels of CEA, staging, histopathological types and their metastases.

ResultThere was no significant difference between preoperative CEA serum levels of the tumor location with the same histopathological type or different (p = 0.231 vs. p = 0.092), did not differ significantly between the location of the tumor with metastasis to histopathologic type of the same or different (p = 0632 vs. p = 0.620). Tendency of metastasis on preoperative CEA serum levels with a cut off point of 36.265 mg/dl (sensitivity 64.7%, specificity 95.1%).

ConclusionDifferences in the anatomical location of the tumor to the peritoneal reflection does not affect the difference in preoperative CEA serum levels and a trend toward metastasis on preoperative CEA serum levels with a cut off point of 36.265 mg/dl at initial diagnosis is made

Keywords: CEA, metastasis, colon cancer, rectum cancer