Department Of Pharmaceutics

Presented By : Guided By :

Mr. Rohit U. Bharti Prof. R. S. Pentewar [HOD]

ChannaBasweshwar Pharmacy College, Kava Road, Latur-413512.1

07/02/2014

Needle free Injection :

Designed for Confidence

PRESENTATION OVERVIEW

Introduction to Needle free injection

State of the art technology

Performance overview and past research

Current applications

Products Available in Market

Recent Technology and ongoing research

References

Questions

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WHAT IS IT ?

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Needle-free injection systems are novel ways to introduce various medicines into patients without piercing the skin with a conventional needle.

Needle-free injection techniques can be used to administer vaccinesand medications in the pork industry.

They are promoted as a possible option for patients with needle phobia

COMPONENTS

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Giving a Needle- free Injection[1]

Fill syringe with injectate

Insert syringe into Biojector

Hold at 90º with firm pressure at injection site

Pull actuator, count to three, maintain pressure

Remove device and hold pressure at site

( patient or parent can hold )

Entire process is fast and easy

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* Sources: GAO, CDC, OSHA, University of Virginia

Figure 4: Types of Parenteral Route 8

Dispersion Patterns: IM Injection

Spherical bolus

lowest possible

SA/V ratio limited tissue

disruption

Amplified dispersion

medication

forced at high speed through a tiny orifice

very high SA/V ratio

enhanced tissue disruption

Injection event lasts less than 0.5 sec.

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BENEFITS OF NEEDLE-FREE INJECTIONS[2]

Eliminates needle phobia

Increased patient compliance

Higher dispersion pattern

Lower pain & stress

Targeted immune response (eg. Vaccine)

Faster injection time (0.5 sec.)

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APPLICATIONS

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1. Intramuscular, subcutaneous and intradermal administration of Vaccinese.g. smallpox, polio, measles

2. Intradermal administration of hormonese.g. growth hormone

3. Intradermal administration of anestheticse.g. Lidocaine

4. Subcutaneous administration of insulin.

5. Used in the treatment of migraine e.g. sumatriptan

It uses pressure from a

spring loaded piston to

create a fine stream of

insulin through a small

bore nozzle, delivering

insulin to the subcutaneous

layer.

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Recojet is India’s first needle-free insulin delivery device.

DIFFERENT NEEDLE FREE INJECTORS

AVAILABLE IN THE MARKET

Technology/product name Company name Description

Implaject Caretek Medical

Simple, hand-held needle

free injection device. Can be

configured to be reusable

with disposable cartridges.[3]

Injex 30 Injex (HNS International)

Spring-powered hand-held

device with disposable

ampoules that delivers

0.05-1 ml. Focused on

insulin delivery.[5]

Intraject Weston Medical

Applicable to drugs including

proteins, peptides,

monoclonal antibodies, small

molecules and vaccines.[6]

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CURRENT TECHNOLOGIES

B-2000 Iject

Vitajet 3

Biojector-2000

ONGOING CLINICAL RESEARCH

Currently, over 30 research collaborations

Pharmaceutical – Biotech – Academic Centers – Government

NIH

– HIV

NCI

– lymphoma

MSK

– melanoma

USNMRC

– malaria

THE FUTURE

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Many of these needle-free alternative technologies are in the development stage.

Inhalers are being improved as are nasal sprays, forced air injectors and patches.

In the future, other foods may be genetically enhanced to deliver vaccines and other drugs.

These include foods like bananas and tomatoes.

ID PEN™

REFRENCES

1. Vivek Ranjan Sinha, Aman Trehan, Pramil Tiwari:”Needle Free Injection Technology”:Express Healthcare Management (1st-15th July 2005)

2. Henry, C. "Special Delivery." Chemical & Engineering News (September 18, 2000): 49-65.

3. Potera, C. "Making Needles Needless." Technology Review (September/October 1998): 67-70.

4. Potera, C. "No-Needle Vaccine Techniques." Genetic Engineering News (August 1998): 19.

5. http://bobbydyer.com/wp-content/uploads/2011/01/Needleless%20injection%20thesis.pdf

6. Mitragotri S. Current status and future prospects of needle-free liquid jet injectors. Nature Reviews Drug Discovery. July 2006; 5: 543-548.

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