Biologia plegable

DNA repair gene involved in tumours and Researchers

unravel secrets of parasites' replication

Jerónimo Escobar RMedical student UPBMolecular BiologyAugust 6th 2012

Folding.

Folding.

Introduction.

DNA repair gene involved in tumours

• Cancer as we know is an uncontrolled cell division caused by problems in the high regulated process, That’s why cells continue growing in an unusual and pathological way causing organ failure and in a large number of cases death.


• Pituitary tumors are rare compared with some others types of cancer and generally they are benign. therefore chemotherapy is the best option for treatment of the disease and MGTM repair gen has an important role as biomarker for chemo.


studyEvaluate 12

Pituitary tumours

12 expressing high levels of

gen MGMT gen

7 expressing low levels of MGMT

gen

Showed activation of

genes implicated in

chemotherapy resistance

Showed activation of

genes implicated in DNA repair and gene

trascription


This molecular discovery show us that loss of MGMT expression may contribute to the progression of pituitary cancer and can be a new perspective for some others researchers interested in finding treatment from the pathological development of the illness.


it is a tremendous achievement in cancer treatment with chemo, denying what is believed about the role of MGMT gene in pituitary cancer disease and even better, this opens a window in investigations in other types of cancer and finally this will help to completely understand all about the molecular origin of cancer and how to stop it once and for all.

Researchers unravel secrets of parasites' replication

• Since the discovery of illness caused by parasites, scientists have been trying to fight them in a similar way as is made with bacterias by using antibiotics , but unfortunately there has been no success. Therefore scientists had to fight them inside the host, achieving destroy the parasite but also sometimes the patient.


• the researchers focused on discovering the process of replication and organization of Trypanosoma brucei mitochondrial DNA, radioactively marking 1 of the 6 polymerases it has, through fluorescence.


after follow-up of the protein, it was able to describe which is the role played by mtDNA polymerase ID (POLID) in the process of Mitochondrial DNA of the parasites


Trypanosoma brucei

using

immunofluorescence

marking

mtDNA polymerase

during

the replication

finding

The paper of the polymerase

in replication cycle


these findings are exciting because of the importance to combating tropical parasitic diseases that cause thousands of deaths per year and have been a major health problem mainly in countries in process of development affecting child population and those in poverty

Opinion of DNA repair gene involved in tumours

• in medical application, the study results are important because by measuring levels of MGMT gene in patients, we can foresee whether the tumor will create immunity to chemotherapy or otherwise stimulate new genes responsible for genetic repair transcription.

Opinion of DNA repair gene involved in tumours

• This study is important as it can be replicated in another different types of cancer other than pituitary and it works to determine how the gene interferes with other types of neoplasms.


Is a breakthrough for the treatment of parasitic diseases since of being found a new mechanism to fight or inhibit the replicative parasite, would not be necessary the use of current medications, which apart from destroying the parasite, cause tremendous systemic and cell harm in the host.


Using the new discovery, the replicative process of Trypanosoma bruci can be inhibited and thereby treat African sleeping sickness in a more efficient way and with fewer side effects and prevent the emergence of new epidemics of the disease such as Africa has suffered since the 19th century.

Bibliography.

•MARTÍNEZ, Lina; Biología molecular, Vol 6. ed. UPB, 2011. Pgs 74-84. •Researchers unravel secrets of parasites' replication; phys; July 10, 2012.http://phys.org/news/2012-07-unravel-secrets-parasites-replication.html •DNA repair gene involved in tumours; sciencealert; July 30, 2012.http://www.sciencealert.com.au/news/20122907-23618.html

Gracias!!

Technology

Biologia plegable