Plegable biologia molecular-Manuela Colorado

Manuela Colorado Builes

Medicine Student

UPB

2012

PROTEIN THAT MAY REPRESENT NEW TARGET FOR TREATING

TYPE 1 DIABETES IDENTIFIED

AND

CHARGES GOING ASTRAY: NEW TRANSFER PATHS FOR

ELECTRONS DISCOVERED

FOLDING

FOLDING

INTRODUCTION

PROTEIN THAT MAY

REPRESENT NEW TARGET

FOR TREATING TYPE 1

DIABETES IDENTIFIEDScienceDaily (Jan. 4, 2012)

PROTEIN THAT MAY REPRESENT NEW TARGET FOR

TREATING TYPE 1 DIABETES IDENTIFIEDScienceDaily (Jan. 4, 2012)

• Only 5% of people with diabetes have this

form of the disease.

• Type 1 diabetes is usually diagnosed in

children and young adults, and was previously

known as juvenile diabetes. In type 1

diabetes, the body does not produce insulin.

• IHOP (Islet Homeostasis Protein), is located in

the islets of the pancreas, next to cells that

secret insulin and glucagon.

Inhibited glucagon

IHoP lost it’s expression

Insulin decrease

Glucagon increase

Deaths of cells that produce insuline



If IHoP isn’t found, the pancreas goes into a critical state

initiating the process of type I diabetes.

IHoP creates balance between glucagon and insulin

• The high IHop was present in health people.

• The IHop didn’t express in people with diabetes.



OBSERVATION

I Think that this investigation is very

important, because help to find a

treatment to type 1 diabetes in the future,

but it’s essential investigate more about

this disease at the molecular level to

reduce its morbidity and mortality in the

world.

CHARGES GOING STRAY:

NEW TRANSFER PATHS FOR

ELECTRONS DISCOVEREDScienceDaily (Jan. 13, 2012)

CHARGES GOING STRAY: NEW TRANSFER PATHS FOR


• Electron transfer is one of the most important

classes of chemical reactions, because The chains

of this process, provide energy in a gradient

concentration of H, and electrical to make ATP in

the membrane transport protein.

• The study was carried out in

the cytochrome photolyase protein family.

+

• Even if the family protein share the same cascade of amino acids and structural similarities, the electrons did not have the same behavior.

• In the cyanobacterial cryptochrome the electrons have different paths although had to cover a larger distance.

Known (top) and newly discovered (bottom) charge

transfer path. (Credit: Image courtesy of Albert-

Ludwigs-Universität Freiburg).



• The aminoacids are very important to

the transfer of electrons.

• The orientation of the aminoacids has

a stronger influence on electron-

transfer efficiency.



OBSERVATION

• This investigation is very important,

because the transfer of electrons, is a

chemical reaction very important at

level molecular.

• I think that this issue receives little

attention in research, so it is necessary

to stimulate this kind of investigation.

MEDICAL UTILITY

MEDICAL UTILITY

• The investigation is very important in

our area because it allows new medical

treatments and advances for the

health.

• The best way to gain new knowledge is

involved in research projects, either as

a medical student or doctor.

MEDICAL UTILITY

Scientific investigation

Research of solutions to problems

• Find a cure

• New and better treatment

• Find improvement in the quality of life.

MEDICAL UTILITY

• In these case the investigations are

very important in the area of

medicine and the molecular biology,

because one of them found a

treatment to a incurable disease, like

type 1 diabetes, and the other

research to get better forms and

materials for the production and

distribution of energy.

BIBLOGRAPHY

• Martínez Sánchez, LM. Vargas Grisales N, Toro Montoya AE, Pamplona Sierra AP, Quevedo Orrego E. Biología Molecular. 6 Ed. Medellín. UPB: Fac. de Medicina; 2011.

• VOET D, VOET, JG. Bioquímica. 3 ed. Buenos Aires. Medica Panamericana; 2006. p. 591-592.

• MINSAL, S. Guía Clínica Diabetes Mellitus Tipo 1. 1. Ed. Ministerio De Salud. 2005. 7-8 p.

¡THANKS!

Health & Medicine

Plegable biologia molecular-Manuela Colorado