Lymph Lymph NodeNode

Prof. Dr. Yehia El AlfyProf. Dr. Yehia El Alfy

Patterns of reactive Patterns of reactive hyperplasiahyperplasia

Benign reactive lymph node

Reactive follicular Reactive follicular hyperplasiahyperplasia

TUMORS OF LYMPH NODESTUMORS OF LYMPH NODES11- Primary tumors- Primary tumors LymphomaLymphoma: : Malignancy of lymphocytes. (within lymph nodes

or extranodal tissues) , including: a. a. Hodgkin’s lymphomaHodgkin’s lymphoma (HL), with important (HL), with important

clinical & histological distinctionclinical & histological distinctionb. Non-Hodgkin’s lymphoma (NHLsb. Non-Hodgkin’s lymphoma (NHLs), ),

comprising all forms besides HL comprising all forms besides HL LeukemiasLeukemias:: usually exhibit widespread involvement of bone usually exhibit widespread involvement of bone

marrow, accompanied by large numbers of circulating tumor marrow, accompanied by large numbers of circulating tumor cellscells

2- Secondary tumors or 2- Secondary tumors or metastasismetastasis:: More frequent than the primary group More frequent than the primary group and occur in the L.N.s draining cancerand occur in the L.N.s draining cancer. The nodes become . The nodes become enlarged, firm and fixed. The cut surface is grayish-white enlarged, firm and fixed. The cut surface is grayish-white

Burkitt’s LymphomaBurkitt’s Lymphoma

Lymphoma, Lymph nodeLymphoma, Lymph node

SplenomegalySplenomegaly

Spleen

Non-Hodgkin’s Lymphoma Non-Hodgkin’s Lymphoma (NHL(NHL))

Malignant neoplasms characterized by proliferation of the cells originating from lymphoid tissue (lymphocytes, histiocytes and their precursors and derivatives) .

Classification of NHLClassification of NHL- Based on the - Based on the clinical behaviour and prognosisclinical behaviour and prognosis::1- Low-grade NHL1- Low-grade NHL::

Small lymphocytic * Follicular small cellSmall lymphocytic * Follicular small cell 2- 2- Intermediate-grade NHLIntermediate-grade NHL::

Follicular large cell * Diffuse small cellFollicular large cell * Diffuse small cell 3- 3- High-grade NHLHigh-grade NHL::

Immunoblastic * Lymphoblastic * Burkitt’s lymphomaImmunoblastic * Lymphoblastic * Burkitt’s lymphoma

4- Miscellaneous4- Miscellaneous: : Histiocytic lymphoma, Mycosis fungoides ..etcHistiocytic lymphoma, Mycosis fungoides ..etc..

Follicular lymphomaFollicular lymphoma 1- Section of lymph node.1- Section of lymph node. 2- 2- Complete lossComplete loss of normal lymph of normal lymph

node architecture andnode architecture and Effaced by Effaced by folliclesfollicles formed of formed of

monotonous malignant lymphocytes with monotonous malignant lymphocytes with deeply staining pleomorphic deeply staining pleomorphic hyperchromatic nuclei and thin rim of hyperchromatic nuclei and thin rim of cytoplasm. cytoplasm.

Follicular lymphomaFollicular lymphoma

Follicular lymphomaFollicular lymphoma

Follicular lymphomaFollicular lymphoma

Diffuse Non Hodgkin’s Diffuse Non Hodgkin’s lymphomalymphoma

1- Section of lymph node.1- Section of lymph node. 2- 2- Complete lossComplete loss of normal lymph of normal lymph

node architecture andnode architecture and Effaced by diffuseEffaced by diffuse monotonous monotonous

malignant lymphocytes with deeply malignant lymphocytes with deeply staining pleomorphic hyperchromatic staining pleomorphic hyperchromatic nuclei and thin rim of cytoplasm. nuclei and thin rim of cytoplasm.

Diffuse NHLDiffuse NHL

Diffuse NHLDiffuse NHL

Diffuse NHLDiffuse NHL

Diffuse NHLDiffuse NHL

Lymphoma

Metastasis of lymph Metastasis of lymph nodenode

1- Section of lymph node.1- Section of lymph node. 2- Lymph node tissue is 2- Lymph node tissue is partially partially

or or totallytotally replaced by replaced by masses masses or sheets or irregular glandular or sheets or irregular glandular structures, of pleomorphic structures, of pleomorphic hyperchromatic hyperchromatic malignant cellsmalignant cells separated by fibrous tissue separated by fibrous tissue stromastroma

3 R’s3 R’s of success: of success:

RRespect for self, espect for self, RRespect for others espect for others and and RResponsibility esponsibility for all your actions.for all your actions.