1. Glucagon Like Peptide-1 (GLP-1) Analogue

2. Liraglutide GLP-1 analogue with 97% homology to the human natural GLP. 3. Significance Better than natural GLP in Human body Longer half life periodHalf life period Natural GLP-1 -> 1.5 minutes Liraglutide-> 13 hours Therefore, can control blood glucose level for a longerperiod. 4. Advantages Helps promoting weight loss Increase insulin secretion Will not cause hypoglycaemia Reduce glucagon secretion 5. Adverse Effects Mild Nausea Vomiting Diarrhoea Constipation 6. Severe -Pancreatitis -Allergic reactions (Rashes, difficulty in breathing, tightness of chest, swelling of mouth, face, lips or tongue) -Symptoms of thyroid Cancer (Lump or swelling in neck, trouble swallowing, hoarseness of voice) 7. Critic Phase III LEAD studies LEAD- Liraglutide Effect and Action in Diabetes)LEAD 1 & 2 Add on therapyLEAD 3 - MonotherapyLEAD 4 & 5 - Triple TherapyLEAD 6 - Liraglutide Vs Exenatide (another GLP-1 analogue) 8. Inclusion criteria Type 2 diabetic patients Age 18-80 years Under Oral Glucose lowering agents(OGLA) for thepast 3 months or more BMI