Click here to load reader

Liraglutide as Additional Tt tiT 1DibtTreatment in Type 1 ... · PDF file Liraglutide as Additional Tt tiT 1DibtTreatment in Type 1 Diabetes Ajay Varanasi, Natalie Bellini, Deepti

  • View
    1

  • Download
    0

Embed Size (px)

Text of Liraglutide as Additional Tt tiT 1DibtTreatment in Type 1 ... · PDF file Liraglutide as...

  • Liraglutide as Additional T t t i T 1 Di b tTreatment in Type 1 Diabetes

    Ajay Varanasi, Natalie Bellini, Deepti Rawal, Mehul Vora, AntoineMakdissi, Sandeep Dhindsa, Ajay Chaudhuri and

    P h D dParesh Dandona

    Division of Endocrinology Diabetes and MetabolismDivision of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo

  • "J.L." before insulin on December 7, 1922 (15 pounds) and after insulin on February 26, 1923 (30 pounds).

  • *

    Incretin Effect*

    * *

    * **

    *

  • St d dStandard Deviation decreased

    average of 20 g mg/dl

  • 1) DF Pre- Victoza HBA1C = 7.4

    On Victoza

    Post Victoza

  • The Pathogenesis of Type 2 DiabetesThe Pathogenesis of Type 2 Diabetes BetaBeta--Cell Workload Outpaces BetaCell Workload Outpaces Beta--Cell ResponseCell Response The Pathogenesis of Type 2 DiabetesThe Pathogenesis of Type 2 Diabetes BetaBeta--Cell Workload Outpaces BetaCell Workload Outpaces Beta--Cell ResponseCell Response

    Healthy Subjects (n = 14)

     Beta-Cell Workload  Beta-Cell Workload

    Type 2 Diabetes (n = 12)

     Beta-Cell Workload  Beta-Cell Workload

    Carbohydrate Meal

     Beta-Cell Response  Beta-Cell Response

    WorkloadWorkload

     Beta-Cell Response  Beta-Cell Response

    WorkloadWorkload

     Beta-Cell Beta-Cell

    ResponseResponse

     Beta-Cell Beta-Cell

    ResponseResponse

     Beta-Cell Workload  Beta-Cell Workload  Beta-Cell Workload  Beta-Cell Workload

    EuglycemiaEuglycemiaEuglycemiaEuglycemiaHyperglycemiaHyperglycemia

    Mean (SE)

  • 3) KG Pre Vi tVictoza A1C 6.5

    O Vi tOn Victoza

Search related