Liraglutide as Additional Tt tiT 1DibtTreatment in Type 1 ... · PDF file Liraglutide as Additional Tt tiT 1DibtTreatment in Type 1 Diabetes Ajay Varanasi, Natalie Bellini, Deepti

Liraglutide as Additional T t t i T 1 Di b tTreatment in Type 1 Diabetes

Ajay Varanasi, Natalie Bellini, Deepti Rawal, Mehul Vora, AntoineMakdissi, Sandeep Dhindsa, Ajay Chaudhuri and

P h D dParesh Dandona

Division of Endocrinology Diabetes and MetabolismDivision of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo

"J.L." before insulin on December 7, 1922 (15 pounds) and after insulin on February 26, 1923 (30 pounds).

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Incretin Effect*

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St d dStandard Deviation decreased

average of 20 g mg/dl

1) DF Pre- Victoza HBA1C = 7.4

On Victoza

Post Victoza

The Pathogenesis of Type 2 DiabetesThe Pathogenesis of Type 2 Diabetes BetaBeta--Cell Workload Outpaces BetaCell Workload Outpaces Beta--Cell ResponseCell Response The Pathogenesis of Type 2 DiabetesThe Pathogenesis of Type 2 Diabetes BetaBeta--Cell Workload Outpaces BetaCell Workload Outpaces Beta--Cell ResponseCell Response

Healthy Subjects (n = 14)

 Beta-Cell Workload  Beta-Cell Workload

Type 2 Diabetes (n = 12)

 Beta-Cell Workload  Beta-Cell Workload

Carbohydrate Meal

 Beta-Cell Response  Beta-Cell Response

WorkloadWorkload

 Beta-Cell Response  Beta-Cell Response

WorkloadWorkload

 Beta-Cell Beta-Cell

ResponseResponse

 Beta-Cell Beta-Cell

ResponseResponse

 Beta-Cell Workload  Beta-Cell Workload  Beta-Cell Workload  Beta-Cell Workload

EuglycemiaEuglycemiaEuglycemiaEuglycemiaHyperglycemiaHyperglycemia

Mean (SE)

3) KG Pre Vi tVictoza A1C 6.5

O Vi tOn Victoza