DNA REPLICATION

Isabella Montoya Botero.Medicine Student.

UPB.

DNA is composed of two strands.

DNA replication occurs in the S phase of the cell cycle.There are human diseases associated with defects in DNA replication.

NEW STUDY REVEALS THE NEW STUDY REVEALS THE STRUCTURE OF DNA STRUCTURE OF DNA

HELICASE AT THE HELICASE AT THE REPLICATION FORK.REPLICATION FORK.

Van Andel Research Institute.(2017, January 16).


HELICASE AT THE HELICASE AT THE REPLICATION FORKREPLICATION FORK

Helicase activity has long been recognized as a critical part of DNA replication. It separates double-stranded DNA into single strands.



Scientists at the Van Andel Research Institute have successfully described how the CMG helicase works from a purified sample of Saccharomyces cerevisiae.



This investigation showed that helicase presents a different orientation to the commonly accepted model, which helps us to understand how it acts in DNA replication.

OPINIONOPINIONThis discovery is important to know the orientation and mechanism of action of this enzyme, because it has important implications in understanding the replication process. Also, helicase activity has been recognized as a fundamental part in the propagation of life.

DNA DUPLICATOR SMALL DNA DUPLICATOR SMALL ENOUGH TO HOLD IN YOUR ENOUGH TO HOLD IN YOUR

HAND.HAND.Vanderbilt University.

(2017, January 11).


HANDHAND

Engineers at Vanderbilt University have developed a prototype adaptive PCR device, which is used to control the DNA duplication process.


HANDHANDThis prototype uses fluorescently labeled L-DNA which provides information about molecular reactions that take place during the PCR process.


HANDHAND

The prototype adaptive PCR device is easy to handle and has less sensitive to environmental conditions.

OPINIONOPINIONThis prototype is an important breakthrough that could help to identify more effectively when bacteria or viruses are causing an infection, and allow us to detect tumor cells, mutations, and polymorphisms. In addition, it can make molecular and genetic analysis with less margin of error.

MEDICAL MEDICAL UTILITYUTILITY

MEDICAL UTILITY: MEDICAL UTILITY: NEW STUDY NEW STUDY

REVEALS THE REVEALS THE STRUCTURE OF DNA STRUCTURE OF DNA


Several human genetic syndromes are associated with defects in DNA replication mechanisms.

It’s necessary to know the helicase activity, which has an important role in DNA replication, because this allows us to understand the origin of the disease to perform a timely intervention.

MEDICAL MEDICAL UTILITY: DNA UTILITY: DNA DUPLICATOR DUPLICATOR

SMALL ENOUGH SMALL ENOUGH TO HOLD IN TO HOLD IN YOUR HANDYOUR HAND

This discovery will allow us to perfect the different applications of PCR, such as establishment of polymorphisms, mutation tracking, prenatal diagnosis of genetic diseases, detection of infectious microorganisms and tumor cells, etc.

Both researches offer information that helps us to understand the phenomenon that guarantees the succession of life and the basic mechanism of conservation of species.

BIBLIOGRAPHYBIBLIOGRAPHY◦ Van Andel Research Institute. (2017, January 16). New study reveals the structure of DNA helicase at the replication fork. ScienceDaily. Retrieved February 06, 2017 from https://www.sciencedaily.com/releases/2017/01/170116160548.htm.

◦ Vanderbilt University. (2017, January 11). DNA duplicator small enough to hold in your hand. ScienceDaily. Retrieved February 06, 2017 from https://www.sciencedaily.com/releases/2017/01/170111131101.htm.

◦ Martínez Sánchez, Lina María. Biología Molecular. 8 ed. Medellín: UPB. School of Medicine, 2015.

https://www.sciencedaily.com/releases/2017/01/170116160548.htm

https://www.sciencedaily.com/releases/2017/01/170111131101.htm

Health & Medicine

DNA REPLICATION