Danny Arroyave ZuluagaMedicine student

III semesterMolecular biology

“Cell division discovery could offer fresh insight into cancer” and “Blood

test to locate gene defects associated with cancer

may not be far off”

news dealing with the different

forms and types we have

studied the DNA and the major

influence on cellular activity.

These newswire are clear

examples of how sophisticated

new methods for a large

component of the body such as

the blood can give us new

solutions to major pathologies.

INTRODUCTION

Cell division discovery could offer fresh insight into cancer

sciencedaily, January 14, 2014

• In molecular biology, mitosis is a process that occurs in the nucleus of eukaryotic cells and immediately preceding cell division comprising the characteristic equal distribution of genetic material (DNA)

• there are 4 different stages: prophase, metaphase, anaphase and telophase

Cell division discovery could offer fresh insight into

cancer

sciencedaily, January 14, 2014

• Ska complex (proteins), help anchor DNA, the form of chromosomes, by interacting with strands of cell material. Chromosomes remain attached to these strands as they are separated, in a process that helps distribute DNA correctly to the newly formed cells.

Cell division discovery could offer fresh insight into

cancer

sciencedaily, January 14, 2014• Scientists determined

the structure of the relevant part of the protein complex by analysing crystals of it with lab tools and cell-based experiments. This showed how the Ska complex attaches to the strands, helping to bind the DNA material.

Cell division discovery could offer fresh insight into

cancer

sciencedaily, January 14, 2014• "Our findings

represent a milestone in resolving the mystery of how these key proteins enable new cells to separate properly and equally, in this essential process for life. The findings of our work have the potential to create new avenues in drug discovery towards fighting cancer."

observation

I think the meaning of this important discovery at the molecular level, shows us the advances in medical science and

through this will come at last to save lives from something such as the

cancer

• simple blood test could be developed to determine whether gene mutations associated with pancreatic cancer exist without the need of locating and testing tumor tissue.

Blood test to locate gene defects associated with cancer may

not be far off

sciencedaily January 8, 2014

Blood test to locate gene defects associated with cancer

may not be far off

sciencedaily January 8, 2014

• the discovery that tiny particles the size of viruses called 'exosomes,' which are shed by cancer cells into the blood, contain the entire genetic blueprint of cancer cells.

Blood test to locate gene defects associated with cancer

may not be far off

sciencedaily January 8, 2014

• that DNA derived from exosomes carried the same cancer-related genetic mutations compared to the cancer cells taken from tumor.

• The analysis of exosome DNA taken from blood samples may not only help determine the presence of a cancerous tumor somewhere in the body but also identify mutations without a need for tumor sample

Blood test to locate gene defects associated with cancer may not be far off

sciencedaily January 8, 2014

observation

this study seems very interesting as it talked about how to identify a

possible cancer will be easier and faster by the greater chance of cure

for people who suffer from this.

• with the discovery of these proteins that play an important role in a process such as the cell division, should make the most as these could be a great start to lessen a disease such as cancer and better able to deal effectively with these.

Cell division discovery could offer fresh insight into

cancer

Blood test to locate gene defects associated

with cancer may not be far off• with this new

opportunity to discover mutations in an early stage, it should be performed in all individuals even so you have no suspicion as they would be talking about prevention of disease which today claims thousands of lives.

• a very important thing to consider in this discovery is that this method to detect cancer in patients is minimally invasive, and not to take samples of the tumor, avoiding costly and unnecessary risks.

Blood test to locate gene defects associated

with cancer may not be far off

Blood test to locate gene defects associated

with cancer may not be far off• with the discovery

that cells cencerigenas leave "traces" are drugs and should make this road may lead us to the probable site of the tumor in the body and thus act more quickly and effectively

BIBLIOGRAPHY• Martínez S, Lina María. Biología Molecular. 7 ed. Medellín: UPB.

Facultad de Medicina, 2012. 59-67.P• Maria Alba Abad, Bethan Medina, Anna Santamaria, Juan Zou,

Carla Plasberg-Hill, Arumugam Madhumalar, Uma Jayachandran, Patrick Marc Redli, Juri Rappsilber, Erich A. Nigg, A. Arockia Jeyaprakash. Cell division discovery could offer fresh insight into cancer. Sciencedaily, (online magazine), 2014(January 14) available online: http://www.sciencedaily.com/releases/2014/01/140114103013.htm

• C. Kahlert, S. A. Melo, A. Protopopov, J. Tang, S. Seth, M. Koch, J. Zhang, J. Weitz, L. Chin, A. Futreal, R. Kalluri. Blood test to locate gene defects associated with cancer may not be far off. Sciencedaily, (online magazine), 2014 (January 8) available online: http://www.sciencedaily.com/releases/2014/01/140108154041.htm

THANKS