1. Summer School 2nd June - 6th June 2014 TROMS EPINOR
2. 3 Index Welcome............................. 4 - 7 The
Programme .......................... 9 - 11 The
Lecturers........................... 13 - 19 The
Abstracts........................... 21 - 81 General
Information....................... 83 - 87 Photos: Brd Lken
Destination Troms
3. 5 Welcome to the Index Main Chapter
4. 7 Welcome to the very first EPINOR Summer School. With this
I would like to use the opportunity to wish you welcome to the
first Summer School organized through EPINOR. I would also like to
thank you for deciding to participate! By being here you are laying
the foundation for this being a successful week and furthermore you
are influencing how we will plan this in the future. Without you
EPINOR is nothing and by your engagement you are shaping EPINOR. We
are sure you will find the program planned for this week exciting,
both the scientific writing and the social program. We have put
together a program on scientific writing since that has been
requested by a number of you. Janet Holmn who is responsible for
this week has extensive experience editing papers and commenting
texts, and we are fortunate that she took on this responsibility.
We are also looking forward to Sven Sandin focusing on statistics
in papers. Through the social program and the use of
Villmarkssenteret on Thursday we are hoping to show you some of the
amazing nature Troms has to offer. We are not only showing it to
you, but giving you the opportunity to feel it by jumping in the
sea from the Vulcana spa boat Monday and paddling kayaks on
Thursday. I hope you will enjoy all aspects of this week and help
us make this a successful week be engaging actively in discussions
and activities. With this we will build the foundation for a
lasting tradition of EPINOR. Enjoy! Torkjel M Sandanger Index Main
Chapter
5. 9 The Programme The week at a glance Index Main Chapter
6. 11 Index Main Chapter
7. 13 The Lecturers Janet
Holmn...............................14 - 15 Sven
Sandin................................16 - 17 Carel
Jacobs............................... 18 - 19 Index Main
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8. 15 Janet Holmen Janet Holmn is a freelance linguistic editor
and teacher of scientific communication. Her basic scientific
training was in biology, chemistry and earth sciences at Stockholm
University. After graduating she worked for nearly two decades as
an administrator at Swedens main biomedical university, Karolinska
Institutet, where an important part of her job was to edit sci-
entific manuscripts. In 1998, Janet started teaching courses in
scientific writing for PhD students at Karolinska Insti- tutet.
Writing Science quickly became one of the Institutes most popular
courses and Janet still teaches it there several times each year.
Janet has also worked for nearly a decade in the editorial offices
of two international peer-re- viewed journals: Life Sciences, where
she served as editorial assistant and managing editor, and Polar
Research, where she was editor. This gives her extensive experience
of an aspect of publication that researchers seldom see with their
own eyes. In her courses, Janet gives pro- spective authors a
glimpse of what goes on behind the scenes at an editorial office.
Asked why she teaches scientific writing, Janet says Some young
researchers feel so intimi- dated by the scientific literature that
they never manage to write anything at all. I want them to
understand enough about the publication process that they can relax
a bit. My goal is to demys- tify scientific writing maybe even make
it fun!Janet Holmn is available to do freelance work as linguistic
editor, translator and teacher. She currently lives in Svalbard.
Index Main Chapter
9. 17 Sven Sandin is a statistician and epidemiologist with
more than 25 years of experience. He has a broad experience from
the pharmaceutical industry running clinical trials, phases I to
IV, pre-clinical, production and toxicology, on a project level as
well as for individual studies in different areas such as
cardiovascular and pain relief. In epidemiology he has been
involved in questionnaire based cohort and case-control studies as
well as register based studies follow- ing individuals in full
national populations. He has participated in planning and execution
of studies collecting data using modern techniques such as mobile
phones, web questionnaires and java applications in areas such as
influenza surveillance, hearing aid and children weight control
programs. His research areas in epidemiology have mainly been
psychiatric epidemiology, cancer epi- demiology with focus on
female cancers and epidemiology involving cardiovascular diseases.
He has been involved in mapping risk associated with physical
activity, diet and diet patterns, parental age and co-morbidity.
His interest has all the time been aimed at integrating recent
modern statistical methods to solve real-life-problems in research.
He has especial interest in problems associated with study design,
survival analysis, family and longitudinal data and correlated data
and graphical pres- entations. He has interest and experience in
data management and statistical programming using a variety of
software such as SAS, R/S-Plus and Stata or working with relational
databases using SQL. Ongoing research include: Autism aetiology and
autism risk in family perspective, e.g. studying risk across
generations separating maternal and paternal risk, studying the
role of grandparental risk and in acting in families by
heritability and individual risk measures Generally, aetiology
associated with pre- and perinatal risk factors The effect of
physical activity, diet and nutrition on female cancer, car-
diovascular and psychological diseases and disorders The effect of
D-vitamin on cardiovascular and psychiatric disorders and diseases
Epidemiology and surveillance of Legionnaire disease in Europe
Karolinska Institutet Sven Sandin Index Main Chapter
10. 19 Carel Jacobs is associate partner of Itim. He is also
Certification Agent for the Educational Sector of the Hofstede
Centre. He has a Masters degree from Tilburg University (The
Nether- lands) in social sciences with a specialisation in the
sociology of organisations and management of change. Carel has
always been working in the world of organisation development,
managing change, training and education. He was consultant,
trainer, project manager, interim manager and director in different
organisations in both the public sector (e.g. institutes for
professional education, Fire Service Academy, Dutch National
Training Institute) and private sector. Due to his international
meetings and projects he became interested in cultural differences
between participants from different countries and became
enthusiastic about the scientific research of professor Hofstede.
Now, as a senior consultant he supports organisations in drafting
strategic business and strate- gic marketing, community building,
integrated management, change management, total quality management,
intercultural management, organisation culture and diversity, in
both the public sector (universities, government, the Dutch
National Bank) and the private sector. He was project manager and
trainer in a number of international projects, e.g. in the Czech
Republic (consulting about international affairs for the Czech
Chamber of Commerce), Romania (developing mission, strategy and
marketing for the National Training Institute) and Slovakia
(training of HR directors in developing education policy and
managing training programmes). He is also professional moderator of
strategic conferences and is trainer in moderation, man- agement
skills and intercultural management. Carel has published books
(integrated management, information management, total quality
management), produced a tv-programme (TELEAC Television on
integrated management) and educational videotapes (skills training
in the fire service) and wrote articles about integrated
management, how to attract and capture professionals, management of
change, total qual- ity management, information management,
intercultural management, organisation culture, training needs
analysis, new learning methods and transfer of training. Carel
Jacobs itim International/ The Hofstede Centre Schimmelpennincklaan
19 6871 T Renkum The Netherlands email: [email protected]
Telephone: + 31 6 23495074 Web: www.itim.org Index Main
Chapter
12. 23 Project Title Personal Care Products and female health:
exploring endocrine effects of parabens on Cancer of breast and
endometrium and genomic pathways Personal interests Skiing,
Climbing Department of Epidemiology, UiT-The Arctic University of
Norway Parabens are a group of chemical compounds used as
preservatives in lotions, food and phar- maceuticals due to their
antimicrobial and antifungal properties. Parabens are alkyl esters
of p-hydroxybenzoid acid, related to the naturally occurring
benzoid azid in plants. The exposure to humans is expected to be
widespread due to the heavy use of parabens. One of the major
exposure routes is dermal absorption from cosmetic products such as
skin lotion. The aim of my project is to do an epidemiological
study on the potential endocrine disruptive effect of paraben, with
breast cancer and endometrial cancer as endpoints. A majority of
pre- vious studies on health effects of parabens are animal studies
and cell lines. The study is based on a paper published by
Sandanger et al. 2010, where blood samples from 332 participants of
the NOWAC study were analysed and compared to their use of skin
care products. A strong correlation between self-reported use of
skin lotion and concentration of methylparaben and propylparaben
was found, indicating that despite a short half-life, high
concentrations are maintained in blood with the continuous use of
skin care products. I will characterize women highly exposed to
methyl- and propyl parabens through frequent use of personal care
products, then study the effects of personal care product use on
hormone sen- sitive cancers of breast and endometrium. Finally I
will study the effects of paraben exposure from personal care
products on blood gene expression. Parabens are they really
endocrine disruptors? Boel Aniansson Index Main Chapter
13. 25 UiT-The Arctic University of Norway email:
[email protected] telephone: 99273106 Vivian Berg Project title
The northern Norway mother-and-child con- taminant cohort study
(misa). Investigation of emerging persistent toxic substances
Personal interests Music, books and outdoor activities Determining
maternal concentrations of per- and polyfluoroalkyl substances
(PFASs) and the relative impact of various demographic and dietary
predictors is important for assessing foetal exposure and for
developing proper lifestyle advisories for pregnant women. This
study was conducted to investigate maternal PFAS concentrations and
their predictors in years when the production and use of several
PFASs declined, and to assess the relative impor- tance of
significant predictors. Blood from 391 pregnant women participating
in The Northern Norway Mother-and-Child con- taminant Cohort Study
(MISA) was collected in the period 2007-2009 and serum analyses of
26 PFASs were conducted. Associations between PFAS concentrations,
sampling date, and demo- graphic and dietary variables were
evaluated by multivariate analyses and linear models includ- ing
relevant co-variates. Parity was the strongest significant
predictor for all the investigated PFASs, and nulliparous women had
higher concentrations compared to multiparous women (10 ng/mL
versus 4.5 ng/ mL in median PFOS, respectively). Serum
concentrations of PFOS and PFOA of women recruited day 1-100 were
25% and 26% higher, respectively, compared to those women recruited
in the last 167 days of the study (day 601-867), and the
concentrations of PFNA, PFDA and PFUnDA increased with age. Dietary
predictors explained 0-17% of the variation in concentrations for
the different PFASs. Significantly elevated concentrations of PFOS,
PFNA, PFDA and PFUnDA were found among high consumers of marine
food. The concentrations of PFHxS, PFHpS and PFNA were also
increased in high consumers of game and elevated concentrations of
PFHpS and PFOS were detected in high consumers of white meat. Study
subjects with a high intake of salty snacks and beef had
significantly higher concentrations of PFOA. The present study
demonstrates that parity, sampling date and birth year are the most
impor- tant predictors for maternal PFAS concentrations in years
following a decrease in production and use of several PFASs.
Further, dietary predictors of PFAS concentrations were identified
and varied in importance according to compound. The northern Norway
mother-and-child contaminant cohort study (misa). Investigation of
emerging persistent toxic substances Index Main Chapter
14. 27 Maria Carlsson Department of Clinical Medicine, UiT-The
Arctic University of Norway email: [email protected] Project
title Temporal trends in incidence, risk factors and fatality of
intracerebral hemorhage . The troms study 1974-2010 Personal
interests Outdoor life, photography Career ambitions/interests
Finish my phd degree. Continue my career as a MD and continuing
research about stroke. Introduction Intracerebral hemorrhage (ICH)
is a disease with high morbidity and mortality. The possibilities
for treatment are limited. Aim The aim of the study was to explore
temporal trends in incidence of ICH in a Norwegian community.
Methods The Troms study, started in 1974, is an ongoing
population-based study which has included 40 051 individuals. All
participants are being followed up with registration of incident
primary intracerebral hemorrhage. Crude and adjusted incidence
rates for first-ever ICH were calcu- lated. Age- and sex-adjusted
trends in incidence rates over time were analysed using Poisson
regression. Because older birth cohorts were not enrolled in the
earliest surveys, analyses were made for the period 1995-2010.
Results We identified 199 ICH events in the study-population aged
30 years in 1995-2010. The overall age- and sex-adjusted incidence
rate was 0.43 (95% CI 0.37-0.49) per 1000 person-years. The crude
and adjusted incidence rate in women was 0.45 (95% CI 0.370.55) and
0.36 (95% CI 0.28- 0.43) and in men 0.53(95% CI 0.440.64) and 0.52
(95% CI 0.42-0.62) per 1000 person-years, respectively. In
participants
