Social Entrepreneurship

September 2010 Harvard Business Review

“If you’re not thinking about [social entrepreneurial] collaboration, you’ll soon be guilty of strategy malpractice.”

Four Keys to Building a Successful Social Entrepreneurial Organization

Four Keys#1 Take on a Global Problem#2 Create an Innovative New

Solution#3 Tap into the Passion of the

Public#4 Find New Ways to Fairly

Compensate Participants

#1 Take on a Global Problem

Malnutrition

“Malnutrition kills five million children under the age of five each year in developing countries.” – UNICEF

“Between one-third to one-half of all childhood deaths in the world are linked to malnutrition.” – New York Times

Classic Malnutrition

Malnutrition affects more than 925 million people globally. In developed countries it is under diagnosed and undertreated because it is largely unrecognizable.

Malnutrition is Now a Global Epidemic

Both could be dramatically undernourished.

What might these two kids have in common?The New “Hidden Hunger”

Micronutrient DeficiencyA Missing Link in Overweight Children

Study shows that odds of being overweight or obese were 80.8% higher for children deficient in essential vitamins and minerals.

JAAIM, Fall 2010

• Is the leading cause of death in the U.S. – Up to 580,000 deaths per year.

• Is a major cause of disability in seniors.

• Is linked to about 75% of total health care costs.

Unhealthy Eating and Physical Inactivity

Nutritional Fact Approximately 90% of the

money Americans spend on food is used to buy processed food.

U.S. Department of Commerce, 1999

“A lot of what we see in the supermarket I would argue is not really food. It’s what I call edible, food-like substances.”

Documentary Food, Inc.

Which do you think offers the best nutrition?

Fruits, Veggies Not as Vitamin-Rich as in Past, Says New DataLarger Fruits and Vegetables Mean More Plentiful but Less Potent BountyBy MEGAN CARPENTER March 1, 2006 — Fruits and veggies aren't what they used to be, new data suggests. Of the 13 major nutrients found in fruits and vegetables, six have declined substantially, according to a study by Donald Davis, a biochemist at the University of Texas at Austin.Using data from the U.S. Department of Agriculture, Davis concludes that recently grown crops have shown decreases of up to 38 percent in protein, calcium, vitamin C, phosphorus, iron and riboflavin when compared with produce from past decades.What accounts for this negative trend? Like any other competitive industry, farmers' attempts to drive up profits have led them to use new techniques to increase production, Davis said. The faster-grown fruits don't have as much time to develop the nutrients. "Farmers get paid by the weight of a crop, not by amount of nutrients," Davis said. He called this the "dilution effect": As fruits and vegetables grown in the United States become larger and more plentiful, they provide fewer vitamins and minerals.

“It’s as though the food industry and the medical industry are conspiring against the consumer.”

Commercial FarmingIndustry

that profits from growing fruits and vegetables bigger and faster

Processed FoodIndustry

that profits from making inexpensive “food-like substances”

Poor Health

Pharmaceutical Industrythat profits from the management of poor health

associated with poor nutrition

For the First Time in Over 100 Years

The life expectancy of U.S. kids might actuallydecline, according to a 2005 study published inThe New England Journal of Medicine.

#2 Create an Innovative New Solution to a Global Problem Because What

We’re Doing is Not Working

Innovative SolutionMannatech has Developed and

PatentedReal Food Technology® Solutions

Foods are comprised of synergistic blends of various nutrients bound together into what’s called the food matrix.

It is the food matrix, not its individual nutritional constituents, that best supports human biological processes. Nutrition Reviews, Vol. 65, No. 10

October 2007

Synthetically Made Plant-Sourced

Standardized Nutrient SourcesWhat do people really want?

Coal Tar Petroleum

Do consumers know that most synthetic vitamins are made from

fossil fuels?

Vitamin Facts• Vitamins originate primarily from plant

tissues• Synthetically made vitamins are not

the same• Bioavailability of natural food complex

vitamins is better than most synthetically made vitamins

Medical Hypothesis (2000) 55 (6) 461-469

Synthetic Vitamin Studies#1. Study using synthetic beta

carotene and Vitamin E halted.29,000 male smokers were given synthetic beta carotene and synthetic Vitamin E. The study was stopped when rates of lung cancer, heart attacks and death increased. – New England Journal of Medicine, 1994.

#2. Birth defects increased for women on synthetic supplements.22,000 pregnant women were given synthetic Vitamin A. The study was halted because birth defects increased 400%. – New England Journal of Medicine, 1995.

New Study in Journal of Medical Association Says Synthetic Vitamins

Increase Risk of Death A meta-analysis of 47 clinical trials found that the supplementation of synthetic forms of vitamin A, beta carotene, and vitamin E, at doses larger than commonly found in a balanced diet, actually increased mortality risk.

Researchers pointed out that their observations do not apply to natural antioxidants [vitamins] such as those found in fruits and vegetables.

JAMA February 28, 2007

Mineral Facts: “Minerals are generally

recovered by mining ores or from byproducts of chemical processes. Tests have shown that the minerals contained in the most popular brands of multivitamins do not dissolve (they are not soluble) in either the stomach or small intestine. They probably pass through the body without being absorbed.”

Minerals and Diet, Burt D. Ensley, PhD

Plant-Sourced MineralsPlants uptake minerals through their root systems, predigest them and then bond them into a food matrix. This provides for increased solubility.

Patented hydroponic growing techniques and new whole-food stabilizing processes provide for standardized, food-based nutrients.

Real Food Technology® Solutions

Technology Patent Filed 2007

The Real Food Technology ® Solution for

Vitamin/Mineral and PhytoNutrient Supplementation

Discovery

“The Missing Link”in

Human Nutrition

1990

The first Journal of Glycobiology was published. In less than 10 years, the science of glycobiology had exploded to become one of the “hottest” new fields of medical and nutritional research.

Scientific Discovery

Of the 200 sugars in nature, our cells use these eight like letters of an alphabet to make cellular words call glycoproteins.

Harper’s Biochemistry Vol. 24. 1996

*Glucose Xylose Fucose N-acetylglucosamine Mannose N-acetylgalactosamine *Galactose N-acetylneuraminic acid

*Only two are commonly found in our diet

Glyconutrients

“Cell surface sugar [structures] are necessary for proper recognition and immune function.” Nature, Vol. 373. Feb 16, 1995

Sweet Language of Life

Immune cells read the cell surface sugar structures on other cells to determine if they’re healthy, need repair or need to be destroyed.

Missing Sugars Spell Trouble

When cells turn against the body, as in degenerative type functions, research has shown that sugars are missing from their glycoprotein structures.

“Removing a sugar [from its cell surface structures] turns protective antibodies (repair cells) into attackers.”

Capitalizing on Carbohydrates, 1991

Rockefeller University, July 4, 2007

Glycocompound Symposium:In 1998, executives from 22 companies met to discuss how to develop drug-based glycocompound therapeutics.

Archer Daniels Midland MerckBayer AG MITDow Chemical Monsanto Life SciencesDupont Proctor & GambleGenentech Stanford University

Sweet Medicine: Building Better Drugs from Sugars

(Synthesized Sugar Structures)Scientific American, July, 2002

Medicine’s Last Frontier

New Theory

Father of Nutritional Glycobiology

Altered glycoprotein structures might be a result of dietary deficiency of vital sugars.

Ambrotose® Glyconutrient Complex

•The first standardized blend of plant-sourced polysaccharides.

•45 patents obtained worldwide for technology related to the Ambrotose® complex formulation.

“The notion that any saccharide mixture will improve health is flawed…”

“It’s none of our business as glycobiologists if nutraceutical companies want to sell bark extracts. When they begin to tie it to our discipline, that is a problem.”

Science, 2 November 2007, Vol. 318

Study Results:• For first time science has shown that the ingestion of a

standardized blend of plant polysaccharides [Ambrotose] can induce significant changes in cell surface glycoprotein structures.

• No adverse events.

An open-label dosing study to evaluate the safety and effects of dietary plant-derived polysaccharide supplement on the N-glycosylation status of serum glycoproteins in healthy subjects

#3 Tap into the Passion that

the Public Feels for Your Cause

It Takes an Army of Concerned and Compassionate Individuals

to Make a Global Impact

Mannatech’s Donation Through Consumption Program

The model works best when

• The product is the social vehicle that triggers social change;

• The product is a response to market demand;

• The business cannot be separated from the social mission. (Tom’s Shoes donates a pair for every pair sold.)

May 2011

#4 Find New Ways to Fairly Compensate Those Who are Willing to Participate

Direct Marketing Model of Distribution and Compensation

• Five million children under the age of five die each year from malnutrition.• 500 million people in world take a vitamin/mineral supplement.GOAL: Educate and inspire 1% of them to switch from synthetically sourced to real food sourced vitamin/mineral.

How You Can Help• Choose to become a consumer of products

based on Real Food Technology® solutions.• Choose to take advantage of our Referral

Rewards Plan.• Choose to become part of our Social

Entrepreneurial movement that will change the world.

“Social Entrepreneurship is not about a few extraordinary people saving the day for everyone else. At its deepest level, it is about revealing possibilities that are currently unseen and releasing the capacity within each person to reshape a part of the world. It does not require an elite education; it requires a back-pack.”