SNEIDER ALEXANDER TORRES SOTO BIOLOGY MOLECULARUPB-MEDELLIN

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The cytogenetics is the study of chromosomes in number and in structure,

The main technique for human cytogenetics study is represented by fluorescence in situ hybridization (FISH), which is considered a technique that revolutionized the chromosome analysis in human cytogenetics and emerges as a promising technique in the field clinicalgenetics, clinical oncology and clinical researchs.

The investigation is to

ascertain whether the

suppression of

chromosome 9p in clear

cell renal carcinoma

(ccRCC) predicts worse

disease-specific survival

(DSS).

When you

suppress the

chromosome 9p it

stops removing

large tumors,

creating a greater

likelihood of

having a high

tumor

classification.

Chromosome 9p.

http://dermatology.cdlib.org/

Deletion of chromosome 9p confers a

worse prognosis independent in patients

with localized disease ccRCC, and most

notably, in patients with localized mass,

small kidney

Histological appearance of renal cell carcinoma the identification of

patients with 9p

deletions improve risk

stratification and help

select appropriate

patients for surveillance

protocols or aggressive

treatment.

http://escuela.med.puc.cl

I think that this study has great clinical

application, since it allows to determine

which patients are at high risk of

developing renal cancer and through

this to prevent decreasing the morbidity

and mortality.

long arm of

chromosome 20 is an

abnormality of acute

myeloid leukemia

(AML)and

myelodysplastic (MDS)

syndrome and is

presumed to cause the

loss of a tumor

suppressor gene in the

20q12.

Additional copies of chromosome 20

may generate an amplification of the

regions of the chromosome where the

gene suppressor as in a translocation.

By RT-PCR has shown a correlation

between amplification and increased

expression of gen.

Localized and high-level amplification of

the 250 kb region common is a test for

the activation of an oncogene in this

region in these cases of MDS and AML.

20q11.21 amplified

cases tended to

have a high

proportion of

erythroblasts in the

bone, with two

cases diagnosed as

erythroleukemia

Suppressor gene inactivation

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from my point of view this investigation

allows for a more information about

acute myeloid leukemia resulting in a

better perspective on this and be able to

act at the site of the error causing a possible diagnosis.

Cytogenetic is the branch of genetic that

studies the diseases of chromosomal inheritanc.

The cytogenetic allows determining the

type of chromosomal abnormality is a

diagnostic tool that allows confirmation

of the diagnosis of such diseases and

also the proper genetic counseling of

patients and their families ;.

The cytogenetic in the cancer represents

and avvantadge for a rapid prevention

of many diseases, including cancer

recurrent recurring chromosome in

certain malignant tumors

the cytogenetics plays an important role

in these two aforementioned

pathologies such as leukemia, renal

carinoma mieloidy and enabling you to

identify genetically affected site and

provides a pattern in their evolution.

MARTINEZ SÁNCHEZ, Lina María.

Biología molecular. 5. ed. Medellín:

UPB. Fac. de Medicina, 2009. 71-72 p.