“A chaperone system guides tail-anchored membrane proteins to their destined membrane” & “Chaperone enzyme provides new target for cancer treatments” By Carolina Severiche Mena Medical School UPB
1. A chaperone system guides tail-anchored membrane proteins to
their destinedmembrane& Chaperone enzyme provides new target
for cancertreatments By Carolina Severiche Mena Medical School
UPB
2. SECCIONS 1, 5 & 6 3. SECCIONS 2, 3 & 4 4.
INTRODUCTION Using molecular biology techniques, can be
extrapolated to the field of medicine to find different solutions
and develop clinical disease solutions. The useof
enzymeschaperonesappears to bean important optionin treating of
various diseases likecancer,whichalterkeycell cycleproteins. 5. A
chaperone system guides tail-anchored membrane proteins to their
destinedmembrane: Biology& Nature: Tuesday, July 5, 2011. 6.
The acquisition ofthree-dimensional structureof
proteinsneededinterveciof chaperonesthatcangive thecorrect
foldingand subsequentto,the protein canbe incorporated intothe cell
membrane. 7. 8. 9. In my opinion, I believe that progress in these
studies could help us develop strategies to Protein Biotechnology,
so we can prevent diseases that can kill unborn. 10. Chaperone
enzyme provides new target for cancertreatments:Biology&
Nature: Tuesday, January 18, 2011. 11. Faulty DNA repair due to Pol
eta deficiency is responsible for the genetic disease xeroderma
pigmentosum-variant, which makes patients extremely susceptible to
skin cancers caused by exposure to sunlight. 12. 13. According to
Vaziri, the dual role that Cdc7 plays in the cell lifecycle and DNA
repair offers a promising target for potential cancer therapies.
14. I think the use of enzymes chaperones in therapy against cancer
is very promising for all the utility that would imply the
treatment of this disease. However and in spite of the evidence for
further research is needed on the subject for best drill results .
15. MEDICAL UTILITY 16. 17. 18. The utilityof thechaperone
proteinsin the clinicis still unknownand thereforeit is necessary
to delve intothe mechanismswhichareinvolve.It remains to
investigatesuch important areas asprion diseasesand hereditary
diseases. 19. BIBLIOGRAPHY
PMID: 21404411 [PubMed- indexed for MEDLINE]
University of North Carolina School of Medicine. "Chaperone
enzyme provides new target for cancer treatments." ScienceDaily, 20
Jan. 2011. Web. 4 Sep. 2011
