1. The mitosis is the more importantpart in the DNA replication and init, we find the principal step of theregulation Cancer is the most important problem of the DNA and involve the replication, mediate by the DNApolymerase. 2. ADCT, CRT sign agreements todevelop ADCs against cancerCancer Research Technology(CRT), the commercial arm ofCancer Research UK, and Switzerland-based ADCTherapeutics Sarl (ADCT) announce today that they have signed agreements to develop cancer treatmentscalled Antibody DrugConjugates (ADCs) usingCRT antibodies and peptides, and ADCTs warhead and linker chemistries.ADCT, CRT sign agreements todevelop ADCs againstcancerNews Medical July 6 2012 3. ADCT, CRT sign agreements todevelop ADCs against cancer Its important in the The antibodyinvestigation of cancer component selectively treatmenttargets the cancer cells to deliver tumor- destroying chemicals which are internalizedinto the cancer cell while avoidingdamage to healthytissue 4. ADCT, CRT sign agreements to developADCs against cancerADCTs toxicchemicals interactwith DNA withoutdisrupting thedouble helixstructure which avoids triggering DNA repair processes - with the prospect that this will prevent drug resistance 5. ADCT, CRT sign agreements to develop ADCs against cancer1 Once inside the cancer cell, the linker degrades andthe active toxin is released, binding to thecells DNA and killing the cancer cell.2 ADCTs toxic chemicals interact with DNA withoutdisrupting the double helix structure which avoidstriggering DNA repair processes - with the prospectthat this will prevent drug resistance3 ADCTs warheads are based on proprietarypyrrolobenzodiazepines (PBDs) technologydeveloped by London-based Spirogen Limited 6. I think that this new is veryrelevant in the way that is abig base to future studies ofcancer and all types oftreatments about it and withthat they can be a beginningto help a lot of lives 7. Secrets of Parasites ReplicationUnraveledAdvances have not come easily, in part because these parasites have the mostcomplex mitochondrial genome structure in nature, say Klingbeil andConcepcin-Acevedo Klingbeil says, "so if we can inhibit the replication process and take away thekDNA, the parasites will die.Thats one way we might beable to kill them. ScienceDaily July 10, 2012 8. Secrets of Parasites ReplicationUnraveledAdvances have not comeeasily, in part because these parasites have the most complex mitochondrial They finally could genome structurehave an ideain naturearound how can domore investigations about DNA takingpart of the parasities 9. Secrets of Parasites ReplicationUnraveled Klingbeil says, "so if we can inhibit the replication process and take away the kDNA, the parasites will die. Thats one way we might be able to kill them." kDNA is found as a nucleoid in the mitochondrion, where it holds many copies of catenated or networked minicircles and maxicircles These molecules pass information on to daughter cells via DNA polymerases whose job it is to copy all circles in the network 10. Secrets of Parasites ReplicationUnraveledTrypanosomes have six mtDNA polymerases, while humans have just oneTo figure out how these trypanosomalpolymerases know when to initiate DNA replication set up immunofluorescenceexperiments focused on tracking mtDNApolymerase ID (POLID)Their ultimate success would be to find a chemical to inhibit POLID from carryingout its role during replication and targetall parasites with kDNA structures 11. In my opinion this newstart to take relevance inthe way that use thisinvestigation in parasites,to make more studiesabout the mitochondrialDNA but in humans andwith that can makesome important findings 12. ADCT, CRT sign agreements to develop ADCs against cancer This provides a very promising and rapidroute to develop ADCs for cancertherapy 13. Potent PBD-based warheads combinedwith CRTs leading tumor-targeting antibodies and peptidesADCT, CRT sign agreements todevelop ADCs against cancer 14. Secrets of Parasites Replication Unraveled It is an important step to do investigationabout the hereditary obesity in humans The mitochondrial DNA is relationshipwith this hereditary problem 15. Secrets of Parasites ReplicationUnraveled This important discovery explains howPOLID engages in kDNA replication andopens up new avenues to study andintervene in mitochondrial proteindynamics 16. MartinezS, Lina Maria. BiologaMolecular. 7 ed Medelln: UPB. FacMedicina ADCT, CRT sign agreements to developADCs against cancer. News Medical.(July 6, 2012) Secrets of Parasites ReplicationUnraveled. ScienceDaily. (July 10, 2012) 17. THANKS