- 1. NEW HOPES FOR HUNTINGTON DISEASE HEYLY MILENA ORTEGA THIRD
SEMESTER MEDICINE UPB 2011-I
2. 3. 4. INTRODUCTION Huntington disease is autosomic dominant
disorder, causes by a repeating of a CAG sequence Actually there
are no many treatments that helpimprove the develop of the disease
5. New Hope in Fight Against Huntington's Disease ScienceDaily
(Jan. 18, 2011) TEACHER: Lina Martinez APRIL 4, 2011 MEDELLN,
COLOMBIA NEW HOPES FOR HUNTINGTON`S DISEASE This two articles have
relevance in the medical ambit, because the Huntington disease, is
a disease wich has been taking importance in our actual society,
and taking into count that there are 35.000 people afected by this
disease anually(3),to be able to find new cures or treatments for
delay thethe appearance of the disease could reduce the mortality
of the disease MEDICAL UTILITY Heyly Milena Ortega Third
semesterMolecular biology BIBLIOGRAFA. . MARTINEZ S. Lina Mara.
Biologa molecular. 5. ed. Medelln: UPB. Fac. de Medicina, 2006. pp
196 . TAUBER. E, New Hope in Fight Against Huntington's
Disease,ScienceDaily. Jan. 18, 2011 . CHEN. J,A major leap forward
in understanding Huntington's disease may give patients hope for a
cure.Science Daily. Feb. 23, 2011 6. New Hope in Fight Against
Huntington's Disease
- The studies with baker's yeast, are used regularly for the
implementation of new drugsspeciallyfor neurodegenerative
disease,like Parkinson disease, that's why they chose it for this
trial. In some other studies its also been used the drosophila
melanogaster. (2)
7.
- research has taken advantage of cutting edge genomics
approaches using a simple model organism to identify a novel area
for potential therapeutic intervention for Huntington's disease and
try to develop a new drug that can be used for treatment of this
disease. (2)
New Hope in Fight Against Huntington's Disease 8.
- Using this mechanism of investigation with bakers yeast,
scientist found many of the protective genes are involved in
translation -- a cellular process in which messenger RNA (mRNA) is
decoded by the ribosome to produce specific proteins; the HD has
not been related with this mechanism in the past. With this they
could find a way to create a new drug following this principle.
(2)
New Hope in Fight Against Huntington's Disease 9. PERSONAL
OPINION
- To discover new ways of treat the Huntington disease, and be
able to understand the mechanism of the disease offers the
community new advantages over the HD, cause be could finally been
getting closer to the discovery of an effective treatment for this
disease, and even cure it.
10. A MAJOR LEAP FORWARD IN UNDERSTANDING HUNTINGTON`S DISEASE
MAY GIVE PATIENNTS HOPE FOR A CURE Science Daily (Feb. 23, 2011)
11. A MAJOR LEAP FORWARD IN UNDERSTANDING HUNTINGTON`S DISEASE MAY
GIVE PATIENNTS HOPE FOR A CURE
- DRP1 is needed for mitochondrial division. The scientists found
that in Huntington's disease, DRP1 becomes overactive and causes
too much mitochondrial division without balancing fusion; toning
down the reaction might kept the brain cells alive.(3)
12.
- They were gonna try to see in patients and animals, if this
protein (DRP1), has a protecting role in the brain; if that's the
case this could be implemented in patients with the mutant gene
before the apparition of the disease .(3)
A MAJOR LEAP FORWARD IN UNDERSTANDING HUNTINGTON`S DISEASE MAY
GIVE PATIENNTS HOPE FOR A CURE 13.
- They`re hope is to delay the onset of disease by improving the
energy metabolism of the brain. The scientist team toned down the
activity of DRP1, showing restored a normal balance of
mitochondrial division and fusion and improved the energy
metabolism and survival of neurons.(3)
A MAJOR LEAP FORWARD IN UNDERSTANDING HUNTINGTON`S DISEASE MAY
GIVE PATIENNTS HOPE FOR A CURE 14. PERSONAL OPINION
- This is a good and refreshing discovery for the treatment of
Huntington disease, if they can approach to use the toning down of
the protein DRP1, it will be good for the patients not having to
wait for the disease beginning to look if there is a treatment to
control it, but they could prevent the develop of HD, I think this
could be very beneficial for the patients, and propose a great
advance in Huntington disease treatment.
15. 16. MEDICAL UTILITY
- The propose of using simple organism like baker's yeast and
drosophila melanogaster is very benefaction for medical tryouts and
essays, cause is more simple to study some diseases, as
neurodegenerative ones in this organisms, and be able to
extrapolate the findings to use in human patients. (2)
17.
- The discovery of the protein DRP1 give us a better
understanding of the Huntington disease, if we are able to
understand better the pathogenesis of a disease, we could develop
better ways of treat it and even find a way to cure it. (3)
MEDICAL UTILITY 18.
- According to the finding of the relation of the DRP1 with the
neurogenic decrease of HD, toning down the protein would help to
stop the develop of the disease, without having to wait until the
apparition of the disease, and using it in patients with the mutant
gene, it could give us better results, cause the damages in the
brain haven't started yet, and it could be even possible to make
them not to appear. (3)
MEDICAL UTILITY 19. BILIOGRAPHY
- 1.MARTINEZ S. Lina Mara. Biologa molecular. 5. ed. Medelln:
UPB. Fac. de Medicina, 2006. pp 196
- 2.TAUBER. E. et al,New Hope in Fight Against Huntington's
Disease,ScienceDaily. Jan. 18, 2011
- 3.CHEN. J. et al,A major leap forward in understanding
Huntington's disease may give patients hope for a cure.Science
Daily. Feb. 23, 2011
20.
