PHARMACY Major STUDY PROGRAM 2012/2013 …aok.pte.hu/docs/th/file/2012/tantervek_2012/course_eng_pha_ppt... · Pharmaceutical Professional Theoretical Knowledge and Practical Skills

UP MS Pharmacy major – subjects of the Pharmaceutical Professional Theoretical… module – academic year of 2012/2013

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The University of Pécs Medical School

PHARMACY Major

STUDY PROGRAM 2012/2013

Subjects of the Pharmaceutical Professional Theoretical Knowledge and

Practical Skills module (Obligatory subjects)


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OPGBFM BIOPHARMACY

Course director: DR. ATTILA DÉVAY , associate professor Department of Pharmacotechnology

2 credit ▪ midsemester grade ▪ Pharmaceutical Professional Theoretical ... module ▪ autumn semester ▪ recommended semester: 5

Number of hours/semester: 28 lectures + 0 practices + 0 seminars = total of 28 hours Headcount limitations (min-max.): min. 1 – max. 50

Prerequisites: OPGGT1 parallel + OPOEL1 completed

Topic Aim of this course is to introduce biopharmaceutical aspects of medicines taking into account dosage forms and routes of administration. Basic pharmacokinetic aspects (kinetics of active agents, compartmental analysis, routes of administration), some in vitro and in silico biopharmaceutical practices (using special biopharmaceutical softwares) are presented, bioequivalence studies of medicines are discussed. Students learn to design and develop pharmaceutical dosage forms according to biopharmaceutical requirements. Single and repeated dosing calculations are discussed according to pharmaceutical and physiological aspects.

Conditions for acceptance of the semester Accepted work report Accepted written assessments

Making up for missed classes Students must fulfill requirements determined by the Code of Studies and Examinations.

Reading material Applied biopharmaceutics and pharmacokinetics, Leon Shargel, A. B.C. Yu, Stamford Biopharmaceutical Drug Design and Development, Susanna Wu-Pong, Yon Rojanasakul, Humana Press Modern pharmaceutics, Gilbert S. Banker, Christopher T. Rhodes, Marcel Dekker Inc., New York- Basel www.boomer.org www.gytsz.pte.hu www.sciencedirect.com

Lectures 1-28 1. Subject and general approach of biopharmacy Dr. Dévay Attila 2. Drug delivery systems and the input options I. Dr. Dévay Attila 3. Drug delivery systems and the input options II. Dr. Dévay Attila 4. Examination of drug-liberation Dr. Dévay Attila 5. Drug-liberation I. Dr. Dévay Attila 6. Drug-liberation II. Dr. Dévay Attila 7. WRITTEN TEST Dr. Dévay Attila 8. Drug-absorption Dr. Dévay Attila 9. Drug-distribution and drug-metabolisms Dr. Dévay Attila 10. Drug-excreation Dr. Dévay Attila 11. Biopharmaceutical analysis and modeling Dr. Dévay Attila 12. Biopharmaceutical tests I. Dr. Dévay Attila 13. Biopharmaceutical tests II. Dr. Dévay Attila 14. End year consultation and assessment Dr. Dévay Attila

Practices

Seminars

Exam topics/questions

Participants Dr. Dévay Attila (DEAHABO.PTE), Dr. Pál Szilárd (PASMAAO.PTE)


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OPGFG1 PHARMACOGNOSY 1

Course director: DR. M OLNÁR PÉTER, egyetemi tanár Department of Pharmacognosy

5 credit ▪ semester exam ▪ Pharmaceutical Professional Theoretical ... module ▪ autumn semester ▪ recommended semester: 5


Prerequisites: OPOGN2 completed

Topic Pharmacognosy covers general aspects of medicinal plants (such as industrial applications, research, cultivation and cultivars, gene technology, critical evaluation of holistic medicine and homeopathy, possibilities of phytotherapy) and discusses the chemical composition and other qualitative characteristics, as well as the most important areas of usage and pharmacology of herbal drugs and drug fractions such as oils and essential oils. Based on their previous pharmacobotanic knowledge students become acquainted with medicinal plants and drugs that are used in pharmacotherapy (especially in phytotherapy) both in Hungary and abroad. Students are required to recognize the most important tea drugs and drugs with strong physiological effect that are traded and/or imported in Hungary. In the frame of practices students obtain experience in drug analysis and identification methods and the ability to solve daily arising problems, with special emphasis on processing information from literature, databases and the internet. Course objective and role in the curriculum: students should become familiar with plant materials and drugs, as well as their effective substances in general, preparing for the detailed knowledge and analysis of drugs in the spring semester

Conditions for acceptance of the semester Satisfactory fulfilment of 1 written test based on the lectures. Fulfilment of all laboratory practices and 4 written tests based on the material of the practices. Absences and missed practices: participation is compulsory in the lab practices, 1 absence is allowed. Students are allowed to make up for the missed lab practice, but should agree with the lab instructor in advance.

Making up for missed classes Students are allowed to make up for the missed lab practice, but should agree with the lab instructor in advance.

Reading material Compulsory literature: Evans W.C.: Trease and Evans Pharmacognosy. Saunders, London-New York, 2000 Recommended literature: 1. Aronson J.K. (ed): Meylers Side Effects of Herbal Medicines. Elsevier, Amsterdam-Oxford-Tokyo, 2009 2. Barnes J., Anderson L.A., Phillipson J.D.: Herbal Medicines. 2nd edition. Pharmaceutical Press, London-Chicago, 2002 3. ESCOP Monographs, The Scientific Foundation for Herbal Medicinal Products. 2nd edition. Thieme, Exeter; Stuttgart; New

York, 2003 4. Poole C.F., Poole S.K.: Chromatography today. Elsevier, Amsterdam-Oxford-New York-Tokyo, 1991 5. WHO Guidelines on good agricultural and collection practices (GACP) for medicinal plants, 2003

Lectures 1 Scope and subject of pharmacognosy. Dr. Farkas Ágnes 2 Scientific and Hungarian name of medicinal plants and drugs. Basic ethnobotany. Dr. Farkas Ágnes 3 Wild, protected and cultivated medicinal plants; medicinal plant breeding. Dr. Farkas Ágnes 4 Plant biotechnology, gene technology. Dr. Farkas Ágnes 5 Natural substances in pharmaceutical research. Dr. Horváth Györgyi 6 (Traditional) herbal medicines and dietary supplements. Dr. Horváth Györgyi 7 Tea drugs, primary processing of medicinal plants, plant extracts. Industrial medicinal plants. Dr. Farkas Ágnes 8 Qualification and phytochemical evaluation of medicinal plants. Dr. Farkas Ágnes 9 Phytotherapy. Dr. Horváth Györgyi 10 Aromatherapy. Dr. Horváth Györgyi 11 Medicinal plants in the homeopathy. Dr. Horváth Györgyi


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12 Drugs of fungus and animal origin. Dr. Horváth Györgyi 13 Photosynthesis and related methabolic pathways of effective substances. Dr. Molnár Péter 14 Role of nitrate- and sulphate-reduction in synthesis of effective substances. Dr. Molnár Péter 15 Synthesis, role of carbohydrates. Dr. Molnár Péter 16 Usage of carbohydrates. Dr. Molnár Péter 17 Synthesis, role and usage of lipids. Dr. Molnár Péter 18 Oils and waxes. Dr. Molnár Péter 19 Biosynthesis of terpenoids. Dr. Molnár Péter 20 Classification of terpenoids. Dr. Molnár Péter 21 Test. Dr. Farkas Ágnes 22 Test. Dr. Horváth Györgyi 23 Biosynthesis and role of amino acids and proteins. Dr. Molnár Péter 24 Biosynthesis and role of amino acids and proteins. Dr. Molnár Péter 25 General features of alkaloids. Dr. Molnár Péter 26 Classification of alkaloids. Dr. Molnár Péter 27 General features of phenoloids. Dr. Molnár Péter 28 Classification of phenoloids. Dr. Molnár Péter

Practices 1 Methods of analysis for medicinal plants in the current Pharmacopoeia Hungarica. 2 Methods of analysis for medicinal plants in the current Pharmacopoeia Hungarica. 3 Methods of analysis for medicinal plants in the current Pharmacopoeia Hungarica. 4 Drugs with carbohydrate content. 5 Microscopic distinction of starch grains. 6 Cytochemical detection of starch and inulin. 7 Drugs containing inorganic and organic acids. 8 Drugs containing inorganic and organic acids. 9 Equiseti herba contamination with Equisetum palustre; analysis of the epidermis and other morpho-anatomical features. 10 Drugs with essential oil I. Lamiaceae. 11 Menthae piperitae folium. 12 Identification of Thymi vulgaris herba and Serpylli herba on the basis of glandular trichomes. 13 Drugs with essential oil II. Apiaceae. 14 Identification of Anisi vulgaris fructus, Carvi fructus, Foeniculi fructus, Coriandri fructus on the basis of histological

features, with the help of a drug atlas. 15 Investigation of Lupuli flos. 16 Drugs with essential oil III. Asteraceae. 17 Investigation of Matricariae flos on the basis of Ph.Hg. VIII. 18 Distinction of Solidaginis herba and Solidaginis virgaureae herba based on micromorphological features. 19 Iridoids, diterpenes. 20 Triterpene saponins. 21 Histological comparison of Valerianae radix and Primulae radix. 22 Alkaloid-containing drugs I. Solanaceae. 23 Alkaloid-containing drugs I. Boraginaceae, Fabaceae, Papaveraceae.


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24 Comparison of Belladonnae folium and Stramonii folium on the basis of cleared preparations. 25 Alkaloid-containing drugs II. Erythroxylaceae, Strychnaceae. 26 Alkaloid-containing drugs II. Rubiaceae. 27 Alkaloid-containing drugs II. Theaceae, Sterculiaceae, Apocynaceae. 28 Amino acids. 29 Peptides and proteins. 30 Identification of Phaseoli pericarpium by calcium-oxalate prisms. 31 Steroid-containing drugs. Investigation of Avenae herba. 32 Cardenolic glycosides. 33 Characterisation of Digitalis purpureae folium and Digitalis lanatae folium. 34 Phenoloids I. 35 Morphological and histological investigation of Hyperici herba. 36 Histological characterisation of Sennae folium, Sennae fructus acutifoliae and Sennae fructus angustifoliae. 37 Phenoloids II. 38 Characterisation of Cotini folium with histochemical reactions. 39 Cleared preparations of Juglandis folium. 40 Final test. 41 Final test. 42 Final test.

Seminars

Exam topics/questions 1. Scope and subject of Pharmacognosy. Herbaria. 2. Scientific and Hungarian name of medicinal plants; binomial nomenclature; pharmaceutical name of drugs. 3. Ethno-pharmacobotany. 4. Natural compounds in pharmaceutical research. 5. Classification of herbal medicines. 6. Significance of photosynthesis, structure and chemical composition of the chloroplast. Light reactions of photosynthesis. 7. The nitrogen cycle, nitrogen fixation. 8. Nitrogen assimilation and sulphate reduction. Nitrogen- and sulphur-containing compounds in the pharmaceutical practice. 9. Carbohydrate synthesis during photosynthesis: the Calvin-cycle; structure and role of phosphoenolpyruvate (PEP) and malic

acid; C4 and CAM type plants. 10. Synthesis, role and usage of di- and polysaccharides [sucrose, maltose, starch (amylose, amylopectin), cellulose]. Pectins,

mannans, gummi arabicum, heteropolysaccharides: occurrence, medicinal usage. 11. Biological functions and classes of lipids. Building blocks of phosphoglycerides: L-α-phosphatidic acid, cholamine, choline,

serine, inositol. Structure of cephalin, lecithine, phosphatidyl serine and phosphatidyl inositol. General characterisation of sphingosine, sphingo- and glycolipids.

12. Fats and oils. Biosynthesis of fatty acids. Structure of important saturated and unsaturated fatty acids occurring in plants. 13. Structure of arachidonic acid, ricinoleic acid, ricinine and ricin; occurrence, biological and medicinal importance. Physical

and chemical parameters of fats and oils, occurrence in plants, medicinal usage. 14. Oils of animal origin: chemical structure of the most important compounds in cod-liver oil, medicinal usage. Structure and

utilisation of waxes. 15. Prostaglandins: discovery, occurrence; chemical structure; biosynthetic precursor; biological effects, medicinal usage.

Polyacetylenes: synthesis, features, occurrence in plants, biological role. 16. Isoprenoid compounds I. Isoprene rule; modes of linking of isoprene units; natural and artificial polyisoprenes. 17. Isoprenoid compounds II. General features of terpenes; occurrence; precursors of biosynthesis [mevalonic acid (MVA),

isopentenyl pyrophosphate (IPP)]; main steps of biosynthesis. 18. Isoprenoid compounds III. Classification of terpenes. Chemical structure of linear and cyclic monoterpenes with a few

examples; occurrence, biological role, medicinal usage. 19. Isoprenoid compounds IV. Iridoids, pyrethroids, sesquiterpenes: chemical structure; occurrence in plants, biological role,

application in medicine. 20. Isoprenoid compounds V. Diterpenes, triterpenes. Chemical structure, occurrence and biological significance of phytol and

squalene. Occurrence, biological role and medicinal usage of triterpenoid saponins. 21. Proteinogenic amino acids I.: structural formula and chemical name of alanine, arginine, aspartic acid, asparagine, cysteine,

glycine, glutamic acid, glutamine, histidine, leucine, isoleucine. 22. Proteinogenic amino acids II.: Structural formula and chemical name of lysine, methionine, phenylalanine, proline,

hydroxyproline, serine, threonine, tryptophan, tyrosine, valine. 23. Important amino acid reactions I. a.) Basic reaction of transamination; b.) reductive desamination →formation of α-amino

acids from α-keto acids α-oxo acids); c.) formation of glutamine from glutamic acid. 24. Important amino acid reactions II.: a.) Decarboxylation; b.) oxidative desamination; c.) formation of asparagine from

aspartic acid 25. Breakdown of xanthine, caffeine and other purine-derived effective substances: formation of ureids, glycolic acid, glyoxylic

acid and carbamide. Allantoin, as the most well-known plant ureid.


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26. Specific amino acids: chemical structure of γ-amino-butyric acid (GABA), β-amino-butyric acid (BABA) and β-alanine; formation, significance in plants; chemical transformation.

27. Occurrence and significance of canavanine. Structure, occurrence and biological effect of L-dihydroxy-phenylalanine (L-DOPA). Occurrence of alkyl- and allyl-derivatives of cysteine; chemical structure and occurrence of diallyl-sulfide and diallyl-disulfide. Occurrence of propenyl-cysteine.

28. Peptids, proteins. Classification of proteins based on solubility relations. Biological and biochemical role of enzymes, classification according to their functions. Occurrence and medicinal usage of some enzymes (papain, bromelain, ficin).

29. The place and main steps of plant protein biosynthesis. Occurrence and biological role of stored proteins. Features, occurrence, biological role and application of lectins (phytohemagglutinins), toxic (ricin) and other plant proteins.

30. Alkaloids I. Definition and general characteristics of alkaloids; natural occurrence. Structure of the most important amino acids in their biosynthesis (ornitin, lysine, phenylalanine, tyrosine, tryptophan, histidine).

31. Alkaloids II. Structure of N-containing heterocyclic compounds, characteristic for alkaloids (pyrrole, pyrrolidine, pyridine, piperidine, indole, quinoline, isoquinoline, pyrimidine, imidazole, purine, sterane structure).

32. Alkaloids III. Phenylethylamine-type alkaloids: ephedrine as a protoalkaloid. Mescaline as a protoalkaloid. Occurrence, biological features, application.

33. Alkaloids IV. Alkaloids containing pyridine, pyrrolidine, piperidine cycle: chemical formula and name, biological effect of nicotine and coniine. Occurrence of other alkaloids with pyperidine cycle (piperine, lobeline).

34. Alkaloids V. Tropane alkaloids -Alkaloids with a condensed pyrrolidine- and piperidine cycle. Structure of nortropane, tropane, tropine (3αhydroxi-tropane) and tropic acid. Atropine, hyosciamine, scopolamine -structure, occurrence, biological effect, application in medicine and elsewhere.

35. Alkaloids VI. Structure of pseudotropine (3β-hydroxi-tropane), ecgonine and cocaine; occurrence and biological effects of cocaine. Structural comparison of novocaine (non-alkaloid) and cocaine, focusing on the atom group responsible for biological effect.

36. Alkaloids VII. Alkaloids with quinoline structure. Structure, occurrence, biological effects and application of quinine. 37. Alkaloids VIII. Opium alkaloids: a.) Structure, biological effect and usage of papaverine as an isoquinoline structure

alkaloid. 38. Alkaloids IX. Opium alkaloids: b.) Structure of morphine; biological effect, medical usage. Structure, biological effects and

medical application of some important morphine derivatives [codeine, tebaine, ethylmorphine (dionine), heroin]. 39. Alkaloids X. LSD as the most important representative of ergot alkaloids: chemical structure, biological effects. Biological

effects and medical application of further important ergot alkaloids. 40. Alkaloids XI. Purine alkaloids: tautomeric lactam-lactim equilibrium of xanthine; structure of theophylline, theobromine and

caffeine; occurrence, biological effects, usage. 41. Alkaloids XII. Sterane alkaloids (pseudoalkaloids): chemical structure of tomatidine and solanidin; occurrence in plants;

usage. Occurrence of protoalkaloids with a special structure (colchicine, aristolochic acid) and colouring agents containing quaternary nitrogen. The most important alkaloid-containing plant families.

42. Phenoloids I. Structure of amino acids in their biogenesis (phenylalanine, tyrosine). Structure of β-phenyl-propionic acid, trans (E)-cinnamic acid, cis (Z)-cinnamic acid (allo-cinnamic acid), para-coumaric acid, caffeic acid and chlorogenic acid (the ester of caffeic acid and quinic acid).

43. Phenoloids II. The hydroquinone -para-benzoquinone transformation. Quinone derivatives and their significance in plant biochemistry. Phenol-carboxylic acids of benzoic acid origin (protocatechuic acid, vanillic acid, gallic acid): structure, occurrence in plants, significance in biology and medicine.

44. Phenoloids III. Structure and occurrence of salicin in plants. Chemical structure of salicylic alcohol, salicylic acid, acetylsalicylic acid (Aspirin) and its Ca-salt (Kalmopyrin); their significance in pharmacy. Structure of anise alcohol and anise aldehyde; occurrence in plants.

45. Phenoloids IV. Structure of some unsaturated phenol alcohols. Trans (E)-cinnamic alcohol and its derivatives: para-coumaryl alcohol, coniferyl alcohol, sinapyl alcohol. Features of lignins, lignans, flavonolignans: occurrence, biological and medicinal importance.

46. Phenoloids V. Coumarins. Chemical structure of coumarin, coumaric acid, aesculin, dicoumarol and furanocoumarins; occurrence in plants; biological and medicinal significance.

47. Phenoloids VI. Flavonoids: Structure of α- and γ-pyran, α- and γ-pyrone and coumarin (α-pyrone condensed with benzol). Structure of chromane, chromene, chromone, flavan, flavene, flavon, flavonol (3-hydroxi-flavon) and quercetin. Structure, occurrence and isolation of rutin (vitamin P).

48. Phenoloids VII. Anthocyanins, anthocyanidins, flavylium salts. Structure of flavylium chloride; some derivatives substituted with OH-groups. The pH dependence of the colour of flavylium salts; explanation of their behaviour as indicators. Occurrence in plants, biological effects and medical significance of anthocyanin colouring agents.

49. Phenoloids VIII. Tannins. Classification of tannins. Structure of gallic acid, pyrogallol, meta-digallic acid, penta-meta-digalloyl-β-D-glucose. Occurrence, features and application of tannins.

50. Phenoloids IX. Quinones and terpenophenols. Structure of juglone, anthraquinone (9,10-anthraquinone) and anthrone. Biological effect, features and usage of juglone. Occurrence and medicinal significance of plant effective substances with anthraquinone and anthrone (naphtho-dianthrone) structure. Terpenophenols (cannabinoids). Occurrence and biological effect of THC; effective substances of hop and their structure.

51. Wild and protected medicinal plants, collection of medicinal plants. 52. Cultivation and breeding of medicinal plants; plant biotechnology and gene technology. 53. Tea drugs, primary processing, extracts. 54. Industrial medicinal plants.


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55. Qualification and phytochemical evaluation of medicinal plants, requirements of the pharmacopoeia. 56. Phytotherapy; types, licensing and distribution of herbal medicines. 57. Aromatherapy 58. Homeopathy 59. Drugs of fungus and animal origin.

Participants Dr. Farkas Ágnes (FAADAB.T.JPTE)


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OPGFG2 PHARMACOGNOSY 2

Course director: DR. M OLNÁR PÉTER, egyetemi tanár Department of Pharmacognosy

5 credit ▪ final exam ▪ Pharmaceutical Professional Theoretical ... module ▪ spring semester ▪ recommended semester: 6


Prerequisites: OPGFG1 completed

Topic Pharmacognosy covers general aspects of medicinal plants (such as industrial applications, research, cultivation and cultivars, gene technology, critical evaluation of holistic medicine and homeopathy, possibilities of phytotherapy) and discusses the chemical composition and other qualitative characteristics, as well as the most important areas of usage and pharmacology of herbal drugs and drug fractions such as oils and essential oils. Based on their previous pharmacobotanic knowledge students become acquainted with medicinal plants and drugs that are used in pharmacotherapy (especially in phytotherapy) both in Hungary and abroad. Students are required to recognize the most important tea drugs and drugs with strong physiological effect that are traded and/or imported in Hungary. In the frame of practices students obtain experience in drug analysis and identification methods and the ability to solve daily arising problems, with special emphasis on gathering information from literature, databases and the internet. Course objective and role in the curriculum: students should become familiar with the general, phytochemical and pharmacological features of drugs applied in pharmaco- and phythotherapy.

Conditions for acceptance of the semester Criteria of acceptance of the semester: Satisfactory fulfilment of 1 written test based on the lectures. Fulfilment of all laboratory practices. Students have to write successful tests based on the material of the practices on every week. Absences and missed practices: participation is compulsory in the lab practices, 1 absence is allowed.

Making up for missed classes Students are allowed to make up for the missed lab practice, but should agree with the lab instructor in advance.

Reading material Compulsory literature: Evans W.C.: Trease and Evans Pharmacognosy. Saunders, London-New York, 2000 Recommended literature: 1. Aronson J.K. (ed): Meyler’s Side Effects of Herbal Medicines. Elsevier, Amsterdam-Oxford-Tokyo, 2009 2. Barnes J., Anderson L.A., Phillipson J.D.: Herbal Medicines. 2nd edition. Pharmaceutical Press, London-Chicago, 2002 3. ESCOP Monographs, The Scientific Foundation for Herbal Medicinal Products. 2nd edition. Thieme, United Kingdom-

Stuttgart-USA, 2003 4. Poole C.F., Poole S.K.: Chromatography today. Elsevier, Amsterdam-Oxford-New York-Tokyo, 1991 5. WHO Guidelines on good agricultural and collection practices (GACP) for medicinal plants, 2003 6. Györgyi Horváth: Drug Reactions in the Pharmacognosy. Teaching Supplement for the Pharmacognosy Practices. University

of Pécs, Medical School, 2011.

Lectures 1 Drugs containing monoterpenes, essential oils Dr. Horváth Györgyi 2 Drugs containing monoterpenes, essential oils Dr. Horváth Györgyi 3 Essential oils Dr. Horváth Györgyi 4 Essential oils Dr. Horváth Györgyi 5 Iridoid-containing drugs Dr. Horváth Györgyi 6 Iridoid-containing drugs Dr. Horváth Györgyi 7 Drugs containing sesquiterpenes Dr. Molnár Péter 8 Drugs containing diterpenes and terpenophenols Dr. Molnár Péter 9 Drugs containing triterpenes Dr. Molnár Péter 10 Drugs containing steroids, saponins and cardenolides Dr. Molnár Péter


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11 Drugs containing alkaloids of ornithine, lysine and phenylalanine origin Dr. Molnár Péter 12 Drugs containing alkaloids of ornithine, lysine and phenylalanine origin Dr. Molnár Péter 13 Drugs containing alkaloids of tryptophan and histidine origin Dr. Molnár Péter 14 Drugs containing alkaloids of tryptophan and histidine origin Dr. Molnár Péter 15 Purine-containing drugs Dr. Molnár Péter 16 Drugs containing specific amino acid derivatives Dr. Molnár Péter 17 Drugs containing cyanogenic glycosides Dr. Horváth Györgyi 18 Drugs containing glucosinolates Dr. Horváth Györgyi 19 Drugs containing phenylpropanoid derivatives Dr. Horváth Györgyi 20 Drugs containing phloroglucin derivatives Dr. Horváth Györgyi 21 Drugs containing coumarin derivatives Dr. Horváth Györgyi 22 Drugs containing furanocoumarin derivatives Dr. Horváth Györgyi 23 Drugs containing anthraquinone derivatives Dr. Horváth Györgyi 24 Drugs containing naphthoquinone derivatives Dr. Horváth Györgyi 25 Drugs containing flavonoids Dr. Horváth Györgyi 26 Drugs containing flavonoids Dr. Horváth Györgyi 27 Drugs containing polyphenols Dr. Horváth Györgyi 28 Drugs containing tannins. Dr. Horváth Györgyi

Practices 1 Accident and fire-protection instruction. 2 General methods of analysis for drugs of plant origin. 3 Nitrate detection in drinking water suitable for tea extraction and in nettle tea. 4 Analysis of carbohydrate containing drugs. 5 Analysis of carbohydrate containing drugs. 6 Honey adulteration test. 7 Analysis of oils with methods prescribed in Pharmacopoeia Hungarica VIII. 8 Analysis of oils with methods prescribed in Pharmacopoeia Hungarica VIII. 9 Analysis of oils with methods prescribed in Pharmacopoeia Hungarica VIII. 10 Analysis of essential oil containing drugs. 11 Essential oil extraction for quantitative measurements. 12 Detection of essential oil components. 13 Extraction and detection of nicotine and caffeine. 14 Extraction and detection of nicotine and caffeine. 15 Soxhlet-extraction (demonstration). 16 Extraction and detection of atropine and scopolamine. 17 Extraction and detection of atropine and scopolamine. 18 Written test: Phytochemistry I. 19 Extraction and detection of alliin. 20 Extraction and detection of alliin. 21 Extraction and detection of alliin. 22 Quantitative determination of total flavonoid content.


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23 Quantitative determination of total flavonoid content. 24 Quantitative determination of total flavonoid content. 25 Detection of phenoloids. 26 Detection of phenoloids. 27 Detection of phenoloids. 28 Quantitative determination of total tannin content. 29 Quantitative determination of total tannin content. 30 Quantitative determination of total tannin content. 31 Analysis of anthraglycoside containing drugs according to Ph.Hg. VIII. 32 Analysis of anthraglycoside containing drugs according to Ph.Hg. VIII. 33 Analysis of anthraglycoside containing drugs according to Ph.Hg. VIII. 34 Analysis of drugs containing saponins. 35 Analysis of drugs containing saponins. 36 Written test: phytochemistry II. 37 Separation of carotenoids with column chromatography (demonstration). 38 Separation of carotenoids with column chromatography (demonstration). 39 Separation of carotenoids with column chromatography (demonstration). 40 Drug identification practice: Histology and phytochemistry. 41 Drug identification practice: Histology and phytochemistry. 42 Drug identification practice: Histology and phytochemistry.

Seminars

Exam topics/questions Final exam:

Students are required to demonstrate their theoretical and practical knowledge based on the material of both semesters. Students can sit for the final exam only after the successfully accomplished first semester and the satisfactory fulfilment of all practices in the second semester. In the frame of the entrance exam students must identify and characterise 5 drugs. Following the successful entrance exam students pick 2 exam questions. The grade of the final exam is based on the written tests of the second semester, drug identification and the result of the oral exam. Drugs to be identified at the entrance exam (according to Ph.Hg. VIII.): Absinthii herba, Agar, Agrimoniae herba, Allii ursini herba, Aloë capensis, Althaeae radix, Anethi fructus, Anisi fructus, Anisi stellati fructus, Artemisiae (vulgaris) herba in toto, Aurantii amari epicarpium et mesocarpium, Avenae herba, Belladonnae radix, Betulae folium, Bursae pastoris herba, Calami rhizoma, Calendulae flos, Callunae vulgaris herba, Cannabis sativae fructus, Capsici fructus, Cardamomi fructus, Cardui benedicti herba, Carvi fructus, Caryophylli flos, Centaurii herba in toto, Cerasi stipes, Chamomillae romanae flos, Cichorii radix, Cinnamomi cortex, Coriandri fructus, Cotini folium, Crataegi folium cum flore, Crataegi fructus, Cucurbitae semen, Dulcamarae stipes et fructus, Ephedrae herba, Epilobii herba, Equiseti herba, Eupatorii herba in toto, Farfarae folium, Foeniculi dulcis fructus, Fragariae folium in toto, Frangulae cortex, Galegae herba, Galii veri herba, Gentianae radix, Ginkgo folium, Ginseng radix, Graminis rhizoma, Hederae helicis folium, Helianthi annui flos, Hibisci sabdariffae flos, Hippocastani semen, Hyperici herba, Ipecacuanhae radix, Juglandis folium, Juniperi pseudo-fructus, Lavandulae flos, Leonuri cardiacae herba, Lichen islandicus, Lini semen, Liquiritiae radix, Lupuli flos, Malvae sylvestris flos, Matricariae flos, Melissae folium, Menthae piperitae folium, Menyanthidis trifoliatae folium, Millefolii herba, Ononidis radix, Origani herba, Papaveris rhoeados flos, Papaveris caput, Phaseoli legumen, Plantaginis lanceolatae folium, Podophylli radix et rhizoma, Populi gemma, Primulae radix, Pruni spinosae fructus, Quercus cortex, Robiniae pseudoacaciae flos, Rosae pseudo-fructus c. seminibus/s. seminibus, Rosmarini folium, Rubi fruticosi folium, Salicis cortex, Salviae officinalis folium, Sambuci flos, Sambuci fructus, Saponariae albae radix, Saturejae herba in toto, Secale cornutum, Senna folium, Sennae fructus acutifoliae, Serpylli herba in toto, Silybi mariani fructus, Sinapis albae semen, Solani amylum, Solidaginis herba, Sophorae flos, Spiraeae herba, Tagetes flos, Tanaceti parthenii herba, Taraxaci folium, Thymi herba, Tiliae flos, Tragacantha, Urticae herba in toto, Uvae ursi folium, Valerianae radix, Verbasci flos, Visci stipes.

Exam questions: I. General part. Phytochemistry. 1. Carbohydrate synthesis during photosynthesis: the Calvin-cycle; structure and role of phosphoenolpyruvate (PEP) and malic

acid; C4 and CAM type plants. Synthesis, role and usage of di- and polysaccharides [sucrose, maltose, starch (amylose, amylopectin), cellulose]. Pectins, mannans, gummi arabicum, heteropolysaccharides: occurrence, medicinal usage.

2. Biological functions and classes of lipids. Building blocks of phosphoglycerides: L-α-phosphatidic acid, cholamine, choline, serine, inositol. Structure of cephalin, lecithine, phosphatidyl serine and phosphatidyl inositol. General characterisation of sphingosine, sphingo- and glycolipids. Physical and chemical characteristics of fats and oils. Biosynthesis of fatty acids. Structure of important saturated and unsaturated fatty acids occurring in plants.


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3. Arachidonic acid, prostaglandins: discovery, occurrence, chemical structure, biological effects, medical usage. Structure of ricinoleic acid, ricinine and ricin; occurrence, biological and medicinal importance. Oils of animal origin: chemical structure of the most important compounds in cod-liver oil, medicinal usage. Structure and utilisation of waxes. Polyacetylenes: synthesis, features, occurrence in plants, biological role.

4. Isoprenoid compounds. Isoprene rule; modes of linking of isoprene units; occurrence, biological role, medicinal application; natural and artificial polyisoprenes. General features of terpenes; occurrence; precursors of biosynthesis [mevalonic acid (MVA), isopentenyl pyrophosphate (IPP)]; main steps of biosynthesis. Classification of terpenes. Chemical structure of linear and cyclic monoterpenes with a few examples; occurrence, biological role, medicinal usage.

5. Iridoids, pyrethroids, sesquiterpenes: chemical structure; occurrence in plants, biological role, application in medicine. Diterpenes, triterpenes. Chemical structure, occurrence and biological significance of phytol and squalene. Occurrence, biological role and medicinal usage of triterpenoid saponins.

6. Proteinogenic amino acids: structural formula and chemical name of alanine, arginine, aspartic acid, asparagine, cysteine, glycine, glutamic acid, glutamine, histidine, leucine, isoleucine, lysine, methionine, phenylalanine, proline, hydroxyproline, serine, threonine, tryptophan, tyrosine, valine.

7. Important amino acid reactions a.) Basic reaction of transamination; b.) reductive desamination; formation of alpha-amino acids from alpha-keto acids (alpha-oxo acids); c.) formation of glutamine from glutamic acid; d.) decarboxylation; e.) oxidative desamination; f.) formation of asparagine from aspartic acid. Breakdown of xanthine, caffeine and other purine-derived effective substances: formation of ureids, glycolic acid, glyoxylic acid and carbamide. Allantoin, as the most well-known plant ureid.

8. Specific amino acids: chemical structure of gamma-amino-butyric acid (GABA), beta-amino-butyric acid (BABA) and beta-alanine; formation, significance in plants; chemical transformation. Occurrence and significance of canavanine. Structure, occurrence and biological effect of L-dihydroxy-phenylalanine (L-DOPA). Occurrence of alkyl- and allyl-derivatives of cysteine; chemical structure and occurrence of diallyl-sulfide and diallyl-disulfide. Occurrence of propenyl-cysteine.

9. Peptids, proteins. Classification of proteins based on solubility relations. Biological and biochemical role of enzymes, classification according to their functions. Occurrence and medicinal usage of some enzymes (papain, bromealin, ficin). The place and main steps of plant protein biosynthesis. Occurrence and biological role of stored proteins. Features, occurrence, biological role and application of lectins (phytohemagglutinins), toxic (ricin) and other plant proteins.

10. Alkaloids I. Definition and general characteristics of alkaloids; natural occurrence. Structure of the most important amino acids in their biosynthesis (ornithine, lysine, phenylalanine, tyrosine, tryptophan, histidine). Structure of N-containing heterocyclic compounds, characteristic for alkaloids (pyrrole, pyrrolidine, pyridine, piperidine, indole, quinoline, isoquinoline, pyrimidine, imidazole, purine, sterane structure). Phenylethylamine-type alkaloids: ephedrine as a protoalkaloid. Mescaline as a protoalkaloid. Occurrence, biological features, application.

11. Alkaloids II. Alkaloids containing pyridine, pyrrolidine, piperidine cycle: chemical formula and name, biological effect of nicotine and coniine. Occurrence of other alkaloids with pyperidine cycle (piperine, lobeline). Tropane alkaloids -Alkaloids with a condensed pyrrolidine- and piperidine cycle. Structure of nortropane, tropane, tropine (3α-hydroxi-tropane) and tropic acid. Atropine, hyosciamine, scopolamine -structure, occurrence, biological effect, application in medicine and elsewhere.

12. Alkaloids III. Structure of pseudotropine (3-beta-hydroxi-tropane), ecgonine and cocaine; occurrence and biological effects of cocaine. Structural comparison of novocaine (non-alkaloid) and cocaine, focusing on the atom group responsible for biological effect. Alkaloids with quinoline structure. Structure, occurrence, biological effects and application of quinine.

13. Alkaloids IV. Opium alkaloids: Structure, biological effect and usage of papaverine as an isoquinoline structure alkaloid. Structure of morphine; biological effect, medical usage. Structure, biological effects and medical application of some important morphine derivatives [codeine, tebaine, ethylmorphine (dionine), heroin]. LSD as the most important representative of ergot alkaloids: chemical structure, biological effects. Biological effects and medical application of further important ergot alkaloids.

14. Alkaloids V. Purine alkaloids: tautomeric lactam-lactim equilibrium of xanthine; structure of theophylline, theobromine and caffeine; occurrence, biological effects, usage. Sterane alkaloids (pseudoalkaloids): chemical structure of tomatidine and solanidin; occurrence in plants; usage. Occurrence of protoalkaloids with a special structure (colchicine, aristolochic acid) and colouring agents containing quaternary nitrogen. The most important alkaloid-containing plant families.

15. Phenoloids I. Structure of amino acids in their biogenesis (phenylalanine, tyrosine). Structure of beta-phenyl-propionic acid, trans (E)-cinnamic acid, cis (Z)-cinnamic acid (allo-cinnamic acid), para-coumaric acid, caffeic acid and chlorogenic acid (the ester of caffeic acid and quinic acid). The hydroquinone para-benzoquinone transformation. Quinone derivatives and their significance in plant biochemistry. Phenol-carboxylic acids of benzoic acid origin (protocatechuic acid, vanillic acid, gallic acid): structure, occurrence in plants, significance in biology and medicine.

16. Phenoloids II. Structure and occurrence of salicin in plants. Chemical structure of salicylic alcohol, salicylic acid, acetylsalicylic acid (Aspirin) and its Ca-salt (Kalmopyrin); their significance in pharmacy. Structure of anise alcohol and anise aldehyde; occurrence in plants. Structure of some unsaturated phenol alcohols. Trans (E)-cinnamic alcohol and its derivatives: para-coumaryl alcohol, coniferyl alcohol, sinapyl alcohol. Features of lignins, lignans, flavonolignans: occurrence, biological and medicinal importance.

17. Phenoloids III. Coumarins. Chemical structure of coumarin, coumaric acid, aesculin, dicoumarol and furanocoumarins; occurrence in plants; biological and medicinal significance. Flavonoids: Structure of alpha- and gamma-pyran, alpha- and gamma-pyrone and coumarin alpha-pyrone condensed with benzol). Structure of chromane, chromene, chromone, flavan, flavene, flavon, flavonol (3-hydroxi-flavon) and quercetin. Structure, occurrence and isolation of rutin (vitamin P).

18. Phenoloids IV. Anthocyanins, anthocyanidins, flavylium salts. Structure of flavylium chloride; some derivatives substituted with OH-groups. The pH dependence of the colour of flavylium salts; explanation of their behaviour as indicators. Occurrence in plants, biological effects and medical significance of anthocyanin colouring agents. Tannins. Classification of tannins. Structure of gallic acid, pyrogallol, meta-digallic acid, penta-meta-digalloyl-beta-D-glucose. Occurrence, features and application of tannins.


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19. Phenoloids V. Quinones and terpenophenols. Structure of juglone, anthraquinone (9,10-anthraquinone) and anthrone. Biological effect, features and usage of juglone. Occurrence and medicinal significance of plant effective substances with anthraquinone and anthrone (naphtho-dianthrone) structure. Terpenophenols (cannabinoids). Occurrence and biological effect of THC; effective substances of hop and their structure.

II. Drugs 1. Drugs containing carbohydrates: Mel depuratum, Manna, Pulpa tamarindorum, Rosae pseudo-fructus, Solani amylum,

Tritici amylum, Maydis amylum, Oryzae amylum, Lana gossypii, Agar, Acaciae gummi (Gummi arabicum), Tragacantha, Helianthus tuberosus

2. Drugs containing mucilage-like carbohydrates: Lichen islandicus, Althaeae radix, Althaeae folium, Malvae sylvestris folium et flos, Salep tuber, Graminis rhizoma, Cyamopsidis tetragonolobae semen, Farfarae folium et flos, Lini semen, Cydoniae semen

3. Carbohydrate-containing drugs stimulating non-specific immune reactions: Echinaceae radix, Eupatorii herba, Arnicae flos, Visci stipes, Calendulae flos, Tiliae flos, Foenugraeci semen

4. Drugs containing polar, non-polar fats, oils and waxes of plant origin: Lecitin, Ricini oleum virginale, Helianthi annui oleum raffinatum, Lini oleum virginale, Soiae oleum raffinatum, Carthami oleum raffinatum, Brassicae napae oleum, Arachidis oleum raffinatum, Butyrum cacao, Jojoba, Cera carnauba

5. Drugs containing essential oil: Menthae piperitae folium, Lavandulae flos, Basilici herba, Orthosiphonis folium, Melissae folium, herba, Thymi herba, Serpylli herba, Origani herba, Majoranae herba, Saturejae herba, Hyssopi herba, Salviae officinalis folium, Rosmarini folium, Rosae petalum, Juniperi pseudo-fructus, Camphora, Eucalypti folium, Carvi fructus, Coriandri fructus, Aurantii amari epicarpium et mesocarpium, Cardamomi fructus, Myrrha

6. Essential oils: Anisi aetheroleum, Aurantii amari floris aetheroleum, Aurantii dulcis aetheroleum, Carvi aetheroleum, Caryophylli floris aetheroleum, Cinnamomi zeylanici corticis aetheroleum, Citronellae aetheroleum, Coriandri aetheroleum, Eucalypti aetheroleum, Foeniculi amari fructus aetheroleum, Juniperi aetheroleum, Lavandulae aetheroleum, Limonis aetheroleum, Matricariae aetheroleum, Melaleucae aetheroleum, Menthae piperitae aetheroleum, Myristicae fragrantis aetheroleum, Neroli aetheroleum, Pini silvestris aetheroleum, Rosmarini aetheroleum, Salviae sclareae aetheroleum, Thymi aetheroleum

7. Drugs containing iridoids: Plantaginis lanceolatae folium, Euphrasiae herba, Lamii albi herba, Harpagophyti radix, Agni

casti fructus, Verbenae herba, Valerianae radix, Gentianae radix, Menyanthidis trifoliatae folium, Centaurii herba, Oleae folium

8. Drugs containing sesquiterpenes: Chamomillae romanae flos, Millefolii herba, Matricariae flos, Tanaceti parthenii herba, Cynarae folium, Absinthii herba, Artemisiae vulgaris herba, Abrotani herba, Dracunculi herba, Artemisiae maritimae herba et flos, Cardui benedicti herba, Helenii radix, Arnicae flos, Petasitidis folium, rhizoma, Bardanae radix, Cichorii radix et herba, Taraxaci radix et herba, Pyrethri flos

9. Drugs containing diterpenes and triterpenes: Colophonium, Marrubii herba, Ballotae nigrae herba, Taxi bracteae folium, Liquiritiae radix, Quillajae cortex, Verbasci flos, Saponariae albae radix, Saponariae rubrae radix, Primulae radix, Polygalae radix, Pruni africanae cortex, Hederae helicis folium, Betulae folium, Veronicae herba, Ononidis radix, Herniariae herba, Solidaginis virgaureae herba, Solidagnis herba, Centellae asiaticae herba, Hippocastani semen/folium/cortex, Calendulae flos, Avenae herba

10. Drugs containing adaptogenic triterpenes, sterols and saponins: Ginseng radix, Eleuterococci radix, Urticae radix et folium, Epilobii herba, Cucurbitae semen, Dioscoreae tuber, Trigonellae foenigraeci semen, Rusci rhizoma

11. Drugs containing bufadienolides, cardenolides: Digitalis purpureae folium, Digitalis lanatae folium, Strophanthi semen, Scillae bulbus, Adonidis herba, Erysimi herba et semen, Convallariae herba, Nerii folium, Hellebori radix, Leonuri cardiacae herba

12. Drugs containing specific amino acids, amino acid derivatives and amines: Allii sativi bulbus, Allii ursini folium, Allii cepae bulbus, Bursae pastoris herba, Galegae herba, Phaseoli legumen

13. Drugs containing alkaloids of ornithine and lysine origin: Belladonnae radix et folium, Hyoscyami folium, Stramonii folium, Cocae folium, Nicotianae folium, Pulmonariae herba, Symphyti radix, Lobeliae herba, Laburni semen, Sarothamni scoparii herba

14. Drugs containing alkaloids of phenylalanine origin: Capsici fructus, Ephedrae herba, Papaveris fructus sine seminibus, Opium crudum, Chelidonii herba et radix, Fumariae herba, Berberidis radicis cortex, Colchici tuber, Ipecacuanhae radix, Boldo folium, Tubokurarin-curare

15. Drugs containing alkaloids of tryptophan origin: Secale cornutum, Rauwolfiae radix, Vincae minoris herba, Catharanthi herba, Strychni semen, Curare, Cinchonae cortex, Uncariae tomentosae radix, Passiflorae herba, Physostigmae semen

16. Drugs containing purine structure effective substances: Coffeae semen, Theae folium, Cacao semen, Guarana, Mate folium, Colae semen

17. Drugs containing terpenoid alkaloids: Aconiti tuber, Veratri rhizoma et radix, Solani herba 18. Drugs containing cyanogenic glycosides, isothiocyanate derivatives: Amygdali semen, Lini semen, Sinapis nigrae semen 19. Drugs containing phloroglucin and terpenophenol derivatives: Filicis maris rhizoma, Lupuli flos, Cannabis herba 20. Drugs containing phenol- and phenylpropionic acid derivatives: Cinnamomi cortex, Caryophylli flos, Zingiberis rhizoma,

Anisi fructus, Anisi stellati fructus, Foeniculi dulcis fructus, Asari rhizoma, Calami rhizoma, Petroselini fructus, Balsamum peruvianum, Filipendulae ulmariae herba, Salicis cortex

21. Drugs containing quinone- and anthraquinone derivatives, naphthoquinone- and dianthrone derivatives: Uvae ursi folium, Vitis-idaeae folium, Frangulae cortex, Rhamni purshianae cortex, Rhei radix, Aloe, Juglandis folium, Alkannae radix, Droserae herba, Lawsoniae folium, Sennae folium et fructus, Hyperici herba


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22. Drugs containing coumarins, furocoumarins, lignans and flavanolignans: Meliloti herba, Angelicae radix, Ammeos visnagae fructus, Ammi majoris fructus, Levistici radix, Apii fructus, Podophylli rhizoma, Silybi mariani fructus

23. Drugs containing flavonoids: Tiliae flos, Sambuci flos, Equiseti herba, Crataegi folium cum flore, Crataegi fructus, Violae herba cum floris, Ginkgo folium, Stoechados flos, Populi gemma, Propolis, Ribis nigri folium

24. Drugs containing tannins, polyphenols: Galla, Quercus cortex, Ratanhiae radix, Hamamelidis folium, Tormentillae rhizoma, Anserinae herba, Gei radix et rhizoma, Agrimoniae herba, Fragariae folium, Alchemillae herba, Polygoni avicularis herba, Rubi idaei folium, Rubi fruticosi folium, Coryli folium, Myrtilli folium et fructus

Participants Dr. Horváth Györgyi (HOGAAA.T.JPTE), Dr. Molnár Péter (MOPGAAO.PTE)


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OPGGH1 PHARMACODYNAMICS 1

Course director: DR. GÁBOR PETHŐ, professor Department of Pharmacology and Pharmacotherapy


Number of hours/semester: 28 lectures + 0 practices + 28 seminars = total of 56 hours Headcount limitations (min-max.): min. 5 –

Prerequisites: OPGGK2 completed + OPABA2 completed + OPOEL2 completed

Topic The aim of the course is to provide the students with pharmacological knowledge that is required for their future work in the pharmacy. Important topics are the general principles of pharmacodynamics and pharmacokinetics, pharmacology of the autonomic nervous system and the cardiovascular system. It must be emphasized the knowledge of the physiological principles is absolutely needed for the study of this subject.

Conditions for acceptance of the semester

Making up for missed classes There is no way to make up for missed lectures or seminars.

Reading material Rang, Dale, Ritter, Moore: Pharmacology, 7th edition, Elsevier Churchill Livingstone, 2012 B. G. Katzung (ed.): Basic and Clinical Pharmacology, 11th edition, Lange Medical Books/McGraw-Hill, 2009

Lectures 1 General aspects of neuropharmacology. General characterization of the autonomic nervous system Dr. Barthó Loránd 2 Cholinergic agonists Dr. Barthó Loránd 3 Cholinesterase inhibitors I Dr. Barthó Loránd 4 Cholinesterase inhibitors II Dr. Barthó Loránd 5 Muscarinic receptor antagonists I Dr. Barthó Loránd 6 Muscarinic receptor antagonists II Dr. Barthó Loránd 7 Neuromuscular blocking agents I Dr. Pethő Gábor 8 Neuromuscular blocking agents II. Drugs acting on autonomic ganglia Dr. Pethő Gábor 9 Agents acting on biosynthesis, storage, release and elimination of catecholamines I Dr. Pethő Gábor 10 Agents acting on biosynthesis, storage, release and elimination of catecholamines II Dr. Pethő Gábor 11 Adrenergic receptor agonists I Dr. Barthó Loránd 12 Adrenergic receptor agonists II Dr. Barthó Loránd 13 Adrenergic receptor antagonists I Dr. Barthó Loránd 14 Adrenergic receptor antagonists II Dr. Barthó Loránd 15 Pharmacology of calcium channels I Dr. Pethő Gábor 16 Pharmacology of calcium channels II Dr. Pethő Gábor 17 Drugs acting on the renin-angiotensin-aldosterone system I Dr. Pethő Gábor 18 Drugs acting on the renin-angiotensin-aldosterone system II Dr. Pethő Gábor 19 Diuretics I Dr. Pethő Gábor


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20 Diuretics II Dr. Pethő Gábor 21 Drugs used to treat congestive heart failure I Dr. Barthó Loránd 22 Drugs used to treat congestive heart failure II Dr. Barthó Loránd 23 Antianginal drugs I Dr. Barthó Loránd 24 Antianginal drugs II. Drugs that increase regional blood flow Dr. Barthó Loránd 25 Antihypertensive drugs I Dr. Pethő Gábor 26 Antihypertensive drugs II Dr. Pethő Gábor 27 Antiarrhythmic drugs I Dr. Pethő Gábor 28 Antiarrhythmic drugs II Dr. Pethő Gábor

Practices

Seminars 1 Introduction to pharmacodynamics I 2 Introduction to pharmacodynamics II 3 Basic mechanisms of drug actions 4 Characterization of agonist-receptor interaction I 5 Characterization of agonist-receptor interaction II 6 Characterization of agonist-receptor interaction III 7 Signal transduction mechanisms of drug receptors 8 Mechanisms of drug antagonisms I 9 Mechanisms of drug antagonisms II 10 Tachyphylaxis and tolerance to drugs 11 Transport of drugs across membranes I 12 Transport of drugs across membranes II 13 Pharmacokinetic parameters I 14 Pharmacokinetic parameters II 15 Pharmacokinetic parameters III 16 Pharmacokinetic parameters IV 17 Absorption of drugs 18 Distribution of drugs 19 Biotransformation of drugs I 20 Biotransformation of drugs II 21 Excretion of drugs I 22 Excretion of drugs II 23 Discussion of the pharmacology of the autonomic nervous system and the neuromuscular junction I 24 Discussion of the pharmacology of the autonomic nervous system and the neuromuscular junction II 25 Computer program demonstrating the cardiovascular effects of agents acting on the autonomic nervous system I 26 Computer program demonstrating the cardiovascular effects of agents acting on the autonomic nervous system II 27 Local anaesthetics I 28 Local anaesthetics II

Exam topics/questions 1. Basic mechanisms of drug actions (examples of drug effects on receptors, ion channels, enzymes, carrier systems and effects

mediated by physicochemical interactions) 2. Characterisation of agonist-receptor interaction: occupancy, affinity, dose-response curve, potency, efficacy 3. Significance of signal transduction mechanisms in the effects of drugs. 4. Mechanisms of drug antagonisms. Tachyphylaxis and tolerance to drugs 5. Transport of drugs across membranes 6. Absorption of drugs, oral bioavailability and presystemic elimination 7. Plasma protein binding and tissue distribution of drugs 8. Biotransformation of drugs 9. Excretion of drugs


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10. Pharmacokinetics: zero and first order elimination, volume of distribution, clearance, elimination half-life, oral bioavailability, calculation of loading and maintenance doses

11. Cholinergic agonists and cholinesterase inhibitors 12. Muscarinic receptor antagonists 13. Neuromuscular blocking agents. Drugs acting on autonomic ganglia 14. Agents acting on the biosynthesis, storage, release and elimination of catecholamines 15. Adrenergic receptor agonists 16. Adrenergic receptor antagonists 17. Local anaesthetics 18. Calcium channel blockers 19. Drugs acting on the renin-angiotensin-aldosterone system 20. Diuretic drugs 21. Positive inotropic and other drugs used to treat congestive heart failure 22. Antianginal drugs. Drugs that increase regional blood flow 23. Antihypertensive drugs 24. Antiarrhythmic drugs In addition to the exam topics, an important part of the exam are questions that aim at assessing the general knowledge of the

student.

Participants Dr. Barthó Loránd (BALIAAO.PTE), Dr. Gregus Zoltán (GRZMAAO.PTE), Dr. Pethő Gábor (PEGGAAO.PTE)


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OPGGH2 PHARMACODYNAMICS 2

Course director: DR. GÁBOR PETHŐ, professor Department of Pharmacology and Pharmacotherapy

4 credit ▪ semester exam ▪ Pharmaceutical Professional Theoretical ... module ▪ spring semester ▪ recommended semester: 8

Number of hours/semester: 28 lectures + 0 practices + 28 seminars = total of 56 hours Headcount limitations (min-max.): min. 5 –

Prerequisites: OPGGH1 completed + OPGGK3 completed + OPGGT3 completed

Topic The aim of the course is to provide the students with pharmacological knowledge that is required for their future work in the pharmacy. Important topics are pharmacology of the blood, parmacology of histamine, serotonin and eicosanoids, pharmacology of the respiratory tract and the gastrointestinal tract, pharmacology of the central nervous system. Drug abuse and dependence as well as non-steroidal anti-inflammatory drugs will also be discussed.

Conditions for acceptance of the semester

Making up for missed classes There is no way to make up for missed lectures or seminars.

Reading material Rang, Dale, Ritter, Moore: Pharmacology, 7th edition, Elsevier Churchill Livingstone, 2012 B. G. Katzung (ed.): Basic and Clinical Pharmacology, 11th edition, Lange Medical Books/McGraw-Hill, 2009

Lectures 1 Drugs used to treat hyperlipoproteinaemias I Dr. Pethő Gábor 2 Drugs used to treat hyperlipoproteinaemias II Dr. Pethő Gábor 3 Drugs affecting haemostasis I Dr. Pethő Gábor 4 Drugs affecting haemostasis II Dr. Pethő Gábor 5 Drugs affecting haemostasis III Dr. Pethő Gábor 6 Drugs affecting haematopoiesis I Dr. Pethő Gábor 7 Drugs affecting haematopoiesis II Dr. Pethő Gábor 8 Drugs affecting haematopoiesis III Dr. Pethő Gábor 9 Introduction into the pharmacology of the central nervous system I Dr. Barthó Loránd 10 Introduction into the pharmacology of the central nervous system II Dr. Barthó Loránd 11 Antianxiety and hypnotic drugs I Dr. Barthó Loránd 12 Antianxiety and hypnotic drugs II Dr. Barthó Loránd 13 Pharmacology of alcohols I Dr. Barthó Loránd 14 Pharmacology of alcohols II Dr. Barthó Loránd 15 Antipsychotic drugs I Dr. Barthó Loránd 16 Antipsychotic drugs II Dr. Barthó Loránd 17 Antidepressants I Dr. Barthó Loránd 18 Antidepressants II Dr. Barthó Loránd 19 Antiepileptic drugs I


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Dr. Pethő Gábor 20 Antiepileptic drugs II Dr. Pethő Gábor 21 Opioid analgesic drugs I Dr. Barthó Loránd 22 Opioid analgesic drugs II Dr. Barthó Loránd 23 Opioid analgesic drugs III Dr. Barthó Loránd 24 Opioid analgesic drugs IV Dr. Barthó Loránd 25 Non-steroidal antiinflammatory drugs I Dr. Pethő Gábor 26 Non-steroidal antiinflammatory drugs II Dr. Pethő Gábor 27 Non-steroidal antiinflammatory drugs III Dr. Pethő Gábor 28 Adjuvant analgesics. Drugs used to treat gout Dr. Pethő Gábor

Practices

Seminars 1 Histamine, H1 receptor antagonists 2 H2 receptor antagonists 3 Serotonin, serotonin receptor agonists 4 Serotonin receptor antagonists 5 Pharmacology of eicosanoids 6 Drugs acting on the smooth muscle including uterine muscle 7 Pharmacology of the respiratory tract I 8 Pharmacology of the respiratory tract II 9 Pharmacology of the respiratory tract III 10 Pharmacology of the respiratory tract IV 11 Pharmacology of the gastrointestinal tract I 12 Pharmacology of the gastrointestinal tract II 13 Pharmacology of the gastrointestinal tract III 14 Pharmacology of the gastrointestinal tract IV 15 Pharmacology of the gastrointestinal tract V 16 Centrally-acting muscle relaxants. Nootropic drugs 17 General anaesthetics I 18 General anaesthetics II 19 Drug treatment of neurodegenerative disorders I 20 Drug treatment of neurodegenerative disorders II 21 Central nervous system stimulants I 22 Central nervous system stimulants II 23 Drug abuse I 24 Drug abuse II 25 Drug abuse III 26 Drug abuse IV 27 Drug abuse V 28 Drug abuse VI

Exam topics/questions 1. Antianxiety and hypnotic drugs 2. Alcohols: pharmacology, toxicology 3. Antipsychotic drugs 4. Antidepressants 5. Central nervous system stimulants. Nootropic drugs 6. Drug treatment of neurodegenerative disorders 7. General anaesthetics 8. Antiepileptic drugs 9. Opioid analgesic drugs: morphine and codeine


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10. Opioid analgesic drugs: semisynthetic, synthetic opioids, opioid antagonists 11. Non-steroidal antiinflammatory drugs: aspirin, paracetamol 12. Non-steroidal antiinflammatory drugs: drugs other than aspirin or paracetamol 13. Adjuvant analgesics. Drugs used to treat gout. Centrally-acting muscle relaxants 14. Basic terms of drug abuse. Psychedelics, nicotine, cannabis, inhalants 15. Drugs used to treat hyperlipoproteinaemias 16. Drugs affecting haemostasis 17. Drugs affecting haematopoiesis 18. Histamine, H1 and H2 receptor antagonists 19. Serotonin, serotonin receptor agonists and antagonists 20. Pharmacology of eicosanoids. Drugs acting on the smooth muscle: smooth muscle relaxants, pharmacology of the uterine

muscle 21. Drugs used in bronchial asthma 22. Drugs used in allergic rhinitis. Antitussive, expectorant and mucolytic agents 23. Drugs used in the treatment of peptic ulcer 24. Emetics, antiemetics and prokinetic drugs. Digestives, drugs used in cholelithiasis 25. Laxatives, antidiarrhoeal agents, drug treatment of inflammatory bowel diseases In addition to the exam topics, an important part of the exam are questions that aim at assessing the general knowledge of the

student.

Participants Dr. Barthó Loránd (BALIAAO.PTE), Dr. Pethő Gábor (PEGGAAO.PTE)


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OPGGI1 BASIC PRINCIPLES OF PHARMACY 1

Course director: DR. LAJOS BOTZ , professor Dept. of Pharmaceutics and University Pharmacy

2 credit ▪ midsemester grade ▪ Pharmaceutical Professional Theoretical ... module ▪ spring semester ▪ recommended semester: 4


Prerequisites: OPOMB2 completed

Topic Overview of pharmacy and the introduction to the principles of pharmaceuticals: definition of the different groups of pharmaceuticals, synopsis of the process of drug development, evolution and role of pharmacopoeias, sites and aims of small-, medium- and large scale drug manufacturing. Visiting pharmacies and the role of community and clinical pharmacies. Attendance at the lectures and understanding of given topics are the basic requirements for the seminar. Topics discussed during the lectures, but not included in the notes/books will also be included in the exams. Students will receive the slides of the lectures. Fundamental knowledge of earlier theoretical studies is beneficial. Aims of lectures in pharmaceutical studies: Basic aim of the studies are to draw the attention of students towards specific topics of pharmacy practice and to support further studies in this field. The main goal is to obtain fundamental pharmaceutical knowledge which will support the professional practical course in summer. Further aim is to help students to gain interest in practical aspects of pharmaceutical work and also in other professional studies.

Conditions for acceptance of the semester Midterm examination: oral and written Acceptance criteria of semester: attendance of at least 75 % of lectures, successful exam

Making up for missed classes Compensation is possible following personal discussion

Reading material All presentations can be downloaded from the webside of department http://aok.pte.hu/index.php?page=egyseg&egy_id=50&menu=okt_anyag&nyelv=eng

Lectures 1 Introduction to Basic Principles of Pharmacy. Short presentation of the Pharmaceutical Institute - Central Clinical

Pharmacy Dr. Fittler András Tamás 2 Pharmacy as a profession. Areas of pharmacy practice Dr. Fittler András Tamás 3 Introduction of the product categories found in community pharmacies Dr. Fittler András Tamás 4 Routes of administration Dr. Fittler András Tamás 5 Dosage forms Dr. Fittler András Tamás 6 Classification of medications Dr. Fittler András Tamás 7 How acive substances and medicines are named. Index Nominum Dr. Fittler András Tamás 8 Development of pharmacopoeias, The European Pharmacopoeia Dr. Fittler András Tamás 9 Pharmacopoeias and Formularies Dr. Fittler András Tamás 10 Contents and format of the medical prescription Dr. Fittler András Tamás 11 Handling of the prescription by the pharmacist: Pharmacy Practice Procedures Dr. Fittler András Tamás 12 Labelling of dispensed medicines Dr. Fittler András Tamás 13 Latin terms and abbreviations Dr. Fittler András Tamás 14 Pharmaceutical calculations Dr. Fittler András Tamás 15 On site visit to the University Pharmacy Dr. Fittler András Tamás


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16 Getting familiar with ingredients and dosage forms of pharmaceuticals made in pharmacies Dr. Fittler András Tamás 17 Manufacturing of medicines and the importance of good manufacturing practice Dr. Fittler András Tamás 18 Structure and tasks of a community pharmacy, On site visit Dr. Fittler András Tamás 19 Structure and tasks of a clinical pharmacy, On site visit Dr. Fittler András Tamás 20 Reserach and develpoment of medicines, Clinical trials Dr. Fittler András Tamás 21 Structure and tasks of the pharmaceutical industry, On site visit Dr. Fittler András Tamás 22 Large scale manufacturing of pharmaceuticals, On site visit Dr. Fittler András Tamás 23 Oral presentations of students on pre-arranged topics 1. Dr. Fittler András Tamás 24 Oral presentations of students on pre-arranged topics 2. Dr. Fittler András Tamás 25 History of Pharmacy and Medicine (1) from the ancient world to 1100 AD Dr. Fittler András Tamás 26 History of Pharmacy and Medicine (2) in the medieval world form 1100 to 1617 AD Dr. Fittler András Tamás 27 History of Pharmacy (3) in the modern world 1841-1986. Dr. Fittler András Tamás 28 Where are we heading? Pharmacy in the 21st century Dr. Fittler András Tamás

Practices

Seminars

Exam topics/questions Based on the topics of the lectures

Participants


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Prerequisites: OPGGI1 completed

Topic The topic of the semester in the first place is to introduce the basic functioning of medical market, the fundamentals and specifications of economic relations. It also aims to demonstrate the specific professional methods for the evaluation of drug therapies. Basic knowledge of earlier theoretical studies is beneficial. Aims of lectures in pharmaceutical studies: Basic aim of these studies is to solidify pharmacy practice and related economic knowledge in order to understand pharmacoeconomics, drug allocation, pharmaceutical management, health economics, evidence based medicine and in general pharmaceutics. These knowledge will support later studies in these fields. Further goal is to help students to gain insight into practical pharmaceutical work and into other professional studies. The interactive group work during the seminars will develop analytical, problem solving and creative thinking skills.

Conditions for acceptance of the semester FMidterm examination: oral and written Accepting criteria of semester: attendance of at least 70 % of lectures, successful exam

Making up for missed classes Compensation is possible following personal discussion.

Reading material All presentations can be downloaded from the webside of department (http://aok.pte.hu/index.php?page=egyseg&egy_id=50&nyelv=hun&menu=okt_anyag). Principles of Pharmacoeconomics, Ed.: J.L. Bootman, R. J. Townsend, W. F. McGhan, Harvey Whitney Book Company, 2002.

Lectures 1 Statistical tests and examples for the evaluation of market trends. Dr. Botz Lajos 2 Methods for the comparative appraisal of drug utilizations. Dr. Botz Lajos 3 Significance of the determination of „quality of life” Dr. Botz Lajos 4 Quality of life measurement methods. Dr. Botz Lajos 5 Pharmaceutical industry of the world. Dr. Fittler András Tamás 6 International trends in drug development and pharmaceutical markets. Dr. Botz Lajos 7 Definition of pharmacoeconomics, its function and significance. Dr. Fittler András Tamás 8 Investigation methods in pharmacoeconomics. Dr. Botz Lajos 9 Drug efficiency evaluations and basic methods. Dr. Botz Lajos 10 Cost-effectiveness in medicine. Dr. Botz Lajos 11 Basics of health economics I. Dr. Botz Lajos 12 Basics of health economics II. Dr. Botz Lajos 13 Health care market. Dr. Botz Lajos 14 Evaluation of drug utilization Dr. Botz Lajos 15 The pharmaceutical market and „market trends” Dr. Fittler András Tamás


23

16 Introduction of the work and research profile of the Department of Pharmaceutics. Introduction to pharmacy practice and management 2

Dr. Botz Lajos 17 A basic (but not the only) question of drug therapy Dr. Botz Lajos 18 Clinical studies in the process of developing a pharmaceutical drug I. Dr. Botz Lajos 19 Clinical studies in the process of developing a pharmaceutical drug II. Dr. Botz Lajos 20 Basic steps and procedures of developing a pharmaceutical drug. Dr. Szücs Ferenc 21 Pharmaco-economic aspects of developing a pharmaceutical drug and evaluation methods. Dr. Szücs Ferenc 22 Price structure of drugs. Dr. Botz Lajos 23 Change of a price of a medication during its life cycle. Dr. Fittler András Tamás 24 Pricing of drugs in Hungary. Dr. Botz Lajos 25 Reasons of the international differences in the prices of medications. Dr. Fittler András Tamás 26 Methods for the regulation of prices of medications. Dr. Fittler András Tamás 27 Reasons for the increase of drug expenses. Dr. Botz Lajos 28 Health and medical expenses. Dr Botz Lajos

Practices

Seminars Interactive appraisal of topics discussed during the lecture, discussion and case study

Exam topics/questions Based on the topics of the lectures and seminars

Participants


24





Prerequisites: OPGGI2 completed + OPGGH1 completed + OPGGT3 completed

Topic The topic of the semester primarily is to introduce the basic function of the health care system and pharmaceutical supply system; in respect of general legal, pharmaceutical, economical (marketing) relations and specialities. The undergraduates acquire knowledge of the innovation of a new drug from a drug candidate, the formation of the legal validity of official indications, as well as grouping and professional explanation of unwanted effects. Methods of comprehensive analysis, evaluation and development of drug therapy, the framework and regulation of pharmaceutical supply system will be covered throughout the semester. Basic knowledge of earlier theoretical studies is beneficial. Aims of lectures are to consolidate students; legal, marketing and pharmacoeconomical knowledge (pharmaceutical management, health economy, pharmaceutical supply, pharmacoeconomy, evidence based medicine and pharmaceutics), and to lay the foundations of practical pharmaceutical work and further professional development. Interactive group work during the seminars will encourage problem solving skills and creative thinking.

Conditions for acceptance of the semester Inter midterm examination: oral and written, Midterm grade: written terminal examination Acceptance criteria of semester: attendance of at least 70 % of lectures, successful exam

Making up for missed classes Compensation is possible following personal discussion

Reading material All presentations can be downloaded from the webside of department (http://aok.pte.hu/index.php?page=egyseg&egy_id=50&menu=okt_anyag&nyelv=eng) .

Lectures 1 Drug authorisation procedure I: basic aspects of drug evaluation before marketing authorisation. Dr. Télessy István 2 Drug authorisation procedure II: establishing the efficacy of drug therapy, relevant explanation of placebo effect. Dr. Botz Lajos 3 Drug authorisation procedure III: stages of human clinical studies. Dr. Botz Lajos 4 Drug authorisation procedure IV: aims and contents of postmarketing surveillance. Dr. Botz Lajos 5 Drug authorisation procedure V: patent of drugs. Dr. Botz Lajos 6 Drug authorisation procedure VI: equivalences, generics, bioequivalence studies. Dr. Fittler András Tamás 7 Drug authorisation procedure VII: side effects of drugs. Dr. Botz Lajos 8 Drug authorisation procedure VIII: European drug authorisation procedure, simplified drug authorisation procedures. Dr. Botz Lajos 9 Methods for rational drug use (SOJA, etc.). Dr. Fittler András Tamás 10 Key problems of traditional drug therapy; importance of compliance/adherence. Dr. Baliné Dr. Háber Ágota 11 Evidence based pharmaceutics. Dr. Baliné Dr. Háber Ágota 12 Evidence based drug evaluation. Dr. Botz Lajos 13 Evidence based drug evaluation I. Dr. Botz Lajos 14 Evidence based drug evaluation II. Dr. Fittler András Tamás 15 Principles of decision analysis. Dr. Nyaka Bernadett


25

16 Practical use of decision analysis. Dr. Nyaka Bernadett 17 Review of pharmaceutical issues according to Drug law I. Dr. Télessy István 18 Review of pharmaceutical issues according to Drug law II. Dr. Télessy István 19 Pharmaceutical care I.: legal aspects of pharmaceutics. The legal basics of the pharmaceutical profession. Dr. Botz Lajos 20 Pharmaceutical care II.: development, principles, applied techniques and practical methods. Dr. Botz Lajos 21 Pharmaceutical care III.: professional fields of pharmaceutical care, pharmaceutical competencies, guided problem

exploration. Dr. Baliné Dr. Háber Ágota 22 Pharmaceutical care IV: special fields. Dr. Botz Lajos 23 Nutrition therapy. Dr. Botz Lajos 24 Nutrition therapy as field of pharmaceutical care. Dr. Botz Lajos 25 Pharmaceutical aspects of cytostatic therapy I. Dr. Botz Lajos 26 Pharmaceutical aspects of cytostatic therapy II. Dr. Fittler András Tamás 27 Evaluation of trial results, significance. Dr. Nyaka Bernadett 28 Professional and legal environment of pharmaceutical issue. Laws relating to pharmaceutics. Dr. Télessy István

Practices 1 Official summary of product characteristics, indications, side effects I. 2 Official summary of product characteristics, indications, side effects II. 3 Basic statistical definitions. 4 Application of drug evaluating methods I. 5 Case study of using drug evaluating methods I. 6 Application of drug evaluating methods II. 7 Case study of using drug evaluating methods II. 8 Professional evaluation of drug descriptions (official and other promotional) 9 Indices of drug efficiency (NNT, NNH, etc.). 10 Pharmaceutical care: non-bacterial originated respiratory diseases. 11 Pharmaceutical care: asthma, COPD, influenza. 12 Pharmaceutical care: pain management, treatment of trivial diseases. 13 Pharmaceutical care: nausea, diarrhoea, constipation. 14 Pharmaceutical care: protocols I. 15 Pharmaceutical care: protocols II. 16 Pharmaceutical care: protocols III. 17 Off-label use. 18 Bioequivalence.

Seminars Interactive appraisal of topics discussed during the lectures, dispute and case study.

Exam topics/questions Based on the topics of the lectures and seminars

Participants

Dr. Baliné Dr. Háber Ágota (BAHRABO.PTE), Dr. Botz Lajos (BOLFAAP.PTE), Dr. Fittler András Tamás (FIAQAAK.PTE), Dr. Nyaka Bernadett (NYBQAAP.PTE), Dr. Télessy István (TEIQAAP.PTE)


26

OPGGK1 PHARMACEUTICAL CHEMISTRY 1

Course director: DR. PÁL PERJÉSI, professor Department of Pharmaceutic Chemistry



Prerequisites: OPABA1 completed + OPAAN2 completed + OPASV1 completed

Topic Introduction to the quality control of substances used in pharmaceutical compounding. Pharmacopoeal analysis of selected inorganic substances. Introduction to the pharmacokinetics and pharmacodynamics of drug action. Molecular aspects and structure activity relationship of selected groups of active pharmaceutical ingredients with central nervous system activity.

Conditions for acceptance of the semester The participation in both the lectures and the practices of the course is obligatory. Maximum 3 absences from lectures and practices. 80 % of the performed quantitative determinations should be accepted. Both semester tests results should be above 60 %.

Making up for missed classes Missed practices could be made up during the make-up opportunities announced by the department. During each make-up session only one missed practice can be executed.

Reading material European Pharmacopoeia. EDQM Publication. Pharmaceutical Chemistry Practice I. Laboratory manual. University of Pécs. D. A. Williams, T. L. Lemke (eds.): Foye’s Principles of Medicinal Chemistry, 5th edition, Lippincott Williams&Wilkins, Philadelphia, 2002 Lecture notes

Lectures 1 Introduction. History and development of drug control. The European Pharmacopoeia. The pharmacopoeial

nomenclature of substances. Dr. Perjési Pál 2 Introduction. History and development of drug control. The European Pharmacopoeia. The pharmacopoeial

nomenclature of substances. Dr. Perjési Pál 3 Identification and qualitative tests of the European Pharmacopoeia Dr. Perjési Pál 4 Identification and qualitative tests of the European Pharmacopoeia Dr. Perjési Pál 5 Physical and physicochemical methods of the European Pharmacopoeia Dr. Perjési Pál 6 Physical and physicochemical methods of the European Pharmacopoeia. Dr. Perjési Pál 7 Instrumental (IR, UV-VIS) and chromatographic (TLC, HPLC) methods of the European Pharmacopoeia Dr. Perjési Pál 8 Instrumental (IR, UV-VIS) and chromatographic (TLC, HPLC) methods of the European Pharmacopoeia Dr. Perjési Pál 9 Molecular mechanisms of drug action. Receptor theories Dr. Perjési Pál 10 Molecular mechanisms of drug action. Receptor theories Dr. Perjési Pál 11 Structural and physical chemistry of drug action. Structure-activity relationships. Dr. Perjési Pál 12 Structural and physical chemistry of drug action. Structure-activity relationships. Dr. Perjési Pál 13 Drug metabolism. Phase 1 and Phase 2 transformations. Dr. Perjési Pál 14 Drug metabolism. Phase 1 and Phase 2 transformations. Dr. Perjési Pál 15 General anaesthetics Dr. Perjési Pál


27

16 General anaesthetics Dr. Perjési Pál 17 Sedative-Hypnotics Dr. Perjési Pál 18 Sedative-Hypnotics Dr. Perjési Pál 19 Narcotic analgesics and their antagonists I Dr. Huber Imre 20 Narcotic analgesics and their antagonists Dr. Huber Imre 21 Narcotic-analgesics and their antagonists II. Dr. Huber Imre 22 Narcotic-analgesics and their antagonists II. Dr. Huber Imre 23 Anticonvulsant drugs Dr. Huber Imre 24 Anticonvulsant drugs Dr. Huber Imre 25 Antipsychotics. Neuroleptics Dr. Perjési Pál 26 Antipsychotics. Neuroleptics Dr. Perjési Pál 27 Anxiolytics. Dr. Perjési Pál 28 Anxiolytics Dr. Perjési Pál

Practices 1 Laboratory safety, accident protection, equipping. Physical test and determination. Experimental error. Calculations.

The pharmacopoeial nomenclature of substances. 2 Laboratory safety, accident protection, equipping. Physical test and determination. Experimental error. Calculations.

The pharmacopoeial nomenclature of substances 3 Laboratory safety, accident protection, equipping. Physical test and determination. Experimental error. Calculations.

The pharmacopoeial nomenclature of substances 4 Laboratory safety, accident protection, equipping. Physical test and determination. Experimental error. Calculations.

The pharmacopoeial nomenclature of substances 5 Identification and qualitative tests of the European Pharmacopoeia. Limit tests. Acidum hydrochloridum dilutum. Natrii

chloridum, Chloraminum. 6 Identification and qualitative tests of the European Pharmacopoeia. Limit tests. Acidum hydrochloridum dilutum. Natrii



chloridum, Chloraminum. 9 Halogens. Halogenids. Iodum. Natrii bromidum. Kalii bromidum, Ammonii bromidum, Kalii chloridum. 10 Halogens. Halogenids. Iodum. Natrii bromidum. Kalii bromidum, Ammonii bromidum, Kalii chloridum. 11 Halogens. Halogenids. Iodum. Natrii bromidum. Kalii bromidum, Ammonii bromidum, Kalii chloridum. 12 Halogens. Halogenids. Iodum. Natrii bromidum. Kalii bromidum, Ammonii bromidum, Kalii chloridum. 13 Oxygen and oxygen compounds. Aqua purificata, Hydrogenii peroxidum 30 per centum, Natrii hydroxidum. 14 Oxygen and oxygen compounds. Aqua purificata, Hydrogenii peroxidum 30 per centum, Natrii hydroxidum. 17 Sulfur and sulfur compounds. Natrii thiosulfas, Natrii metabisulfis, Natrii sulfas, Sulphur ad usum externum. 21 Nitrogen and nitrogen compounds. Ammonii chloridum. Natrii nitris. Kalii nitras, Bismuthi subnitras. 25 Phosphorus and phosphorus compounds. Calcii hydrogenphosphas, Tricalcii phosphas, Natrii dihydrogenphosphas,

Dinatrii phosphas, Arsenii trioxidum. 29 Carbon and carbon compounds. Carbo activatus, Calcii carbonas, Natrii carbonas, Natrii hydrogencarbonas. 33 Silicon and compounds. Alkali metals, Alkaline earth metals. Magnesii sulfas, Magnesii subcarbonas, Magnesii

oxidum, Magnesii trisilicas, Silica colloidalis hydrica. 37 Boron and aluminium compounds. Acidum boricum. Borax. Aluminii sulfas, Alumen. Aluminii oxidum hydricum 41 Transition metals I. Zinci oxidum, Zinci chloridum, Hydrargyrum chloratum amidatum (Ph.Hg.VII.), Barii sulfas 45 Transition metals II. Cupri sulfas, Ferrosi sulfas, Ferri chloridum, Kalii permanganas. 49 Complete pharmacopoeial analysis of one substance. 51 Complete pharmacopoeial analysis of one substance.


28

53 Complete pharmacopoeial analysis of one substance. 55 Complete pharmacopoeial analysis of one substance

Seminars

Exam topics/questions Written exam covering the topics of the lectures and the laboratory practices. Further details: www.gytsz.pte.hu

Participants Dr. Rozmer Zsuzsanna (ROZQAAP.PTE)


29





Prerequisites: OPGGK1 completed + OPGGT1 completed

Topic

Introduction to molecular aspects and structure activity relationship of selected groups of active pharmaceutical ingradients. Pharmacopoeal analysis of selected inorganic substances.

Conditions for acceptance of the semester The participation in both the lectures and the practices of the course is obligatory. Maximum 3 absences from lectures and practices. 80 % of the performed quantitative determinations should be accepted. Both semester tests? results should be above 60 %.


Reading material European Pharmacopoeia. EDQM Publication. Pharmaceutical Chemistry Practice I. Laboratory manual. University of Pécs. D. A. Williams, T. L. Lemke (eds.): Foye’s Principles of Medicinal Chemistry, 5th edition, Lippincott Williams&Wilkins, Philadelphia, 2002 Lecture notes

Lectures 1 Antidepressants. Dr. Perjési Pál 2 Antidepressants. Dr. Perjési Pál 3 Antiparkinson agents Dr. Huber Imre 4 Antiparkinson agents Dr. Huber Imre 5 Nootropics. Analeptics Dr. Huber Imre 6 Nootropics. Analeptics Dr. Huber Imre 7 Non-opioid analgesics and antipyretics. Dr. Perjési Pál 8 Non-opioid analgesics and antipyretics. Dr. Perjési Pál 9 Non-steroid anti-inflammatory agents I Dr. Perjési Pál 10 Non-steroid anti-inflammatory agents I Dr. Perjési Pál 11 Non-steroid anti-inflammatory agents II Dr. Perjési Pál 12 Non-steroid anti-inflammatory agents II Dr. Perjési Pál 13 Antiallergic antihistamines. Drugs for rheumatic gout Dr. Perjési Pál 14 Antiallergic antihistamines. Drugs for rheumatic gout Dr. Perjési Pál 15 Parasympathomimetics Dr. Perjési Pál 16 Parasympathomimetics Dr. Perjési Pál 17 Parasympatholytics Dr. Perjési Pál


30

18 Parasympatholytics Dr. Perjési Pál 19 Sympathomimetics Dr. Perjési Pál 20 Sympathomimetics Dr. Perjési Pál 21 Sympatholytics Dr. Perjési Pál 22 Sympatholytics Dr. Perjési Pál 23 Local anesthetic agents Dr. Huber Imre 24 Local anesthetic agents Dr. Huber Imre 25 Spasmolytics. Muscle relactants. Antitussiv agents. Mucolytics. Dr. Huber Imre 26 Spasmolytics. Muscle relactants. Antitussiv agents. Mucolytics. Dr. Huber Imre 27 Drugs of gastrointestinal disorders Dr. Huber Imre 28 Drugs of gastrointestinal disorders Dr. Huber Imre

Practices 1 Paraffinum liquidum, Vaselinum album, Alcoholes adipis lanae, Macrogola, Ichtammolum, Levomentholum,

Cholesterolum. Alcohols. Ethanolum (96 per centum), Alcohol isopropylicus, Glycerolum, Mannitolum, Sorbitolum, Terpinum

(Ph.Hg.VII.) 2 Paraffinum liquidum, Vaselinum album, Alcoholes adipis lanae, Macrogola, Ichtammolum, Levomentholum,

Cholesterolum. Alcohols. Ethanolum (96 per centum), Alcohol isopropylicus, Glycerolum, Mannitolum, Sorbitolum, Terpinum (Ph.Hg.VII.)

3 Paraffinum liquidum, Vaselinum album, Alcoholes adipis lanae, Macrogola, Ichtammolum, Levomentholum, Cholesterolum. Alcohols. Ethanolum (96 per centum), Alcohol isopropylicus, Glycerolum, Mannitolum, Sorbitolum, Terpinum (Ph.Hg.VII.)

4 Paraffinum liquidum, Vaselinum album, Alcoholes adipis lanae, Macrogola, Ichtammolum, Levomentholum, Cholesterolum. Alcohols. Ethanolum (96 per centum), Alcohol isopropylicus, Glycerolum, Mannitolum, Sorbitolum, Terpinum (Ph.Hg.VII.)

5 Phenols. Phenolum, Thymolum, Resorcinolum, Hexachlorophenum (Ph.Hg.VII.) 6 Phenols. Phenolum, Thymolum, Resorcinolum, Hexachlorophenum (Ph.Hg.VII.) 7 Phenols. Phenolum, Thymolum, Resorcinolum, Hexachlorophenum (Ph.Hg.VII.) 8 Phenols. Phenolum, Thymolum, Resorcinolum, Hexachlorophenum (Ph.Hg.VII.) 9 Amines. Methenaminum, Cholinium chloratum (Ph.Hg.VII.), Triaethanolaminum (Ph.Hg.VII.), Vanillinum 10 Amines. Methenaminum, Cholinium chloratum (Ph.Hg.VII.), Triaethanolaminum (Ph.Hg.VII.), Vanillinum 11 Amines. Methenaminum, Cholinium chloratum (Ph.Hg.VII.), Triaethanolaminum (Ph.Hg.VII.), Vanillinum 12 Amines. Methenaminum, Cholinium chloratum (Ph.Hg.VII.), Triaethanolaminum (Ph.Hg.VII.), Vanillinum 13 Aldehydes and ketones. Carbohydrates. Formaldehydi solutio (35 per centum), Fructosum, Glucosum anhydricum,

Lactosum, Saccharum. 14 Aldehydes and ketones. Carbohydrates. Formaldehydi solutio (35 per centum), Fructosum, Glucosum anhydricum,



Lactosum, Saccharum. 17 Carboxylic acids. Amino acids. Acidum benzoicum. Acidum lacticum, Acidum tartaricum, Acidum sorbicum, Acidum

citricum, Natrii citras, Acidum asparticum. 18 Carboxylic acids. Amino acids. Acidum benzoicum. Acidum lacticum, Acidum tartaricum, Acidum sorbicum, Acidum



citricum, Natrii citras, Acidum asparticum. 21 Sedative-hypnotics I. Carbonic acid derivatives. Chloroformium (Ph.Hg.VII.) Chlorali hydras, Chlorobutanolum,

Ureum, Urethanum (Ph.Hg.VII.).


31

22 Sedative-hypnotics I. Carbonic acid derivatives. Chloroformium (Ph.Hg.VII.) Chlorali hydras, Chlorobutanolum, Ureum, Urethanum (Ph.Hg.VII.).



25 Sedative-hypnotics II. Barbituric acid derivatives. Tautomerism. Barbitalum, Barbitalum natricum, Phenobarbitalum, Phenytoinum.




29 Xantine derivatives. Theophyllinum, Coffeinum. Narcotic analgesics. Codeini hydrochloridum. 30 Xantine derivatives. Theophyllinum, Coffeinum. Narcotic analgesics. Codeini hydrochloridum. 31 Xantine derivatives. Theophyllinum, Coffeinum. Narcotic analgesics. Codeini hydrochloridum. 32 Xantine derivatives. Theophyllinum, Coffeinum. Narcotic analgesics. Codeini hydrochloridum. 33 Non-steroid analgesics and antipyretics. Acidum salicylicum, Acidum acetylsalicylicum, Natrii salicylas,

Salicylamidum (Ph. Hg. VII.), Paracetamolum, Phenacetinum (Ph. Hg. VII.). 34 Non-steroid analgesics and antipyretics. Acidum salicylicum, Acidum acetylsalicylicum, Natrii salicylas,



Salicylamidum (Ph. Hg. VII.), Paracetamolum, Phenacetinum (Ph. Hg. VII.). 37 Non-steroid anti-inflammatory agents. Phenazonum, Aminophenazonum (Ph.Hg.VII.), Metamizolum natricum,

Diclofenacum natricum, Indometacinum. 38 Non-steroid anti-inflammatory agents. Phenazonum, Aminophenazonum (Ph.Hg.VII.), Metamizolum natricum,



Diclofenacum natricum, Indometacinum. 41 Autonomic nervous system drugs. Pilocarpini hydrochloridum, Atropini sulfas, Homatropini methylbromidum,

Homatropini hydrobromidum, Naphazolini hydrochloridum. 42 Autonomic nervous system drugs. Pilocarpini hydrochloridum, Atropini sulfas, Homatropini methylbromidum,



Homatropini hydrobromidum, Naphazolini hydrochloridum. 45 Local anesthetics. Lidocainum, Benzocainum, Procaini hydrochloridum, Tetracaini hydrochloridum. 46 Local anesthetics. Lidocainum, Benzocainum, Procaini hydrochloridum, Tetracaini hydrochloridum. 47 Local anesthetics. Lidocainum, Benzocainum, Procaini hydrochloridum, Tetracaini hydrochloridum. 48 Local anesthetics. Lidocainum, Benzocainum, Procaini hydrochloridum, Tetracaini hydrochloridum. 49 Complete pharmacopoeial analysis of one substance 50 Complete pharmacopoeial analysis of one substance 51 Complete pharmacopoeial analysis of one substance 52 Complete pharmacopoeial analysis of one substance 53 The correlation between structure, the configuration and the conformation of molecules 54 The correlation between structure, the configuration and the conformation of molecules 55 The correlation between structure, the configuration and the conformation of molecules 56 The correlation between structure, the configuration and the conformation of molecules

Seminars


Oral exam covering the topics of Pharmaceutical Chemistry II and selected topics of Pharmaceutical Chemistry I.Before the exam each student should have a Minimum Requirent Test of which result should be at least 80%.

Further details: www.gytsz.pte.hu



32






Topic Intoduction to the most important analytical methods and their applications to pharmacopoeal qualification of active pharmaceutical ingradients and experiments. introduction to molecular aspect and structure-activity relationship of selected group of active pharmaceutical ingredients.

Conditions for acceptance of the semester The participation in both the lectures and the practices of the course is obligatory. Maximum 3 absences from lectures and practices. 80% of the performed quantitative determinations should be accepted. Both semester tests results should be above 60%.

Making up for missed classes Missed practices could be made up during the make-up opportunites annouced by the department. During each make-up session only one missed practice can be executed.

Reading material European Pharmacopoeia. EDQM Publication. Pharmaceutical Chemistry Practice I. Laboratory manual. University of Pécs. D.A. Williams, T.L. Lemke (eds): Foye’s Principles of Medicinal Chemistry, 5th edition, Lippincott Williams - Wilkins, Philadelphia, 2002.

Lectures 1 Application of CD and ORD spectroscopy in pharmaceutical analysis. Dr. Perjési Pál 2 Application of UV-Vis spectroscopy in pharmaceutical analysis. Dr. Perjési Pál 3 Application of UV-Vis spectroscopy in pharmaceutical analysis. Dr. Perjési Pál 4 Application of UV-Vis spectroscopy in pharmaceutical analysis. Dr. Perjési Pál 5 Application of fluorimetry in pharmaceutical analysis. Dr. Kőszegi Tamás 6 Application of fluorimetry in pharmaceutical analysis. Dr. Kőszegi Tamás 7 Application of atomic absorption spectrometry and flame photometry in pharmaceutical analysis. Dr. Perjési Pál 8 Application of IR spectroscopy in pharmaceutical analysis. Dr. Perjési Pál 9 Application of IR spectroscopy in pharmaceutical analysis. Dr. Perjési Pál 10 Application of thermoanalytic methods in pharmaceutical analysis. Dr. Perjési Pál 11 Agents of cardiac failure. Dr. Perjési Pál 12 Agents of cardiac failure. Dr. Perjési Pál 13 Agents of antiarythmic agents. Dr. Perjési Pál 14 Agents of antiarythmic agents. Dr. Perjési Pál 15 Antihipertensire agents. Dr. Perjési Pál 16 Antihipertensire agents. Dr. Perjési Pál 17 Diuretics. Dr. Perjési Pál


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18 Diuretics. Dr. Perjési Pál 19 Antianginal drugs. Dr. Perjési Pál 20 Antianginal drugs. Dr. Perjési Pál 21 Antihiperlidemic agents. Dr. Perjési Pál 22 Antihiperlidemic agents. Dr. Perjési Pál 23 Antithrombotics, Thrombolytics, Coagulants. Dr. Perjési Pál 24 Antithrombotics, Thrombolytics, Coagulants. Dr. Perjési Pál 25 Application of electroanalytical methods in pharmaceutical analysis. Dr. Perjési Pál 26 Application of electroanalytical methods in pharmaceutical analysis. Dr. Perjési Pál 27 Application of electroanalytical methods in pharmaceutical analysis. Dr. Perjési Pál 28 Application of mass spectrometry in pharmaceutical analysis. Dr. Perjési Pál 29 Application of NMR spectroscopy in pharmaceutical analysis. Dr. Berente Zoltán 30 Application of NMR spectroscopy in pharmaceutical analysis. Dr. Berente Zoltán 31 Introduction to separation techniques. Dr. Perjési Pál 32 Introduction to separation techniques. Dr. Perjési Pál 33 Application of TLC in pharmaceutical analysis. Dr. Perjési Pál 34 Application of TLC in pharmaceutical analysis. Dr. Perjési Pál 35 Application of HPLC in pharmaceutical analysis. Dr. Perjési Pál 36 Application of HPLC in pharmaceutical analysis. Dr. Benkő András 37 Application of GC in pharmaceutical analysis. Dr. Benkő András 38 Application of GC in pharmaceutical analysis. Dr. Benkő András 39 Applicationof gel chromatography in pharmaceutical analysis. Dr. Perjési Pál 40 Application of capillary electrophoresis in pharmaceutical analysis. Dr. Perjési Pál 41 Application of capillary electrophoresis in pharmaceutical analysis. Dr. Perjési Pál 42 Application of immunoassay techniques in pharmacetical analysis. Dr. Perjési Pál

Practices 1 Laboratory safety, accident protection, equipping. 2 Preliminary testing and classification of inorganic and organic compounds I. Identification of 20 inorganic and organic

substances I. 5 Preliminary testing and classification of inorganic and organic compounds II. Identification reactions of inorganic

cations and anions. Identification of 20 inorganic and organic substances II. 9 Preliminary testing and classification of inorganic and organic compounds III. Identification reactions of organic

functional groups. Identification of 20 inorganic and organic substances II. 13 Validation of analytical methods. Important performance characteristics. Validation of atitrimetric method. Comparison of different methods, calculatuon of some performance characteristics.


34

17 Spectrophotometry I. Lambert-Beer’s law definition. Determination of specific absorbance. Spectrophotometric determination of drug mixtures containing two components

21 Spectrophotometry II. Determination of drug mixtures containing salicylic acid and acetylsalicylicacidby spectrophotometric and alkalimetric methods.

25 Spectrophotometry III. Determination of isoniazid drug by spectrophotometric and bromatometric methods. 29 Potentiometry I. Principles of potentiometry. Direct potentiometry and potentiometric titration. Calibration of pH-

meter. Determination of a mixture containing a strong and a weak acid. 33 Potentiometry II. Electrodes used in potentiometry. Determination of the pKa os ascorbic acid by direct potentiometric

titration. 37 Potentiometry III. Polarography, amperometry. determination of water by the Karl Fischer method. Determination of

protonation constants of paracetamol by difference titration. 41 Spectrophotometry IV. Buffer solutions. Determination of the pKa of benzocaine by spectrophotometry. 45 The principles of thin-layer chromatography and denzitometry. The characterization of gel chromatography. TLC

investigation of C1-C5 alcohols. The separation of serum albumine and sodium chloride by gel chromatographic method.

49 The principles of high pressure liqiud chromatography. Detremination of 4-nitrophenol, 4-nitrophenyl-glucuronide and 4-nitrophenol-sulphate by HPLC method.

53 The principles of gas chromatography. Detremination of salicylic acid and metabolites by GC method

Seminars

Exam topics/questions Written the topics of the lectures and the laboratory practices. Further details: www.gytsz.pte.hu



35






Topic Introduction to quality control of compounded preparations. Application of instrumental methods in pharmacopoeal quality control of pharmaceutical preparations. Introduction of molecular aspects and structure activity relationship of selected groups of active pharmaceutical ingredients.

Conditions for acceptance of the semester The participation in both the lectures and the practices of the course is obligatory. Maximum 3 absences from lectures and practices. 80 % of the performed quantitative determinations should be accepted. Both semester tests? results should be above 60 %.


Reading material

Lectures 1 Adrenocorticoids. Dr. Perjési Pál 2 Adrenocorticoids. Dr. Perjési Pál 3 Estrogens, Androgens, Progestins. Dr. Perjési Pál 4 Estrogens, Androgens, Progestins. Dr. Perjési Pál 5 Drugs affecting calcium homeostatis. Dr. Perjési Pál 6 Drugs affecting calcium homeostatis. Dr. Perjési Pál 7 Insulin and oral hypoglycemic drugs. Dr. Perjési Pál 8 Insulin and oral hypoglycemic drugs. Dr. Perjési Pál 9 Drug affecting thyroid functions. Dr. Perjési Pál 10 Drug affecting thyroid functions. Dr. Perjési Pál 11 Vitamins. Dr. Perjési Pál 12 Vitamins. Dr. Perjési Pál 13 Antiparasitic agents. Dr. Perjési Pál 14 Antiparasitic agents. Dr. Perjési Pál 15 Antifungal drugs. Dr. Perjési Pál 16 Antifungal drugs. Dr. Perjési Pál 17 Antimicrobial agents. Dr. Perjési Pál 18 Antimicrobial agents. Dr. Perjési Pál 19 Antibiotics I. Dr. Lóránd Tamás


36

20 Antibiotics I. Dr. Lóránd Tamás 21 Antibiotics II. Dr. Lóránd Tamás 22 Antibiotics II. Dr. Lóránd Tamás 23 Antibiotics III. Dr. Lóránd Tamás 24 Antibiotics III. Dr. Lóránd Tamás 25 Anticancer agents. Dr. Perjési Pál 26 Anticancer agents. Dr. Perjési Pál 27 Antiviral agents. Dr. Perjési Pál 28 Antiviral agents. Dr. Perjési Pál

Practices 1-4 The bases of reaction kinetics. The dependence of drug degradation rate of temperature and pH. Analysis of

degradation of acetylsalicylic acid. 5-8 Determination methods of partition coefficients. Determination of logP steroids by thin-layer chromatographic

technique. 9-10 The structure, the configuration and the conformation of molecules. (Hyperchem) 11-12 The analytics of steroid hormones. TLC identification of steroid hormones. Determination of hydrocortisone content

using spectrophotometric method. 13-16 Identification of multi-component drug mixtures I. General principles. Pulvis antispasticus: chemical identification,

chromatographic identification, assay. 17-20 Identification of multi-component drug mixtures II. Determination of bases I. Pulvis chinacisalis cum vitamino C,

Pulvis somniferens. 21-24 Identification of multi-component drug mixtures III. Determination of bases II. Pulvis analgeticus, Tabletta Meristin. 25-28 Identification of multi-component drug mixtures IV. Determination of acids I. Spiritus iodosalicylatus, Spiritus

salicylatus cum resorcino. 29-32 Identification of multi-component drug mixtures V. Unguentum haemorrhoidale, Suppositorium analgeticum. 33-36 Identification of multi-component drug mixtures VI. 37-40 Visit at the Quality Control Laboratory of Hungaropharma Ltd 41-44 Vitamines. Acidum ascorbicum, Acidum folicum, Pyridoxinii ydrochloridum, Riboflavinum, Thiamini

hydrochloridum. Detremination of cyanocobalaminum by spectrophotometric and HPLC method. 45-48 Chemotherapeutic agents. Chinini hydrochloridum, Sulfadimidinum, Sulfaguanidinum, Sulfathiazolum,

Chloramphenicolum 49-52 Spectrum analysis of infrared and nuclear magnetic resonance spectrumes. The nomenclature and plotting of

heterocycles. 53-56 Summary. Repetition.

Seminars


Oral exam covering the topics of Pharmaceutical Chemistry I-IV. Before the exam each student should have a Minimum Requirent Test of which result should be at least 80%.

Further details: www.gytsz.pte.hu



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OPGGPR PHARMACEUTICAL PROPEDEUTICS


1 credit ▪ midsemester grade ▪ Pharmaceutical Professional Theoretical ... module ▪ autumn semester ▪ recommended semester: 1

Number of hours/semester: 14 lectures + 0 practices + 0 seminars = total of 14 hours Headcount limitations (min-max.): min. – max.

Prerequisites: -

Topic This course is an introduction to the discipline of pharmaceutics (propedeutics), within pharmacist’s hierarchy, their relationship with other healthcare workers and current specialties are also introduced. Students get a review on fundamentals and basic terms of pharmacerutics. Design and manufature of medicine, and proper use of dosage forms is also demonstrated.

Conditions for acceptance of the semester - students must fulfill requirements determined by the Code of Studies and Examinations - attendance of the lectures according to the Code of Studies and Examinations - accepted assessments (each above 50%), failed assessments can be repeated only once

Making up for missed classes Students must fulfill requirements determined by the Code of Studies and Examinations. Students have to bring a medical certificate. Topic of missed lectures has to be made up for in the form of a short written report (approx. 1 page, font size: 12)

Reading material Official pharmacopoeias (Ph. Hg. VIII., Ph. Eur.) Formulae Normales ed VII. (FoNo VII.) Compendium

Lectures 1 Origin of pharmacy, present and future Dr. Dévay Attila 2 Characteristics of the pharmaceutical education, its structure, disciplines Dr. Dévay Attila 3 Career opportunities, pharmacist’s competences Dr. Dévay Attila 4 Pharmacy as a healthcare institution Dr. Dévay Attila 5 Role of the pharmaceutical industry and wholesalers, drug control Dr. Dévay Attila 6 Relationship between the healthcare workers (physicians, medical staff, pharmacists, nurses) Dr. Dévay Attila 7 Mid-term written assesment Dr. Dévay Attila 8 Equipments in the pharmacy, appliances for the manufacture of medicines Dr. Dévay Attila 9 Equipments and methods for pharmaceutical measuremenst, concept of the pharmaceutical accuracy; Practice I:

measurement practice Dr. Dévay Attila 10 Manufacture of medicines, use of pharmaceutical dosage forms Dr. Dévay Attila 11 Pharmaceutical literature, pharmacopoeias, Formulae Normales in Hungary Dr. Dévay Attila 12 Practice II: Basics of compounding and dispensing Dr. Dévay Attila 13-14 End year assesment Dr. Dévay Attila

Practices

Seminars


Participants


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OPGGT1 PHARMACEUTICAL TECHNOLOGY 1




Prerequisites: OPAFZ2 completed + OPAKD1 completed + OPRLAT completed

Topic Courses of pharmaceutical technology are taught in the 3rd and 4th years of school of pharmacy. Aim of courses of Pharmaceutical Technology is introducing basic technological processes, preformulation and formulation of pharmaceutical dosage forms taking into account physico-chemical, pharmaceutical and biopharmaceutical properties of active agents and pharmaceutical excipients. Further studies include review of national and international pharmacopoeias. Practices usually begin with seminars where basic introduction of the proper lesson takes place. After seminars students have to prepare medicines according to the laws of pharmaceutical formulation technology in proper dosage forms including calculation of single and daily maximal dose, preparation, labeling and pricing. Students also have to prepare galenic formulations according to the official formula. Practices of quality control of medicines are carried out as well. Course Pharmaceutical Technology 1 includes practice with liquid dosage forms such as solution, syrup, elixir, oral drop, ear drop, nasal drop, parenteral solution and associated calculations with practices of quality control of mentioned dosage forms.

Conditions for acceptance of the semester Accepted preparations made on practices Accepted work reports Accepted practical and theoretical assessments


Reading material International Pharmacopoeias European Pharmacopoeia Hungarian National Formulary: Formulae Normales VII (FoNo VII.) Encyclopedia of Pharmaceutical Technology, James Swarbrick, Informa Healthcare, New York, London Biopharmaceutical Drug Design and Development, Susanna Wu-Pong, Yon Rojanasakul, Humana Press Modern pharmaceutics, Gilbert S. Banker, Christopher T. Rhodes, Marcel Dekker Inc., New York- Basel Pharmaceutical and Clinical Calculations, Mansoor A. Khan, Indra K. Reddy, CRC Press Pharmaceutical Compounding and Dispensing, Chris Langley, Dawn Belcher, Pharmaceutical Press www.gytsz.pte.hu www.sciencedirect.com

Lectures 1-28 1. Introduction to Pharmaceutical Technology. Definition of medical preparations. History of Pharmaceutical Technology Dr. Dévay Attila 2. Solutions, syrups, elixirs, mixtures Dr. Dévay Attila 3. Aromatic waters, alcohol and oil based solutions Infusion, decoction Dr. Dévay Attila 4. Extracts, tincturas Dr. Dévay Attila 5. The physico-chemical properties of active ingredients Dr. Dévay Attila 6. Nasal and ear preparations Dr. Dévay Attila 7. Eye preparations Dr. Dévay Attila 8. Sterilization. The most important injections Dr. Dévay Attila 9. Aseptic and sterile preparations, sterilizing, pyrogen removal methods Dr. Dévay Attila 10. Preparation and examination of injection Dr. Dévay Attila


39

11. Assessment Dr. Dévay Attila 12. Injectable and plantable preparations Dr. Dévay Attila 13. WRITTEN TEST Dr. Dévay Attila 14. Interaction and incompatibility of pharmaceutical preparations Dr. Dévay Attila

Practices General instructions, rules and regulations on practices, measuring, scales, introduction to reading prescriptions Preparation of pure solutions, physical examination of solutions, diluting alcohol, pharmaceutical calculations Complex solutions, mixtures, drops Colloid solutions, examination of pure and colloid solutions, nasal drops and ear drops Preparation and examination of pure solutions, alcoholic solutions Preparation and examination of syrups and colloid solutions Preparation and examination of mucilages and colloid solutions Assessment Sterilizing, isotonisation, calculations, eye drops Preparation of eye drops, ointments Preparation and examination of injections Preparation and examination of infusions Preparation and examination of emulsions and suspensions End semester assessment

Seminars

Exam topics/questions The end-semester exam will be evaluated by a five-grade system. Knowledge acquired is tested based on subject matter defined by a list of topics provided by the institute.

Participants Dr. Mayer Klára (MAKMABO.PTE), Dr. Nagy Sándor Ferenc (NASMAAO.PTE), Dr. Pál Szilárd (PASMAAO.PTE)


40





Prerequisites: OPAFI2 completed + OPGGK1 completed + OPGGT1 completed

Topic This semester include practice with ocular dosage forms. Special formulations of ocular dosage forms are eye ointments and oily and viscous eye drops. Other formulations such as emulsion, suspension and semisolid dosage forms (ointment, cream, gel, paste) are also discussed.

Conditions for acceptance of the semester Accepted preparations made on practices, Accepted work reports, Accepted practical and theoretical assessment

Making up for missed classes Students must fulfil requirements determined by the Code of Studies and Examinations.


Lectures 1. Mixing and stirring, distillation

Dr. Dévay Attila 2. Filtration, sedimentation, centrifugation, extraction

Dr. Dévay Attila 3. Basics of dispers systems, used excipients

Dr. Dévay Attila 4. Emulsions, emulgents

Dr. Dévay Attila 5. Suspensions

Dr. Dévay Attila 6. Dermal and transdermal drug delivery systems

Dr. Dévay Attila 7. Importance and determination of particle size

Dr. Dévay Attila 8. WRITTEN TEST

Dr. Dévay Attila 9. Reologic properties of ointments, Excipients for preparation of ointments

Dr. Dévay Attila 10. Structural properties of ointments, Preparation of ointments

Dr. Dévay Attila 11. Examination of ointments

Dr. Dévay Attila 12. Rectal, vaginal and intrauterine application of drug delivery systems

Dr. Dévay Attila 13. Criteria of magistral drug preparation

Dr. Dévay Attila 14. WRITTEN TEST

Dr. Dévay Attila


41

Practices General instructions, rules and regulations on practices, introduction to emulsions, suspensions and oinments Preparation and examination of suspensions Preparation and examination of magistral emulsions and ointments I. Preparation and examination of magistral emulsions and ointments II. Magistral ointments/creams/pastes/gels Preparation and examination of ointments and creams Preparation and examination of gels and pastes Assessment Preparation and examination of suppositories, calibration Preparation and examination of rectal suppositories Preparation and examination of vaginal suppositories Examination of packaging materials Visiting pharmaceutical company End semester assessment

Seminars




42






Topic

Mainly semisolid dosage forms are prepared in this semester: suppositories and vaginal suppositories. Powders and capsules as solid dosage forms are also prepared and discussed.

Conditions for acceptance of the semester Accepted preparations made on practices Accepted work reports Accepted practical and theoretical assessments


Reading material International Pharmacopoeias Hungarian National Formulary: Formulae Normales VII (FoNo VII.) Encyclopedia of Pharmaceutical Technology, James Swarbrick, Informa Healthcare, New York, London Biopharmaceutical Drug Design and Development, Susanna Wu-Pong, Yon Rojanasakul, Humana Press Modern pharmaceutics, Gilbert S. Banker, Christopher T. Rhodes, Marcel Dekker Inc., New York- Basel Pharmaceutical and Clinical Calculations, Mansoor A. Khan, Indra K. Reddy, CRC Press Pharmaceutical Compounding and Dispensing, Chris Langley, Dawn Belcher, Pharmaceutical Press www.gytsz.pte.hu www.sciencedirect.com

Lectures 1. Milling, sieving, oral powders, dusting powders, granules 2. Basic processes of Pharmaceutical Technology. Drying, lyophilization 3. Basic processes of Pharmaceutical Technology. Crystallization, polymorphism 4. Basic processes of Pharmaceutical Technology. Fluidization 5. Preparation and examination of solid dosage forms. Pharmaceutical excipients of granules and tablets 6. Preparation of granules 7. Preparation of tablets I. 8. Preparation of tablets II. 9. Sugar coating, film coating, dry coating 10. Capsules 11. Assessment 12. Guidelines and conditions of pharmaceutical manufacture. Quality assurance, quality control, good manufacturing

practice (GMP) 13. Guidelines and conditions of pharmaceutical manufacture. Validation, reproducibility, statistical process control 14. Assessment

Practices General instructions, rules and regulations on practices, introduction to solid forms Undivided (bulk) powders, dusting powders, species I. Undivided (bulk) powders, dusting powders, species II. Divided powders I. Divided powders II. Dusting powders Pills, hard gelatin capsules Assessment Preparation of garnules I., drying Preparation of garnules II., examinations Tabletting I., Machines Tabletting II., Direct compression Sugar and film coating process End semester assessment


43

Seminars




44





Prerequisites: OPGGT3 completed

Topic In this semester solid dosage forms, theoretical introduction of granulation, tabletting and tablet coating is discussed. Quality control of prepared dosage forms are also carried out such as disintegration, dissolution, tablet hardness test, etc. Aspects and work in industrial pharmacy is also presented during this semester.

Conditions for acceptance of the semester Accepted preparations made on practices, Accepted work reports, Accepted practical and theoretical assessments



Lectures 1. Drug delivery systems. Microcapsules, micropellets

Dr. Dévay Attila 2. Drug delivery systems. Nano and molecular systems

Dr. Dévay Attila 3. Drug delivery systems. Liposomes, cochleates, dendrimers, liosomes

Dr. Dévay Attila 4. Theoretical fundamentals of drug design I., stabibility of drugs

Dr. Dévay Attila 5. Theoretical fundamentals of drug design II.

Dr. Dévay Attila 6. Theoretical fundamentals of drug design III., modified release systems

Dr. Dévay Attila 7. Drug delivery systems IV., delayed and sustained drug release

Dr. Dévay Attila 8. Drug delivery systems V., local and targeted drug release

Dr. Dévay Attila 9. Assessment

Dr. Dévay Attila 10. Drug delivery systems VI.

Dr. Dévay Attila 11. Aerosols, inhaled therapeutic systems

Dr. Dévay Attila 12. Aerosols, inhalers, pharmaceutical excipients of aerosols, inhalers

Dr. Dévay Attila 13. Assessment

Dr. Dévay Attila 14. Technological aspects of veterinary medicines, surgical bandages

Dr. Dévay Attila


45

Practices General instructions, rules and regulations on practices, solutions, nasal drops, ear drops Emulsions, suspensions Eye oinments, eyes drops, tea mixtures, decoctum, infusum Ointments/creams/pastes/gels Vaginal, rectal suppositories Powders, pills, hard gelatin capsules Personal assessment 1. Personal assessment 2. Personal assessment 3. Personal assessment 4. Personal assessment 5. Personal assessment 6. Personal assessment 7. End-subject assessment of practice

Seminars


Participants Dr. Mayer Klára (MAKMABO.PTE), Dr. Pál Szilárd (PASMAAO.PTE)

Documents

PHARMACY Major STUDY PROGRAM 2012/2013 …aok.pte.hu/docs/th/file/2012/tantervek_2012/course_eng_pha_ppt... · Pharmaceutical Professional Theoretical Knowledge and Practical Skills