Osteoarthritis in the third millenium ; a new era for an

old disease.Semin. Arthritis Reum. 2005

Osteoarthritis

Osteoarthritis

Heat shock proteins and their roles in chondrocyte protection ,an aplication for autologous transplantation. Sawaatzky D A et al. Immunopharmacolo-

gy.2005

Safety study of intrarticular injection of interleukin 1 receptor antagonist inpatients with painful knee osteoarthritis: a multicenter study.Chevalier X. et.

al. J. Reumatol.2005

The protective effect of licofelone on experimental osteoarthritis is correlatedwith the downregulation of gene expression and protein synthesis of severalmajor cartilage catabolic factors: MMP-13,cathepsine k and aggrecanases.

Arthritis Research Therapy .2005

Sinovial tissue inflammation in early and late osteoarthritis .Benito M. J.et. al.Ann. Rheum. Dis.2005

PROTEOMICS

Proteomics in Rheumatology , a new direction for old diseases. Ali M. et.al.

Semin. Arthritits Rheum. 2005

Proteomics characterization of human normal articular chondrocytes, a novel tool for the study of osteoarthritis and other rheumatic diseases. Ruiz-Romero C. et.al.

Proteomics 2005

Gene Therapy

• Osteoarthritis gene therapy . C.H.Evans et.al.Gen. Ther.2004

. Gene transfer to the human joint ,progresstoward a gene therapy of arthritis.C.H.Evans

Proc.Natl.Acad.Sci. 2005. Novel biological approaches to the intra-articular

treatment of osteoarthritis .C.H.Evans.BioDrugs.2005

.Gene therapeutics approaches –transfer in vivo.C.H.Evans.Adv.Drug.Deliv.Rev.May.2006

• The burden of this disease will increase in direct proportion to the increase of the older population…..

• The major barriers to progress are financial rather than intellectual or technical.