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Nefroblastoma (Tumor
Wilms)
Annisa F. Nahlia
13-199
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Denisi
Tumor embrional yg berasal r!aringan embrioni" gin!al yg
timbullm #aren"im gin!al an meru#a"ansisa$ blastoma
nefrogen(metane#hros)
Tumor i "elilingi oleh !aringan
#seuo"a#sul an mene"an sisa#aren"im gin!al normal
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%#iemiologi
&ering ter!ai # ana"$ gn insien'*1++++++ ( , 1
thn)#ertahunnya
un/a"nya # usia $ 0 3 tahun
* 2 4 1 *1$
5nsien lbh srng # ras Afri"a-Ameri"a ibaning"an gn ras Asia
Nefroblastoma bilateral insiennya -1+6
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%tiologi
5io#ati"
Fa"tor geneti" yg iturun"an s/rautosomal ominan
Delesi "romosom 11#13 WilmsTumor 1 (WT1)
Delesi "romosom 11#1 WilmsTumor$ (WT$)
Delesi "romosom 178 WilmsTumor3 (WT3)
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e!ala linis
erut membun/it
:ematuria
:i#ertensi Anemia ; #enurunan
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enyebaran ; metastase
Tumor menesa" !ar gin!al yg normal; membentu" #seuo"a#sul tumor
lama$ menesa"
#seuo"a#sul ii"uti o= inltrasi "elm !ar gin!al itu snr menyebar
"elm !ar #erirenal bermetastasis *
#er"ontinuitatum hematogenlimfogen
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Diagnosis
Anamnesis
>. Fisi"
#>. enung!ang- > lab
- #>. histo#atologi
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%- ?& abomen
- @T &/an Abomen
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7/24/2019 Nefroblastoma (Tumor Wilms)
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enatala"sanaan
1. Farma"ologi
a. asien tan#a metastasis
-. in/ristin ++ mg="gurubi/in
/. &taium 1 ; $ iferensiasi bai"- in/ristin ++ mg="g
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. &taium 3 iferensiasi bai"
- in/ristin ++ mg="g
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f. Tumor iferensiasi buru"
- in/ristin
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A/tinomisin D- &i"lofosfami
- aiotera#i
$. Non Farma"ologi- #embebeahan
