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GenScriptMost Reliable Strategic Research Partner

GenScript is the leading biology CRO in the world.

GenScript is the most referred CRO in peer-reviewed articles in the world.

GenScript is the largest gene synthesis provider in the world.

GenScript provides contract research services to almost all major pharma and biotech

companies.

Founded in 2002, GenScript, as a pioneer company, has grown together with the synthetic biology

and is the now the world's largest gene synthesis supplier. Headquartered in New Jersey, with

subsidiaries in Europe, Japan, and China, GenScript consistently provides the best research services

to the scientific community worldwide. In addition to the world-leading gene synthesis service,

GenScript offers comprehensive services for biological research and early-phase drug discovery,

such as bio-reagents, assay development & screening, antibody drug development, and research

animal model services. By developing and applying innovative synthetic biology technologies,

GenScript assists researchers in advancing and transforming research in biology.

With a proven track record in performance and innovation, GenScript always strives with

competence and confidence to meet and exceed the demands of your needs in biological research

and drug discovery!

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GenScript - Most Reliable Strategic Research Partner

Bio-Reagents Antibody Drug Developement Catalogue Products

GenScript - The Most Cited CRO in the World

In the year 2011, GenScript became the most frequently cited biology CRO in the world in

peer-reviewed journal articles: More than 2300 peer-reviewed journal articles cited GenScript’s

services and products in 2011. Many of these articles were published in the most prestigious

journals, including Cell, Nature, Science, and PNAS.

In 2011, GenSrcipt has been cited about 2,300 times, becoming the most frequently cited biology contract research organization by peer-reviewed journal articles.

Number of Articles Referred GenScript Which Were Published in Most Prestigous Journals:

Cell series journals

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2500

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02008 2009 2010 2011

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25

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5

02008 2009 2010 2011

Nature series journals

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60

80

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40

30

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10

02008 2009 2010 2011

PNAS

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150

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50

02008 2009 2010 2011

Science series journals

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120

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20

02008 2009 2010 2011

4%

96%

Papers Published in Nature Cited GenScript’s Codon Optimization Technology

Many bacteria (e.g. Acidianus) living in volcanic hot wells obtain energy from CS2 instead of CO2. Scientists from Radboud University Nijmegen (Netherlands) found the unique structure of an enzyme that allows the microbe to efficiently utilize CS2 as the main energy source. GenScript used OptimumGeneTM technology to maximize the expression level of the gene in E. coli, making it possible to study the structure biology of this key enzyme.

(Reference: M. J. Smeulders, et al. Evolution of a new enzyme for carbon disulphide conversion by an acidothermophilic archaeon. Nature. 2011. 478: 412-416)

Proteins undergo structural conformations transitions in solution. Some proteins’ structural conformations exist only for short periods of time, making them extremely difficult to study. Scientists from University of Toronto (Canada) established a robust method to model the structures of T4 lysozyme in solution. GenScript used Optimum-GeneTM technology to optimize the expression of the T4 lysozyme gene in E. coli, thereby maximizing the protein production of T4 lysozyme for structural biology study.

(Reference: G. Bouvignies, et al. Solution structure of a minor and transiently formed state of a T4 lysozyme mutant. Nature. 2011. 477: 111-117)

• Story 1. An enzyme allowing an acid-loving bacterium feeding CS2

• Story 3. Structures of T4 lysozyme in solution

Little is known how immunity cells were activated by wounding signals, such as H2O2. Scientists from UW-Madison (USA) found that a neutrophil protein, Lyn, serves as a sensor in this process. GenScript used OptimumGeneTM technology to optimize the expression of zebrafish Lyn gene in HEK293 cells, making it possible to have the protein available in bulk for in vitro assays.

(Reference: S. K. Yoo, et al. Lyn is a redox sensor that mediates leukocyte wound attraction in vivo. Nature. 2011. 480: 109-114)

• Story 2. Lyn protein mediates leukocyte wound attraction

pLyn

pSAM68

Lyn WT

H2O2Ctrl

Papers In Various Research Fields Citing GenScript’s Products

Biochemistry:Reichmann D, et al. 2012. Order out of disorder: Working cycle of an intrinsically unfolded chaperone. Cell. 148: 947-57

Biophysics: Sievers SA, et al. 2011. Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature. 475: 96-100

Cell Biology:Filonov GS, et al. 2011. Bright and stable near-infrared fluorescent protein for in vivo imaging. Nature Biotechnology. 29: 757-61

Chemistry:Shukla D, et al. 2011. Complex interactions between molecular ions in solution and their effect on protein stability. Journal of the American Chemical Society. 133: 18713-18718

Developmental Biology:Deutsch GB, et al. 2011. DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramer. Cell. 144: 566-76

Environmental Sciences:Rubenstein D. 2011. Spatiotemporal environmental variation, risk aversion, and the evolution of cooperative breeding as a bet-hedging strategy. Proceedings of National Academy of Sciences of the United States of America. 108: 10816-10822

Medicine & Pharmacology: Amarnath S, et al. 2011. The PDL1-PD1 axis converts human TH1 cells into regulatory T cells Science Translational Medicine. 3: 111ra120

Mirobiology:Alistair B, et al. 2011. Type VI secretion delivers bacteriolytic effectors to target cells. Nature. 475: 343–347

Plant Biology: Wang J, et al. 2010. EXPO, An exocyst-positive organelle distinct from multivesicular endosomes and autophagosomes, mediates cytosol to cell wall exocytosis in arabidopsis and tobacco cells. Plant Cell. 22: 4009-30

Synthetic Biology:Certo MT, et al. 2011. Tracking genome engineering outcome at individual DNA breakpoints. Nature Methods. 8:671-76

Systems Biology:Lickwar CR, et al. 2012. Genome-wide protein-DNA binding dynamics suggest a molecular clutch for transcription factor function. Nature. 484: 251-5

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CALL GENSCRIPTToll-Free: 1-877-436-7274Telephone: 1-732-885-9188Fax: 1-732-210-0262 1-732-885-5878

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MAIL GENSCRIPTAll CorrespondencesGenScript USA Inc.860 Centennial Ave.Piscataway, NJ 08854USA

Proven Track Record in Performance

Molecular Biology Services "Your constructs have provided us with the ability to make exciting progress in understanding the causes of brain developmental disease."

― Dr. Richard Vallee, Columbia University, USA

Protein Services"GenScript provides fast, professional protein synthesis services at very reasonable prices, … GenScript has made it possible for my lab to focus on our own area of expertise."

— Dr. Barry Bradford, Kansas State University, USA

Peptide Services "I have been using the peptides from your company since 2004. The high quality standard and compet-itive prices of your company will keep us hooked, hopefully for the years to come."

— Dr. Miguel Morales, Universidad de Barcelona, Spain

Antibody Services “ I made use of the custom antibody services, which included antigenic peptide design and production. … In all the performed assays, the antibody proved to be highly specific. I would highly recommendGenScript services to anybody."

—Dr. Soné Ungerer, University of Pretoria, South Africa

To learn more about GenScript, please visit our website at www.genscript.com

www.genscript.com 860 Centennial Ave., Piscataway, NJ 08854, USA | Toll-Free: 1-877-436-7274 | Fax: 1-732-210-0262 | 1-732-855-5878 | Email: info@genscript.com All Rights Reserved. All content described by GenScript is copyright of GenScript Corporation unless specifically identified otherwise. This includes all imagery, text and programmatic computer code.