Genscript Overview

Your Innovation Partner in Drug Discovery!

Introducing GenScript

March 2010

Your Innovation Partner in Drug Discovery!Your Innovation Partner in Drug Discovery!

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Presentation Overview

The Biology CRO

About GenScript

Service Overview

Your Reliable Partner

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About GenScript

Founded in 2002

>800 employees

Headquarters in Piscataway, NJ, USA

Facilities and branches:

New Jersey, USA Nanjing, China

Paris, France

Osaka, Japan

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Fast Growing Company

Organic Growth Since Inception

2002 2003 2004 2005 2006 2007 2008

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The largest provider of custom gene synthesis services in the U.S.

We offer the best antibody service guarantee in the industry

We provide small- and large-molecule one-stop biology CRO services for early drug discovery and development

Local access and 24-hour customer support

ISO 9001:2000-certified and full client IP protection

We offer advanced bioinformatics tools and IT infrastructure for value-added services

Customers include top pharmaceutical companies, major biotech firms, and research institutions in over 70 countries

Seasoned science and business management teams

Key Facts About GenScript

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INVESTORS

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Most respected VC in the world Funded Genentech, Google, Amazon, Pacific Biosciences, etc Invested in > 300 IT , life science, and biotech companies

Leading independent advisory company Top boutique investment banking firm in China Clients include Sinopec, Jiangsu Lihua, Masterrind, Medical Systems

In Search of the Next Big Idea


Comprehensive Biology Services

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Gene Synthesis

— Any gene you desire!Synthesize genesOptimumGeneTM Codon OptimizationLarge-Scale Gene Synthesis

Cloning

—Any construct you want to build! PCR Cloning/SubcloningGenPoolTM ORF CloningKI & KO Vector ConstructionCustom vector construction

Mutagenesis

— Any variant from your design!Mutagenesis Service Site-Directed Mutagenesis LibrariesSequential Permutation Scanning LibrariesRandomized and Degenerated Libraries

Plasmid Preparation

— Any amount to fit your plan!Flexible Scale: 100 μg to 1,000 mgLow Endotoxin Levels: <5 EU/mg

Largest Gene Synthesis Supplier in USA

Transforming Molecular Biology

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GenScript One Stop Protein Services

Gene Services•Largest gene synthesis supplier in US

•Comprehensive portfolio of molecular biology services:

Codon Optimization

Cloning

Vector Construction

Mutagenesis

Plasmid Preparation

etc.

Protein Services•Expression (E.coli, yeast, insect, mammalian)

•Purification

•Production of biologically functional protein

•Large capacity for scale-up (fermentation, protein production from stable cell lines)

Antibody Services•pAb production

•mAb production

•Hybridoma development

Assay Services•Assay development & validation (GPCR, ion channel, enzyme)

•Compound screening & profiling

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Custom Peptide Synthesis Services

Custom Peptide Synthesis Services

Standard Peptide Synthesis

High complexity and purityLong peptides up to 200 aaHigh success rate ≥ 95%

Peptide Libraries

Rapid parallel platformCompetitive prices Guaranteed deliveryFlexible screening tools

Cosmetic Peptides

FlexPeptideTM technologyComprehensive documents

Batch size from mg to 2 kgPeptides up to 50 aa

Recombinant Peptides

Flexible technologyVariety of modifications Any length, any sequence, any scale

Non-GMP Peptides

GMP Peptides

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pAb Services

Affinity-Purified pAbPhospho-Specific pAb

Express AntibodyTM ServicesSpecies: rabbit, goat/sheep, chicken, mouse, rat, etc

mAb services

MonoExpressTM Antibody Services mAb Production ServicesMost Popular: Phospho-Specific pAb Package

Large Scale Antibody Production Services

Additional Services

Ab ModificationAb PurificationAb CharacterizationCell Line StoragePeptide Synthesis Services

Immunoassay Development Services for Drug Discovery & Clinical Studies

Guaranteed Antibody Services

Custom pAb and mAb ServicesCatalog antibodiesExpress servicesBest guaranty in the industry

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Leading the industry standard on antibody guarantee …


In house Project Design

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Antibody Affinity Maturation

Stable Cell Line Generation

Antibody Production

Bioprocess Development

Antibody DrugAntibody Drug

Development CenterDevelopment Center

Target Validation

Industry-scale Antibody Drug Development

Immunon-Immunon-izationization

Hybridoma Selection Maturation Production Target Validation


Antibody Drug Development CenterProtein

Antigen productionMolecular Biology

Library constructionmAb sequencing

Antibody EngineeringAffinity maturationAntibody humanizationAnti-idiotype antibody generationEpitopic mapping

Antibody ProductionHybridomaProtein purification

Bioprocess DevelopmentTransient and stable expression in flexible scales

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Comprehensive Antibody Drug Development

Your Innovation Partner in Drug Discovery!Your Innovation Partner in Drug Discovery! 14

Transient Gene Expression and Protein Production

Proprietary technology Serum free 293 and CHO suspension systems Rapid protein and mAb production up to grams

Stable Cell Line Development and Protein Production

Proprietary expression system High flexibility with parental cell types State-of-the-Art facilities Record proven on-time delivery

Process Development and Transfer

— We pay attention to every single detail

BioProcess Services

Stable cell developmentBioreactors and WAVE-bag technologyIndustry Scale Protein Production

Custom Solution Bioprocess Services


Our Innovation

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Gene-on-Demand TM gene synthesis technology

- best and most economic gene synthesis

FlexChem TM ligation technology

- peptide synthesis up to 200 amino acids

CloneEZ TM seamless cloning technology

- state-of-art cloning into any vector at any site

Nanotechnology for adjuvant mixing

- induction of enhanced immune response

Diversified expression systems

- bacteria, yeast, insect cells, and mammalian cells

T-Max TM adjuvant

- increased titer of at least ten times, and reduced

cost

FoldingArt TM technology

- refold rate of 95% for inclusion bodies and

proteins (virus expression)

OptimumAntigen TM antigen design

- optimized antigen design

293TGE TM system

- most efficient transient expression system

OptimumGene TM codon optimization technology

- optimized gene expression

Innovative technologies for enhanced services


YOUR RELIABLE PARTNER

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Your Innovation Partner in Drug Discovery! 17

Business Model



Confidentiality agreement for each contract project

Secure online information transfer

Account specific document management

Strict access control for dedicated research areas

Client

Client


IP protection is crucial to a sustainable partnership between pharmaceutical clients and GenScript

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Thank you!Thank you!

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Nicole Niu, Ph.D.

Regional Sales Manager

GenScript USA Inc.

120 Centennial Ave, Piscataway, NJ 08854, USA

Tel: 732-885-9188 x 155 Fax: 732-210-0262

Email: [email protected]


Documents

Genscript Overview