7/23/2019 Maria kornjak, M.D., Bioloski tragovi

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uzhlme g {hauvcmhlme

ngiciagb

`iah}hDh~gh ai~lmha# D,@,

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

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$Pgmeaid vi{cme`lmgb leaicgai`e{epcmeh# jg}gag `iah}g#vivup@LH vi{phmu {ze zhlgmg u

ah}lelgd g{p~hohdh,$ Izhazg `iah}g diou {hdi{phcli ginmeapgzli vize}hpg i{udlmgelio {h~pzid }ciglh# vingpg hcgng gcgu{dme~gpg vupeze g{p~hoe,

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

3/28

G}zi~g @LH=

Ji~el}glh @LH depi`h pgvg}hkgmepgmeaid vi{cme`lmgb 85oi`glh v~e`{phzcmhzecgag lhv~e`ha u g{vgpgzhlmu ngiciagb`iah}h g acmulh me depi`h u vi`~umuji~el}glgb }lhli{pg# {u`{ae de`gkgle#hlp~iviciogme# pe{pg~hlmh igl{pzh gp`,

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

4/28

Ngiciag u}i~kg g} aimgb {e

@LH u{vmeli g}icg~h= Ai{pg A~zle {phlgke

[mede g d~cme {ve~de Pagzh g i~ohlg @chae# liapg

]ung [cglh# u~gl g `~uoe ngiciae peaugle

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

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gdnelgkg zhlg }h u{vmelu

@LH hlhcg}u u}i~ah=$ Aicgglh u}i~ah aimh {e die g}`zimgpg g}ngiciaio u}i~ah

$ g{pih u}i~ah "v~i`uelh g}cieli{pv~cmhzpglg g} iaicgh# dh{lig gcg ailphdglhkgmgnhape~gmhdh# ha g zecgaio u}i~ah# die`eo~h`g~hpg @LH g uglgpg oh lev~gach`lgd }h`hcmlme hlhcg}e'

$ G}zi~ u}i~ah "u}i~ha g} ecuhle ag{ecgle gcgjeahcle d~cme die ngpg }lhhmli `eo~h`g~hl'

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

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@LH {h`~hm ngiciagb u}i~hah Peauh a~z >6#666$06#666 lo)dc D~cmh >56$566 lo)kd> [medelh peauglh 856#666$;66#666 lo)dc Vi{paigphclg zhoglhclg n~g{ezg 86$;666 lo){whn Peauh {cglh 8#666$86#666 lo)dc I~hclg in~g{ha 866$8566 lo)in~g{ha U~gl 8$>6 lo)dc Ai{p ;$86 lo)do

Pagzi 56$566 lo)doLh aicgglu }lhhmli upmeu eaiciag gdnelgkg,

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

7/28

V~gmeli{)p~hl{je~ `iah}h=@LH die uvupgpg lh ~h}cggpe vize}hli{pg= I{inh$i{inh I{inh$`~uoh i{inh

I{inh$dme{pi }ciglh

Ngiciag `iah} die ngpg v~ele{el= @g~eaplgd i`chohlmed

[eaul`h~lgd v~gmeli{id

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

8/28

@g~eapli i`chohlme

ngiciaio dhpe~gmhch [zg ngiciag `iah}g "a~z# {mede# pmece{lh pagzh#ai{pg# ai{h# u~gl# {cglh' diou {e v~ele{pg lhpgmeci)i`meu vime`glkh gcg dme{pi }ciglh

`g~eaplgd i`chohlmed, Ngiciae peaugle lhail `evilg~hlmh g v~ghlmhlmh

lh viz~glu vi{phmu d~cme Ngiciag `iah}g aimg lg{u peauglephaie~ {e

v~eli{e `g~eaplgd i`chohlmed gcg {eaul`h~lgdv~gmeli{id,

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

9/28

[eaul`h~lg v~gmeli{ ngiciaio

dhpe~gmhch

A~z# {mede# pagzh# `chah# {cglh# u~gl dioungpg v~ele{elg lh i{inu# inmeap gcg dme{pi

v~eai VI[^E@LGAH "i{inh gcg inmeap',

Ai` {eaul`h~lio v~gmeli{h=

LEDH @G^EAPLIO AILPHAPHg}deug}zi~h ngiciaio dhpe~gmhch g kgcmle viz~gle,

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

10/28

V~evi}lhzhlme `iah}h

V~zg ai~ha v~e{u`hl }h g{bi` g{p~hoe=i`~egzhlme u}i~hah }h `hcmlmh g{vgpgzhlmh((

[u{phzli ikgmelgpg {ze `~hoikmele g}zi~e ngiciaiodhpe~gmhch,V~evi}lhpg `iah}e deu io~idlgd aicgglhdh

lezhlgb {pzh~g,Lv~, v~gauvcmhlme >6 u}i~hah a~zg g} iaicgke uni`ele ~pze le

di~h uvugzhpg lh viglgpecmh ,

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

11/28

@iaudelpg~hlme `iah}lgb

dhpe~gmhch Ciahkgmu g {phlme {zgb ngiciagb `iah}h`iaudelpg~hpg v~gme {auvcmhlmh(

@iah}g le {dgmu ngpg v~edmephlg `ia lmgbizi

v~zipli {phlme g {ze ~echzhlple glji~dhkgme ilmgdh lg{u }hngcmeele( Vhcmgzi `iaudelpg~hme iah}h lh dme{pu

`iohhmh# {hcg }h hupiv{gmu)in`uakgmu#ji~el}glid chni~hpi~gmu me leivbi`li(

U ah}lelgd gcg o~hhl{agd g{p~hohdh i pide izg{gbie cg ahi `iah}lg dhpe~gmhc ngpg v~g}lhpg lh {u`u,

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

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8' lh dme{pu `iohhmh>' u ji~el}glid chni~hpi~gmu;' u {hcg }h hupiv{gme)in`uakgme

I{lizlg v~g{puv ~uaizhlmh

`iah}gdh g lmgbizi`iaudelpg~hlme=

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

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@iaudelpg~hlme)ingcmehzhlme g{v~edhlme `iah}lgb dhpe~gmhch

8' @iah}g lh dme{pu `iohhmh=$Jipio~hjg~hpg `iah}lg dhpe~gmhc v~gme `ipgkhlmh#v~edgmephlmh# v~gauvcmhlmh,$ Uglgpg zg`ei{lgdau `iah}h g lmeoize vi}gkgme lh dme{pu

`iohhmh,$ @iaudelpg~hpg vicihm)ciahkgmu g {phlme `iah}liodhpe~gmhch,$ [agkg~hpg v~i{pi~le i`li{e `iah}h u i`li{u lh `~uoeinmeape lh dme{pu `iohhmh,$[v~edgpg `iah}lg dhpe~gmhc lh v~ivg{hlg lhgl u} lhcmevlgku#

ingcmehzhlme g vehelme vhaeph u aimed me dhpe~gmhc{v~edcmel,

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

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>' @iah}g u ji~el}glid chni~hpi~gmu=$ V~izme~h lhvidele lh lhcmevlgkg vhaeph g {phlmh vehphlh vhaepu,

$ Lhcmevlgkh {h`~g= glgkgmhce# me`gl{pzelu g`elpgjgahkgm{aui}lhau g `hpud,

$ V~izme~h n~imh g i}lhae lh `iah}lid dhpe~gmhcu

g u{vi~e`nh { vi`le{elgd in~h{ked ~h`g v~izme~e mecg}hv~gdcmel g{v~hzhl v~e`dep "`iah}',

$ V~izme~gpg ivg{e g pili{p {phzag,

$ Lhv~hzgpg lhvidelu# {agku g jipio~hjgmu {h`~hmh vhaeph

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

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$ V~gme {pzh~hlmh u}i~hah `iaudelpg~hpg lmgbizu viepluciahkgmu g {phlme ngiciaio u}i~ah i` aimeo vipmeu,[h{phzgpg lhvidelu }h {eaul`h~le ~e}ize { i}lhaid dme{ph{ aimeo vipmeu g { aimeo me v~gauvcmel u}i~ha,[ze {eaul`h~li lh{phce u}i~ae vhag~hpg i`zimeli,

$ Ah` v~izi`gdi pe{pg~hlme ngcmegdi aicgglu ai~gpelgbu}i~ah# g}ze`nu pe{pg~hlmh g `ingzele ~e}ucphpe,

$ Ai` ~uaizhlmh `iah}lgd dhpe~gmhcgdh uzgmea li{gpg g{pe~uahzgke }h me`lia~hplu uvi~hnu ~h`g {dhlmgzhlmhailphdglhkgme,

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

16/28

@iah}g u in`uakgm{aim {hcg$ Jipio~hjg~hlme pgmech g `i`hplgb `iah}h v~gme gelmh pgmech,

$ Lhvg{hpg lhvidele g {agkg~hpg `iah}e,$ [g{pedhpgli v~gauvcmhlme {zhaio aidh`h `iah}h g{pgd

hchpid,$ I`zimeli vhag~hlme {zhaio u}i~ah u i`oizh~hmug {v~edlga

"z~egku# vi{u`u',

$ Lhcmevlgkh { ngcmeaid i aicgglg v~gauvcmelio u}i~ah,$ Le `i`hzhpg ail}e~zhl{e ahi pi me ji~dhc`ebg`,$ V~ivg{li {ach`gpgpg u}i~ae,$ Vhcmgzi v~gauvcmhlme i`mee ahai ng {e g}nmeoci ouncmelme

p~hoizh `iah}h g g}nmeoch ailphdglhkgmh { `~uogd ngiciagd

u}i~kgdh,$ G}`hzhlme `iah}h u {ach`u { v~ivg{hlid v~ike`u~id,

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

17/28

Chni~hpi~gm }h @LH hlhcg}u

H' Chni~hpi~gm }h }hv~gdhlme iah}h

$Jg}gag `iah}g `i{phzcmhmu {e u chni~hpi~gm {h v~hpegd vg{did#glzelph~lgd cg{pid g ngcmeaid i z~{pg v~eoce`h)g{vgpgzhlmh }h{zhag aidh` {uach`li {phl`h~`lgd chni~hpi~gm{agd v~ipiaicgdh,

$ [ze g`elpgjgahkgm{ae glji~dhkgme jg}gagb `iah}h v~izme~gpg v~gmevi`lielmh in~h{kh,Ngci ahazh i`{puvhlmh p~enh g{v~hzli lhvidelupg g ai~gog~hpg,

$ [zhag vhaep p~enh ngpg v~hzgcli }hvhag~hl# }hvehel g i}lhel,Ngci aimg }lha lev~hzgclio vhag~hlmh# vehelmh gcg i}lhhzhlmh

p~enh lhze{pg,$ Lhvidelupg ngi ahaze }lhaize v~ivuphlmh vhaeph gcg ailphdglhkgme,

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

18/28

$ Ngci aime vi{enle }hbpmeze gcg uvupe u ze}g @LH

pe{pg~hlmh p~enh }hngcmegpg lh vi`le{elid in~h{ku,

$ Ai` }hv~gdhlmh `iah}h ngcmegdi `hpud }hv~gdhlmh#z~gmede# gde `ili{gpecmh)hoelkgme# v~e`deplg n~im "n~im{cuhmh'# n~im v~e`deph)h~pgahch# gde v~gdhpecmhv~e`deph,

$ Jg}gag `iah} }h @LH hlhcg}u p~enh `ile{pg pi me v~gmedioue ahai ng @LH ngch vib~hlmelh lh i`oizh~hmuglhgl,

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

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N' Vieplg chni~hpi~gm{ag v~ike{g in~h`e

V~eoce`hle `iah}e ngcmegpg u ji~duch~)in~h}hk }hme`li {h

v~ecgdglh~lgd v~ike{gdh# vime`glhli, Pi vi`~h}udgmezh {cme`ee vi`hpae=h' ivg{ vhaeph {h `iah}lgd dhpe~gmhcid g lmeoiz {pzh~lg

{h`~hmn' lhcmevlgku)epgaepu {h glji~dhkgmhdh# ciahclg n~im v~e`eph

k' ivg{ {phlmh `iah}lio dhpe~gmhch`' chni~hpi~gm{ag {vg{ g n~im {phzaee' `hpud g glgkgmhcg "vipvg{' g{vgpgzhh

@iaudelpg~hpg zecgglu# vicihm g {phlme u}i~ah,Inze}li zhohpg {zengiciae `iah}e ahi pi {u ai{pg# }ung#

liapg# pagzh((

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

20/28

$ Ngcmegpg {ze v~ecgdglh~le ~e}ucphpe pe{pg~hlmh `iah}lgbdhpe~gmhch g {zhag `ingzelg p~ho,

$ Ngcmeelme vi`hphah i {zhaid u}i~au aimg me vi`z~olup@LH hlhcg}g ahai {cgme`g=n~im v~e`deph# n~im {phzae g ivg{# glgkgmhcg "vipvg{'g{vgpgzhh1^ehoel{g v~edh aicgglg g n~imu# v~ipiaic# n~im

uvip~gmencmelgb u}i~hah,$ ^e}ucphpe pe{pg~hlmh }h {zhag v~e`dep p~enh ulgmepg u

i`oizh~hmug ~h`lg cg{p)in~h}hk,$ Vhcmgzi ~uaizhlme u}i~kgdh ahai ng {e g}nmeoci vio~eli

i}lhhzhlme gcg ulha~{lh ailphdglhkgmh,

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

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$Ah` oi` me dioue `gi u}i~ah p~enh {huzhpg }h nu`uehlhcg}e, Izg u}i~kg p~enhmu ngpg vib~hlmelg u }hd~}gzh,

Deupgd# pi e{pi lgme dioue }nio le`izicmle aicggleu}i~ah,U pid {cuhmu u}i~ha p~enh ngpg in~hel v~edh {phl`h~`lgd{dme~lgkhdh ji~el}glgb chni~hpi~gmh,

$ Ngci aime lhalh`li ~e}hlme u}i~ah }h @LH hlhcg}u p~enh{phzgpg u vi{enhl {v~edlga# }hvhag~hpg oh g {uach`li pidev~ivg{li oh i}lhgpg,

$ Leg{ai~gpelg u}i~kg @LH di~hmu ngpg v~ivg{li i}lhelg gvib~hlmelg u }hd~}gzh,

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

22/28

V~gauvcmhlme g uzhlme ngiciagb `iah}h [u`{ai uzhhzhlme `iah}h g }hacmuhah `ingzelgb @LH

depi`hdh uzecgae me upmekhci lh ~h}zim depi`h v~gauvcmhlmh

g uzhlme ngiciagb dhpe~gmhch,

]lhhmlh aicgglh ngiciaio dhpe~gmhch di~h ngpg v~gauvcmelhahai ng {e i{gou~hci u{vmeli @LH pe{pg~hlme,

Deupgd# zhli me io~hlggpg v~gauvcmhlme v~cmhzpgle#dh{lih# peauglh g `~uogb pzh~g g} iaicgh me~ dlioe i` lmgbleohpgzli upmeu lh v~ike{ @LH pgvg}hkgme,

[zhag ngiciag u}i~ha di~h ngpg v~gauvcmel g uzhl {uach`liv~ivg{hlim ji~el}glim v~ha{g g v~hzgcgdh, V~gauvcmelg `iah}g di~hmu {e v~idvpli `i{phzgpg u ji~el}glg

chni~hpi~gm, @h ng {e lmgbizi v~ivh`hlme {zeci lh lhmdhlmu diouu dme~u

vib~hlmumu {e u bch`lid g {ubid ia~uelmu `i `i{phzcmhlmh uji~el}glg chni~hpi~gm,

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

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Uaicgai `iah}g lg{u g{v~hzli `iaudelpg~hlg#v~gauvcmelg# vhag~hlg gcg uzhlg ilg le

}h`izicmhzhmu v~hzle g }lhl{pzele }hbpmeze g

lee ngpg v~gbzhelg ahi `iah} lh {u`u((

$ Hai `iah}g lg{u v~hzgcli `iaudelpg~hl v~gmeuzhlmh lmgbizi vi~gmeaci di~h ngpg v~eg{vgphli,

$ Hai {u iah}g lev~hzgcli v~gauvcmelg gcglev~hzgcli vhag~hlg vizehpg e {e diouli{pailphdglhkgme pi e `g{a~e`gpg~hpg ~e}ucphpe@LH hlhcg}e,

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

24/28

G}h}izg viu}`hli{pg @LH depi`h

$ I` lmgbizio uzielmh u ji~el}gle }lhli{pg#depi`e @LH pgvg}hkgme {u{phzi {u i{vi~hzhle,U{vmehl i`oizi~ lh v~goizi~e iai `ivu{pgzi{pg @LHdepi`h vi{pgolup me lhv~epaid u vhcmgzidv~gauvcmhlmu# uzhlmu g lhalh`lid ~uaizhlmu ngiciagd`iah}gdh,

$ O~eae lh aime {e uah}ume i`li{e {e lh u}i~ae#lmgbizu ailphdglhkgmu# i`{puvhlmh i` v~ivg{hlgbv~ipiaich u chni~hpi~gm{aid ~h`u { u}i~kgdh#

vio~elu glpe~v~ephkgmh ~e}ucphph gp`,$ [ze lhze`eli die `ize{pg `i vio~elio ailhlio

lhch}h ((

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

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]hacmuha V~gdmelh @LH pebliciogme u g{p~hohdh lhoci {e ~h}zgmhch

vi{cme`lmgb 85 oi`glh, @LH hlhcg}h viah}hch {e g}lgdli dilgd i~umed ahai }h ivpunu

phai g }h in~hlu, U {zmep{agd ~h}dme~gdh# ~e}ucphpg `ingzelg @LH hlhcg}id#

v~ugcg {u a~gpgle `iah}e aimg {u `izecg `i dliogb v~e{u`h,

[lhoh @LH depi`h ahi ea{acu}gzlio hchph z~gme`lh mevhlme((Deupgd# @LH hlhcg}h `iah}h aimg lg{u g{v~hzliv~evi}lhpg#`iaudelpg~hlg# v~gauvcmelg gcg {huzhlg uailhlgkgledh z~gme`li{p u g{p~h}g((

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

26/28

G}h}izg `ivu{pgzi{pg @LH depi`h

Oelepgah vgphlmh V~ike`u~hclh)peblgah vgphlmh

Glpe~v~ephkgmh ~e}ucphph [phpg{pgah Ailphdglhkgmh)i{phch {vekgjglh vgphlmh

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

27/28

V~g`hzhlme zeeo }lhhmh vi{puvkgdhv~gauvcmhlmh g uzhlmh `iah}lgb

dhpe~gmhch oh~hlkgmh me `hji~el}glh }lhl{pzelh }hme`lgkhvi{phle }lhhmhl hchp u {cungv~hz`e,

7/23/2019 Maria kornjak, M.D., Bioloski tragovi

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Bzhch lh vhlmg ((