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Takeda et al., eLife 2018 (in press)Zhang et al., Biochem. Biophys. Res. Commun. 480:409-414, 2016 Takeda et al., Open Biol. 7 130081, 2013Yamada et al., J. Neuroscience. 378:478-482, 2013Yamada et al., Biochem. Biophys. Res. Commun.378:478-482, 2009 Yamada et al., J. Biol. Chem. 284:34244-34256, 2009 Yamada et al., Mol. Biol. Cell, 18, 4669-4680, 2007
Cell Biology (cell culture, transfection, RNA interference)Imaging (live imaging, confocal microscopy, electron microscopy)Molecular biology (PCR, DNA cloning, site directed mutagenesis)Biochemistry (protein purification, Western blot, ELISA, in vitro reconstitution)
http://www.okayama-u.ac.jp/user/med/biochem/index.html
“Unveil cells at the molecular level and bring the findings to clinical application” Cells dynamically change their shape depending on developmental stages and/or their functional activities. The morphological changes of cells are driven mainly by cytoskeletal dynamics and intracellular membrane traffic. We study mechanisms of cellular morphogenesis, and their roles in physiological and pathological contexts. Screening of novel inhibitors targeting the cellular morphogenesis are also being carried out.
Techniques
Okayama UniversityGrduate School of Medicine, Dentistry and Pharmaceutical SciencesDepartment of Neuroscience
Division of Biochemistry
Publications Contact information
Kohji Takei, DDS, [email protected]: +81-86-235-7125
Research Topics
❷ Mechanisms of cell differentiation (neurons and muscles)
Erythrocyte
Malaria parasite
-90s 0s 30s 60s 90s 120s 300s
❹ Mechanism of malarial infection and anti-malarial drug screening
❸ Cancer invasion and anti-invasion drug screening
Growth cone of cultured neuron (live imaging )
Membrane dynamicsCell shapes and functions
Molecular mechanisms
❶ Structural dynamics of functional molecules
