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DNASC STANDARD B-4: THE STUDENT WILL DEMONSTRATE AN UNDERSTANDING OF THE MOLECULAR BASIS OF GENETICS
Cornell Notes
Topic: DNA
EQ: How does the overall structure of DNA explain the mechanism of inheritance?
History Griffith’s Experiment
1928: Griffith Transformation :
◦Process by which 1 strain of bacteria is changed into a 2nd strain after being in the presence of the 2nd strain
Hershey-Chase Experiment
Bacteriophages infect bacteria and transfer their genetic material to the bacteria’s DNA. These experiments proved it was the genetic material not the protein that “transformed” the bacteria.
Parts of DNA
DNA
1. 5-carbon sugar: deoxyribose
2. Phosphate group3. Nitrogenous Base
1. Purines1. Adenine2. Guanine
2. Pyrimidines1. Cytosine2. Thymine
Chargaff’s Rules
In same sample of DNA:
cytosine = guanine ◦[ C ] = [ G ]
adenine = thymine◦[ A ] = [ T ]
X-RAY EVIDENCE
Rosalind Franklin
studied DNA using x-ray diffraction
The pattern on the left gave some important clues as to the structure of DNA◦ shaped in a helix◦ nitrogenous bases in
center
THE DOUBLE HELIX
Watson & Crick
Built 3-D models trying to find a structure that explained everything they knew DNA could do
When they saw Franklin’s x-rays the shape became clear to them
DNA
Had to be able to do 3 things:1. carry
information from 1 generation to next
2. use the information to produce traits
3. be easily copied
DOUBLE HELIX
TWISTED LADDER WITH RUNGS OF LADDER MADE UP OF THE NITROGENOUS BASES HELD TOGETHER BY HYDROGEN BONDS