DNA Replication in Eukaryotic Cells Monograph 31 Edited by Melvin L. DePamphilis , National Institute of Child Health and Human Development, National Institutes of Health

DNA replication is a central cog in the machinery of cell and viral proliferation. After significant advances in the past few years, its regulation is now understood in un- precedented depth.

This is the first book to provide a detailed and thoroughly up-to-date review of the complexity of DNA replication in eukaryotic cells. It is organized into three parts: Concepts, a distillation of underlying principles; En- zymes, a description of each protein class involved; and Systems, a review of events over a wide range of or- ganisms. The book is therefore invaluable for teachers who want a current survey of a topic central to the biology syl- labus; investigators of replication who will appreciate a re- markably concise, central source of knowledge in their specialty; and scientists studying other biological functions on which DNA replication has an impact.

C O N T E N T S CONCEPTS Mechanisms for Replicating DNA (G.S. Brush and T.J. Kelly); Origins of DNA Replication (M.L. DePamphilis); Roles of Transcription Factors in DNA Replication (P.C. van der Vliet); Roles of Nuclear Structure in DNA Replication (R. Laskey and M. Madine); Mechanisms for Priming DNA Synthesis (M. Salas, J.T. Miller, J. Leis, and M.L. DePamphilis); Mechan- isms for Completing DNA Replication (D. Bastia and B.K. Mohanty); Fi- delity of DNA Replication (.I.D. Roberts and T.A. Kunkel); DNA Exci- sion Repair Pathways (E.C. Friedberg and R.D. Wood); Chromatin Struc-

ture and DNA Replication: Implications for Transcriptional Activity (A.P. Wolffe); Roles of Phosphorylation in DNA Replication (K. Weisshart and E. Fanning); Control of S Phase (K. Nasmyth); Temporal Order of DNA Replication (I. Simon and H. Cedar); Changes in DNA Replication during Animal Development (J.L. Carminati and T.L. Orr-Weaver); Comparison of DNA Replication in Cells from Prokarya and Eukarya (B. StiUman) ENZYMES CellUlar DNA Polymerases (T.S.-F. Wang); Viral DNA Polymerases (D.M. Coen); DNA Replication Accessory Proteins (U. Hiibscher, G. Maga, and V.N. Podust); DNA Helicases (J.A. Borowiec); DNA Ligases (R. Nash and T. Lindahl); DNA Topoisomerases (A. Hangaard Andersen, C. Bendixen, and O. Westergaard); Teiomerases (C.W. Greider, K. Col- lins, and C. Autexier) SYSTEMS SV40 and Polyomavirus DNA Replication (J.A. Hassell and B.T. Brin- ton); Papillomavirus DNA Replication (A. Stenlund); Adenovirus DNA Replication (R.T. Hay); Herpesvirus DNA Replication (M. Challberg); Epstein-Barr Virus DNA Replication (J.L. Yates); Poxvirus DNA Rep- lication (P. Traktman); Parvovirus DNA Replication (S.F. Cotmore and P. Tattersall); Replication of the Hepatitis Virus Genome (C. Seeger and W.S. Mason); Geminivirus DNA Replication (D.M. Bisaro); Baculovirus

DNA Replication (C.H. Ahrens, D.J. Leisy, and G.F. Rohrmann); DNA Replication in Yeast (C.S. Newlon); DNA Replication in Tetrahymena (G.M. Kapler, D.L. Dobbs, and E.H. Blackburn); DNA Replication in Physarum (G. Pierron and M. B6nard); Dif- ferential DNA Replication in In- sects (S.A. Gerbi and F.D. Ur- nov); DNA Replication in Xeno- pus (J.J. Blow and J.P.J. Chong); DNA Replication in Mammals (N.H. Heintz); DNA Replication in Plants (J. Van't Hof); Mito- chondrial DNA Replication (D.A. Clayton); Kinetoplast DNA Replication (A.F. Torri, L.J. Rocco Carpenter, and P.T. Englund)

1996, 1058 pp., illus., color plates, index Cloth $125

i i i

ISBN 0-87969-459-9 i l l | |

Telomeres Monograph 29 Edited by Elizabeth H. Blackburn, University of California, San Francisco; Carol W. Greider, Cold Spring Harbor Laboratory

--Here's what the reviewers have to say: "...the present book is both timely and much needed. The litera- ture has become increasingly diverse and voluminous, making it difficult for the casual reader or newcomer to the field to gain a balanced perspective. Telomeres provides an excellent, easy-to- read introduction for such readers. Moreover, since the book con- tains a wealth of information on all aspects of telomere biology and biochemistry, it should prove tremendously useful to even the most experienced telomere researcher.

A major strength of the book lies in the breadth of its coverage and the way it links the diverse topics. Each chapter concentrates on a different aspect of telomere research and where necessary describes the experimental system used in performing the re- search. Thus the book covers topics as diverse as telomere addi- tion in ciliates, gene expression and telomere position effect in yeast, construction of mammalian artificial chromosomes, and telomerase and cancer in humans. Yet the various chapters are not isolated units. The authors frequently refer to other chapters and give short accounts of topics that are discussed in detail else- where, providing the reader with a sense of continuity. A further useful and enjoyable feature of the book is its historical perspec- tive, which allows the reader to see how the field developed be- fore being plunged into the intricacies of current knowledge."

--Science 1995, 396 pp., illus., index ISBN 0-87969-457-2 Cloth $80

Reader Service No. 613

VOLUME 10

GENES

DEVELOPMENT N U M B E R 19 PAGES 2383---252.6 October 1, 1996

EDITORIAL BOARD

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Contents GENES & DEVELOPMENT October 1, 1996

Review

Strange bedfellows in even stranger places: the role of ATM in meiotic cells, lymphocytes, tumors, and its functional links to p53 R. Scott Hawley and Stephen Friend

Research papers

Mitotic regulation of TFIID: inhibition of activator-dependent transcription and changes in subcellular localization Neil Segil, Mohamed Guermah, Alexander Hoffmann, Robert G. Roeder, and Nathaniel Heintz

Dual roles of ATM in the cellular response to radiation and in cell growth control Yang Xu and David Baltimore

Targeted disruption of A TM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma Yang Xu, Terry Ashley, Elizabeth E. Brainerd, Roderick T. Bronson, M. Stephen Meyn, and David Baltimore

2383

2389

2401

2411

The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes Kathleen S. Keegan, Douglas A. Holtzman, Annemieke W. Plug, Erik R. Christenson, Elizabeth E. Brainerd, Gail Flaggs, Nicola J. Bentley, Elaine M. Taylor, M. Stephen Meyn, Stuart B. Moss, Antony M. Carr, Terry Ashley, and Merl F. Hoekstra

p53 Levels, functional domains, and DNA damage determine the extent of apoptotic response of tumor cells Xinbin Chen, Linda J. Ko, Lata Jayaraman, and Carol Prives

Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor Matthias Hammerschmidt, George N. Serbedzija, and Andrew P. McMahon

TGF-[31 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells Martin Oft, Janos Peli, Claude Rudaz, Heinz Schwarz, Hartmut Beug, and Ernst Reichmann

Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation Richard Eckner, Tso-Pang Yao, Elizabeth Oldread, and David M. Livingston

Radical mutations reveal TATA-box binding protein surfaces required for activated transcription in vivo Gene O. Bryant, Lisa S. Martel, Stephen K. Burley, and Arnold J. Berk

2423

2438

2452

2462

2478

2491

(continued)

The Drosophila endocycle is controlled by Cyclin E and lacks a checkpoint ensuring S-phase completion Mary A. Lilly and Allan C. Spradling

2514

E2F-induced S phase requires cyclin E Robert J. Duronio, Adam Brook, Nicholas Dyson, and Patrick H. O'Farrell

2505

The Drosophila endocycle is controlled by Cyclin E and lacks a checkpoint ensuring S-phase completion Mary A. Lilly and Allan C. Spradling

2514

Cover TFIID and mitot ic inhibit ion of transcription. These cells are in late telophase and are stained with antibody to the TFIID subunit TAF20/15 ired) and for DNA {blue). {For details, see Segil et al., p. 2389.)