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COMPARISON OF OUTCOMES OF PRESSURE SORERECONSTRUCTIONS AMONG PERFORATOR FLAPS,PERFORATOR-BASED ROTATION FASCIOCUTANEOUSFLAPS, AND MUSCULOCUTANEOUS FLAPS
PAO-JEN KUO, M.D.,1 KHONG-YIK CHEW, M.B.B.S., M.R.C.S.,2 YUR-REN KUO, M.D., Ph.D.,1 and PAO-YUAN LIN, M.D.1*
Background: Pressure sore reconstruction remains a significant challenge for plastic surgeons due to its high postoperative complicationand recurrence rates. Free-style perforator flap, fasciocutaeous flap, and musculocutaneous flap are the most common options in pressuresore reconstructions. Our study compared the postoperative complications among these three flaps at Kaohsiung Chang Gung MemorialHospital. Methods: From 2003 to 2012, 99 patients (54 men and 45 women) with grade III or IV pressure sores received regional flapreconstruction, consisting of three cohorts: group A, 35 free-style perforator-based flaps; group B, 37 gluteal rotation fasciocutaneousflaps; and group C, 27 musculocutaneous or muscle combined with fasciocutaneous flap. Wound complications such as wound infection,dehiscence, seroma formation of the donor site, partial or complete flap loss, and recurrence were reviewed. Results: The mean follow-up period for group A was 24.2 months, 20.8 months in group B, and 19.0 months for group C. The overall complication rate was 22.9%,32.4%, and 22.2% in groups A, B, and C, respectively. The flap necrosis rate was 11.4%, 13.5%, and 0% in groups A, B, and C, respec-tively. There was no statistical significance regarding complication rate and flap necrosis rate among different groups. Conclusions: Inour study, the differences of complication rates and flap necrosis rate between these groups were not statistically significant. Furtherinvestigations should be conducted. VC 2014 Wiley Periodicals, Inc. Microsurgery 34:547–553, 2014.
The problem of pressure sore reconstruction plagues
reconstructive surgeons worldwide and has been an
increasing problem, in part due to improvements in criti-
cal care and life support amid a rapidly ageing popula-
tion. It is a bane for surgeons due to the high
preponderance for complications and recurrence, in turn
leading to diminishing options for reconstruction.
Beginning in the 1970s, musculocutaneous flaps have
been the mainstay of reconstruction in pressure sores.1,2
Further modifications continue to be reported, such as the
use of V-Y advancement of a fasciocutaneous flap for
sacral ulcers reported by Park and Park in 1988.3 With
greater understanding of flap physiology and the perfora-
tor concepts, the perforator-based gluteal flaps were
developed and first reported by Koshima et al. in 1993,
and have gained popularity for reconstruction of pressure
sores.4
Proponents of the different flap types argue about the
superiority of one over the other, although evidence for
it has been scarce. Sameem et al. conducted an extensive
systematic review of pressure sore reconstruction in dif-
ferent flaps and concluded that there were no statistically
significant differences with respect to recurrence or com-
plication rates among musculocutaneous, fasciocutaneous,
or perforator-based flaps.5 They also called for more
comparative studies on determining the ideal flap type
for pressure sore reconstruction.
This study is a review of our unit’s experience in
treatment of this problem, with matched cohorts to com-
pare the outcomes of the various flap types used. In this
study, we compared the complication rates among three
different flap types in pressure sore reconstructions: a)
freestyle perforator-based gluteal flap, b) gluteal rotation
fasciocutaneous flap, and c) musculocutaneous flap or a
combination of muscle and fasciocutaneous flaps.
PATIENTS AND METHODS
From February 2003 to December 2012, a total of 99
patients consisting of 54 males and 45 females with
grade III or IV pressure sores received complete debride-
ment, including bursectomy and partial ostectomy of the
bony prominence where required, followed by immediate
regional flap reconstruction. This study was divided into
three cohorts according to the types of flaps used. During
the period between 2003 and 2008, free-style perforator
based flaps were widely used for reconstruction of pres-
sure sores in our unit. During this period, 35 patients
underwent freestyle perforator-based flaps (group A),
consisting of 26 sacral, 5 ischial, and 4 trochanteric pres-
sure ulcers.6 Between 2008 and 2010, the gluteal rotation
fasciocutaneous flap was performed among 37 patients
(group B), among them 25 cases were pressure sores
involving the sacral region, 11 were ischial wounds, and
1Department of Plastic and Reconstructive Surgery, Kaohsiung ChangGung Memorial Hospital and Chang Gung University, College of Medicine,Kaohsiung, Taiwan2Department of Plastic, Reconstructive and Aesthetic Surgery, KandangKerbau Women’s and Children’s Hospital, Singapore
*Correspondence to: Pao-Yuan Lin, MD, Department of Plastic and Recon-structive Surgery, Kaohsiung Chang Gung Memorial Hospital, 123, Ta-PeiRoad, Naio-Song District, Kaohsiung, Taiwan.E-mail: [email protected]
Received 2 December 2013; Revision accepted 17 March 2014; Accepted24 March 2014
Published online 5 April 2014 in Wiley Online Library (wileyonlinelibrary.com).DOI: 10.1002/micr.22257
� 2014 Wiley Periodicals, Inc.
one with trochanteric ulcer.7 From 2011 to 2012, the
senior author (P.L.) employed the use of musculocutane-
ous flaps or combinations of muscle and fasciocutaneous
flaps (group C) for treatment of 27 pressure ulcers.
There were six sacral sores that were resurfaced with
musculocutaneous flaps, two trochanteric ulcers were
covered with pedicled anterolateral thigh musculocutane-
ous flaps, and 19 cases of ischial pressure sores resur-
faced with a combination of biceps femoris muscle flaps
and posterior thigh fasciocutaneous flaps. The recruit-
ment of a muscle component for reconstruction was cho-
sen for pressure sore reconstruction to allow cushioning
of exposed bone as well as to decrease dead space using
the additional soft tissue bulk. In the cases of ischial
ulcers, a separate fasciocutaneous flap was raised during
the same procedure when the significant cutaneous
defects were encountered or when musculocutaneous
flaps were unlikely to provide sufficient skin cover or
where these were unavailable. Postoperatively, all
patients were kept in supine or lateral decubitus position
for a minimum of 3 weeks. In addition, all subjects
were initiated on a sitting program consisting of grad-
uated weight bearing over increments of time where
possible. At the end of the study, sonography was
undertaken at the location of pressure ulcer to evaluate
the wound healing process.8
Medical records with regard to patient demographics,
existing disorders such as spinal cord disease, medical
co-morbidities, the surgical technique used, and wound
complications and hospital stay were reviewed. Compli-
cations were documented individually, including wound
infection, dehiscence, seroma formation, partial or com-
plete flap loss, and recurrence.
Chi-square test was used to compare statistical differ-
ence of proportion among different groups. A P-value of
less than 0.05 indicated statistically significant results,
and all confidence intervals are reported in the 95%
range. All calculations were performed using SPSS for
Windows, Version 14.0 (Chicago, IL).
RESULTS
In this study, the age of patient population ranged
10–91 years with an average of 59.7 6 17.8 years.
Divided into the separate groups, the average ages were
64 6 17, 58.7 6 18.6, and 55.4 6 16.9 years among
groups A, B, and C. The defect sizes ranged from 4 3 3
cm2 to 27 3 13 cm2, with similar ranges among the
three groups (group A: 7 3 2 cm2 to 27 3 13 cm2,
group B: 4 3 3 cm2 to 12 3 10 cm2, and group C: 5 3
3 cm2 to 12 3 7 cm2 respectively). The mean follow-up
period for group A was 24.2 months (ranging from 0 to
46 months), 20.8 months in group B (0 to 30 months),
and 19.0 months for group C (14 to 26 months).
Complications were common and affected 26.3% of
all patients, excluding two mortality in the early postop-
erative period. For group A, eight patients or 22.9% of
this cohort suffered from such complications, including
one total flap loss, three partial flap necrosis, three
wound dehiscence, and one recurrence (one mortality
were not calculated). Among the group B cohort, five
cases of partial flap necrosis, four wound dehiscence, one
seroma formation, and two recurrences (one death which
was not included in analysis) were reported, indicating a
32.4% complication rate (12 out of 37 cases). In group
C, one case of wound dehiscence, two donor sites seroma
formation, one infection, and two recurrences developed
among 27 patients, or 22.2% of the cohort studied. The
flap necrosis rate was 4/35 (11.4%, including one total
loss) in group A, 5/37 (13.5%) in group B, and 0/27
(0%) in group C. The differences of complication rates
and flap necrosis rate between these groups were not stat-
istically significant (P 5 0.559 and 0.149, respectively).
The recorded complications of these three groups are
summarized in Table 1.
CASE REPORTS
Case 1: A 69-year-old female patient with the history
of end-stage renal disease presented with 6 cm 3 6 cm
grade IV sacral pressure ulcer (Fig. 1) due to long-term
bed ridden during hospitalization. She received adequate
debridement and partial ostectomy of protruded sacral
bone. Immediate gluteal perforator flap (Fig. 2) was ele-
vated and reconstructed for the sacral defect. The flap
was pink in color postoperatively (Fig. 3). However, the
flap was necrosed gradually. No more flap was used for
the wound reconstruction. After discharge, secondary
healing with dressing was applied on the wound and this
patient was followed at clinic regularly. However, the
wound was still not healed at one-year follow-up.
Case 2: A 58-year-old female patient presented with
6 cm 3 4 cm grade IV sacral pressure sore (Fig. 4) for
3 weeks at home. Debridement and partial ostectomy of
sacral bone were undertaken. Left gluteal fasciocutaneous
flap based on inferior gluteal artery (Fig. 5) was elevated
and then rotated to repair the defect immediately. The
wound was healed uneventfully at postoperative 3 weeks.
At 8-month follow-up, the wound was healed without
recurrence.
Case 3: A 43-year-old male patient suffered from spi-
nal cord injury due to traffic accident 5 years ago. He
had 3 cm 3 3 cm grade IV left ischial pressure ulcer
and received debridement and wound repair at first. The
wound was dehiscent few days later. Adequate debride-
ment and ostectomy of ischial bone were performed (Fig.
6). Due to huge defect (7 cm 3 7 cm 3 4 cm), left
biceps femoris muscle (Fig. 7) was harvested and turned
548 Kuo et al.
Microsurgery DOI 10.1002/micr
Tab
le1.
Patient
Dem
ogra
phic
s,P
osto
pera
tive
Com
plic
ation,
and
Com
plic
ation
Rate
Sex
(M/F
)
Ave
rage
age
inye
ars
Loca
tion
and
num
bers
of
pre
ssure
sore
s
Defe
ct
siz
e(c
m2)
Posto
pera
tive
com
plic
ations
Fla
pnecro
sis
rate
aC
om
plic
ation
rate
bM
ean
follo
w-u
p
(range)
inm
onth
s
Gro
up
A
Fre
esty
leperf
ora
tor
flaps
12/2
264
617
Sacru
m–
26
73
2–27
313
1flap
tota
llo
ss
a11.4
%22.9
%24.2
(0–46)
Ischiu
m–
53
part
ialflap
necro
sis
a
Hip
–4
3w
ound
dehis
cence
1die
db
1re
curr
ence
Gro
up
B
Fascio
cuta
neous
flaps
24/1
358.7
618.6
Sacru
m–
25
43
3–12
310
5tip
necro
sis
a13.5
%32.4
%20.8
(0–30)
Ischiu
m–
11
4w
ound
dehis
cence
Hip
–1
1sero
ma
1die
db
2re
curr
ence
Gro
up
C
Myo
cuta
neous
flaps
or
com
bin
ed
muscle
&fa
scio
-cuta
neous
flaps
18/9
55.4
616.9
Sacru
m–
65
33–12
37
1w
ound
dehis
cence
0%
22.2
%19
(14–26)
Ischiu
m–
19
2donor
site
sero
ma
2re
curr
ence
Hip
–2
1w
ound
infe
ction
aT
he
case
of
tota
lflap
necro
sis
,part
ialflap
necro
sis
and
tip
necro
sis
were
inclu
ded
the
calc
ula
tion
of
flap
necro
sis
rate
bD
ied
cases
were
exclu
ded
from
calc
ula
tions
of
short
-term
com
plic
ation.
Figure 1. Patient presented with grade IV sacral pressure ulcer.
[Color figure can be viewed in the online issue, which is available
at wileyonlinelibrary.com.]
Figure 2. Perforator flap was elevated during the operation. [Color
figure can be viewed in the online issue, which is available at
wileyonlinelibrary.com.]
Figure 3. Immediately postoperative wound that was reconstructed
by free-style perforator flap. [Color figure can be viewed in the
online issue, which is available at wileyonlinelibrary.com.]
Comparison of Outcomes of Pressure Sore Reconstructions 549
Microsurgery DOI 10.1002/micr
upwardly to obliterate the dead space at left ischium.
Posterior thigh fasciocutaneous flap was elevated and
then advanced to close the skin defect (Fig. 8). The
wound seemed good postoperatively. However, wound
was dehiscent due to poor postoperative care and patient
compliance. Debridement was performed and negative
pressure wound therapy was applied. Six weeks later, the
wound was healed. However, left ischial pressure sore
was recurred at 4-month follow-up. He received further
debridement and negative pressure wound therapy was
applied postoperatively.
DISCUSSION
Pressure sore reconstruction using regional flap is a
standard surgical modality for reconstructive surgeon.
The free-style perforator flap is supported by one or two
perforators which mother vessel at gluteal region is not
identified. This kind of flap could be advanced or rotated
to achieve wound repair. The rotational gluteal flap is
supported by the main trunk of superior or inferior glu-
teal artery and may have additional perforator to promote
the vascularity of the flap.7 It could be rotated only to
repair the wound.
Figure 4. Patient presented with grade IV sacral pressure sore.
[Color figure can be viewed in the online issue, which is available
at wileyonlinelibrary.com.]
Figure 5. Left gluteal rotation fasciocutaneous flap was used to
reconstruct sacral defect. Immediately postoperative wound. [Color
figure can be viewed in the online issue, which is available at
wileyonlinelibrary.com.]
Figure 6. Left ischial pressure sore, Gr IV, post debridement. [Color
figure can be viewed in the online issue, which is available at
wileyonlinelibrary.com.]
Figure 7. Left biceps femoris muscle flap was elevated and this
muscle was turned upwardly to obliterate the dead space at left
ischium. [Color figure can be viewed in the online issue, which is
available at wileyonlinelibrary.com.]
550 Kuo et al.
Microsurgery DOI 10.1002/micr
Comparing the different types of flap, the complication
rate was 22.9% for free-style perforator flap, 32.4% for
rotational gluteal fasciocutaneous flap, and 22.2% for mus-
culocutaneous flap or muscle combined fasciocutaneous
flap after long-term (at least 6 months) follow-up. Hence,
this study only included small series of cases, which may
be the reason for that the results of statistical analysis
were negative. A systematic review by Sameem et al.
reported overall complication rates of 19.6% for perforator
based flaps, 11.7% for fasciocutaneous flaps, and 18.6%
for musculocutaneous flaps, although the review similarly
failed to demonstrate statistical significance between the
different complication rates of these flaps.5 The reason, as
pointed out by the authors, is that majority of research
into pressure sore reconstruction are limited by small sam-
ple sizes, lack of control groups, population heterogeneity,
and a large preponderance for case series, which tends to
be susceptible to selection bias.
In the first cohort of this study (group A), free-style
perforator-based flaps were used as a standard method of
repair for pressure ulcers.6 Wei and Mardini introduced
the concept of free-style perforator flap surgery as a rou-
tine procedure and formed our basis for this flap choice
in the first group studied.9 This technique allows for
recruitment of healthy surrounding tissue with an axial
vascular supply and has the added advantage of allowing
for custom-designed flap shape and size to fit the defect.
Perforator dissection allows for a long pedicle length and
enhances its reach and facilitates inset and positioning of
the flap. Moreover, the use of perforator flaps avoids
damage to underlying muscle and underling structures
such as sciatic nerves, preserving the ambulatory poten-
tial of these patients. Consequently, preservation of the
underlying muscle allows for future use in the event of
recurrence.10 However, total flap necrosis could happen
in the case of perforator injury. Then we shifted free
style perforator flap to perforator-based rotational gluteal
flap reconstruction in our series.
In 1997, Yamamoto and Tsutsumida reported the
superiority of fasciocutaneous flaps and argued for its use
as a first line treatment in pressure ulcer reconstruction,11
based on various experimental studies on muscle toler-
ance to pressure and anatomical studies on typical pres-
sure points,12 as well as the significant muscle atrophy
observed in the long-term.11 Our experience with gluteal
rotation fasciocutaneous flaps reflects this sentiment,7 as
these flaps have a broad-based cutaneous component,
bestowing it with generous dermal blood supply comple-
menting the superior or inferior gluteal vessels, but more
importantly allows for adequate venous drainage.10,13
The use of this technique preserves many of the advan-
tages of the perforator flaps, such as muscle preservation,
excellent durability, minimal donor site morbidity, and in
select cases the added ability for re-use in the event of
recurrence. The main caveat for these flaps is the require-
ment of a large rotation arc for adequate tissue transfer
and coverage.
The idea of incorporating muscle for pressure sore
reconstruction has been challenged as early as 1977 by
Grabb.3 According to the study of Daniel and Faibisoff
in 1982, the normal soft tissue coverage of various pres-
sure points in cadavers and noted the absence of muscle
over the sacrum and trochanter,14 for which Yamamoto
et al. surmised that muscle coverage of pressure points
“violates normal soft-tissue coverage of bony prom-
inences.”15 However, a significant layer of muscle (5.0–
45 mm) has been shown to cover the ischium, although
the muscle slides away on hip flexion in a sitting pos-
ture.14 By this rationale, we believe that muscle flaps
remain necessary for anatomical replacement of deep
ischial pressure ulcers.
With experience and long-term analysis,11 however,
even proponents of fasciocutaneous flaps (long-term out-
come paper) concur that pressure sores with deep ulcer
cavities are the main limitation for its use, especially
with ischial ulcers. Yamamoto claimed against the use of
musculocutaneous flaps, noting that muscles atrophy with
loss of dynamic function, but in his review of 12
patients, a musculocutaneous flap was ultimately used for
salvage of a failed fasciocutaneous flap with deep
Figure 8. Immediately postoperative wound. [Color figure can be
viewed in the online issue, which is available at wileyonlinelibrary.
com.]
Comparison of Outcomes of Pressure Sore Reconstructions 551
Microsurgery DOI 10.1002/micr
wounds. In the latest cohort of patients of this series, we
recruited the use of musculocutaneous flap, or in select
cases, a muscle flap combined with a fasciocutaneous
flap for pressure sore reconstruction. In this group, most
patients suffered from spinal cord injury contributing to
the formation of ischial sores, where fasciocutaneous
flaps alone did not provide adequate bulk.
Musculocutaneous flap has the effects of bacterial
count reduction and blood flow increase. In a series of
animal studies, Calderon et al. compared in great detail
the hemodynamic features, histological changes, and
bacteriology responses between the musculocutaneous
and fasciocutaneous flaps.16 Detailed statistical analysis
and control measurements revealed significantly
increased blood flow to the undersurface of muscle-
bearing flaps during the first 24 hours, which correlated
with a significantly reduced bacterial count within the
wound bed during this same period in musculocutane-
ous flaps. The effect of decreased bacterial count
remains 30–60 times greater than fasciocutaneous flaps
even at days 3–5. Besides demonstrating the superior
suppression of bacterial proliferation, histological
examination at day 6 showed enhanced fibrous tissue
ingrowth and collagen deposition at the wound bed.16,17
The combination of greater pressure distribution,
enhanced bacterial suppression, and higher tissue
ingrowth represent significant factors in decreasing
short-term complications, improving reconstructive suc-
cess, thus making the musculocutaneous flap an ideal
candidate for reconstruction for deep, potentially
infected pressure sores typically seen in ischial ulcers.
Even with complete muscle atrophy beyond 1–2 years,
we speculate that the established tissue ingrowth com-
bined with fibrotic change of the muscle likely serves
to strengthen the subcutaneous tissue and confers
increased resistance to shear.
The major argument against using musculocutaneous
flap as a first option is the sacrifice of muscle and should
be considered carefully in ambulant patients. However,
re-use of musculocutaneous flaps or the split muscle flap
techniques have been documented.18,19 On the other
hand, muscle atrophy is a significant long-term issue,
results in loss of muscle padding function and may cause
pressure ulcer recurrence. However, this phenomenon
was not shown in our study, possibly owing to a shorter
follow-up period.
Ultimately, in case of huge lumbosacral defect or
recurrent pressure sore without adequate or suitable soft
tissue near the wound for reconstruction, free tissue
transfer such as transverse rectus abdominis myocutane-
ous flap using superior gluteal artery perforator vessel
should be considered.20
The limitations (weaknesses) of this study were small
numbers for each group, different case numbers for each
location of pressure sore, not long enough length of
follow-up, and not all of cases being followed-up long
enough, which made the real complication rate and out-
comes could not compare among different flap recon-
struction in our study. Further study with respect to more
cases recruited and longer follow-up period should be
conducted.
CONCLUSIONS
The complications and flap necrosis rate showed no
statistical significance among perforator flap, rotational
gluteal fasciocutaneous flap, and musculocutaneous flap
in pressure sore reconstruction in our study. The reliabil-
ity of study is not strong enough based on above weak-
nesses. Further investigations are warranted.
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