Camilo Mora-Navarro, Ph.D. Ph.D. Chemical Engineering, University of Puerto Rico Mayaguez, PR. Postdoctoral Research Scholar PI: Donald O. Freytes, Ph.D. Address: Joint Department of Biomedical Engineering UNC-CH/NCSU North Carolina State University Biomedical Partnership Center 1060 William Moore Drive Raleigh, NC Email: [email protected] [email protected] Development of an in vitro testing platform to study multicellular interaction Research emphasis: Dr. Mora’s interests center on exploring innovative platforms to further understand the dynamics of cellular cross- talking involved in the wound healing process. Our research focuses on three main components: cellular engineering, in vitro testing platforms, and biomaterial improvements. The cellular engineering component involves the use of CRISPR/Cas9 as gene editing tool to generate cell reporter lines. In vitro testing platforms are centered on the development of an adequate optical microdevice to monitor the cell reporter lines. Lastly, biomaterial improvements are proposed and tested based on the enhancement of the antimicrobial properties. Applications: § Generation of cell reporter lines § Antimicrobial materials for medical use § Optical devices for in vitro assessment of new therapies § Microdevices for in vitro characterization of cellular interactions Publications and Abstracts: Mora-Navarro C, Méndez-Vega J, Caraballo-León J, Lee MR, Palecek S, Torres- Lugo M, Ortiz- Bermúdez P. Hydrophobicity of Antifungal β-Peptides Is Associated with Their Cytotoxic Effect on In Vitro Human Colon Caco-2 and Liver HepG2 Cells. 2016 Erratum in: PLoS One. 2016;11(6):e0157025. Herrera-Posada S, Mora-Navarro C, Ortiz-Bermudez P, Torres-Lugo M, McElhinny KM, Evans PG, Calcagno BO, Acevedo A. Magneto-responsive liquid crystalline elastomer nanocomposites as potential candidates for dynamic cell culture substrates. 2016 Aug 1 Mora-Navarro C, Caraballo-León J, Torres-Lugo M, Orez-Bermúdez P. Synthetic antimicrobial β- peptide in dual treatment with fluconazole or ketoconazole enhances the in vitro inhibition of planktonic and biofilm Candida albicans. J Pept Sci. 2015 Dec. Research Strengths: § Epigenetics § Molecular biology § Antimicrobial materials § Cytotoxicity assessment

Camilo Mora-Navarro, Ph.D. Development of an in vitro testing … · [email protected] Development of an in vitro testing platform to study multicellular interaction Researchemphasis:

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CamiloMora-Navarro,Ph.D.

Ph.D.ChemicalEngineering,UniversityofPuertoRicoMayaguez,PR.

PostdoctoralResearchScholar

PI:DonaldO.Freytes,Ph.D.

Address:JointDepartmentofBiomedicalEngineeringUNC-CH/NCSUNorthCarolinaStateUniversityBiomedicalPartnershipCenter1060WilliamMooreDriveRaleigh,NC

Email:[email protected]@upr.edu

Developmentofaninvitrotestingplatformtostudymulticellularinteraction

Research emphasis:

Dr.Mora’sinterestscenteronexploringinnovativeplatformstofurtherunderstandthedynamicsofcellularcross-talkinginvolvedinthewoundhealingprocess.Ourresearchfocusesonthreemaincomponents:cellularengineering,invitrotestingplatforms,andbiomaterialimprovements.ThecellularengineeringcomponentinvolvestheuseofCRISPR/Cas9asgeneeditingtooltogeneratecellreporterlines.Invitrotestingplatformsarecenteredonthedevelopmentofanadequateopticalmicrodevice tomonitorthecellreporterlines.Lastly,biomaterialimprovementsareproposedandtestedbasedontheenhancementoftheantimicrobialproperties.

Applications:

§ Generationofcellreporterlines§ Antimicrobialmaterialsfor

medicaluse§ Opticaldevicesforinvitro

assessmentofnewtherapies§ Microdevices forinvitro

characterizationofcellularinteractions

PublicationsandAbstracts:

Mora-NavarroC,Méndez-VegaJ,Caraballo-LeónJ,LeeMR,PalecekS,Torres-LugoM,Ortiz-BermúdezP.HydrophobicityofAntifungalβ-PeptidesIsAssociatedwithTheirCytotoxicEffectonInVitroHumanColonCaco-2andLiverHepG2Cells.2016Erratumin:PLoSOne.2016;11(6):e0157025.

Herrera-PosadaS,Mora-NavarroC,Ortiz-BermudezP,Torres-LugoM,McElhinnyKM,EvansPG,CalcagnoBO,AcevedoA.Magneto-responsiveliquidcrystallineelastomernanocompositesaspotentialcandidatesfordynamiccellculturesubstrates.2016Aug1

Mora-NavarroC,Caraballo-LeónJ,Torres-LugoM,Orez-BermúdezP.Syntheticantimicrobialβ-peptideindualtreatmentwithfluconazoleorketoconazoleenhancestheinvitroinhibitionofplanktonicandbiofilmCandidaalbicans.JPeptSci.2015Dec.

ResearchStrengths:

§ Epigenetics§ Molecularbiology§ Antimicrobialmaterials§ Cytotoxicityassessment