BIOSTAT Standard Systems Compact|Efficient|Convenient · BIOSTAT® Standard Systems Compact|Efficient|Convenient ... – Single or Twin configurations available ... Single Twin BIOSTAT

BIOSTAT® Standard SystemsCompact|Efficient|Convenient

turning science into solutions

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Vidrolab 2, S.A. www.vidrolab.pt

The BIOSTAT® family of fermentors and

bioreactors is a new generation of tech-

nology featuring high quality and indus-

try proven hardware manufactured in an

ISO-9001 certified facility. The capabili-

ties Sartorius Stedim Biotech supplies in

these compact system designs are second

to none – each featuring powerful and

user-friendly control.

Our ready-to-use microbial or cell culture

packages are designed to meet various

application needs and are offered with

a full range of accessories.

The systems are easy to use, reducing

the training efforts and saving time.

Overview of Volume RangesBIOSTAT®

Standard Systems

Fermentor| Vessel size [L]

Bioreactor

Working Minimum

Autoclavable volume volume

BIOSTAT® Qplus 0.5 0.15

1 0.4

BIOSTAT® Aplus 1 0.4

2 0.6

5 0.6

BIOSTAT® B plus 1 0.4

2 0.6

5 0.6

10 5|1.5

BIOSTAT® B-DCU II 0.5 0.15

1 0.4

2 0.6

5 0.6

10 5|1.5

In-situ sterilizable

BIOSTAT® Cplus 2 –|0.9

5 –|1.6

10 3.5|4.5*

15 5.0|5.5*

20 5.5|7.5*

30 7|9*

Photobioreactor

BIOSTAT® PBR 2S 3 3

Single use Bioreactor

BIOSTAT®

CultiBag RM 0.5 0.05

1 0.1

5 0.5

10 1

25 5

50 10

100 20

300 60

BIOSTAT®

CultiBag STR Plus 50 12.5

200 50

500** 125**

1000** 250**

* H:D 3:1|2:1

** Under development

To accelerate your research activities,

each system is supplied with BioPAT®

MFCS | DA data storage and plotting soft-

ware for simultaneous control and data

collection. Your process can be enhanced

by our configurable BioPAT® MFCS SCADA

Supervisory Control package.

Environmental Requirements

Required bench space approx. W + H + D [mm]

BIOSTAT® A plus 1 L 840 + 580 + 425

BIOSTAT® A plus 2 L 870 + 640 + 425

BIOSTAT® A plus 5 L 900 + 750 + 425

Required inner autoclave dimension d + H [mm]

UniVessel® 1 L 220 + 500 (*340)

UniVessel® 2 L 250 + 550 (*400)

UniVessel® 5 L 280 + 700 (*510)

Utility Requirements

Utility lines Customer supply

Power supply 120 VAC|15 A or 230 VAC|10 A

Gasses Controlled @ 1.5 barg;

dry, particle and oil-free

Water Controlled @ 2 barg

Drain Gravity drain with zero backpressure

* Optional flexible adapter for the exhaust cooler (BB-8844593)

is available to reduce autoclave height requirements.

Plug in and Grow with

the BIOSTAT® Aplus!

This compact Fermentor | Bioreactor comes

as “ready-to-use” benchtop system

for microbial or cell culture applications.

Our compact controller provides measure-

ment and control of temperature, pH, DO,

stirrer speed, gas mixing, Foam| Level and

substrate.

Fully-equipped culture vessels are part of

every package.

The whole system is operated by a powerful

notebook PC. Its well-known operating

principle makes it easy for all users – from

beginners to experts.

Suit your needs!

– Specially developed for education

and research

– Compact benchtop design saves

valuable laboratory space

Make your choice!

– 1 – 4 units may be operated by one

powerful Notebook PC

– Single-wall culture vessels are

available and interchangeable in the sizes

of 1 L, 2L or 5L working volume

Save your time!

– Packages come fully-equipped,

no additions needed

– Installation video and user-guide are

included in every package to get started

immediately “out of the box”

BIOSTAT® Aplus

BIOSTAT® Bplus

Gain R&D convenience with the

BIOSTAT® Bplus!

This flexible system solution has been

designed for your research and development,

process development and small-scale produc-

tion. Its pre-configured microbial or cell

culture versions offer a variety of solutions for

your application.

Our compact controller provides measure-

ment and control of temperature, pH, DO,

stirrer speed, gas mixing, Foam | Level

and substrate as well as optional Redox and

Turbidity measurement.

All systems come with a fully-equipped

single- or double-wall culture vessel.

Offering four different gassing strategies as

well as optional mass flow controllers the

BIOSTAT® Bplus adjusts to your individual

demands.

Save your Space!

– Single or Twin configurations available

– Snap-in pumps pre-installed in the

controller

Save your Time!

– Sanitary steel housing for convenient

cleaning

– Fully-equipped vessel – no additions needed

– User-friendly touch screen interface

for easy operation

Gain more flexibility!

– All culture vessels are available and inter-

changeable in the sizes of 1L, 2L, 5L or 10L

– Gassing strategies may be enhanced by

optional mass flow controllers


Required bench space approx. W + H + D [mm] Single Twin

BIOSTAT® B plus 1 L 560 + 730 + 565 800 + 730 + 565

BIOSTAT® B plus 2 L 590 + 730 + 565 860 + 730 + 565

BIOSTAT® B plus 5 L 620 + 730 + 565 920 + 730 + 565

BIOSTAT® B plus 10 L 670 + 820 + 565 1040 + 820 + 565


UniVessel® 1 L 240 + 500 (*340)

UniVessel® 2 L 270 + 550 (*400)

UniVessel® 5 L 300 + 700 (*510)

UniVessel® 10 L 350 + 820 (*620)




Gasses Controlled @1.5 barg;

dry, particle and oil free





BIOSTAT® B-DCU II

The BIOSTAT® B-DCU II is the second genera-

tion of a well proven Fermentor|Bioreactor

system, designed for meeting demanding

requirements in both research and process

development.

A newly engineered control system launches

many of its well-proven design features into a

new era, offering unprecedented advantages

for process development laboratories around

the world. Unrivaled for scale-down and

scale-up modeling of various culture process-

es, the BIOSTAT® B-DCU II provides a new level

of power and flexibility:

– Independent process control

for up to six culture vessels

– Up to six integrated peristaltic

pumps with choices for fixed and speed

controlled pumps

– Superior gas mixing with up to 6 Rotameter

and Mass Flow Controller

– Choice of pre-configured systems or

customize from an extensive list of options



1fold | 2fold | 3fold | 800 | 1200 | 1700 |

4fold | 5fold | 6fold 2050 | 3000 + 780 (10 L : 820) + 800


UniVessel® 0.5 L 170 + 340

UniVessel® 1 L 240 + 500 (*340)

UniVessel® 2 L 270 + 550 (*400)

UniVessel® 5 L 300 + 700 (*510)

UniVessel® 10 L 350 + 820 (*620)




Gasses controlled @ 1.5 barg;






BIOSTAT® Qplus

For fast track results and parallel operation,

the BIOSTAT® Qplus is a new generation of

fermentor|bioreactor systems with high

throughput capabilities. A new era of

biotechnology screening is born with its

highly engineered control system and small

scale cultivation vessels. Application-

driven configured packages allow an

immediate start-up.

– 3|6|9|12-fold versions for multiple or

parallel fermentations

– Sanitary stainless steel housing for easy

cleaning

– Powerful and user-friendly digital

controller with 15” color touch screen

display

– Culture vessels with 0.5 L or 1 L

working volume



3fold | 6fold | 9fold | 12fold – BIOSTAT® Qplus 0,5 L 850 |1320 |1860 |2400 + 900 + 750

3fold | 6fold | 9fold | 12fold – BIOSTAT® Qplus 1 L 1100 |1800 |2550 | 3300 + 900 + 800


UniVessel® 0.5 L |

3fold vessel assembly with tray 0,5 L 170 + 340 | 480 + 400

UniVessel® 1 L

3fold vessel assembly 240 + 500* | 460 + 500 (*340)




Gasses Controlled @ 1.5 barg



Drain Gravity drain with zero back pressure



BIOSTAT® Cplus

The BIOSTAT® Cplus fulfills your require-

ments in academic and industrial research,

process development and small scale pro-

duction. It is designed for users who need a

scaleable, reliable industrial Sterilizable-In-

Place (SIP) fermentor | bioreactor with no

room for compromises.

It provides outstanding state-of-the-art

technology and design. Pre-defined “ready

to use” packages include all components

needed for powerful and convenient oper-

ation, in microbial or cell culture applica-

tions. Furthermore, the modular design

philosophy of the BIOSTAT® Cplus, enables

individual system configurations to fullfill

your specific application requirements.

The broad range of accessories will fit

seamlessly into your ever-changing

research and development needs.

The BIOSTAT® Cplus is the floor standing

version, available with culture vessels from

10 L – 30 L working volume.

The BIOSTAT® CTplus is the benchtop

version available with culture vessels

providing 2 L or 5 L working volume.

– Compact laboratory scale fermentor with

in-situ sterilizable culture vessels

– Scaleable culture vessels

from 2 L up to 30 L

– Sanitary stainless steel design for easy

cleaning

– Choice between steam or electric heating

– User-friendly touch screen interface

for easy operation


BIOSTAT® CTplus required bench space approx. W + H + D [mm] 860 + 1010 + 670

BIOSTAT® Cplus required floor space approx. W + H + D [mm] 1020 + 1760 + 670


Utility lines customer supply

Air controlled, prefiltered @ 4 – 6 barg dry, particle and oil free

Gasses controlled, prefiltered @ 2 barg

Water controlled, prefiltered @ 2 – 4 barg

Steam controlled, prefiltered

@ 2.5 – 3 barg

Clean steam controlled, prefiltered

@ 1.5 – 2 barg

Cooling Water Return To close loop cooling-water

system or drain

Drain | Condensate Open, gravity-type drain

Power supply 208 VAC|3 + 15 A or 400 VAC|3 + 16 A

BIOSTAT® PBR 2S

The BIOSTAT® PBR 2S is a new photobio-

reactor system which expands the Sartorius

Stedim bioreactor product line with its

photosynthetic power. Specifically

designed for cultivation of phototrophic

organisms, this system unites a number of

features enabling even the most shear

sensitive cell types to be cultivated under

optimal conditions.

– Thin pipe helix design with recirculation

vessel provides maximum illumination

per surface area

– Illumination control Loop offers light

intensity based on culture demand

– Working volume 3 L

– Compact system design allows a small

footprint

– Easy to use “out of the box”



BIOSTAT® PBR 2S 890 + 735 + 565

Illuminated area 5350 cm2

Light impact

Photosynthetic active radiation

(PHAR) @ 400 – 700 mm 5 – 480 μE | m2s


Photosynthesis module 390 + 500 | *340








required



BIOSTAT® CultiBag RM

The BIOSTAT® CultiBag RM is a single use

bioreactor, available with single use

optical sensors for both pH and DO with

powerful control capabilities. Including

a four-stage cascade control system,

integrated overpressure control and

feed back controlled gas mixing, maxi-

mum process control is achievable.

The BIOSTAT® CultiBag RM is ideal for

a wide range of applications including

mammalian cell culture, stem cells,

plant cells and microorganisms.

– Application-driven packages in basic,

optical and perfusion versions

– Basic packages include a rocker with

temperature, agitation and gassing

control

– Optical packages include one or two

rocker and a BIOSTAT® RM Control

Tower optical for superior process con-

trol with single use pH and DO sensors

– Perfusion packages include one or two

rocker and a BIOSTAT® RM Control

Tower perfusion for superior process

control with single use pH and DO

sensors and gravimetric feed | harvest

controls

– A user-friendly touch screen interface

makes it very easy to operate this

single use bioreactor

– Available as a single rocker or twin

rocker version (optical and perfusion)

– A heating|cooling unit is available

as an add-on module for optical and

perfusion systems.

Bag Technical Specifications [L]

Total volume Min Working Max Working

volume volume

1 0.05* 0.5

2 0.1* 1

10 0.5* 5

20 1* 10

50 5* 25

100 10* 50

200 20* 100

600 60* 300

* Depending on process parameters such as angle and rocking speed, for bags with optical sensors

Technical Specifications

(dimensions W + H + D [mm]) Dimensions Weight Bag Sizes

[kg]

BIOSTAT® RM Control Tower 320 + 735 + 565 60

Rocker 20 | 50 with Holder 20 710 + 400 + 560 27 1 L, 2 L, 10 L, 20 L

Rocker 20 | 50 with Holder 50 1030 + 450 + 580 32 50 L

200 L optical system 1998 + 1241 + 830 272 100 L, 200 L

600 L optical system 1790 + 1330 + 1470 340 600 L


Power supply 120 VAC|15 A or 230 VAC|10 A for up to 50 L,

total volume

208 VAC|3x15 A or 400 VAC|3x16 A for up to 600 L,

total volume



BIOSTAT® CultiBag STR Plus

The BIOSTAT® CultiBag STR Plus is a new

line of single use stirred tank bioreactors.

The system is comprised of a stainless steel

support housing, a single use bioreactor

chamber and a superior control system

utilizing single use sensors.

The BIOSTAT® CultiBag STR Plus is the first

completely single use and scaleable

solution in the fermentation | bioreactor

market. Its design is based on the golden

standards which are coming from the

classical bioreactors. This exceptional

feature gives a significant benefit during

the upscaling process as it will gain you

time, effort and cost.

The advanced control platform of the

BIOSTAT® CultiBag STR Plus offers an

excellent solution for every budget and

every need. The system is available in a

single and twin set-up.

Bag Technical Specifications [L]

Total volume Min Working Max Working

volume volume

68 12.5 50

280 50 200

700* 125* 500*

1300* 250* 1000*

Technical Specifications

Hardware dimensions W + H + D (mm)

BIOSTAT® CultiBag STR Plus, single or double wall

BIOSTAT® CultiBag STR Plus 50 L, Single 1723 + 1663 + 754

BIOSTAT® CultiBag STR Plus 200 L, Single 1723 + 1663 + 754

BIOSTAT® CultiBag STR Plus 500 L* 2148 + 2680 + 1204

BIOSTAT® CultiBag STR Plus 1000 L* 2148 + 2680 + 1204

BIOSTAT® CultiBag STR Plus 50 L|50 L Twin 2652 + 1663 + 754





Power supply 208 VAC|3 + 30 A or 400 VAC|3 + 32 A

Gasses Controlled @ 2-4 barg dry, particle and oil-free

Water Delivered to control tower at 2-5 barg; reduced in control tower to 2 barg; only required for double wall vessels

Drain Gravity drain with zero backpressure required

* Under development

Improve your scale up process!

– First single use bioreactor with

a classical bioreactor design

– Scalable from R&D to Production scale

– Advanced control for all critical process

parameters

Transform your single-purpose facility

into a multi-purpose facility!

– State-of-the-art gassing strategy

offering ultimate flexibility

– Wide range of different impellers,

spargers, tubing and connectors

Increase your comfort!

– Bag holder with two hemispherical doors

for easy installation of the single use bag

along the side

– Pre-installed stirrer inside the

single use bag

– Single use sensors for DO and pH avoids

risky insertion of classical, reusable probes

BioPAT® MFCS SCADA Software

BioPAT® MFCS, provides various solutions

to help you at every stage of your process.

BioPAT® MFCS | DA is ideal for capturing,

storing and visualizing process data, from

1 to 4 bioprocess units in a research &

development setting.

BioPAT® MFCS | win is a feature-rich, GAMP

category 4 software package capable of

supporting the most demanding research

or production environment, including

S88- and 21CFRpart11-compliance.

Both systems are built upon batch-oriented

data management, meaning all your

process data will be traceable to a unique

batch name | ID.

BioPAT® MFCS |DA

Designed as a “plug and play” tool when

used in conjunction with our range of

standard BIOSTAT® fermentors | bioreactors.

This combination helps you get started

acquiring and analyzing your important

process data quickly.

Data may be acquired from 1 to 4 systems,

either serially or via Ethernet. Features like

the Sample Data Management function

simplify the inclusion of external, manually-

entered data (e.g., glucose analyzer, cell

density, etc.) into your batch record. Visual-

ization of the batch data is made possible

with a powerful Plotting function, allowing

for multiple variables, from multiple batches

to be displayed simultaneously. The Export

function may be used to export batch data

to other data analysis programs.

– Up to 4 process units

– Batch oriented software package

– Sample Data Management

– Enhanced Plotting

– Export functions

– Easy to use programming interface

BioPAT® MFCS |win

BioPAT® MFCS | win provides advanced func-

tionality for supervisory process control and

data acquisition, including on-line and off-

line calculations, extensive batch reporting,

software configuration management and

multi-user network access to up to 16

systems.

BioPAT® MFCS | win is an open system, with

an OPC (OLE for Process Control) interface,

facilitating connectivity to other OPC-

compliant, third-party software packages.

For connectivity to legacy devices, a

comprehensive driver library exists.

ISA-88 (Instrument Society of America)

compliant batch management features allow

for the utilization of procedural batch con-

trol, even in bench-scale applications.

Resulting in consistent process operation

for scale-down or scale-up activities.

Fully validatable, according to GAMP cate-

gory 4 (Configurable System), and compliant

with 21CFR part 11 electronic signatures

and records. BioPAT® MFCS | win has all the

necessary functionality for operation in a

regulated cGMP production.

– Up to 16 process units

– Validatable

– 21 CFRPart 11 compliant

– ISA-S88 compliant

– OPC client and server interface

– Networking and Remote Alarming

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Sales and Service ContactsFor further contacts, visit www.sartorius-stedim.com

Europe

GermanySartorius Stedim Biotech GmbHAugust-Spindler-Strasse 1137079 Goettingen

Phone +49.551.308.0Fax +49.551.308.3289

www.sartorius-stedim.com

Sartorius Stedim Systems GmbHSchwarzenberger Weg 73–7934212 Melsungen

Phone +49.5661.71.3400Fax +49.5661.71.3702

www.sartorius-stedim.com

FranceSartorius Stedim Biotech S.A.ZI Les PaludsAvenue de Jouques – BP 105113781 Aubagne Cedex

Phone +33.442.845600Fax +33.442.845619

Sartorius Stedim France SASZI Les PaludsAvenue de Jouques – CS 7105813781 Aubagne Cedex

Phone +33.442.845600Fax +33.442.846545

AustriaSartorius Stedim Austria GmbHFranzosengraben 12A-1030 Vienna

Phone +43.1.7965763.18Fax +43.1.796576344

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Phone +32.2.756.06.80Fax +32.2.756.06.81

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Phone +45.7023.4400Fax +45.4630.4030

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Phone +36.23.457.227Fax +36.23.457.147

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Phone +39.055.63.40.41Fax +39.055.63.40.526

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Phone +31.30.6025080Fax +31.30.6025099

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Phone +41.52.354.36.36Fax +41.52.354.36.46

U.K.Sartorius Stedim UK LimitedLongmead Business ParkBlenheim Road, EpsomSurrey KT19 9 QQ

Phone +44.1372.737159Fax +44.1372.726171

America

USASartorius Stedim North America Inc.5 Orville DriveBohemia, NY 11716

Toll-Free +1.800.368.7178Fax +1.631.254.4253

Sartorius Stedim SUS Inc.1910 Mark CourtConcord, CA 94520

Phone +1.925.689.6650Toll Free +1.800.914.6644Fax +1.925.689.6988

Sartorius Stedim Systems Inc. 201 South Ingram Mill RoadSpringfield, MO 65802

Phone +1.417.873.9636Fax +1.417.873.9275

ArgentinaSartorius Argentina S.A. Int. A. Avalos 4251 B1605ECS Munro Buenos Aires

Phone +54.11.4721.0505 Fax +54.11.4762.2333

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Phone +55.11.4451.6226Fax +55.11.4451.4369

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Phone +52.5555.62.1102Fax +52.5555.62.2942

Asia|Pacific

AustraliaSartorius Stedim Australia Pty. Ltd.Unit 5, 7-11 Rodeo DriveDandenong South Vic 3175

Phone +61.3.8762.1800Fax +61.3.8762.1828

ChinaSartorius Stedim BeijingRepresentative OfficeNo. 33, Yu’an Road,Airport Industrial Zone B, Shunyi DistrictBeijing 101300

Phone +86.10.80426516Fax +86.10.80426580

Sartorius Stedim ShanghaiRepresantative OfficeRoom 618, Tower 1, German Centre,Shanghai, PRC., 201203

Phone +86.21.28986393Fax +86.21.28986392.11

Sartorius Stedim Guangzhou OfficeRoom 704, Broadway Plaza,No. 233–234 Dong Feng West RoadGuangzhou 510180

Phone +86.20.8351.7921Fax +86.20.8351.7931

IndiaSartorius Stedim India Pvt. Ltd.#69/2-69/3, JakkasandraKunigal Road, Nelamangala TqBangalore – 562 123

Phone +91.80.4350.5361Fax +91.80.4350.5253

JapanSartorius Stedim Japan K.K.KY Building, 8–11 Kita Shinagawa 1-chomeShinagawa-kuTokyo 140-0001

Phone +81.3.3740.5407Fax +81.3.3740.5406

MalaysiaSartorius Stedim Malaysia Sdn. Bhd.Lot L3-E-3B, Enterprise 4Technology Park MalaysiaBukit Jalil57000 Kuala Lumpur

Phone +60.3.8996.0622Fax +60.3.8996.0755

SingaporeSartorius Stedim Singapore Pte. Ltd.1 Science Park Road, The Capricorn, #05-08A,Singapore Science Park 2Singapore 117528

Phone +65.6872.3966Fax +65.6778.2494

Distribuído por:

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Vidrolab 2, S.A. www.vidrolab.pt

Documents

BIOSTAT Standard Systems Compact|Efficient|Convenient · BIOSTAT® Standard Systems Compact|Efficient|Convenient ... – Single or Twin configurations available ... Single Twin BIOSTAT