StrokeAN A H A / A S A J O U R N A L

Volume 46 ◼ Number 9September 2015

This article contains online supplementary information that is available at http://www.stroke.ahajournals.org

In MemoriamDan Adams—Bugher Foundation Champion for Training and CollaborationRalph L. Sacco, MS, MD; Jaime Aron, BJ ................................................................................................................. 2401

EditorialCerebral Microbleeds and Thrombolysis-Associated Intracerebral Hemorrhage: Cause for Concern, or Just a Distraction?David J. Werring, PhD ................................................................................................................................................ 2403

Stroke: Highlights of Selected Articles .......................................................................................................... 2406

Original Contributions

Clinical SciencesGenetic Architecture of Lacunar StrokeMatthew Traylor, PhD; Steve Bevan, PhD; Jean-Claude Baron, ScD; Ahamad Hassan, MD; Cathryn M. Lewis, PhD; Hugh S. Markus, DM ......................................................................................................... 2407

Long-Term Blood–Brain Barrier Permeability Changes in Binswanger DiseaseBranko N. Huisa, MD; Arvind Caprihan, PhD; Jeffrey Thompson, BS; Jillian Prestopnik, PhD; Clifford R. Qualls, PhD; Gary A. Rosenberg, MD ..................................................................................................... 2413

Elevated Total Homocysteine Levels in Acute Ischemic Stroke Are Associated With Long-Term MortalityZhihong Shi, MD, PhD; Yalin Guan, MD, MS; Ya Ruth Huo, BA, MD; Shuling Liu, RN, MS; Meilin Zhang, PhD; Hui Lu, MD, MS; Wei Yue, MD, MS; Jinhuan Wang, MD, PhD; Yong Ji, MD, PhD ........................................................................................................................................... 2419

Copeptin Levels in Patients With Acute Ischemic Stroke and Stroke MimicsMatthias Wendt, MD; Martin Ebinger, MD; Alexander Kunz, MD; Michal Rozanski, MD; Carolin Waldschmidt, MD; Joachim E. Weber, MD; Benjamin Winter, MD; Peter M. Koch, MD; Christian H. Nolte, MD; Sabine Hertel, PhD; Tim Ziera, PhD; Heinrich J. Audebert, MD; for the STEMO Consortium ........................................................................................................................................ 2426

Patients With Ischemic Stroke and Incident Atrial Fibrillation: A Nationwide Cohort StudyLaurent Fauchier, MD; Nicolas Clementy, MD; Christele Pelade, PhD; Cecile Collignon, PharmD; Emmanuelle Nicolle, MD, MSc; Gregory Y.H. Lip, MD ............................................................................................. 2432

Role of Acute Lesion Topography in Initial Ischemic Stroke Severity and Long-Term Functional OutcomesOna Wu, PhD; Lisa Cloonan, BA; Steven J.T. Mocking, MS; Mark J.R.J. Bouts, PhD; William A. Copen, MD; Pedro T. Cougo-Pinto, MD; Kaitlin Fitzpatrick, BS; Allison Kanakis, MD; Pamela W. Schaefer, MD; Jonathan Rosand, MD, MSc; Karen L. Furie, MD, MPH; Natalia S. Rost, MD, MPH ............................................ 2438

STROKE (ISSN 0039-2499) is published monthly by Lippincott Williams & Wilkins, at 16522 Hunters Green Parkway, Hagerstown, MD 21740. Business offices are located at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103. Production offices are located at 351 West Camden Street, Baltimore, MD 21201-2436. In the US, individuals may subscribe in print for their personal use at the following annual rates: $249 for members of any American Heart Association (AHA) sci-entific council or $528 for non-members. International: $329 for AHA members or $654 for non-members. Online-only and other additional rates can be found online at http://lww.com/stroke. AHA membership information can be found online at http://my.americanheart.org/membership. Periodicals postage paid at Hagerstown, MD, and additional mailing offices. POSTMASTER: Send address changes to STROKE, American Heart Association, Lippincott Williams & Wilkins, 16522 Hunters Green Parkway, Hagerstown, MD 21740.

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Remote Ischemic Conditioning Alters Methylation and Expression of Cell Cycle Genes in Aneurysmal Subarachnoid HemorrhageElina Nikkola, BS; Azim Laiwalla, MS; Arthur Ko, BS; Marcus Alvarez, BS; Mark Connolly, BS; Yinn Cher Ooi, MD; William Hsu, PhD; Alex Bui, PhD; Päivi Pajukanta, MD, PhD; Nestor R. Gonzalez, MD ............................................................................................................................................. 2445

Clipping and Coiling of Unruptured Intracranial Aneurysms Among Medicare Beneficiaries, 2000 to 2010Jessica J. Jalbert, PhD; Abby J. Isaacs, MSc; Hooman Kamel, MD; Art Sedrakyan, MD, PhD ............................. 2452

Microbleed Status and 3-Month Outcome After Intravenous Thrombolysis in 717 Patients With Acute Ischemic StrokeGuillaume Turc, MD; Asmaa Sallem, MD; Solène Moulin, MD; Marie Tisserand, MD; Alexandre Machet, MD; Myriam Edjlali, MD; Jean-Claude Baron, ScD; Xavier Leclerc, PhD; Didier Leys, PhD; Jean-Louis Mas, MD; Charlotte Cordonnier, PhD; Catherine Oppenheim, PhD CME ................................................................................. 2458

High-Resolution Intracranial Pressure Burden and Outcome in Subarachnoid HemorrhageFederico Magni, MD; Matteo Pozzi, MD; Matteo Rota, PhD; Alessia Vargiolu, PhD; Giuseppe Citerio, MD ....... 2464

Accuracy of the ABC/2 Score for Intracerebral Hemorrhage: Systematic Review and Analysis of MISTIE, CLEAR-IVH, and CLEAR IIIAlastair J.S. Webb, DPhil; Natalie L. Ullman, BS; Tim C. Morgan, MPH; John Muschelli, ScM; Joshua Kornbluth, MD; Issam A. Awad, MD; Stephen Mayo, MD; Michael Rosenblum, PhD; Wendy Ziai, MD; Mario Zuccarrello, MD; Francois Aldrich, MD; Sayona John, MD; Sagi Harnof, MD; George Lopez, MD; William C. Broaddus, MD; Christine Wijman, MD; Paul Vespa, MD; Ross Bullock, MD, PhD; Stephen J. Haines, MD; Salvador Cruz-Flores, MD; Stan Tuhrim, MD; Michael D. Hill, MD; Raj Narayan, MD; Daniel F. Hanley, MD; for the MISTIE and CLEAR Investigators ............................................. 2470

Risk Factors of Ischemic Stroke and Subsequent Outcome in Patients Receiving HemodialysisMark D. Findlay, MBChB, MRCP; Peter C. Thomson, MD; Rachael L. Fulton, PhD; Marit D. Solbu, PhD; Alan G. Jardine, MD; Rajan K. Patel, PhD, MRCP; Kathryn K. Stevens, PhD, MRCP; Colin C. Geddes, MBChB; Jesse Dawson, MD; Patrick B. Mark, PhD .................................................................... 2477

Prognostic Significance of Short-Term Blood Pressure Variability in Acute Stroke: Systematic ReviewLisa S. Manning, MBChB; Peter M. Rothwell, FMedSci; John F. Potter, DM; Thompson G. Robinson, MD .......... 2482

Recurrent Stroke: The Value of the CHA2DS2VASc Score and the Essen Stroke Risk Score in a Nationwide Stroke CohortSøren Due Andersen, MD; Anders Gorst-Rasmussen, MSc, PhD; Gregory Y.H. Lip, MD; Flemming W. Bach, MD, DMSc; Torben Bjerregaard Larsen, MD, PhD .................................................................. 2491

Rate of Contrast Extravasation on Computed Tomographic Angiography Predicts Hematoma Expansion and Mortality in Primary Intracerebral HemorrhageH. Bart Brouwers, MD, PhD; Thomas W.K. Battey, BS; Hayley H. Musial, BA; Viesha A. Ciura, MD; Guido J. Falcone, MD, PhD, MPH; Alison M. Ayres, BA; Anastasia Vashkevich, BA; Kristin Schwab, BA; Anand Viswanathan, MD, PhD; Christopher D. Anderson, MD; Steven M. Greenberg, MD, PhD; Stuart R. Pomerantz, MD; Claudia J. Ortiz, MD; Joshua N. Goldstein, MD, PhD; R. Gilberto Gonzalez, MD, PhD; Jonathan Rosand, MD, MSc; Javier M. Romero, MD ......................................... 2498

Intracranial Carotid Calcification on Cranial Computed Tomography: Visual Scoring Methods, Semiautomated Scores, and Volume Measurements in Patients With StrokeDeepak Subedi, FRCR; Umme Sara Zishan, MBBS; Francesca Chappell, PhD; Maria-Lena Gregoriades, FRCR; Cathie Sudlow, DPhil; Robin Sellar, FRCR; Joanna Wardlaw, FRCR, MD .................................................. 2504

Younger Stroke Patients With Large Pretreatment Diffusion-Weighted Imaging Lesions May Benefit From Endovascular TreatmentMarc D. Gilgen, MSc; Dariusz Klimek; Kai T. Liesirova, MD; Julia Meisterernst; Pascal P. Klinger-Gratz, MD; Gerhard Schroth, MD; Pasquale Mordasini, MD; Kety Hsieh, MD; Johannes Slotboom, PhD; Mirjam R. Heldner, MD; Anne Broeg-Morvay; Marie-Luise Mono, MD; Urs Fischer, MD; Heinrich P. Mattle, MD; Marcel Arnold, MD; Jan Gralla, MD; Marwan El-Koussy, MD; Simon Jung, MD ......... 2510

Combined Multimodal Computed Tomography Score Correlates With Futile Recanalization After Thrombectomy in Patients With Acute StrokeMariano Espinosa de Rueda, MD; Guillermo Parrilla, PhD; Sergio Manzano-Fernández, PhD; Blanca García-Villalba, MD; Joaquín Zamarro, MD; Francisco Hernández-Fernández, PhD; Cristina Sánchez-Vizcaino, MD; Ester Carreón, MD; Ana Morales, PhD; Antonio Moreno, MD ........................... 2517

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Residual Risk of Stroke and Death in Anticoagulated Patients According to the Type of Atrial Fibrillation: AMADEUS TrialKeitaro Senoo, MD; Gregory Y.H. Lip, MD; Deirdre A. Lane, PhD; Harry R. Büller, PhD; Dipak Kotecha, PhD ................................................................................................................................................... 2523

Combined Approach to Lysis Utilizing Eptifibatide and Recombinant Tissue-Type Plasminogen Activator in Acute Ischemic Stroke-Full Dose Regimen Stroke TrialOpeolu Adeoye, MD, MS; Heidi Sucharew, PhD; Jane Khoury, PhD; Achala Vagal, MD, MS; Pamela A. Schmit, RN, BSN; Irene Ewing, RN, BSN; Steven R. Levine, MD; Stacie Demel, DO, PhD; Bryan Eckerle, MD; Brian Katz, MD; Dawn Kleindorfer, MD; Brian Stettler, MD; Daniel Woo, MD, MS; Pooja Khatri, MD, MSc; Joseph P. Broderick, MD; Arthur M. Pancioli, MD .......................................................... 2529

Clinical Implications of Changes in Individual Platelet Reactivity to Aspirin Over Time in Acute Ischemic StrokeJoon-Tae Kim, MD, PhD; Suk-Hee Heo, MD; Kang-Ho Choi, MD; Tai-Seung Nam, MD; Seong-Min Choi, MD; Seung-Han Lee, MD; Man-Seok Park, MD; Byeong C. Kim, MD; Myeong-Kyu Kim, MD; Jeffrey L. Saver, MD, PhD; Ki-Hyun Cho, MD .......................................................................................................... 2534

Low-Versus Standard-Dose Alteplase for Ischemic Strokes Within 4.5 Hours: A Comparative Effectiveness and Safety StudyBeom Joon Kim, MD; Moon-Ku Han, MD; Tai Hwan Park, MD; Sang-Soon Park, MD; Kyung Bok Lee, MD; Byung-Chul Lee, MD; Kyung-Ho Yu, MD; Mi Sun Oh, MD; Jae Kwan Cha, MD; Dae-Hyun Kim, MD; Jun Lee, MD; Soo Joo Lee, MD; Youngchai Ko, MD; Jong-Moo Park, MD; Kyusik Kang, MD; Yong-Jin Cho, MD; Keun-Sik Hong, MD; Joon-Tae Kim, MD; Jay Chol Choi, MD; Dong-Eog Kim, MD; Dong-Ick Shin, MD; Wook-Joo Kim, MD; Juneyoung Lee, PhD; Ji Sung Lee, PhD; Byung-Woo Yoon, MD; Philip B. Gorelick, MD, MPH; Hee-Joon Bae, MD, PhD ......................................................................................... 2541

Safety and Tolerability of Desmoteplase Within 3 to 9 Hours After Symptoms Onset in Japanese Patients With Ischemic StrokeEtsuro Mori, MD, PhD; Kazuo Minematsu, MD, PhD; Jyoji Nakagawara, MD, PhD; Yasuhiro Hasegawa, MD, PhD; Shinji Nagahiro, MD, PhD; Yasushi Okada, MD, PhD; Thomas Truelsen, MD, DMSc; Annika Lindsten, BSc; Akira Ogawa, MD, PhD; Takenori Yamaguchi, MD; on behalf of DIAS-J Investigators ............................................................................................................................... 2549

Non–Vitamin K Antagonist Oral Anticoagulants for Stroke Prevention in Asian Patients With Nonvalvular Atrial Fibrillation: Meta-AnalysisKang-Ling Wang, MD; Gregory Y.H. Lip, MD; Shing-Jong Lin, MD, PhD; Chern-En Chiang, MD, PhD ........................................................................................................................... 2555

Do Patient Characteristics Explain the Differences in Outcome Between Medically Treated Patients in SAMMPRIS and WASID?Seemant Chaturvedi, MD; Tanya N. Turan, MD; Michael J. Lynn, MS; Colin P. Derdeyn, MD; David Fiorella, MD, PhD; L. Scott Janis, PhD; Marc I. Chimowitz, MBChB; for the SAMMPRIS Trial Investigators ....................................................................................................................... 2562

Associations of Circulating Growth Differentiation Factor-15 and ST2 Concentrations With Subclinical Vascular Brain Injury and Incident StrokeCharlotte Andersson, MD, PhD; Sarah R. Preis, ScD; Alexa Beiser, PhD; Charles DeCarli, MD; Kai C. Wollert, MD; Thomas J. Wang, MD; James L. Januzzi Jr, MD; Ramachandran S. Vasan, MD; Sudha Seshadri, MD ................................................................................................................................................... 2568

Deferoxamine, Cerebrovascular Hemodynamics, and Vascular Aging: Potential Role for Hypoxia-Inducible Transcription Factor-1–Regulated PathwaysFarzaneh A. Sorond, MD, PhD; Can Ozan Tan, PhD; Sarah LaRose, BA; Andrew D. Monk, BS; Raina Fichorova, MD, PhD; Stanthia Ryan, BS; Lewis A. Lipsitz, MD .................................................................... 2576

Spouses of Stroke Survivors Report Reduced Health-Related Quality of Life Even in Long-Term Follow-Up: Results From Sahlgrenska Academy Study on Ischemic StrokeJosefine Persson, MSc; Lukas Holmegaard, MD, MSc; Ingvar Karlberg, MD, PhD; Petra Redfors, MD, PhD; Katarina Jood, MD, PhD; Christina Jern, MD, PhD; Christian Blomstrand, MD, PhD; Gunilla Forsberg-Wärleby, Reg. OT, PhD ................................................................................................................... 2584

Cost-Utility Analysis of Mechanical Thrombectomy Using Stent Retrievers in Acute Ischemic StrokeJeban Ganesalingam, MBBS, MRCP (Neuro), PhD; Elena Pizzo, PhD; Stephen Morris, PhD; Tom Sunderland, MSc; Diane Ames, MBBS, FRCP; Kyriakos Lobotesis, MBBS, FRCR .............................. 2591

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Basic SciencesNeurorestorative Therapy of Stroke in Type 2 Diabetes Mellitus Rats Treated With Human Umbilical Cord Blood CellsTao Yan, PhD; Poornima Venkat, BS; Michael Chopp, PhD; Alex Zacharek, MS; Ruizhuo Ning, MD; Yisheng Cui, BS; Cynthia Roberts, BS; Nicole Kuzmin-Nichols, BS, MBA; Cyndy Davis Sanberg, PhD; Jieli Chen, MD ............................................................................................................................................................ 2599

Role of Neurexin-1β and Neuroligin-1 in Cognitive Dysfunction After Subarachnoid Hemorrhage in RatsHaitao Shen, MM; Zhouqing Chen, MM; Yang Wang, MM; Anju Gao, MM; Haiying Li, PhD; Yonghua Cui, MD; Li Zhang, MD; Xiang Xu, MM; Zhong Wang, MD; Gang Chen, MD, PhD .................................................. 2607

Intravenous Bone Marrow Stem Cell Grafts Preferentially Migrate to Spleen and Abrogate Chronic Inflammation in StrokeSandra A. Acosta, PhD; Naoki Tajiri, PhD; Jaclyn Hoover, MS; Yuji Kaneko, PhD; Cesar V. Borlongan, PhD ................................................................................................................................ 2616

Rosiglitazone Promotes White Matter Integrity and Long-Term Functional Recovery After Focal Cerebral IschemiaLijuan Han, MD; Wei Cai, MD; Leilei Mao, MD, PhD; Jia Liu, MD; Peiying Li, MD, PhD; Rehana K. Leak, PhD; Yun Xu, MD; Xiaoming Hu, MD, PhD; Jun Chen, MD ........................................................ 2628

Activation of Dopamine D2 Receptor Suppresses Neuroinflammation Through αB-Crystalline by Inhibition of NF-κB Nuclear Translocation in Experimental ICH Mice ModelYang Zhang, MD, PhD; Yujie Chen, MD, PhD; Jiang Wu, MD; Anatol Manaenko, PhD; Peng Yang, MD; Jiping Tang, MD, PhD; Weiling Fu, MD, PhD; John H. Zhang, MD, PhD .............................................................. 2637

Recombinant ADAMTS 13 Attenuates Brain Injury After Intracerebral HemorrhagePing Cai, PhD; Haiyu Luo, BS; Haochen Xu, BS; Ximin Zhu, MS; Wenfang Xu, BS; Yiqin Dai, MS; Jin Xiao, BS; Yongliang Cao, BS; Yuwu Zhao, MD; Bing-Qiao Zhao, MD, PhD; Wenying Fan, MD, PhD ................................... 2647

Brief ReportsVascular Neurologists as Directors of Stroke Centers in the United StatesLucas Ramirez, MD; Aaron Krug, BS; Heng Nhoung, BS; Suzie Kazaryan, BS; Gregory Gasparian, BA; Joshua Perese, BA; Ali Razmara, MD; David S. Liebeskind, MD; Jennifer J. Majersik, MD, MS; Nerses Sanossian, MD ................................................................................................................................................ 2654

Cavernous Sinus Thrombosis in Children: Imaging Characteristics and Clinical OutcomesCraig A. Press, MD, PhD; Aaron Lindsay, MD; Nicholas V. Stence, MD; Laura Z. Fenton, MD; Timothy J. Bernard, MD; David M. Mirsky, MD ....................................................................................................... 2657

White Matter Hyperintensities Relate to Clinical Progression in Subjective Cognitive DeclineMarije R. Benedictus, MSc; Argonde C. van Harten, PhD; Annebet E. Leeuwis, MSc; Teddy Koene, MSc; Philip Scheltens, PhD; Frederik Barkhof, PhD; Niels D. Prins, PhD; Wiesje M. van der Flier, PhD ..................... 2661

Altered Fibrin Clot Properties in Patients With Cerebral Venous Sinus Thrombosis: Association With the Risk of RecurrenceJakub Siudut, MSc; Maciej Świat, MD, PhD; Anetta Undas, MD, PhD ................................................................... 2665

Increase in [18F]-Fluoroacetate Uptake in Patients With Chronic Hemodynamic Cerebral IschemiaHiroshi Yamauchi, MD, PhD; Shinya Kagawa, MS; Yoshihiko Kishibe, RT; Masaaki Takahashi, RT; Ryuichi Nishii, MD, PhD; Hiroshi Mizuma, PhD; Kazuhiro Takahashi, PhD; Hirotaka Onoe, PhD; Tatsuya Higashi, MD, PhD ......................................................................................................................................... 2669

Stroke and Neurodegeneration Induce Different Connectivity Aberrations in the InsulaIndira García-Cordero, PhD; Lucas Sedeño, PhD; Daniel Fraiman, PhD; Damian Craiem, PhD; Laura Alethia de la Fuente, MSc; Paula Salamone, PhD; Cecilia Serrano, MD; Luciano Sposato, PhD; Facundo Manes, PhD; Agustín Ibañez, PhD .............................................................................................................. 2673

Hypotension During Endovascular Treatment of Ischemic Stroke Is a Risk Factor for Poor Neurological OutcomePia Löwhagen Hendén, MD; Alexandros Rentzos, MD; Jan-Erik Karlsson, MD, PhD; Lars Rosengren, MD, PhD; Henrik Sundeman, MD, PhD; Björn Reinsfelt, MD, PhD; Sven-Erik Ricksten, MD, PhD ....................................... 2678

Safety of Statin Pretreatment in Intravenous Thrombolysis for Acute Ischemic StrokeGeorgios Tsivgoulis, MD, PhD; Pavla Kadlecová, MS; Adam Kobayashi, MD, PhD; Anna Czlonkowska, MD, PhD; Miroslav Brozman, MD, PhD; Viktor Švigelj, MD; Laszlo Csiba, MD, PhD; Janika Kõrv, MD, PhD; Vida Demarin, MD, PhD; Aleksandras Vilionskis, MD; Dalius Jatuzis, MD, PhD; Aristeidis H. Katsanos, MD; Jobst Rudolf, MD, PhD; Yakup Krespi, MD; Robert Mikulik, MD, PhD .................... 2681

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Dabigatran Therapy in Acute Ischemic Stroke Patients Without Atrial FibrillationMahesh Kate, DM; Laura Gioia, MD; Brian Buck, MD; Leka Sivakumar, MSc; Thomas Jeerakathil, MD; Ashfaq Shuaib, MD; Kenneth Butcher, MD, PhD ...................................................................................................... 2685

Occurrence and Predictors of Falls in People With Stroke: Six-Year Prospective StudyLisbeth Rosenbek Minet, PhD; Elizabeth Peterson, PhD; Lena von Koch, PhD; Charlotte Ytterberg, PhD ............ 2688

Effects of Postconditioning on Neurogenesis and Angiogenesis During the Recovery Phase After Focal Cerebral IschemiaElga Esposito, PhD; Kazuhide Hayakawa, PhD; Takakuni Maki, MD, PhD; Ken Arai, PhD; Eng H. Lo, PhD ..... 2691

Comments and OpinionsOutcome Following Decompressive Hemicraniectomy for Malignant Cerebral Infarction: Ethical ConsiderationsStephen Honeybul, FRCS (SN), FRACS; Kwok Ming Ho, FCICM, PhD; Grant Gillett, MSc, MB ChB(Auck), DPhil(Oxf), FRACS, FRSNZ ............................................................................ 2695

Topical ReviewsMinimally Invasive Microsurgery for Cerebral AneurysmsJohnny Ho Yin Wong, PhD; Rachel Tymianski; Ivan Radovanovic, PhD; Michael Tymianski, MD, PhD ................ 2699

Treatment Concepts for Wake-Up Stroke and Stroke With Unknown Time of Symptom OnsetGötz Thomalla, MD; Christian Gerloff, MD .............................................................................................................. 2707

Palliative Care: A Core Competency for Stroke NeurologistsClaire J. Creutzfeldt, MD; Robert G. Holloway, MD, MPH; J. Randall Curtis, MD, MPH ..................................... 2714

State-of-the-Science Nursing ReviewTemperature Management and Nursing Care of the Patient With Acute Ischemic StrokePimen Kurashvili, MD; DaiWai Olson, PhD, RN Web Site Feature ................................................................... e205

Stroke Literature Synopses: Clinical ScienceMichelle P. Lin, MD, MPH; Amytis Towfighi, MD Web Site Feature ................................................................. e208

Illustrative Teaching CasesInflammatory Cerebral Amyloid Angiopathy, Amyloid-β–Related Angiitis, and Primary Angiitis of the Central Nervous System: Similarities and DifferencesAimen Moussaddy, MD; Ariel Levy, MD, FRCP; Daniel Strbian, MD, PhD; Sophia Sundararajan, MD, PhD; France Berthelet, MD, FRCP; Sylvain Lanthier, MD, OD, CSPQ Web Site Feature ........................................ e210

Organizational UpdateOrganizational Update: Report From the European Stroke Organisation 2015Kennedy R. Lees, MD; Valeria Caso, MD; Urs Fischer, MD Web Site Feature ................................................. e214

Letters to the EditorLetter by van Klei and Dieleman Regarding Article, “Type of Anesthesia and Differences in Clinical Outcome After Intra-Arterial Treatment for Ischemic Stroke”Wilton A. van Klei, MD, PhD; Jan M. Dieleman, MD Web Site Feature ........................................................... e216

Letter by Campbell and Short Regarding Article, “Type of Anesthesia and Differences in Clinical Outcome After Intra-Arterial Treatment for Ischemic Stroke”Doug Campbell, MD, FRCA, FANZCA; Timothy G. Short, MB, ChB, MD, FANZCA Web Site Feature .......... e217

Response to Letter Regarding Article, “Type of Anesthesia and Differences in Clinical Outcome After Intra-Arterial Treatment for Ischemic Stroke”Lucie A. van den Berg, MD; Yvo B.W.E.M. Roos, MD, PhD Web Site Feature ................................................. e218

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Letter by Rebello et al Regarding Article, “Cryptic Loss of Consciousness in a 36-Year-Old Woman”Letícia C. Rebello, MD; Diogo C. Haussen, MD; Raul G. Nogueira, MD Web Site Feature ........................... e219

Response to Letter Regarding Article, “Cryptic Loss of Consciousness in a 36-Year-Old Woman”Nicolas Martinez-Majander, MD; Jukka Putaala, MD, PhD, MSc (Stroke Med) Web Site Feature .................. e220

Letter by Spence Regarding Article, “Diet and Stroke: Recent Evidence Supporting a Mediterranean-Style Diet and Food in the Primary Prevention of Stroke”J. David Spence, MD Web Site Feature .............................................................................................................. e221

Corrections Web Site Feature ................................................................................................................... e222–e223

On the cover: The image is taken from an article in this issue, “Minimally Invasive Microsurgery for Cerebral Aneurysms” by Wong et al (Stroke. 2015;46:2699–2706).

The image is Figure 2D.

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46 (9)

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