1
corrections A mouse model of Greig cephalapolysyndactyly syndrome: the extra-toes J mutation contains an intragenic deletion of the Gli3 gene Chi-chung Hui & Alexandra L. Joyner Nature Genet. 3, 241–246 (1993). Originally, we reported that the 3´ end of Gli3 is not deleted in the Xt J allele (Fig. 4). U. Rüther brought to our attention that the Xt J allele indeed contains a deletion including the 3´ UTR of Gli3. Subsequently, we repeated the experiments and found that the data described in Fig. 4 using probe d was due to probe d containing sequences other than Gli3. These findings indicate that the deletion in the Xt J allele might not be intragenic; however, it does not affect our main conclusion that Xt J is a mouse model of GCPS. We regret this error. © 1998 Nature America Inc. • http://genetics.nature.com

document

Embed Size (px)

Citation preview

404 nature genetics volume 19 august 1998

corrections

A mouse model of Greig cephalapolysyndactyly syndrome: the extra-toesJ mutationcontains an intragenic deletion of the Gli3 geneChi-chung Hui & Alexandra L. Joyner

Nature Genet. 3, 241–246 (1993).

Originally, we reported that the 3´ end of Gli3 is not deleted in the XtJ allele (Fig. 4). U. Rüther brought to our attention that the XtJ alleleindeed contains a deletion including the 3´ UTR of Gli3. Subsequently, we repeated the experiments and found that the data described inFig. 4 using probe d was due to probe d containing sequences other than Gli3. These findings indicate that the deletion in the XtJ allelemight not be intragenic; however, it does not affect our main conclusion that XtJ is a mouse model of GCPS. We regret this error.

Short GCG expansions in the PABP2 gene cause oculopharyngeal muscular dystrophyBernard Brais et al.

Nature Genet. 18, 164–167 (1998).

Spelling errors were inadvertantly made in the names of two co-authors: Sergiu Blumen and Amos D. Korczyn. We apologize forthese mistakes.

Bleomycin hydrolase is associated with risk of sporadic Alzheimer’s diseaseSusana E. Montoya et al.

Nature Genet. 18, 211–212 (1998).

Due to a typographical error, the genotypefrequencies for the ADRC confirmed casesin Table 1 were reported incorrectly as0.426 instead of 0.490. The corrected tableis shown on the right. We regret this error.

Table 1 • BH-PEN allele frequency and genotype distribution

Total Allele frequencies Genotype frequencies

A G A/A A/G G/G

ADCR clinical cases 131 0.70 ± 0.03 0.30 ± 0.05 0.489 0.412 0.100IADC confirmed cases 75 0.65 ± 0.05 0.35 ± 0.07 0.426 0.440 0.133ADRC confirmed cases 151 0.67 ± 0.03 0.33 ± 0.05 0.490 0.358 0.152AD casesa 357 0.68 ± 0.02 0.33 ± 0.03 0.476 0.398 0.127

IADC controls 57 0.69 ± 0.05 0.30 ± 0.08 0.456 0.474 0.070ADRC controls 124 0.70 ± 0.04 0.30 ± 0.05 0.468 0.460 0.073Pittsburgh controlsb 139 0.73 ± 0.03 0.27 ± 0.05 0.511 0.432 0.058AD controlsa 320 0.71 ± 0.02 0.29 ± 0.04 0.484 0.450 0.066aPooled population. bRandom population sample from the Pittsburgh geographical area.

© 1998 Nature America Inc. • http://genetics.nature.com©

199

8 N

atu

re A

mer

ica

Inc.

• h

ttp

://g

enet

ics.

nat

ure

.co

m