2012 Portfolio Analysis Projects: Question 2: How can I ......2012 Portfolio Analysis Projects Please note that data are not yet final; additional projects may be added. QUESTION 2:

2012 Portfolio Analysis Projects Please note that data are not yet final; additional projects may be added.

QUESTION 2: HOW CAN I UNDERSTAND WHAT IS HAPPENING?

2.S.A

Support at least four research projects to identify mechanisms of fever, metabolic and/or immune system interactions with the central nervous system that may influence ASD during prenatal-postnatal life by 2010. IACC Recommended Budget: $9,800,000 over 4 years. (Fever studies to be started by 2012.)

Project Title Principal

Investigator

Systematic characterization of the

immune response to gluten and

casein in autism spectrum disorders

Alaedini,

Armin

Autoimmunity against novel antigens

in neuropsychiatric dysfunction

Balice-

Gordon,

Rita

Convergence of immune and genetic

signaling pathways in autism and

schizophrenia

Barrow,

Stephanie

Altered placental tryptophan

metabolism: A crucial molecular

pathway for the fetal programming of

neurodevelopmental disorders

Bonnin,

Alexandre

Brain mitochondrial abnormalities in

autism

Chauhan,

Abha

Mechanisms of synaptic alterations in

a neuroinflammation model of autism

Dunaevsky

, Anna

Institution Funding Funder

Weill Cornell Medical

College

$0.00 Department

of Defense

University of

Pennsylvania

$320,000.

00

National

Institutes of

Health

University of

California, Davis

$0.00 Brain &

Behavior

Research

Foundation

University of

Southern California

$535,699.

00

Department

of Defense

New York State

Institute for Basic

Research in

Developmental

Disabilities

$20,000.0

0

Autism

Research

Institute

University of

Nebraska Medical

Center

$579,882.

00

Department

of Defense -

Autism

Research

Program

This document is for discussion purposes only and does not reflect the decisions of the IACC

IL-1beta and IL1RAPL1: Gene-

environment interactions regulating

synapse density and function in ASD

Estes,

Myka

University of

California, Davis

$28,600.0

0

Autism

Speaks

Redox abnormalities as a vulnerability

phenotype for autism and related

alterations in CNS development

Hepel,

Maria

State University of

New York at

Potsdam

$0.00 Department

of Defense

Sensitive periods in cerebellar

development

Hoffman,

Jessica

University of

Maryland, Baltimore

$32,941.0

0

National

Institutes of

Health

Hyperthermia and the amelioration of

autism symptoms

Hollander,

Eric

Montefiore Medical

Center

$66,153.0

0

Simons

Foundation

Exploring metabolic dysfunction in the

brains of people with autism

Hu, Valerie

George Washington

University

$0.00

Simons

Foundation

Redox abnormalities as a vulnerability

phenotype for autism and related

alterations in CNS development

James,

Sandra

Arkansas Children's

Hospital Research

Institute

$0.00 Department

of Defense

Autism spectrum disorders – inflammatory subtype: Molecular

characterization

Jyonouchi,

Harumi

University of

Medicine & Dentistry

of New Jersey

$30,000.0

0

Autism

Research

Institute

The Study of Toddlers with Autism

and Regression (STAR) Protocol – Screening for treatable disorders and

biomarkers of inflammation and

Loh, Alvin

Surrey Place Centre,

Toronto

$0.00

Health

Resources

and Services

Administratio

n immune activation in the plasma and

CNS

Prostaglandins and cerebellum

development

McCarthy,

Margaret

University of

Maryland, Baltimore

$371,250.

00

National

Institutes of

Health


Redox abnormalities as a

vulnerability phenotype for autism

and related alterations in CNS

development

Noble, Mark University of

Rochester

$0.00 Department

of Defense

GABRB3 and placental vulnerability

in ASD

Palmer,

Theo

Stanford University $642,258.

00

National

Institutes of

Health

GABA(A) and prenatal immune

events leading to autism

Palmer,

Theo

Stanford University $125,000.

00

Simons

Foundation

A non-human primate autism model

based on maternal infection

Patterson,

Paul

California Institute of

Technology

$0.00 Simons

Foundation

The mechanism of the maternal

infection risk factor for autism

Patterson,

Paul

California Institute of

Technology

$150,000.

00

Autism

Speaks

Influence of maternal cytokines

during pregnancy on effector and

regulatory T helper cells as

etiological factors in autism

Ponzio,

Nicholas

University of

Medicine & Dentistry

of New Jersey

$0.00 Autism

Speaks

To study the relationship between

low GAD2 levels and anti-GAD

antibodies in autistic children

Russo, A.J. Hartwick College $7,260.00 Autism

Research

Institute

Mechanisms of mitochondrial

dysfunction in autism

Shoffner,

John

Georgia State

University

$0.00 Department

of Defense

Role of microglial activation in the

serotonergic and neuroimmune

disturbances underlying autism

Takei, Nori Hamamatsu

University School of

Medicine

$50,000.0

0

Brain and

Behavior

Research

Foundation

Project 2: Immunological

susceptibility of autism (supplement)

Van de

Water, Judy

University of

California, Davis

$30,784.0

0

National

Institutes of


Health

2.S.B

Launch three studies that specifically focus on the neurodevelopment of females with ASD, spanning basic to clinical research on sex differences by 2011. IACC Recommended Budget: $8,900,000 over 5

years.


Investigator Institution Funding Funder

Behavioral and cognitive

characteristics of females and males

with autism

Frazier,

Thomas

Cleveland Clinic

Foundation

$60,000.0

0

Simons

Foundation

ACE Network: Multimodal

developmental neurogenetics of

females with ASD

Pelphrey,

Kevin

Yale University $3,118,98

5.00

National

Institutes of

Health

Why are autistic females rare and

severe? An approach to autism gene

identification.

Turner,

Tychele

Johns Hopkins

University

$28,600.0

0

Autism

Speaks

A sex-specific dissection of autism

genetics

Weiss,

Lauren

University of

California, San

Francisco

$150,000.

00

National

Institutes of

Health

Investigation of sex differences

associated with autism candidate

gene, Cyfip1

Werling,

Donna

University of

California, Los

Angeles

$32,413.0

0

National

Institutes of

Health

2.S.C

Identify ways to increase awareness among the autism spectrum community of the potential value of brain and tissue donation to further basic research by 2011. IACC Recommended Budget: $1,400,000

over 2 years

PrincipalInvestigator

Project Title Institution Funding Funder

Building awareness of the value of

brain tissue donation for autism

research

Singer,

Alison

Autism Science

Foundation

$90,120.0

0

Simons

Foundation


Baylor College of Medicine

2.S.D

Launch three studies that target improved understanding of the underlying biological pathways of genetic conditions related to autism (e.g. Fragile X, Rett syndrome, tuberous sclerosis complex) and how these

conditions inform risk assessment and individualized intervention by 2012. IACC Recommended Budget: $9,000,000 over 5 years.

Project Title

Language development in fragile X syndrome

Neurobiological mechanism of 15q11-13 duplication autism spectrum

disorder

Anderson, Matthew

In-vivo imaging of neuronal structure and function in a reversible mouse model for autism.

TMLHE deficiency and a carnitine hypothesis for autism

Role of Sema7A in functional organization of neocortex

Autism phenotypes in Tuberous Sclerosis: Risk factors, features &

architecture

Genetic and developmental analyses of fragile X mental retardation protein

Broadie, Kendal

Abnormal network dynamics and "learning" in neural circuits from

Fmr1-/- mice

Functional circuit disorders of sensory cortex in ASD and RTT

Neural mechanisms underlying autism behaviors in SCN1A mutant mice

Nav1.1 channels, neural circuits, and autism

Principal Investigator

Abbeduto, Leonard

Ash, Ryan

Beaudet, Arthur

Benson, Deanna

Bolton, Patrick

Buonoman o, Dean

Carlson, Gregory

Catterall, William

Catterall, William

Institution Funding Funder

University of California, Davis

$584,381. 00

National Institutes of

Health

Beth Israel Deaconess Medical

Center

$380,625. 00


Health


$0.00 Autism Speaks

$60,000.0 0

Autism Speaks

Mount Sinai School of Medicine

$423,750. 00


Health

King's College London

$149,881. 00

Autism Speaks

Vanderbilt University Medical Center

$438,391. 00


Health

University of California, Los

Angeles

$192,500. 00


Health

University of Pennsylvania

$254,976. 00


Health

University of Washington

$94,903.0 0

Simons Foundation


$10,213.0 0

Simons Foundation


Regulation of cortical critical periods in a mouse model of autism

Elucidation and rescue of amygdala abnormalities in the Fmr1 mutant mouse model of fragile X syndrome

Synaptic phenotype, development, and plasticity in the fragile X mouse

The functional link between DISC1 and neuroligins: Two genetic factors in the etiology of autism

Allelic choice in Rett syndrome

Mechanisms of motor skill learning in the fragile X mouse model

Predicting phenotypic trajectories in Prader-Willi syndrome

Activity-dependent phosphorylation of MeCP2

Pleiotropic roles of dyslexia genes in neurodevelopmental language impairments

Probing synaptic receptor composition in mouse models of autism

Probing the neural basis of social behavior in mice

BDNF and the restoration of spine plasticity with autism spectrum disorders

The microRNA pathway in translational regulation of neurona

Contractor, Anis

Corbin, Joshua

Cox, Charles

DiDonato, Christine

Donohoe, Mary

Dunaevsky, Anna

Dykens, Elisabeth

Ebert, Daniel

Eicher, John

Fagiolini, Michela

Feng, Guoping

Gall, Christine

Gao, Fen-Biao

Northwestern University

George Washington University

University of Illinois at Urbana Champaign

Children's Memorial Hospital, Chicago

Winifred Masterson Burke Medical Research Institute

University of Nebraska Medical Center

Vanderbilt University Medical Center

Harvard Medical School

Yale University

Boston Children's Hospital

Massachusetts Institute of Technology

University of California, Irvine

University of Massachusetts

$60,000.0 0

Simons Foundation

$150,000. 00

Autism Speaks

$395,134. 00

National Institutes of Health

$0.00 Department of Defense

$390,481. 00


$308,138. 00


$310,752. 00


$177,055. 00


$42,232.0 0


$124,998. 00

Simons Foundation

$62,500.0 0

Simons Foundation

$470,063. 00


$352,647. 00



Genotype-phenotype relationships in fragile X families

development Medical School Health

Cortical circuit changes and mechanisms in a mouse model of fragile X syndrome Multigenic basis for autism linked to 22q13 chromosomal region

Gibson, Jay University of Texas Southwestern Medical Center

$278,656. 00


Goldfarb, Mitchell

Hunter College of the City University of New York (CUNY) jointly with Research Foundation of CUNY

$125,000. 00

Simons Foundation

The role of UBE3A in autism Greenberg, Michael


$312,501. 00

Simons Foundation

Hagerman, Randi


$612,413. 00


Bi-directional regulation of Ube3a stability by cyclic AMP-dependent kinase

Hahn, Klaus University of North Carolina at Chapel Hill

$60,000.0 0

Autism Speaks

A longitudinal MRI study of brain development in fragile X syndrome

Hazlett, Heather

University of North Carolina at Chapel Hill

$610,416. 00


Study of fragile X mental retardation protein in synaptic function and plasticity

Huber, Kimberly

University of Texas Southwestern Medical Center

$317,077. 00


Mechanisms of mGluR5 function and dysfunction in mouse autism models

Huber, Kimberly


$406,760. 00


Coordinated control of synapse development by autism-linked genes

Huber, Kimberly

University of Texas Southwestern

$0.00 Simons Foundation

Medical Center Mechanisms of synapse elimination by autism-linked genes

Huber, Kimberly


$434,883. 00

Simons Foundation

Making the connection between autism, serotonin and hedgehog signaling

Jacob, John Medical Research Council-National Institute for Medical Research

$125,635. 00

Simons Foundation

Genetically defined stem cell models of Rett and fragile X syndrome

Jaenisch, Rudolf

Whitehead Institute for Biomedical Research

$350,000. 00

Simons Foundation

Quantitative proteomic approach towards understanding and treating autism

Jin, Peng Emory University $75,000.0 0

Simons Foundation

TrkB agonist therapy for sensorimotor dysfunction in Rett syndrome

Katz, David Case Western Reserve University

$147,806. 00

Autism Speaks

MicroRNAs in synaptic plasticity and behaviors relevant to autism

Kelleher, Raymond

Massachusetts General Hospital

$131,220. 00



Regulation of 22q11 genes in embryonic and adult forebrain

Lamantia, Anthony

The George Washington University

$308,631. 00


The role of MeCP2 in Rett syndrome LaSalle, Janine


$382,858. 00


Physiological studies in a human stem cell model of 15q duplication syndrome

Levine, Eric University of Connecticut

$60,000.0 0

Autism Speaks

Studying Rett and Fragile X syndrome in human ES cells using TALEN technology

Li, Yun Whitehead Institute for Biomedical Research

$0.00 Brain & Behavior Research Foundation

Modulation of fxr1 splicing as a treatment strategy for autism in fragile X syndrome

Lin, Michael Stanford University $0.00 Department of Defense

Revealing protein synthesis defects in fragile X syndrome with new chemical tools

Lin, Michael Stanford University $340,520. 00


A family-genetic study of autism and fragile X syndrome

Losh, Molly Northwestern University

$751,420. 00


Neurobiology of RAI1, the causal gene for Smith-Magenis syndrome

Luo, Liqun Stanford University $155,380. 00

Simons Foundation

Mesocorticolimbic dopamine circuitry in mouse models of autism

Malenka, Robert

Stanford University $436,362. 00

Simons Foundation

Functional and anatomical recovery of synaptic deficits in a mouse model of Angelman Syndrome

McCoy, Portia


$56,000.0 0

Autism Speaks

Investigating the homeostatic role of MeCP2 in mature brain

McGraw, Christopher


$35,832.0 0


A stem cell based platform for identification of common defects in autism spectrum disorders

Nazor, Kristopher

Scripps Research Institute

$0.00 Autism Speaks

Role of intracellular mGluR5 in fragile X syndrome and autism

O'Malley, Karen

Washington University in St. Louis

$75,000.0 0

Simons Foundation

L-type calcium channel regulation of neuronal differentiation

Panagiotak os, Georgia

Stanford University $33,002.0 0


Mouse models of human autism spectrum disorders: Gene targeting in specific brain regions

Parada, Luis


$400,000. 00

Simons Foundation

Mechanism of UBE3A imprint in neurodevelopment

Powell, Weston


$34,439.0 0



Identification of targets for the neuronal E3 ubiquitin ligase PAM

Johns Hopkins University

$351,575. 00

Santelli, Rebecca

$32,875.0 0

The role of genetics in communication deficits in autism spectrum disorders

MeCP2 modulation of BDNF signaling: Shared mechanisms of Rett and autism The role of intracellular metabotropic glutamate receptor 5 at the synapse

Pozzo-Miller, Lucas Purgert, Carolyn

University of Alabama at Birmingham Washington University in St. Louis

$314,059. 00


$13,400.0 0


Ramesh, Vijaya



Pathophysiology of MeCP2 spectrum disorders

Ramocki, Melissa


$179,981. 00


Underlying mechanisms in a cerebellum-dependent model of autism

Regehr, Wade


$60,000.0 0

Simons Foundation

Longitudinal MRI study of brain development in fragile X

Reiss, Allan Stanford University $901,844. 00


Emergence and stability of autism in fragile X syndrome (supplement)

Roberts, Jane

University of South Carolina

$87,314.0 0


Emergence and stability of autism in fragile X syndrome

Roberts, Jane

University of South Carolina

$358,000. 00


Olfactory abnormalities in the modeling of Rett syndrome

Ronnett, Gabriele


A cerebellar mutant for investigating mechanisms of autism in Tuberous Sclerosis

Sahin, Mustafa

Children's Hospital Boston

$149,958. 00

Autism Speaks

Sex differences in early brain development; Brain development in Turner syndrome


$155,873. 00


Cortactin and spine dysfunction in fragile X

Seese, Ronald



New approaches to local translation: SpaceSTAMP of proteins synthesized in axons

Segal, Rosalind

Dana-Farber Cancer Institute

$419,095. 00


Siegel, Steven


$60,000.0 0

Simons Foundation

Upper motor neuron plasticity in the MeCP2-duplication syndrome of autism

Smirnakis, Stelios


$62,500.0 0

Simons Foundation

Dysregulation of protein synthesis in fragile X syndrome

Smith, Carolyn


$1,117,73 1.00



Grammatical development in boys with fragile X syndrome and autism

Sterling, Audra

University of Wisconsin - Madison

$148,500. 00


Health Aberrant synaptic form and function due to TSC-mTOR-related mutation in autism spectrum disorders

Sulzer, David

Columbia University $300,000. 00

Simons Foundation

Understanding the basic neurobiology of Pitt-Hopkins

syndrome

Sweatt, J. David

The University of Alabama at Birmingham

$60,000.0 0

Simons Foundation

Investigation of protocadherin-10 in MEF2- and FMRP-mediated synapse

elimination

Tsai, Nien- Pei

University of Texas Southwestern

Medical Center

$53,942.0 0


Health

Probing a monogenic form of autism from molecules to behavior

Tsien, Richard

Stanford University $0.00

Simons Foundation

Fragile X syndrome target analysis and its contribution to autism

Tuschl, Thomas

The Rockefeller University

$134,477. 00

Simons Foundation

Translational regulation of adult neural stem cells

Zhao, Xinyu


$396,944. 00


Dysregulation of mTOR signaling in fragile X syndrome (supplement)

Zukin, R. Suzanne

Albert Einstein College of Medicine

of Yeshiva University

$72,034.0 0


Health

Dysregulation of mTOR signaling in fragile X syndrome

Zukin, R. Suzanne



$415,000. 00


Health

Genetic rescue of fragile X syndrome in mice by targeted deletion of PIKE

Zukin, R. Suzanne






Single-unit recordings from the amygdala in people with autism

Adolphs, Ralph

California Institute of Technology

$0.00

Simons Foundation

Direct recording from autism brains Adolphs, Ralph


$60,074.0 0

Simons Foundation

2.S.E

Launch three studies that target the underlying biological mechanisms of co-occurring conditions with autism, including seizures/epilepsy, sleep disorders, wandering/elopement behavior, and familial

autoimmune disorders, by 2012. IACC Recommended Budget: $9,000,000 over 5 years.


Barnes, Gregory

University of Melbourne

Characterization of the sleep phenotype in adolescents and adults with autism spectrum disorder

University of Colorado Denver

Assessing sleep regulation, sleep-dependent memory consolidation, and sleep-dependent synaptic plasticity in mouse genetic models of schizophrenia and autism spectrum disorders

Aton, Sara J.


$45,000.0 0

Brain and Behavior Research Foundation

Epileptiform discharges and its relation to cognition and behavior in children with autism spectrum disorders

Vanderbilt University $0.00 Health Resources and Services Administration

Molecular mechanisms linking early life seizures, autism and intellectual disability

Benke, Timothy


$333,473. 00


Altered gastrointestinal function in the neuroligin-3 mouse model of autism

Bornstein, Joel


Selective disruption of hippocampal dentate granule cells in autism: Impact

of PTEN deletion (supplement)

Danzer, Steve

Cincinnati Children's Hospital Medical

Center

$14,596.0 0


Health

Selective disruption of hippocampal dentate granule cells in autism: Impact

of PTEN deletion

Danzer, Steve

Cincinnati Children's Hospital Medical

Center

$411,292. 00


Health

The role of mTOR inhibitors in the treatment of autistic symptoms in symptomatic infantile spasms

Galanopou lou, Aristea

Albert Einstein College of Medicine of Yeshiva University

$0.00 Autism Speaks

Goldman, Suzanne

Vanderbilt University $150,000. 00

Autism Speaks

Neuroendocrine regulation of metabolism and neurocognition

Han, Joan National Institutes of Health

$402,805. 00



Hill, Elisa University of Melbourne


Salivary melatonin as a biomarker for response to sleep interventions in children with autism

Laudensla ger, Mark

$0.00 Autism Speaks

Characterizing sleep disorders in autism spectrum disorder

O'Hara, Ruth


Simons Foundation


$192,365. 00


Molecular components of A-type K+ channels

Rudy, Bernardo

New York University School of Medicine

$363,366. 00


Self-regulation and sleep in children at risk for autism spectrum disorders

Schwichten berg, Amy


$87,899.0 0


The effects of disturbed sleep on sleep-dependent memory consolidation and daily function in individuals with ASD

Stickgold, Robert

Beth Israel Deaconess Medical Center

$90,480.0 0

Autism Speaks

Treatment of medical conditions among individuals with autism spectrum disorders

Swedo, Susan


$339,591. 00


Sensory mechanisms and self-injury Symons, Frank

University of Minnesota

$447,738. 00


Functional neuroimaging of attention in autism

Yerys, Benjamin

University of Pennsylvania/Childr en's Hospital of Philadelphia



Young, Heather

University of Melbourne


2.S.F

Launch two studies that focus on prospective characterization of children with reported regression to investigate potential risk factors by 2012. IACC Recommended Budget: $4,500,000 over 5 years.

PrincipalInvestigator

Project Title Institution Funding Funder

Investigating the etiology of childhood disintegrative disorder

Pelphrey, Kevin

Yale University

$149,953. 00

Simons Foundation

Neuroimmunologic investigations of autism spectrum disorders (ASD)

Swedo, Susan

$101,877. 00


2.S.G

Support five studies that associate specific genotypes with functional or structural phenotypes, including behavioral and medical phenotypes (e.g., nonverbal individuals with ASD and those with cognitive

impairments) by 2015. IACC Recommended Budget: $22,600,000 over 5 years.


$126,453. 00

Simons Variation in Individual Project (Simons VIP) Core Leader Gift

ACE Center: Genetics of language & social communication: Connecting genes to brain & cognition

$252,243. 00

Simons Variation in Individuals Project (VIP) Site

Bernier, Raphael


$436,833. 00

Simons Foundation

Simons Variation in Individuals Project (VIP) Imaging Analysis Site

Buckner, Randy

Harvard University $137,106. 00

Simons Foundation

Simons Variation in Individuals Project (Simons VIP) Principal Investigator

Gift

Chung, Wendy

Columbia University $73,534.0 0

Simons Foundation

Simons Variation in Individuals Project (VIP) Principal Investigator

Chung, Wendy

Columbia University Simons Foundation

Autistic traits: Life course & genetic structure

Constantin o, John

Washington University

$531,127. 00


ACE Center: Neuroimaging signatures of autism: Linking brain function to genes and behavior

Dapretto, Mirella

University of California, Los Angeles

$191,823. 00


The genetic basis of mid-hindbrain malformations

Dobyns, William

Seattle Children's Hospital

$798,866. 00


Simons Variation in Individuals Project (VIP) Recruitment Coordination Site

Faucett, W.Andrew

Weis Center For Research - Geisinger Clinc

$98,087.0 0

Simons Foundation

Genetic investigations of motor stereotypies

Fernandez, Thomas

Yale University $62,136.0 0

Simons Foundation

Geschwind , Daniel



Hanson, Ellen

Children's Hospital Boston



Hanson, Children's Hospital Boston

$768,296. 00

Simons Foundation

A neuroimaging study of twin pairs with autism

Hardan, Antonio




Principal

InvestigatorProject Title Institution Funding Funder

A collaborative translational autism research program for the military.

Herman, Gail

Nationwide Children's Hospital

$903,888. 00

Department of Defense - Air Force

Autism: Neuropeptide hormones and potential pathway genes

Jacob, Suma

University of Illinois at Chicago

$185,338. 00


Genetic dissection of restricted repetitive behavior (RRB)

Kim, Soo-Jeong


$177,736. 00


Factors influencing early associative learning as a precursor to social behavior heterogeneity

Knoll, Allison

University of Southern California

$53,000.0 0

Autism Speaks


Kochel, Robin


$466,763. 00

Simons Foundation

Comprehensive phenotypic characterization of the 17q12 deletion syndrome

Ledbetter, David

Weis Center for Research - Geisinger Clinc

$62,500.0 0

Simons Foundation

Identifying the gene in 17q12 responsible for neuropsychiatric phenotypes

Lese Martin, Christa

Emory University $180,140. 00

Simons Foundation

Simons Variation in Individuals Project (Simons VIP)

Lese Martin, Christa


Simons Foundation

A family-genetic study of language in autism

Losh, Molly Northwestern University

$391,295. 00


Health

High throughput sequencing of autism spectrum disorder (ASD) endophenotypes

Lu, James Baylor College of Medicine

$39,432.0 0


Neural correlates of restricted, repetitive behaviors in autism spectrum disorders Children with 7q11.23 duplication syndrome: shared characteristics with autism

Manoach, Dara



Mervis, Carolyn

University of Louisville

$125,000. 00

Simons Foundation

Characterization of infants and toddlers with the 16p copy-number variation

Nelson, Charles


$190,766. 00

Simons Foundation


Pelphrey, Kevin

Simons Variation in Individuals Project (VIP) Structural Imaging and Phenotyping Site - SCAP-local

Children's Hospital of Philadelphia

Neural correlates of restricted, repetitive behaviors in autism spectrum disorders


Genome-wide identification of variants affecting early human brain development

Santelli, Rebecca


$611,005. 00

University of California, San Francisco

$513,646. 00

$120,328. 00


Language processing in children with 22q11 deletion syndrome and autism

Ousley, Opal

Emory University $0.00 Simons Foundation

Developmental neurogenetics in adolescents with autism

Yale University $124,769. 00

Simons Foundation

Animal model of genetics and social behavior in autism spectrum disorders

Platt, Michael

Duke University $791,070. 00


Social cognition in 22q11.2 deletion syndrom (DS) adolescents with ASD vs. without ASD: Imaging and genetic correlates

Radoeva, Petya

State University of New York Upstate Medical University

$0.00 Autism Speaks

Simons Variation in Individuals Project (VIP) Functional Imaging Site

Roberts,Tim Children's Hospital of Philadelphia

$736,449. 00

Simons Foundation

Roberts,Tim $217,322. 00

Simons Foundation

Santangelo, Susan



Relating copy number variants to head and brain size in neuropsychiatric disorders

Sebat, Jonathan

University of California, San Diego

$322,286. 00

Simons Foundation

Simons Variation in Individuals Project (VIP) Functional Imaging Site

Sherr, Elliott $320,196. 00

Simons Foundation

Simons Variation in Individuals Project (VIP) Core Neuroimaging Support Site

Sherr, Elliott University of California, San Francisco

Simons Foundation

Simons Variation in Individuals Project (Simons VIP) Core Leader Gift

Sherr, Elliott University of California, San Francisco

$1,299,08 3.00

Simons Foundation

Genomic and epigenomic effects of large CNV in neurons from iPSC

Urban, Alexander

Stanford University $2,355,00 0.00


Simons Variation in Individuals Project (VIP) Statistical Core Site

Vaughan, Roger

Columbia University $136,125. 00

Simons Foundation

Characterizing the genetic systems of autism through multi-disease analysis (supplement)

Wall, Dennis



Characterizing the genetic systems of autism through multi-disease analysis

Wall, Dennis

$524,280. 00


Social processing, language, and executive functioning in twin pairs: Electrophysiological and behavioral

Webb, Sara University of Washington

$150,000. 00

Autism Speaks




Longitudinal characterization of functional connectivity in autism

Anderson, Jeffrey

University of Utah $182,352. 00


Pediatric brain imaging Giedd, Jay National Institutes of Health

$2,419,58 3.00


MRI study of brain development in school age children with autism

Hazlett, Heather Cody


$127,479. 00

Autism Speaks

Amygdala connectivity in autism spectrum disorder

Johnson, Ryan


$49,934.0 0


Understanding the etiological significance of attentional disengagement in infants at-risk for ASD

Keehn, Brandon


$46,000.0 0

Autism Speaks

Investigation of the link between early brain enlargement and abnormal functional connectivity in autism spectrum disorders

Electrophysiologic biomarkers of language function in autism spectrum

disorders

Kleinhans, Natalia


$0.00 Autism Speaks

McEvoy, Kevin

University of California, Los

Angeles

$28,600.0 0

Autism Speaks

20-year outcome of autism McMahon, William

University of Utah $149,964. 00

Autism Speaks

ACE Network: A longitudinal MRI study of infants at risk for autism

Piven, Joseph


$2,619,59 0.00


ACE Network: A longitudinal MRI study of infants at risk for autism (supplement)

Piven, Joseph


$565,115. 00


endophenotypes

Functional imaging of flexibility in autism: Informed by SLC6A4

Yerys, Benjamin

Children's Research Institute

$132,748. 00


2.L.A

Complete a large-scale, multi-disciplinary, collaborative project that longitudinally and comprehensively examines how the biological, clinical, and developmental profiles of individuals, with a special emphasis on females, youths, and adults with ASD, change over time as compared to typically developing people

by 2020. IACC Recommended Budget: $126,200,000 over 12 years.


Launch at least three studies which evaluate the applicability of ASD phenotype and/or biological signature findings for performing diagnosis, risk assessment, or clinical intervention by 2015. IACC

Recommended Budget: $7,200,000 over 5 years.

Agam, Yigal

2.L.B



The Brain Genomics Superstruct Project

Buckner, Randy

Harvard University $150,000. 00

Simons Foundation

Functional neuroimaging of psychopharmacologic intervention for autism

Dichter, Gabriel


$162,369. 00


ACE Center: Predicting risk and resilience in ASD through social visual engagement

Jones, Warren



Local functional connectivity in ASD Kenet, Tal Massachusetts General Hospital

$50,811.0 0

Simons Foundation

A study of autism Krieger, Abba


$162,232. 00

Simons Foundation

Near-infrared spectroscopy studies of early neural signatures of autism

Pelphrey, Kevin

Yale University $149,917. 00

Autism Speaks

ACE Center: Auditory perception and perceptual organization in minimally verbal children with ASD

Shinn-Cunningha m, Barbara

Boston University $288,440. 00


2.O

Not specific to any objective



Towards an endophenotype for amygdala dysfunction

Adolphs, Ralph


$380,304. 00


Multimodal studies of executive function deficits in autism spectrum disorders


$54,570.0 0



Characterizing the regulatory pathways and regulation of AUTS2

Ahituv, Nadav

University of California, San

Francisco

$57,964.0 0

Simons Foundation

Autism and the insula: Genomic and neural circuits

Allman, John


$254,696. 00

Simons Foundation

Transcriptional responsiveness in lymphoblastoid cell lines

Alter, Mark University of Pennsylvania


Role of CNTNAP2 in neuronal structural development and synaptic

transmission

Anderson, Garret

Stanford University $53,500.0 0

Autism Speaks

Multisensory processing in autism Angelaki, Dora


$60,000.0 0

Simons Foundation

The social brain in schizophrenia and autism spectrum disorders

Assaf, Michal

Hartford Hospital $594,733. 00


ACE Center: Ontogeny and neural basis of social visual engagement in monkeys

Bachevalier, Jocelyne



Learning and plasticity in the human brain

Baker, National Institutes of Health

$351,533. 00


Christopher

The neural bases of top-down attentional control in autism spectrum

disorders

Banerjee, Snigdha

City College of New York

$27,578.0 0


PI3K/mTOR signaling as a novel biomarker and therapeutic target in autism

Bassell, Gary

Emory University $0.00 Autism Speaks

Eye movement dynamics in autism spectrum disorders

Behrmann, Marlene

Carnegie Mellon University


Social and affective components of communication

Bellugi, Ursula

Salk Institute For Biological Studies

$317,715. 00


Early expression of autism spectrum disorder in experimental animals

Ben-Ari, Yehezkel

Neurochlore $0.00 Simons Foundation


Taste, smell, and feeding behavior in autism: A quantitative traits study

Bennetto, Loisa

University of Rochester

$570,508. 00


Structural and functional neuroimaging of the auditory system in autism

Berman, Jeffrey


$157,905. 00


Genetic studies of autism-related Drosophila neurexin and neuroligin

Bhat, Manzoor

The University of North Carolina at Chapel Hill

$489,104. 00

Simons Foundation

Engrailed targets and the control of synaptic circuits in Drosophila

Blagburn, Jonathan

University of Puerto Rico Medical Sciences Campus

$352,100. 00


The genetic control of social behavior in the mouse (supplement)

Blanchard, Robert

University of Hawai'i at Manoa

$201,966. 00


Elucidation of the developmental role of Jakmip1, an autism-susceptibility gene

Bomar, Jamee


$31,474.0 0


Multimodal neuroimaging of motor dysfunction in autism spectrum disorders

Buard, Isabelle


$56,000.0 0

Autism Speaks

Controlling interareal gamma coherence by optogenetics, pharmacology and behavior

Buschman, Timothy


$84,775.0 0


Neurobehavioral investigation of tactile features in autism spectrum disorders

Cascio, Carissa



Development of brain connectivity in autism

Castellanos , Francisco Xavier; Lord, Catherine

New York University School of Medicine; University of Michigan

$0.00 Autism Speaks

Neocortical mechanisms of categorical speech perception

Chang, Edward


$239,255. 00


Characterization of the pathological and biochemical markers that correlate to the clinical features of autism

Chauhan, Abha

Research Foundation for Mental Hygiene, Inc.


Corticothalamic circuit interactions in autism

Chen, Chinfei


$250,000. 00

Simons Foundation



Atypical architecture of prefrontal cortex in young children with autism

Functional analysis of patient mutations in EPHB2, an ASD candidate gene- Core

$335,103. 00

Identification of genetic pathways that regulate neuronal circuits in C. elegans

Cherra, Salvatore


$47,114.0 0


SHB: Type II (INT): Synthesizing self-model and mirror feedback imageries with applications to behavior modeling for children with autism

Cheung, Sen-ching

University of Kentucky Research Foundation

$798,912. 00

National Science Foundation

The role of the GRIP protein complex in AMPA receptor trafficking and autism spectrum disorders

Chiu, Shu-Ling


Abnormal connectivity in autism Clark, Kristi A.


$30,000.0 0

Brain & Behavior Research Foundation

Caspr2 as an autism candidate gene: A proteomic approach to function & structure

Comoletti, Davide

University of Medicine & Dentistry of New Jersey - Robert Wood Johnson Medical School

$312,000. 00


A neural model of fronto-parietal mirror neuron system dynamics

Contreras-Vidal, Jose

University of Maryland

$183,960. 00


Psychobiological investigation of the socioemotional functioning in autism

Corbett, Blythe



The role of the new mTOR complex, mTORC2, in autism spectrum disorders

Costa-Mattioli, Mauro


$625,998. 00

Department of Defense - Autism Research Program

Courchesne , Eric


Simons Foundation

Cowan, Christopher

McLean Hospital $62,475.0 0

Simons Foundation

Neural mechanisms of imitative behavior: Implications for mental health

Cross, Kathryn


$33,128.0 0


Behavioral and neural correlates of reward motivation in children with autism spectrum disorders

Damiano, Cara


$0.00 Autism Speaks

RNA dysregulation in autism Darnell, Robert


$125,000. 00

Simons Foundation



EEG-based assessment of functional connectivity in autism

Kennedy Krieger Institute

$175,042. 00

University of California, Berkeley

$328,644. 00

Shank3 in synaptic function and autism

$401,250. 00

Functional analysis of EFR3A mutations associated with autism

De Camilli, Pietro


Simons Foundation

CLARITY: circuit-dynamics and connectivity of autism-related behavior

Deisseroth, Karl


Simons Foundation

Self-injurious behavior: An animal model of an autism endophenotype CAREER: The role of prosody in word segmentation and lexical access

Devine, Darragh Dilley, Laura

University of Florida $0.00 Department of Defense

Michigan State University

$0.00 National Science Foundation

Mapping functional connectivity networks in autism spectrum disorder with diffuse optical tomography

Eggebrecht, Adam

Washington University in St. Louis

$55,170.0 0

Autism Speaks

Executive function in children with typical and atypical language abilities

Ellis-Weismer, Susan


$564,177. 00


Magnetoencephalographic studies of lexical processing and abstraction in autism

Embick, David

$321,156. 00


Functional properties and directed connectivity in the face-processing network

Engell, Andrew



Ewen, Joshua


Characterizing mechanistic heterogeneity across ADHD and autism

Fair, Damien

Oregon Health & Science University

$611,788. 00


Electrophysiological response to executive control training in autism

Faja, Susan University of Washington

$89,670.0 0


Molecular controls over callosal projection neuron subtype specification and diversity

Fame, Ryan Harvard University $42,232.0 0


Neural mechanisms of tactile sensation in rodent somatosensory cortex

Feldman, Daniel

University of California, Berkeley

$255,940. 00


Inhibitory mechanisms for sensory map plasticity in cerebral cortex

Feldman, Daniel


Feng, Guoping






Probing the temporal dynamics of aberrant neural communication and its relation to social processing deficits in autism spectrum disorders

Enhancing neurobehavioural and clinical definitions in autism spectrum disorders

Fielding, Joanne

Monash University $14,000.0 0


Preference acquisition in children and adolescents with and without autism spectrum disorder

Filliter, Jillian

Dalhousie University $0.00 Autism Speaks

Behavioral, fMRI, and anatomical MRI investigations of attention in autism

Fischer, Jason


$47,114.0 0


Multimodal imaging of social brain networks in ASD

Fishman, Inna

San Diego State University

$150,036. 00


Examining connectivity patterns of brain networks participating in social cognition in ASD

Fishman, Inna


$40,000.0 0

Autism Science Foundation

CAREER: Statistical models and classification of time-varying shape

Fletcher, Preston Thomas

University of Utah $8,000.00 National Science Foundation

The role of FOX-1 in neurodevelopment and autistic spectrum disorder

Fogel, Brent University of California, Los Angeles

$145,757. 00


Neural mechanisms underlying an extended multisensory temporal binding window in ASD

Foss-Feig, Jennifer

Vanderbilt University $0.00 Autism Speaks

Brain bases of language deficits in SLI and ASD

Gabrieli, John

$614,180. 00


The role of CNTNAP2 in embryonic neural stem cell regulation

Gaiano, Nicholas

Johns Hopkins University School of Medicine


Understanding the role of Epac2 in cognitive function

Gao, Ruoqi Northwestern University

$47,232.0 0


Dual modulators of GABA-A and Alpha7 nicotinic receptors for treating autism

Gee, Kelvin $615,849. 00

Department of Defense - Autism Research Program

A functional genomic analysis of the cerebral cortex

Geschwind, Daniel


$256,413. 00

Simons Foundation

Ghuman, Avniel S.

University of Pittsburgh



RI: Small: Addressing visual analogy problems on the raven's intelligence test

Goel, Ashok Georgia Tech Research Corporation

$284,454. 00

National Science Foundation

Role of negative regulators of FGF signaling in frontal cortex development and autism

Golonzhka, Olga


$45,000.0 0


Monolingual and bilingual infants' sensitivity to agreement morphology in Spanish

Gouvea, Ana

Florida International University

$144,100. 00


Using fruit flies to map the network of autism-associated genes

Greenspan, Ralph


$156,245. 00

Simons Foundation

Face perception: Mapping psychological spaces to neural responses Identification and analysis of ASD patients with PI3K/mTOR signalopathies

Grill-Spector, Kalanit Gross, Christina

Stanford University

Emory University

$0.00

$66,500.0 0

National Science Foundation Simons Foundation

Spatial attention in autism spectrum disorders

Grubb, Michael

New York University $28,600.0 0

Autism Speaks

Identification of candidate genes at the synapse in autism spectrum disorders Functional analysis of patient mutations in EPHB2, an ASD candidate gene- Project 1

Gupta, Abha

Gupta, Abha

Yale University

Yale University

$168,839. 00

$177,512. 00

National Institutes of Health Simons Foundation

The neural substrates of social interactions

Gupta, Rupa

University of Iowa $15,865.0 0


Molecular signatures of autism genes and the 16p11.2 deletion

Gusella, James


$62,500.0 0

Simons Foundation

Development of the functional neural systems for face expertise

Haist, Frank University of California, San Diego

$507,685.00 National Institutes of Health

Cerebellar plasticity and learning in a mouse model of autism

Hansel, Christian

University of Chicago $156,250.00 Simons Foundatio n

Canonical neural computation in autism spectrum disorders

Heeger, David

New York University $365,741.00 Simons Foundatio n


Defining cells and circuits affected in autism spectrum disorders

Heintz, Nathaniel


$336,872.00

Simons Foundatio n

Homeostatic regulation of presynaptic function by dendritic mTORC1

Henry, Fredrick

University of Michigan $32,747.00 National Institutes of Health

3 Tesla 31Phosphorus magnetic resonance spectroscopy in disorder with abnormal bioenergetics

Herbert, Martha

Treatment Research and Neuroscience Evaluation of Neurodevelopmental Disorders (TRANSCEND) Research Laboratory, Massachusetts General Hospital

$3,250.00 Autism Research Institute

Perturbed cortical patterning in autism

Hevner, Robert


$60,000.00 Simons Foundatio n

Integrative functions of the planum temporale (supplement)

Hickok, Gregory


$34,768.00


Integrative functions of the planum temporale

Hickok, Gregory


$440,810.00


Neural basis of cross-modal influences on perception

Hillyard, Steven


$158,282.00 National Science Foundatio n

Exploring the uncanny valley Hodgins, Jessica


$0.00 National Science Foundatio n

Collaborative research: Learning complex auditory categories

Holt, Lori Carnegie Mellon University


Vasopressin receptor polymorphism and social cognition

Hopkins, William

Georgia State University


Proteome and interaction networks in autism

Howley, Peter


$156,250.00

Simons Foundatio n

Functional role of IL-6 in fetal brain development and abnormal behavior

Hsiao, Elaine


$42,232.00



Collaborative research: Modeling perception and memory: Studies in priming

Huber, David University of California, San Diego


High throughput screen for small molecule probes for neural network development

Huganir, Richard



High metabolic demand of fast-spiking cortical interneurons underlying the etiology of autism

Inan, Melis Weill Cornell Medical College

$54,500.00 Autism Speaks

Neurobiological signatures of audiovisual speech perception in children in ASD

Irwin, Julia Haskins Laboratories, Inc.


Analysis of Shank3 complete and temporal and spatial specific knockout mice

Jiang, Yong-Hui

Duke University $481,448.00 National Institutes of Health

Stimulus-driven attention deficits in autism

Jiang, Yuhong

University of Minnesota

$0.00 Simons Foundatio n

Macrocephalic autism: Exploring and exploiting the role of PTEN

Johnston, Sean


$0.00 Autism Speaks

The neural basis of weak central coherence in autism spectrum disorders

Jou, Roger J. Yale University $13,040.00 Brain & Behavior Research Foundatio n

Engrailed genes and cerebellum morphology, spatial gene expression and circuitry

Joyner, Alexandra

Memorial Sloan-Kettering Cancer Center


Using high definition fiber tracking to define developmental neurobiologic mechanisms & a neural basis for behavioral heterogeneity

Just, Marcel Carnegie Mellon University


Neurexin-neuroligin trans-synaptic interaction in learning and memory

Kandel, Eric Columbia University $200,000.00 Simons Foundatio n

Role of neurexin in the amygdala and associated fear memory

Kandel, Eric Columbia University $175,000.00 Simons Foundatio n

Retrograde synaptic signaling by Neurexin and Neuroligin in C. elegans

Kaplan, Joshua




Investigating brain connectivity in autism at the whole-brain level

Kennedy, Daniel



Investigating brain connectivity in autism at the whole-brain level

Kennedy, Daniel

Indiana University $249,001.00 National Institutes of Health

Investigating brain organization and activation in autism at the whole-brain level

Kennedy, Daniel P.


$0.00 Brain & Behavior Research Foundatio n

Developing novel automated apparatus for studying battery of social behaviors in mutant mouse models for autism Excessive cap-dependent translation as a molecular mechanism underlying ASD

Kimchi, Tali Weizmann Institute of Science

$0.00 Departme nt of Defense

Klann, Eric New York University $0.00 Departme nt of Defense

Multimodal brain imaging in autism spectrum disorders

Kleinhans, Natalia



Role of GluK6 in cerebella circuitry development

Kubera, Cathryn

Yale University $58,442.00 National Institutes of Health

Semaphorin4D and PlexinB1 mediate GABAergic synapse development in mammalian CNS

Kuzirian, Marissa

Brandeis University


The microstructural basis of abnormal connectivity in autism

Lainhart, Janet

University of Utah $332,991.00 National Institutes of Health

ERK signaling in autism associated with copy number variation of 16p11.2

Landreth, Gary

Case Western Reserve University


Development of face processing expertise

Lee, Kang University of Toronto $351,984.00 National Institutes of Health

Multiple systems in theory of mind development

Leslie, Alan Rutgers, The State University of New Jersey - New Brunswick


Function and structure adaptations in forebrain development

Levitt, Pat University of Southern California



Genetic model to study the ASD-associated gene A2BP1 and its target PAC1

Levkowitz, Gil

Weizmann Institute of Science


Neurobiological correlates of language dysfunction in autism spectrum disorders

Lewine, Jeffrey

The Mind Research Network


Synchronous activity in networks of electrically coupled cortical interneurons

Lewis, Timothy


$0.00

National Science Foundatio n

Roles of miRNAs in regulation of Foxp2 and in autism

Li, XiaoChing Louisiana State University

$45,000.00 Brain & Behavior Research Foundatio n

MTHFR functional polymorphism C677T and genomic instability in the etiology of idiopathic autism in simplex families

Liu, Xudong Queen's University $0.00 Departme nt of Defense

Role of major vault protein in autism

Lombroso, Paul

Yale University $59,972.00 Simons Foundatio n

Pragmatics and semantics in autism spectrum disorder

Lopez, Karece

City University of New York Graduate School and University Center


Collaborative research: Learning complex auditory categories

Lotto, Andrew

University of Arizona $0.00

National Science Foundatio n

The impact of Pten signaling on neuronal form and function

Luikart, Bryan

Dartmouth College $346,014.00 National Institutes of Health

Social interaction and reward in autism: Possible role for ventral tegmental area

Luscher, Christian

University of Geneva $62,496.00 Simons Foundatio n

Behavioral and neural responses to emotional faces in individuals with ASD

Luyster, Rhiannon J.

Harvard University $14,935.00 Brain & Behavior Research Foundatio n


Regulation of spine morphogenesis by NrCAM

Maness Tidwell, Patricia



Investigation of a possible role of the protocahderin gene cluster in autism

Maniatis, Tom

Columbia University $150,000.00 Simons Foundatio n

The cognitive neuroscience of autism spectrum disorders

Martin, Alex National Institutes of Health

$1,074,095. 00


Cellular density and morphology in the autistic temporal human cerebral cortex

Martinez Cerdeno, Veronica



Cognitive control of emotion in autism

Mazefsky, Carla



Social brain networks for the detection of agents and intentions

McCarthy, Gregory


Neural underpinning of emotion perception and its disorders

Meng, Ming

Dartmouth College


Mathematical cognition in autism: A cognitive and systems neuroscience approach

Menon, Vinod

Stanford University $652,461.00 National Institutes of Health

Decoding 'what' and 'who' in the auditory system of children with autism spectrum disorders

Menon, Vinod


CDI-TYPE II: From language to neural representations of meaning

Mitchell, Tom Carnegie Mellon University


Alterations in brain-wide neuroanatomy in autism mouse models

Mitra, Partha Cold Spring Harbor Laboratory


Cerebellar modulation of frontal cortical function

Mittleman, Guy

University of Memphis


Linguistic perspective-taking in adults with high-functioning autism: Investigation of the mirror neuron system

Mizuno, Akiko


$0.00 Autism Speaks


Sensory processing and integration in autism

Molholm, Sophie



Social behavior deficits in autism: Role of amygdala

Mooney, Sandra

State University of New York Upstate Medical Center

$0.00 Autism Speaks

HCC:Small:Computational studies of social nonverbal communication

Morency, Louis-Philippe

University of Southern California


Endosomal NHE6 in long-range connectivity and autism

Morrow, Eric Brown University $62,500.00 Simons Foundatio n

Motor control and cerebellar maturation in autism

Mosconi, Matthew



Motor skill learning in autism Mostofsky,

Stewart Kennedy Krieger Institute


Linking local activity and functional connectivity in autism (supplement)

Mueller, Ralph-Axel



Linking local activity and functional connectivity in autism

Mueller, Ralph-Axel



Cell adhesion molecules in CNS development

Mueller, Ulrich

The Scripps Research Institute


Networked cortical responses to movement associated with ASD

Murias, Michael


$449,700.00


Thalamocortical connectivity in children and adolescents with ASD-A combined fcMRI and DTI approach

Nair, Aarti San Diego State University


Brain electrophysiology of interactive social stimuli

Naples, Adam

Yale University $52,984.00 Autism Speaks

Understanding the brain basis of impaired imitation learning in autism

Nebel, Mary Beth




How autism affects speech understanding in multitalker environments

Newman, Rochelle

University of Maryland, College Park

$0.00 National Institutes of Health

Experience and cognitive development in infancy

Oakes, Lisa University of California, Davis


Infants' developing representation of object function

Oakes, Lisa University of California, Davis


Development of ventral stream organization

O'Hearn, Kirsten



Deciphering the function and regulation of AUTS2

Oksenberg, Nir


$0.00 Autism Speaks

White matter glial pathology in autism

Ordway, Gregory

East Tennessee State University


Investigation of social brain circuits in mouse models of the 16p11.2 locus

Osten, Pavel Cold Spring Harbor Laboratory


Cell adhesion molecules in autism: A whole-brain study of genetic mouse models



Investigation of social brain circuits and fever-evoked response in 16p11.2 mice



Extended tracking of single synaptic proteins with upconverting nanoparticles

Ostrowski, Alexis

University of California; Lawrence Berkeley National Laboratory


Elucidating the function of class 4 semaphorins in GABAergic synapse formation (supplement)

Paradis, Suzanne

Brandeis University $23,015.00 National Institutes of Health

Elucidating the function of class 4 semaphorins in GABAergic synapse formation

Paradis, Suzanne

Brandeis University $336,922.00 National Institutes of Health

Effect of paternal age on mutational burden and behavior in mice

Pardo-Manuel De Villena, Fernando




Transcriptional regulators in normal human brain development and autism

Parikshak, Neelroop



Behavioral and neural processing of faces and expressions in nonhuman primates

Parr, Lisa Emory University $435,600.00 National Institutes of Health

Synaptic processing in the basal ganglia

Perkel, David University of Washington


Neuronal basis of vicarious reinforcement dysfunction in autism spectrum disorder

Platt, Michael

Duke University $310,081.00 National Institutes of Health

Neural basis of empathy and its dysfunction in autism spectrum disorders (ASD)

Platt, Michael

Duke University $0.00 Departme nt of Defense

Diffusion tensor MR spectroscopic imaging in human brain

Posse, Stefan

University of New Mexico Health Sciences Center


GABAergic dysfunction in autism Puts, Nicolaas


Autism Speaks

MET signaling in neural development and circuitry formation

$48,000.00

Qiu, Shenfeng

University of Arizona $249,000.00 National Institutes of Health

Neuroligin, oxidative stress and autism

Rand, James Oklahoma Medical Research Foundation

$150,000.00 Simons Foundation

Serotonin signal transduction in two groups of autistic patients

Rasenick, Mark

University of Illinois at Chicago


Evaluating the time-dependent unfolding of social interactions in autism

Richardson, Michael

University of Cincinnati


CAREER: Integrative behavioural and neurophysiological studies of normal and autistic cognition using video game environments Neural synchrony dysfunction of gamma oscillations in autism (supplement)

Robertson, Steven

Cornell University $0.00 National Science Foundation

Rojas, Donald



Neural synchrony dysfunction of gamma oscillations in autism

Rojas, Donald




Auditory and integrative functions of the prefrontal cortex

Romanski, Lizabeth

University of Rochester


Autism Speaks

A novel transplantation assay to study human PTEN ASD alleles in GABAergic interneurons

Rubenstein, John


$60,000.00

Development of a connectomic functional brain imaging endophenotype of autism

Rubinov, Mikail

University of Cambridge

$0.00

Brain & Behavior Research Foundatio n

Molecular mechanisms of the synaptic organizer alpha-neurexin

Rudenko, Gabrielle

University of Michigan $383,267.00 National Institutes of Health

Impact of SynGAP1 mutations on synapse maturation and cognitive development

Rumbaugh, Gavin

The Scripps Research Institute - Florida


Urokinase-type plasminogen activator plasma concentration and its relationship to hepatocyte growth factor (HGF) and GABA levels in autistic children

Russo, A.J. Hartwick College $8,505.00 Autism Research Institute

Cortical dynamics in autism Said, Chris New York University $52,190.00 National

Institutes of Health

Multisensory integration in children with ASD

Saron, Clifford



Impairments of theory of mind disrupt patterns of brain activity

Saxe, Rebecca



CAREER: Typical and atypical development of brain regions for theory of mind

Saxe, Rebecca



Collaborative research: RUI: Perceptual pick-up processes in interpersonal coordination

Schmidt, Richard

College of the Holy Cross


Testing the hyperspecificity hypothesis: A neural theory of autism

Schultz, Robert



Typical and pathological cellular development of the human amygdala

Schumann, Cynthia




Glial control of neuronal receptive ending morphology

Shaham, Shai



Molecular dissection of calmodulin domain functions

Shea, Madeline

University of Iowa $321,473.00 National Institutes of Health

The effects of autism on the sign language development of deaf children (supplement)

Shield, Aaron

Boston University $1,188.00 National Institutes of Health

The effects of autism on the sign language development of deaf children

Shield, Aaron

Boston University $59,419.00 National Institutes of Health

Autism spectrum disorders and the visual analysis of human motion

Shiffrar, Maggie

Rutgers, The State University of New Jersey


Metacognition in comparative perspective

Smith, J. David

University at Buffalo, The State University of New York

$210,561.00 National


The neural substrates of higher-level learning in autism

Solomon, Marjorie



Learning in autism spectrum disorders

Solomon, Marjorie



Brain-behavior interactions and visuospatial expertise in autism: a window into the neural basis of autistic cognition

Soulieres, Isabelle

Hospital Riviere-des-Praires, University of Montreal, Canada

$0.00 Brain & Behavior Research Foundatio n

Computational characterization of language use in autism spectrum disorder

Sproat, Richard

Oregon Health & Science University


ACE Center: Neuroimaging studies of connectivity in ASD

Staib, Lawrence


The computational basis of theory of mind in the human brain

Stanley, Damian



Stimulus preceding negativity and social stimuli in autism spectrum disorder

Stavropoulos , Katherine




Role of neuronal migration genes in synaptogenesis and plasticity

Sudarov, Anamaria

Weill Cornell Medical College


Function of neurexins Sudhof,

Thomas Stanford University $473,710.00 National


Function and dysfunction of neuroligins in synaptic circuits

Sudhof, Thomas

Stanford University $750,000.00 Simons Foundatio n

Modeling 5-HT-absorbing neurons in neuropathology of autism

Sze, Ji Albert Einstein College of Medicine of Yeshiva University


Subependymal zone function in autism spectrum disorders

Szele, Francis

University of Oxford $59,560.00 Simons Foundatio n

Kinetics of drug macromolecule complex formation

Taylor, Palmer



Attentional distribution and word learning in children with autism

Tenenbaum, Elena

Women & Infants Hospital


Influence of attention and arousal on sensory abnormalities in ASD

Townsend, Jeanne



Imaging PTEN-induced changes in adult cortical structure and function in vivo

Trachtenberg , Joshua



In vivo targeted gene silencing, a novel method

Truitt, William

Indiana University-Purdue University Indianapolis


Regulation of synaptogenesis by cyclin-dependent kinase 5

Tsai, Li-Huei Massachusetts Institute of Technology


CAREER: Dissecting the neural mechanisms for face detection

Tsao, Doris California Institute of Technology


Structural and functional connectivity of large-scale brain networks in autism spectrum disorders

Uddin, Lucina


Presynaptic regulation of quantal size by the cation/H+ exchangers NHE6 & NHE9

Ullman, Julie University of California, Berkeley



Functional anatomy of face processing in the primate brain

Ungerleider, Leslie


$1,660,304. 00


Morphogenesis and function of the cerebral cortex

Vaccarino, Flora


Neuroimaging of top-down control and bottom-up processes in childhood ASD (supplement)

Vaidya, Chandan

Georgetown University


Neuroimaging of top-down control and bottom-up processes in childhood ASD

Vaidya, Chandan

Georgetown University


Neuropeptide regulation of juvenile social behaviors

Veenema, Alexa

Boston College $29,550.00 Brain & Behavior Research Foundatio n

Statistical word learning and non-social visual attention in children with autism

Venker, Courtney



Novel computational methods for higher order diffusion MRI in autism

Verma, Ragini



Head-fixed recording of sensory learning in mouse autism models

Wang, Samuel

Princeton University $0.00 Simons Foundatio n

Defining the dynamics of the default network with direct brain recordings and functional MRI

Weaver, Kurt University of Washington


Physiology of attention and regulation in children with ASD and LD

Webb, Sara Seattle Children's Hospital


Characterization of the pathological and biochemical markers that correlate to the clinical features of autism Dimensions of mind perception

Wegiel, Jerzy



Wegner, Daniel

Harvard University $0.00 National Science Foundatio n

Neural basis of behavioral flexibility Weiss, Klaudiusz

Mount Sinai School of Medicine


BRIGE: Emotion mapping of children through human-robot interaction and affective computing

Welch, Karla University of Louisville Research Foundation Inc



Neuroprotective effects of oxytocin receptor signaling in the enteric nervous system

Welch, Martha

Columbia University


The striatal circuitry underlying autistic-like behaviors

Wells, Michael

Duke University


Role of autism-susceptibility gene, CNTNAP2, in neural circuitry for vocal communication

White, Stephanie



Modulation of RhoA signaling by the mRNA binding protein hnRNPQ1

Williams, Kathryn

Emory University $30,912.00


Characterization of the pathological and biochemical markers that correlate to the clinical features of autism A preliminary investigation of the neurobehavioral basis of sensory behavior in autism

Wisniewski, Thomas



Wodka, Ericka


$10,000.00 Organizati on for Autism Research

Action anticipation in infants Woodward, Amanda

University of Chicago $102,258.00 National Science Foundatio n

Dynamic regulation of Shank3 and ASD

Worley, Paul Johns Hopkins University


Bayesian variable selection in generalized linear models with missing variables

Yang, Xiaowei

Hunter College (City University of New York)


Imaging signal transduction in single dendritic spines

Yasuda, Ryohei

Duke University $382,200.00


Local connectivity in altered excitation/inhibition balance states

Yizhar, Ofer Weizmann Institute of Science


Young development of a novel PET ligand for detecting oxytocin receptors in brain (supplement)

Young, Larry Emory University $176,000.00 National Institutes of Health

Young development of a novel PET ligand for detecting oxytocin receptors in brain

Young, Larry Emory University $261,360.00 National Institutes of Health


High-throughput DNA sequencing method for probing the connectivity of neural circuits at single-neuron resolution Novel regulatory network involving non-coding role of an ASD candidate gene PTEN

Zador, Anthony

Cold Spring Harbor Laboratory


Zheng, Deyou



Statistical analysis of biomedical imaging data in curved space

Zhu, Hongtu University of North Carolina at Chapel Hill


Functional analysis of neurexin IV in Drosophila

Zipursky, Larry



The role of neurexin IV in central nervous system development

Zipursky, Larry


$100,466.00

Simons Foundatio n


Documents

2012 Portfolio Analysis Projects: Question 2: How can I ......2012 Portfolio Analysis Projects Please note that data are not yet final; additional projects may be added. QUESTION 2: