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8/13/2019 10. Immune Response Part 1 (Reupload)
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Assoc. Prof. Ma. Jennifer R. Tiburcio,MSMT
Department of Med Tech
UST Faculty of Pharmacy
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Immune responsehos t react ion to a foreign substance ant igen
humora l
cel lu lar
tolerance
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Fate of the ant ig en
Mode of entry Site of Ag trapping
Ingested/Inhaled Peyers patches
Intestinal mucosa
Alveolar liningIntracutaneous/ Regional lymph node
Subcutaneous
Intravenous/ SpleenIntraperitoneal
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Regardless of the route of administration
macrophagespivotal role
present the Aglymphoid cells
in phagocytosis
function as effector cellsrecognize, engulf &destroy the Ags
accessory cells
major APCs
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Processing of exogenous Ags in association w/
MHC II molecules
1. Phagocytosis or endocytosis of antigen
2. Digestion of antigen into peptide fragments (APC)
3. Fusion of vesicles containing peptide fragments and
MHC II molecules
4. Peptide fragments bind to MHC II molecules
5. Vesicle undergoes exocytosis and Ag-MHC II
complexes are inserted into the membrane
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Processing of Ags in association with MHC I
Molecules1. Class I molecules bind peptides that have been synthesized within
the cell --- viral proteins
2. Peptides from degraded viral proteins are transported into the
endoplasmic reticulum
3. Partially folded MHC I molecules bound by calnexin meets viralpeptide in the ER
4. Peptide binding completes MHC I folding releasing calnexin; only
folded molecules are exported to the Golgi apparatus
5. Bound viral peptide is carried by MHC class I to the cell surface
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Collaboration among cells
Humoral
T helper, B cell & macrophage
B cell undergoes blastogenesis & differentiation under
the influence of various cytokines(intracellular adhesion molecules)
Cellular
T helper, Tcell precursor & macrophage
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Activation of T cells
1. TH&
TDTHpresentation of Ag with MHC class II
CD28 on the T cell binding to B7 on APC
2. TCTCR-CD8 & MHC Class II
release of interleukins3. TSAg appears to be capable of directly activating
TS cells
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Activation of B cells
1. Provided by the interactions between Ag and B cell Igreceptor
2. Contact between T helper cells & B cells mediated by
soluble materials released from T helper cells
3. Various interleukins (BCGF) also affect B cell
proliferation & maturation
Additional adhesion molecules important in cell
activation
CD28T cells
B7 (also BB1)B cells
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